hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03424

Confidence: Medium High

Genename	Protein Name	Links
SPAST	Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)	UniProt NCBI
CHMP1A	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	UniProt NCBI
CHMP4B	Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)	UniProt NCBI
IST1	IST1 homolog (hIST1) (Putative MAPK-activating protein PM28)	UniProt NCBI
CHMP1B	Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1186	1.62061692851e-07	0.6	CHMP4B CHMP1A CHMP1B	ESCRT-III complex
GO:0061640	4.02855487991e-07	1.0	IST1 CHMP4B CHMP1B SPAST CHMP1A	cytoskeleton-dependent cytokinesis
GO:0036258	3.33813219873e-06	0.8	CHMP4B CHMP1B CHMP1A IST1	multivesicular body assembly
GO:0036257	3.83246409504e-06	0.8	CHMP4B CHMP1B CHMP1A IST1	multivesicular body organization
GO:0000910	4.84634480447e-06	1.0	IST1 CHMP4B CHMP1B SPAST CHMP1A	cytokinesis
GO:0032506	6.37612051417e-06	0.8	CHMP4B CHMP1B SPAST CHMP1A	cytokinetic process
KEGG:04144	1.32635921507e-05	0.8	CHMP4B CHMP1B CHMP1A IST1	Endocytosis
GO:0051301	2.47128315338e-05	1.0	IST1 CHMP4B CHMP1B SPAST CHMP1A	cell division
GO:0000281	9.31770903001e-05	0.8	CHMP4B CHMP1B SPAST CHMP1A	mitotic cytokinesis
GO:0000815	0.000108905457596	0.6	CHMP4B CHMP1A CHMP1B	ESCRT III complex
GO:1904896	0.000108905457596	0.6	IST1 CHMP1A CHMP1B	ESCRT complex disassembly
GO:1904903	0.000108905457596	0.6	IST1 CHMP1A CHMP1B	ESCRT III complex disassembly
GO:0007032	0.000111444253056	0.8	CHMP4B CHMP1B CHMP1A IST1	endosome organization
GO:0010256	0.000271222069362	1.0	IST1 CHMP4B CHMP1B SPAST CHMP1A	endomembrane system organization
GO:0006997	0.000339213476695	0.8	CHMP4B CHMP1B SPAST CHMP1A	nucleus organization
GO:0007052	0.000438392708191	0.8	CHMP4B CHMP1B SPAST CHMP1A	mitotic spindle organization
KEGG:04217	0.00048888248268	0.6	CHMP4B CHMP1A CHMP1B	Necroptosis
GO:0061952	0.000616695699567	0.6	CHMP4B CHMP1A CHMP1B	midbody abscission
GO:1901673	0.000739960245213	0.6	CHMP4B CHMP1A CHMP1B	regulation of mitotic spindle assembly
GO:1902850	0.000962610785502	0.8	CHMP4B CHMP1B SPAST CHMP1A	microtubule cytoskeleton organization involved in mitosis
GO:0039702	0.00120569794977	0.6	CHMP4B CHMP1A CHMP1B	viral budding via host ESCRT complex
GO:0030496	0.00133388073681	0.8	CHMP4B CHMP1B SPAST IST1	midbody
GO:1902410	0.00139593056214	0.6	CHMP4B CHMP1A CHMP1B	mitotic cytokinetic process
GO:0090169	0.00183428165932	0.6	CHMP4B CHMP1A CHMP1B	regulation of spindle assembly
GO:0007051	0.00207968006832	0.8	CHMP4B CHMP1B SPAST CHMP1A	spindle organization
GO:0046755	0.00208420080219	0.6	CHMP4B CHMP1A CHMP1B	viral budding
GO:0036452	0.00208420080219	0.6	CHMP4B CHMP1A CHMP1B	ESCRT complex
GO:0060236	0.00541762673764	0.6	CHMP4B CHMP1A CHMP1B	regulation of mitotic spindle organization
GO:0010824	0.00541762673764	0.6	CHMP4B CHMP1A CHMP1B	regulation of centrosome duplication
GO:0090224	0.00703245670927	0.6	CHMP4B CHMP1A CHMP1B	regulation of spindle organization
GO:0019068	0.00826983957236	0.6	CHMP4B CHMP1A CHMP1B	virion assembly
GO:0007080	0.0119783897598	0.6	CHMP4B CHMP1A CHMP1B	mitotic metaphase plate congression
GO:0140014	0.0129837343661	0.8	CHMP4B CHMP1B SPAST CHMP1A	mitotic nuclear division
GO:0046605	0.0146610377831	0.6	CHMP4B CHMP1A CHMP1B	regulation of centrosome cycle
GO:0019058	0.0151765771023	0.8	CHMP4B CHMP1B CHMP1A IST1	viral life cycle
GO:0090307	0.0199719657189	0.6	CHMP4B CHMP1A CHMP1B	mitotic spindle assembly
GO:0051310	0.0237016209836	0.6	CHMP4B CHMP1A CHMP1B	metaphase plate congression
GO:0051298	0.0250406933376	0.6	CHMP4B CHMP1A CHMP1B	centrosome duplication
GO:0016050	0.0252719643298	0.8	CHMP4B CHMP1B CHMP1A IST1	vesicle organization
GO:0051303	0.0308999432136	0.6	CHMP4B CHMP1A CHMP1B	establishment of chromosome localization
GO:0050000	0.0324949337356	0.6	CHMP4B CHMP1A CHMP1B	chromosome localization
GO:0000280	0.0441192366731	0.8	CHMP4B CHMP1B SPAST CHMP1A	nuclear division
GO:0051656	0.0470565437665	0.8	CHMP4B CHMP1B SPAST CHMP1A	establishment of organelle localization
CORUM:6569	0.0499494897235	0.2	SPAST	SPG4-SPG33 complex
CORUM:6615	0.0499494897235	0.2	SPAST	SPG4-SPG12 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SPAST	IST1	0.833	0.78	hein_WMM bioplex (SPAST) bioplex_WMM hein (SPAST)
IST1	CHMP1B	0.051	0.299	hein_WMM Guru fraction
CHMP4B	CHMP1A	0.049	0.295	hein_WMM bioplex_WMM hein (CHMP4B)
IST1	CHMP1A	0.042	0.27	hein_WMM bioplex (IST1) bioplex_WMM
CHMP4B	IST1	0.038	0.264	hein_WMM bioplex (IST1) bioplex_WMM hein (CHMP4B)
SPAST	CHMP1A	0.008	0.028	hein_WMM hein (SPAST)
CHMP1B	CHMP1A	0.007	0.003	hein_WMM WMM_only
SPAST	CHMP1B	0.007	0.003	hein_WMM WMM_only
CHMP4B	SPAST	0.003	0.014	hein_WMM bioplex (SPAST) bioplex_WMM youn_WMM hein (CHMP4B,SPAST)
CHMP4B	CHMP1B	0.0	0.005	hein_WMM Guru youn_WMM hein (CHMP4B) fraction

Images

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Complex HuMAP2_03424 has an average edge precision of 0.196 which is ranked 6227 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SPAST	HuMAP2_00139 HuMAP2_01825 HuMAP2_03424 HuMAP2_03551 HuMAP2_03593 HuMAP2_04165 HuMAP2_05586
CHMP1A	HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528
CHMP4B	HuMAP2_00024 HuMAP2_00246 HuMAP2_01637 HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528
IST1	HuMAP2_00139 HuMAP2_03424 HuMAP2_04165
CHMP1B	HuMAP2_01607 HuMAP2_02591 HuMAP2_03056 HuMAP2_03424

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03424