hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03443
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) | UniProt NCBI |
| GBA | Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) | UniProt NCBI |
| AGXT | Serine--pyruvate aminotransferase (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44) | UniProt NCBI |
| ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | UniProt NCBI |
| CAT | Catalase (EC 1.11.1.6) | UniProt NCBI |
| GALE | UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) | UniProt NCBI |
| GPX4 | Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01100 | 1.82723672184e-06 | 1.0 | GALE AGXT GBA GPX4 CAT OXCT1 ALDH7A1 | Metabolic pathways |
| HP:0000007 | 0.000936799485409 | 1.0 | GALE AGXT GBA GPX4 CAT OXCT1 ALDH7A1 | Autosomal recessive inheritance |
| REAC:R-HSA-1430728 | 0.00415508232387 | 0.857142857143 | AGXT GPX4 GBA OXCT1 GALE ALDH7A1 | Metabolism |
| KEGG:00630 | 0.00428986512 | 0.285714285714 | CAT AGXT | Glyoxylate and dicarboxylate metabolism |
| KEGG:00380 | 0.00655764034054 | 0.285714285714 | CAT ALDH7A1 | Tryptophan metabolism |
| KEGG:00260 | 0.00729284489491 | 0.285714285714 | AGXT ALDH7A1 | Glycine, serine and threonine metabolism |
| KEGG:00280 | 0.0106200361328 | 0.285714285714 | OXCT1 ALDH7A1 | Valine, leucine and isoleucine degradation |
| HP:0001939 | 0.0107934419213 | 0.857142857143 | AGXT GBA OXCT1 GALE CAT ALDH7A1 | Abnormality of metabolism/homeostasis |
| HP:0002795 | 0.0115811451167 | 0.714285714286 | GPX4 ALDH7A1 OXCT1 AGXT GBA | Functional respiratory abnormality |
| WP:WP176 | 0.0137210105003 | 0.285714285714 | CAT GPX4 | Folate Metabolism |
| HP:0000005 | 0.0193235311829 | 1.0 | GALE AGXT GBA GPX4 CAT OXCT1 ALDH7A1 | Mode of inheritance |
| HP:0003110 | 0.0207026447632 | 0.571428571429 | GALE OXCT1 AGXT GBA | Abnormality of urine homeostasis |
| WP:WP15 | 0.0226063476649 | 0.285714285714 | CAT GPX4 | Selenium Micronutrient Network |
| KEGG:04146 | 0.027091781087 | 0.285714285714 | CAT AGXT | Peroxisome |
| HP:0000118 | 0.0317978942459 | 1.0 | GALE AGXT GBA GPX4 CAT OXCT1 ALDH7A1 | Phenotypic abnormality |
| HP:0000001 | 0.0321049061652 | 1.0 | GALE AGXT GBA GPX4 CAT OXCT1 ALDH7A1 | HP root |
| REAC:R-HSA-9033241 | 0.0464649349278 | 0.285714285714 | CAT AGXT | Peroxisomal protein import |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAT | GPX4 | 0.179 | 0.438 | bioplex_WMM fraction |
| CAT | AGXT | 0.166 | 0.423 | fraction |
| GALE | GPX4 | 0.124 | 0.395 | bioplex (GALE) bioplex_WMM Guru fraction |
| OXCT1 | GPX4 | 0.106 | 0.371 | fraction |
| GPX4 | GBA | 0.081 | 0.351 | bioplex_WMM fraction |
| CAT | ALDH7A1 | 0.061 | 0.334 | bioplex_WMM fraction treiber_WMM |
| CAT | OXCT1 | 0.06 | 0.336 | bioplex_WMM fraction treiber_WMM |
| AGXT | GPX4 | 0.06 | 0.335 | fraction |
| ALDH7A1 | GPX4 | 0.052 | 0.3 | bioplex_WMM fraction |
| GALE | ALDH7A1 | 0.0 | 0.008 | fraction |
| CAT | GALE | 0.0 | 0.012 | fraction |
| CAT | GBA | 0.0 | 0.012 | bioplex_WMM fraction |
| ALDH7A1 | GBA | 0.0 | 0.003 | bioplex_WMM fraction |
| ALDH7A1 | OXCT1 | 0.0 | 0.002 | bioplex_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_03443 has an average edge precision of 0.237 which is ranked 5583 out of all 6965 complexes.
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