hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03440
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF19 | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | UniProt NCBI |
| CDC5L | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | UniProt NCBI |
| BCAS2 | Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27) | UniProt NCBI |
| PLRG1 | Pleiotropic regulator 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1182 | 6.80173643643e-13 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | CDC5L core complex |
| CORUM:1183 | 1.07698694734e-09 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | CDC5L complex |
| GO:0000974 | 1.74428263667e-08 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | Prp19 complex |
| GO:0005662 | 4.43999216606e-08 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | DNA replication factor A complex |
| KEGG:03040 | 2.052638918e-07 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | Spliceosome |
| GO:0043601 | 3.08603851103e-07 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | nuclear replisome |
| GO:0030894 | 4.28142101727e-07 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | replisome |
| GO:0071007 | 6.68560358851e-07 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | U2-type catalytic step 2 spliceosome |
| CORUM:351 | 6.95120006013e-07 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | Spliceosome |
| GO:0043596 | 2.47053849812e-06 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | nuclear replication fork |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | mRNA Splicing |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005657 | 1.55003541896e-05 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | replication fork |
| GO:0071013 | 4.48297714516e-05 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | catalytic step 2 spliceosome |
| CORUM:1181 | 5.11748339077e-05 | 0.75 | PLRG1 PRPF19 CDC5L | C complex spliceosome |
| GO:0005684 | 6.52012849586e-05 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | U2-type spliceosomal complex |
| GO:0032993 | 0.000342608092204 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | protein-DNA complex |
| GO:0005681 | 0.000657808747052 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | spliceosomal complex |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | Metabolism of RNA |
| HPA:035010_13 | 0.005495872704 | 0.75 | PLRG1 PRPF19 CDC5L | placenta; decidual cells[Supported,High] |
| HPA:007030_13 | 0.0066268155894 | 0.75 | PLRG1 PRPF19 CDC5L | cerebellum; cells in molecular layer[Supported,High] |
| HPA:040010_13 | 0.00705633972179 | 0.75 | PLRG1 PRPF19 CDC5L | seminal vesicle; glandular cells[Supported,High] |
| GO:0016607 | 0.00713971525321 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | nuclear speck |
| HPA:013020_13 | 0.00770136360784 | 0.75 | PLRG1 PRPF19 CDC5L | endometrium 1; glandular cells[Supported,High] |
| HPA:053010_13 | 0.00859673358264 | 0.75 | PLRG1 PRPF19 CDC5L | testis; Leydig cells[Supported,High] |
| GO:0000398 | 0.00944788787297 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00944788787297 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00981835447646 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | RNA splicing, via transesterification reactions |
| HPA:016010_13 | 0.0125874733426 | 0.75 | PLRG1 PRPF19 CDC5L | esophagus; squamous epithelial cells[Supported,High] |
| HPA:008030_13 | 0.0129586703655 | 0.75 | PLRG1 PRPF19 CDC5L | cerebral cortex; neuronal cells[Supported,High] |
| HPA:015010_13 | 0.0135289372622 | 0.75 | PLRG1 PRPF19 CDC5L | epididymis; glandular cells[Supported,High] |
| HPA:007030_03 | 0.01651997263 | 0.75 | PLRG1 PRPF19 CDC5L | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:055010_13 | 0.0170761600268 | 0.75 | PLRG1 PRPF19 CDC5L | thyroid gland; glandular cells[Supported,High] |
| HPA:035010_03 | 0.0186990413257 | 0.75 | PLRG1 PRPF19 CDC5L | placenta; decidual cells[Uncertain,High] |
| GO:0008380 | 0.0187431053955 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | RNA splicing |
| HPA:001040_13 | 0.0188187097484 | 0.75 | PLRG1 PRPF19 CDC5L | adrenal gland; glandular cells[Supported,High] |
| HPA:032010_13 | 0.0201686361907 | 0.75 | PLRG1 PRPF19 CDC5L | pancreas; exocrine glandular cells[Supported,High] |
| HPA:018010_13 | 0.0209312173501 | 0.75 | PLRG1 PRPF19 CDC5L | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | PLRG1 PRPF19 CDC5L | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0211895818928 | 0.75 | PLRG1 PRPF19 CDC5L | bronchus; respiratory epithelial cells[Supported,High] |
| GO:0006397 | 0.0251226492241 | 1.0 | PLRG1 PRPF19 BCAS2 CDC5L | mRNA processing |
| HPA:035020_13 | 0.025175887812 | 0.75 | PLRG1 PRPF19 CDC5L | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | PLRG1 PRPF19 CDC5L | caudate; glial cells[Supported,Medium] |
| HPA:013010_12 | 0.02561445023 | 0.75 | PLRG1 PRPF19 CDC5L | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:031020_12 | 0.0259096106078 | 0.75 | PLRG1 PRPF19 CDC5L | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:012010_13 | 0.0283521381117 | 0.75 | PLRG1 PRPF19 CDC5L | duodenum; glandular cells[Supported,High] |
| HPA:013020_03 | 0.0307757765426 | 0.75 | PLRG1 PRPF19 CDC5L | endometrium 1; glandular cells[Uncertain,High] |
| HPA:011030_12 | 0.0312763482879 | 0.75 | PLRG1 PRPF19 CDC5L | colon; peripheral nerve/ganglion[Supported,Medium] |
| HPA:026020_12 | 0.031444391961 | 0.75 | PLRG1 PRPF19 CDC5L | liver; hepatocytes[Supported,Medium] |
| HPA:040010_03 | 0.031444391961 | 0.75 | PLRG1 PRPF19 CDC5L | seminal vesicle; glandular cells[Uncertain,High] |
| HPA:046010_12 | 0.0316130305275 | 0.75 | PLRG1 PRPF19 CDC5L | smooth muscle; smooth muscle cells[Supported,Medium] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | PLRG1 PRPF19 CDC5L | gallbladder; glandular cells[Supported,High] |
| HPA:008020_12 | 0.0340369984952 | 0.75 | PLRG1 PRPF19 CDC5L | cerebral cortex; glial cells[Supported,Medium] |
| HPA:035010_12 | 0.0347513998463 | 0.75 | PLRG1 PRPF19 CDC5L | placenta; decidual cells[Supported,Medium] |
| HPA:007020_12 | 0.0365805245307 | 0.75 | PLRG1 PRPF19 CDC5L | cerebellum; cells in granular layer[Supported,Medium] |
| HPA:024010_12 | 0.038664676769 | 0.75 | PLRG1 PRPF19 CDC5L | kidney; cells in glomeruli[Supported,Medium] |
| HPA:027020_12 | 0.0418336999884 | 0.75 | PLRG1 PRPF19 CDC5L | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.0438987109299 | 0.75 | PLRG1 PRPF19 CDC5L | skeletal muscle; myocytes[Supported,Medium] |
| HPA:007030_12 | 0.0447431662559 | 0.75 | PLRG1 PRPF19 CDC5L | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:043020_12 | 0.0458137035926 | 0.75 | PLRG1 PRPF19 CDC5L | skin 1; fibroblasts[Supported,Medium] |
| HPA:032020_12 | 0.0460298167372 | 0.75 | PLRG1 PRPF19 CDC5L | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | PLRG1 PRPF19 CDC5L | skin 1; Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | PLRG1 PRPF19 CDC5L | caudate; neuronal cells[Supported,Medium] |
| HPA:002020_12 | 0.0469009879466 | 0.75 | PLRG1 PRPF19 CDC5L | appendix; lymphoid tissue[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLRG1 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L) bioplex (PLRG1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| PLRG1 | PRPF19 | 1.0 | 0.949 | hein_WMM youn (PRPF19) bioplex (PLRG1,PRPF19) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| BCAS2 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L) bioplex_WMM Guru youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
| PRPF19 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L,PRPF19) bioplex (PRPF19) bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM |
| BCAS2 | PLRG1 | 1.0 | 0.949 | hein_WMM bioplex (PLRG1) bioplex_WMM Guru youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
| BCAS2 | PRPF19 | 1.0 | 0.949 | hein_WMM youn (PRPF19) bioplex (PRPF19) bioplex_WMM youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
Images
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Complex HuMAP2_03440 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
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