hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03428
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | UniProt NCBI |
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065678 | 3.17414367033e-12 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 1.9044862022e-11 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | Processing and activation of SUMO |
| REAC:R-HSA-3065676 | 1.35032606227e-08 | 0.75 | SUMO2 SAE1 UBA2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-2990846 | 3.19306292696e-06 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | SUMOylation |
| GO:0044388 | 3.6323771075e-06 | 0.75 | UBE2I SAE1 UBA2 | small protein activating enzyme binding |
| CORUM:5756 | 5.02777038712e-06 | 0.5 | SAE1 UBA2 | SUA1-UBA2 complex |
| CORUM:5755 | 1.50819606993e-05 | 0.5 | SAE1 UBA2 | SUMO1-SUA1-UBA2 complex |
| GO:0016925 | 2.10899871844e-05 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | protein sumoylation |
| KEGG:04120 | 9.56545898299e-05 | 0.75 | UBE2I SAE1 UBA2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-196791 | 0.000452175281072 | 0.5 | SUMO2 UBE2I | Vitamin D (calciferol) metabolism |
| REAC:R-HSA-3232118 | 0.00136571756437 | 0.5 | SUMO2 UBE2I | SUMOylation of transcription factors |
| REAC:R-HSA-4090294 | 0.00253927088831 | 0.5 | SUMO2 UBE2I | SUMOylation of intracellular receptors |
| GO:0019948 | 0.00270494046827 | 0.5 | SAE1 UBA2 | SUMO activating enzyme activity |
| REAC:R-HSA-4085377 | 0.00466369436644 | 0.5 | SUMO2 UBE2I | SUMOylation of SUMOylation proteins |
| GO:0018205 | 0.00665909549353 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | peptidyl-lysine modification |
| REAC:R-HSA-3899300 | 0.0078166615373 | 0.5 | SUMO2 UBE2I | SUMOylation of transcription cofactors |
| GO:0031510 | 0.00811409485621 | 0.5 | SAE1 UBA2 | SUMO activating enzyme complex |
| REAC:R-HSA-4615885 | 0.00862684444961 | 0.5 | SUMO2 UBE2I | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.00862684444961 | 0.5 | SUMO2 UBE2I | SUMOylation of RNA binding proteins |
| REAC:R-HSA-5696395 | 0.00904685478976 | 0.5 | SUMO2 UBE2I | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-597592 | 0.0094488419023 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | Post-translational protein modification |
| REAC:R-HSA-4551638 | 0.0207977326435 | 0.5 | SUMO2 UBE2I | SUMOylation of chromatin organization proteins |
| KEGG:03013 | 0.0229847574757 | 0.5 | SUMO2 UBE2I | RNA transport |
| REAC:R-HSA-3108214 | 0.0248339118539 | 0.5 | SUMO2 UBE2I | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-5696399 | 0.0347967852364 | 0.5 | SUMO2 UBE2I | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | UBE2I SUMO2 SAE1 UBA2 | Metabolism of proteins |
| REAC:R-HSA-5693607 | 0.0464213162589 | 0.5 | SUMO2 UBE2I | Processing of DNA double-strand break ends |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.988 | 0.901 | hein_WMM bioplex (UBA2) bioplex_WMM Guru youn_WMM hein (SAE1) gupta_WMM fraction |
| SAE1 | SUMO2 | 0.605 | 0.672 | hein_WMM bioplex_WMM youn_WMM hein (SAE1) gupta_WMM fraction |
| UBE2I | SUMO2 | 0.574 | 0.656 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| UBE2I | UBA2 | 0.533 | 0.638 | hein_WMM bioplex (UBA2,UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| UBE2I | SAE1 | 0.07 | 0.35 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| SUMO2 | UBA2 | 0.009 | 0.093 | hein_WMM bioplex (UBA2) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_03428 has an average edge precision of 0.552 which is ranked 2186 out of all 6965 complexes.
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