hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03427
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PMPCB | Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) | UniProt NCBI |
| ODAPH | Odontogenesis associated phosphoprotein | UniProt NCBI |
| SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | UniProt NCBI |
| SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) | UniProt NCBI |
| SUCLA2 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4236 | 2.35360703486e-08 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Disorders of the Krebs cycle |
| WP:WP78 | 4.56811629309e-07 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | TCA Cycle (aka Krebs or citric acid cycle) |
| GO:0004774 | 9.08185760231e-07 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | succinate-CoA ligase activity |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 3.60987410111e-06 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Citric acid cycle (TCA cycle) |
| KEGG:00640 | 5.15964451204e-06 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Propanoate metabolism |
| CORUM:394 | 6.70868171695e-06 | 0.4 | SUCLG1 SUCLA2 | Succinyl-CoA synthetase, ADP-forming |
| CORUM:393 | 6.70868171695e-06 | 0.4 | SUCLG2 SUCLG1 | Succinyl-CoA synthetase, GDP-forming |
| GO:0006104 | 1.81582264982e-05 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | succinyl-CoA metabolic process |
| REAC:R-HSA-71406 | 5.97963045475e-05 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:01200 | 0.000205667969449 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | Carbon metabolism |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016878 | 0.00208420080219 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | acid-thiol ligase activity |
| GO:0006099 | 0.00367721278555 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | tricarboxylic acid cycle |
| GO:0042709 | 0.00450823411379 | 0.4 | SUCLG2 SUCLA2 | succinate-CoA ligase complex |
| GO:0004775 | 0.00450823411379 | 0.4 | SUCLG1 SUCLA2 | succinate-CoA ligase (ADP-forming) activity |
| HP:0012120 | 0.00487153229182 | 0.4 | SUCLG1 SUCLA2 | Methylmalonic aciduria |
| GO:0016877 | 0.00541762673764 | 0.6 | SUCLA2 SUCLG2 SUCLG1 | ligase activity, forming carbon-sulfur bonds |
| HP:0001298 | 0.0151772229235 | 0.6 | SUCLA2 PMPCB SUCLG1 | Encephalopathy |
| HP:0003215 | 0.0308081945037 | 0.4 | SUCLG1 SUCLA2 | Dicarboxylic aciduria |
| HP:0001941 | 0.0347361605983 | 0.6 | SUCLA2 PMPCB SUCLG1 | Acidosis |
| HP:0004360 | 0.0450566918732 | 0.6 | SUCLA2 PMPCB SUCLG1 | Abnormality of acid-base homeostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUCLA2 | SUCLG1 | 0.988 | 0.901 | bioplex (SUCLA2,SUCLG1) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| SUCLG2 | SUCLG1 | 0.924 | 0.843 | bioplex (SUCLG1,SUCLG2) bioplex_WMM Guru fraction |
| ODAPH | PMPCB | 0.06 | 0.336 | bioplex (ODAPH) |
| PMPCB | SUCLG1 | 0.052 | 0.302 | bioplex (SUCLG1) bioplex_WMM Guru youn_WMM fraction |
| PMPCB | SUCLG2 | 0.019 | 0.184 | bioplex_WMM Guru fraction |
| SUCLA2 | PMPCB | 0.005 | 0.007 | bioplex (PMPCB,SUCLA2) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SUCLA2 | SUCLG2 | 0.004 | 0.012 | bioplex (SUCLA2,SUCLG2) bioplex_WMM Guru fraction |
Images
Click to enlarge
Complex HuMAP2_03427 has an average edge precision of 0.369 which is ranked 3652 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PMPCB | HuMAP2_01412 HuMAP2_03235 HuMAP2_03427 HuMAP2_05037 |
| ODAPH | HuMAP2_01412 HuMAP2_01497 HuMAP2_03427 HuMAP2_05037 |
| SUCLG2 | HuMAP2_02509 HuMAP2_03050 HuMAP2_03427 HuMAP2_03979 |
| SUCLG1 | HuMAP2_02703 HuMAP2_03050 HuMAP2_03427 |
| SUCLA2 | HuMAP2_00179 HuMAP2_03050 HuMAP2_03427 HuMAP2_04460 HuMAP2_05892 |