hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03461
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDCD4 | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | UniProt NCBI |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | UniProt NCBI |
| HDGF | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | UniProt NCBI |
| YWHAH | 14-3-3 protein eta (Protein AS1) | UniProt NCBI |
| YWHAQ | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | UniProt NCBI |
| YWHAE | 14-3-3 protein epsilon (14-3-3E) | UniProt NCBI |
| YWHAG | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5615 | 6.14574034576e-12 | 0.714285714286 | YWHAQ IQGAP1 HDGF YWHAE PDCD4 | Emerin complex 52 |
| CORUM:5199 | 1.64999296982e-09 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Kinase maturation complex 1 |
| REAC:R-HSA-75035 | 2.03884182735e-09 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| REAC:R-HSA-111447 | 3.89107916309e-09 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-114452 | 7.7932067567e-08 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Activation of BH3-only proteins |
| REAC:R-HSA-109606 | 6.52796408062e-07 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-1445148 | 2.30170723977e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-5628897 | 4.46137289934e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | TP53 Regulates Metabolic Genes |
| KEGG:04114 | 4.54258153483e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Oocyte meiosis |
| WP:WP179 | 6.3872910282e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Cell Cycle |
| KEGG:04110 | 7.21558485144e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Cell cycle |
| WP:WP536 | 7.3230510088e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-5625740 | 8.21877381145e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | RHO GTPases activate PKNs |
| REAC:R-HSA-69473 | 8.58266296478e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | G2/M DNA damage checkpoint |
| WP:WP706 | 9.49788417783e-06 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 1.04264299585e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Myometrial Relaxation and Contraction Pathways |
| GO:1900739 | 1.07646157797e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| GO:1900740 | 1.07646157797e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| KEGG:05160 | 1.19447655628e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Hepatitis C |
| REAC:R-HSA-195258 | 1.26333656441e-05 | 0.714285714286 | YWHAG YWHAQ YWHAH YWHAE IQGAP1 | RHO GTPase Effectors |
| KEGG:04390 | 1.42094075825e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Hippo signaling pathway |
| GO:0001844 | 2.01980560179e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| GO:1901030 | 3.47762626669e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| KEGG:05203 | 4.37888853972e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Viral carcinogenesis |
| REAC:R-HSA-194315 | 6.56229556872e-05 | 0.714285714286 | YWHAG YWHAQ YWHAH YWHAE IQGAP1 | Signaling by Rho GTPases |
| GO:1901028 | 6.98341385223e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| REAC:R-HSA-69481 | 8.69344777459e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | G2/M Checkpoints |
| REAC:R-HSA-109581 | 9.11840957805e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Apoptosis |
| REAC:R-HSA-5357801 | 9.7846880833e-05 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Programmed Cell Death |
| GO:0051204 | 0.000115164588825 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | protein insertion into mitochondrial membrane |
| GO:0097345 | 0.00016496565098 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | mitochondrial outer membrane permeabilization |
| GO:1902110 | 0.00019518612601 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO:1902686 | 0.000229373391109 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | mitochondrial outer membrane permeabilization involved in programmed cell death |
| GO:0051205 | 0.000248057665948 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | protein insertion into membrane |
| GO:1902108 | 0.000248057665948 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO:0035794 | 0.000248057665948 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of mitochondrial membrane permeability |
| GO:1905710 | 0.000267858993773 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of membrane permeability |
| GO:1903749 | 0.000267858993773 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of establishment of protein localization to mitochondrion |
| KEGG:04151 | 0.000282169949161 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | PI3K-Akt signaling pathway |
| GO:0046902 | 0.000359116957816 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of mitochondrial membrane permeability |
| GO:1903747 | 0.000537283108697 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of establishment of protein localization to mitochondrion |
| GO:0090559 | 0.00057242223549 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of membrane permeability |
| REAC:R-HSA-69620 | 0.000755017672692 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Cell Cycle Checkpoints |
| MIRNA:hsa-miR-4464 | 0.00119483549938 | 0.428571428571 | PDCD4 YWHAE YWHAH | hsa-miR-4464 |
| MIRNA:hsa-miR-4748 | 0.00119483549938 | 0.428571428571 | PDCD4 YWHAE YWHAH | hsa-miR-4748 |
| REAC:R-HSA-3700989 | 0.00162185785521 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Transcriptional Regulation by TP53 |
| REAC:R-HSA-9614399 | 0.00173796966748 | 0.285714285714 | YWHAQ YWHAG | Regulation of localization of FOXO transcription factors |
| CORUM:0000000 | 0.00178557880024 | 1.0 | IQGAP1 YWHAE YWHAH YWHAQ HDGF PDCD4 YWHAG | CORUM root |
| GO:0008637 | 0.00225019801643 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | apoptotic mitochondrial changes |
| GO:1905477 | 0.00256621622647 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of protein localization to membrane |
| GO:0010822 | 0.00303783780058 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of mitochondrion organization |
| GO:2001235 | 0.00449957152016 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | positive regulation of apoptotic signaling pathway |
| GO:0007006 | 0.00467022701645 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | mitochondrial membrane organization |
| GO:0072655 | 0.00785622984216 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | establishment of protein localization to mitochondrion |
| GO:0070585 | 0.00837931834451 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | protein localization to mitochondrion |
| MIRNA:hsa-miR-30e-3p | 0.0100064693768 | 0.428571428571 | YWHAH YWHAE YWHAG | hsa-miR-30e-3p |
| GO:0010821 | 0.0117361179993 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of mitochondrion organization |
| GO:1905475 | 0.0120844889275 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | regulation of protein localization to membrane |
| REAC:R-HSA-199991 | 0.0122104245536 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Membrane Trafficking |
| MIRNA:hsa-miR-30a-3p | 0.0145420418846 | 0.428571428571 | YWHAH YWHAE YWHAG | hsa-miR-30a-3p |
| GO:0043065 | 0.0147437200207 | 0.714285714286 | YWHAG YWHAQ YWHAH YWHAE PDCD4 | positive regulation of apoptotic process |
| REAC:R-HSA-5653656 | 0.0150589916515 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Vesicle-mediated transport |
| MIRNA:hsa-miR-4311 | 0.0153209907279 | 0.428571428571 | YWHAQ HDGF YWHAH | hsa-miR-4311 |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | YWHAQ YWHAG YWHAE YWHAH | Cell Cycle |
| GO:0043068 | 0.0158606753809 | 0.714285714286 | YWHAG YWHAQ YWHAH YWHAE PDCD4 | positive regulation of programmed cell death |
| MIRNA:hsa-miR-195-5p | 0.0240411900324 | 0.571428571429 | YWHAQ YWHAH HDGF PDCD4 | hsa-miR-195-5p |
| GO:0010942 | 0.0240595300171 | 0.714285714286 | YWHAG YWHAQ YWHAH YWHAE PDCD4 | positive regulation of cell death |
| CORUM:6729 | 0.0249993571594 | 0.142857142857 | IQGAP1 | IQGAP1-CXCR2 complex |
| CORUM:6730 | 0.0249993571594 | 0.142857142857 | YWHAG | 14-3-3 gamma-CXCR2 complex, unstimulated |
| GO:0021762 | 0.0311716432999 | 0.428571428571 | YWHAQ YWHAE YWHAH | substantia nigra development |
| MIRNA:hsa-miR-15a-5p | 0.0372555642451 | 0.571428571429 | YWHAQ YWHAH HDGF PDCD4 | hsa-miR-15a-5p |
| GO:0048857 | 0.0389125948999 | 0.428571428571 | YWHAQ YWHAE YWHAH | neural nucleus development |
| MIRNA:hsa-miR-15b-5p | 0.0464525947268 | 0.571428571429 | YWHAQ YWHAH HDGF PDCD4 | hsa-miR-15b-5p |
| CORUM:1844 | 0.0499886427319 | 0.142857142857 | IQGAP1 | APC-IQGAP1 complex |
| CORUM:2145 | 0.0499886427319 | 0.142857142857 | YWHAE | HSF1-YWHAE complex |
| CORUM:5189 | 0.0499886427319 | 0.142857142857 | YWHAQ | YWHAQ-CALM1-CABIN1 complex |
| CORUM:6676 | 0.0499886427319 | 0.142857142857 | YWHAQ | WWTR1-YWHAQ complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| YWHAH | YWHAG | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAH | YWHAQ | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAG | YWHAE | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt (YWHAE) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAG | YWHAQ | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAH | YWHAE | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt (YWHAE) hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAQ | YWHAE | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt (YWHAE) gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAQ | IQGAP1 | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| IQGAP1 | YWHAE | 0.988 | 0.901 | boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PDCD4 | IQGAP1 | 0.988 | 0.901 | youn (PDCD4) youn_WMM fraction |
| PDCD4 | YWHAE | 0.988 | 0.901 | youn (PDCD4) gupta_WMM fraction |
| PDCD4 | YWHAQ | 0.988 | 0.901 | youn (PDCD4) youn_WMM gupta_WMM fraction |
| HDGF | YWHAE | 0.868 | 0.802 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| PDCD4 | HDGF | 0.197 | 0.45 | youn (PDCD4) youn_WMM gupta_WMM fraction |
| YWHAH | IQGAP1 | 0.061 | 0.339 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| IQGAP1 | HDGF | 0.038 | 0.263 | bioplex_WMM youn_WMM fraction |
| YWHAQ | HDGF | 0.034 | 0.259 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| YWHAG | HDGF | 0.008 | 0.032 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| YWHAG | IQGAP1 | 0.008 | 0.041 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| YWHAG | PDCD4 | 0.007 | 0.007 | youn_WMM gupta_WMM WMM_only |
| YWHAH | PDCD4 | 0.007 | 0.003 | youn (PDCD4) youn_WMM gupta_WMM |
| YWHAH | HDGF | 0.003 | 0.014 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_03461 has an average edge precision of 0.591 which is ranked 1983 out of all 6965 complexes.
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