hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03425
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | UniProt NCBI |
| IGF2BP3 | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | UniProt NCBI |
| YBX3 | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428359 | 2.00852924023e-05 | 0.666666666667 | IGF2BP1 IGF2BP3 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA |
| GO:0003730 | 0.00588722337212 | 1.0 | YBX3 IGF2BP1 IGF2BP3 | mRNA 3'-UTR binding |
| MIRNA:hsa-miR-5195-5p | 0.0059964998071 | 0.666666666667 | IGF2BP1 IGF2BP3 | hsa-miR-5195-5p |
| WP:WP3302 | 0.0285649389616 | 0.333333333333 | IGF2BP1 | eIF5A regulation in response to inhibition of the nuclear export system |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IGF2BP1 | IGF2BP3 | 0.993 | 0.918 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| YBX3 | IGF2BP3 | 0.583 | 0.664 | hein_WMM bioplex_WMM gupta_WMM fraction treiber_WMM |
| IGF2BP1 | YBX3 | 0.568 | 0.655 | youn (IGF2BP1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03425 has an average edge precision of 0.746 which is ranked 1185 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IGF2BP1 | HuMAP2_00556 HuMAP2_03425 HuMAP2_04560 HuMAP2_04632 HuMAP2_06751 |
| IGF2BP3 | HuMAP2_03425 HuMAP2_04560 HuMAP2_06751 |
| YBX3 | HuMAP2_01695 HuMAP2_02631 HuMAP2_03425 HuMAP2_03637 HuMAP2_05476 HuMAP2_06751 |