hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03465
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | UniProt NCBI |
| BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | UniProt NCBI |
| BTBD10 | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | UniProt NCBI |
| KCTD20 | BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) | UniProt NCBI |
| BUB3 | Mitotic checkpoint protein BUB3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4240 | 2.44602530201e-07 | 0.6 | BUB3 BUB1 BUB1B | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| HP:0100650 | 5.24049381299e-07 | 0.6 | BUB3 BUB1 BUB1B | Vaginal neoplasm |
| HP:0001682 | 4.25489865349e-06 | 0.6 | BUB3 BUB1 BUB1B | Subvalvular aortic stenosis |
| HP:0011103 | 5.23627053194e-06 | 0.6 | BUB3 BUB1 BUB1B | Abnormal left ventricular outflow tract morphology |
| HP:0006721 | 6.3576876244e-06 | 0.6 | BUB3 BUB1 BUB1B | Acute lymphoblastic leukemia |
| CORUM:1851 | 6.70868171695e-06 | 0.4 | BUB3 BUB1 | BUB1-BUB3 complex |
| HP:0002859 | 1.06552534153e-05 | 0.6 | BUB3 BUB1 BUB1B | Rhabdomyosarcoma |
| HP:0012126 | 1.43910367231e-05 | 0.6 | BUB3 BUB1 BUB1B | Stomach cancer |
| HP:0009728 | 2.14866062081e-05 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of striated muscle |
| HP:0010880 | 2.42867577851e-05 | 0.6 | BUB3 BUB1 BUB1B | Increased nuchal translucency |
| HP:0002247 | 2.42867577851e-05 | 0.6 | BUB3 BUB1 BUB1B | Duodenal atresia |
| CORUM:190 | 4.0241279111e-05 | 0.4 | BUB3 BUB1B | Mitotic checkpoint complex (MCC) |
| HP:0002101 | 5.09288575021e-05 | 0.6 | BUB3 BUB1 BUB1B | Abnormal lung lobation |
| HP:0011100 | 6.1081767866e-05 | 0.6 | BUB3 BUB1 BUB1B | Intestinal atresia |
| HP:0002667 | 6.66279335018e-05 | 0.6 | BUB3 BUB1 BUB1B | Nephroblastoma |
| HP:0003003 | 7.24995537039e-05 | 0.6 | BUB3 BUB1 BUB1B | Colon cancer |
| HP:0011794 | 7.24995537039e-05 | 0.6 | BUB3 BUB1 BUB1B | Embryonal renal neoplasm |
| HP:0200008 | 0.00014151146773 | 0.6 | BUB3 BUB1 BUB1B | Intestinal polyposis |
| HP:0002898 | 0.000171700780036 | 0.6 | BUB3 BUB1 BUB1B | Embryonal neoplasm |
| HP:0002589 | 0.000194037496444 | 0.6 | BUB3 BUB1 BUB1B | Gastrointestinal atresia |
| HP:0005266 | 0.000194037496444 | 0.6 | BUB3 BUB1 BUB1B | Intestinal polyp |
| HP:0100273 | 0.000194037496444 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of the colon |
| HP:0007565 | 0.000218228311494 | 0.6 | BUB3 BUB1 BUB1B | Multiple cafe-au-lait spots |
| HP:0002246 | 0.000231041940505 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the duodenum |
| HP:0001360 | 0.000231041940505 | 0.6 | BUB3 BUB1 BUB1B | Holoprosencephaly |
| KEGG:04110 | 0.000240055495634 | 0.6 | BUB3 BUB1 BUB1B | Cell cycle |
| HP:0001659 | 0.000258151477707 | 0.6 | BUB3 BUB1 BUB1B | Aortic regurgitation |
| HP:0006753 | 0.000272465709143 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of the stomach |
| HP:0001680 | 0.000302658877703 | 0.6 | BUB3 BUB1 BUB1B | Coarctation of aorta |
| REAC:R-HSA-141424 | 0.000338412904811 | 0.6 | BUB3 BUB1 BUB1B | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.000338412904811 | 0.6 | BUB3 BUB1 BUB1B | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| HP:0002797 | 0.000351997622505 | 0.6 | BUB3 BUB1 BUB1B | Osteolysis |
| HP:0002863 | 0.000351997622505 | 0.6 | BUB3 BUB1 BUB1B | Myelodysplasia |
| HP:0100834 | 0.000406414519902 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of the large intestine |
| HP:0001541 | 0.000531468488208 | 0.6 | BUB3 BUB1 BUB1B | Ascites |
| REAC:R-HSA-69618 | 0.000534065976599 | 0.6 | BUB3 BUB1 BUB1B | Mitotic Spindle Checkpoint |
| HP:0000142 | 0.000578226462924 | 0.6 | BUB3 BUB1 BUB1B | Abnormal vagina morphology |
| HP:0003560 | 0.000653369933832 | 0.6 | BUB3 BUB1 BUB1B | Muscular dystrophy |
| REAC:R-HSA-2500257 | 0.000754665480287 | 0.6 | BUB3 BUB1 BUB1B | Resolution of Sister Chromatid Cohesion |
| HP:0001711 | 0.00079256546738 | 0.6 | BUB3 BUB1 BUB1B | Abnormal left ventricle morphology |
| HP:0002488 | 0.000822579716856 | 0.6 | BUB3 BUB1 BUB1B | Acute leukemia |
| HP:0000445 | 0.000853340168558 | 0.6 | BUB3 BUB1 BUB1B | Wide nose |
| HP:0030448 | 0.000853340168558 | 0.6 | BUB3 BUB1 BUB1B | Soft tissue sarcoma |
| HP:0009726 | 0.00101865238815 | 0.6 | BUB3 BUB1 BUB1B | Renal neoplasm |
| REAC:R-HSA-5663220 | 0.00102865345201 | 0.6 | BUB3 BUB1 BUB1B | RHO GTPases Activate Formins |
| HP:0000957 | 0.00112737333582 | 0.6 | BUB3 BUB1 BUB1B | Cafe-au-lait spot |
| HP:0000062 | 0.00116525680626 | 0.6 | BUB3 BUB1 BUB1B | Ambiguous genitalia |
| HP:0000003 | 0.00128396303463 | 0.6 | BUB3 BUB1 BUB1B | Multicystic kidney dysplasia |
| HP:0000325 | 0.00128396303463 | 0.6 | BUB3 BUB1 BUB1B | Triangular face |
| HP:0031652 | 0.00163917495247 | 0.6 | BUB3 BUB1 BUB1B | Abnormal aortic valve physiology |
| HP:0000457 | 0.00163917495247 | 0.6 | BUB3 BUB1 BUB1B | Depressed nasal ridge |
| HP:0010786 | 0.00168769249288 | 0.6 | BUB3 BUB1 BUB1B | Urinary tract neoplasm |
| HP:0100242 | 0.00178757045499 | 0.6 | BUB3 BUB1 BUB1B | Sarcoma |
| HP:0001305 | 0.00183894882664 | 0.6 | BUB3 BUB1 BUB1B | Dandy-Walker malformation |
| HP:0005445 | 0.00189129875245 | 0.6 | BUB3 BUB1 BUB1B | Widened posterior fossa |
| HP:0010787 | 0.00199894912552 | 0.6 | BUB3 BUB1 BUB1B | Genital neoplasm |
| HP:0002198 | 0.00228570439764 | 0.6 | BUB3 BUB1 BUB1B | Dilated fourth ventricle |
| HP:0010950 | 0.00228570439764 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the fourth ventricle |
| REAC:R-HSA-141430 | 0.00230284247734 | 0.4 | BUB3 BUB1B | Inactivation of APC/C via direct inhibition of the APC/C complex |
| REAC:R-HSA-141405 | 0.00230284247734 | 0.4 | BUB3 BUB1B | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| HP:0002350 | 0.00234614920866 | 0.6 | BUB3 BUB1 BUB1B | Cerebellar cyst |
| HP:0000932 | 0.00266433352331 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the posterior cranial fossa |
| HP:0001909 | 0.00266433352331 | 0.6 | BUB3 BUB1 BUB1B | Leukemia |
| REAC:R-HSA-2467813 | 0.00268268573517 | 0.6 | BUB3 BUB1 BUB1B | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.00304975168622 | 0.6 | BUB3 BUB1 BUB1B | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.00304975168622 | 0.6 | BUB3 BUB1 BUB1B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00309784557874 | 0.6 | BUB3 BUB1 BUB1B | Mitotic Metaphase and Anaphase |
| HP:0002693 | 0.00330690735156 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the skull base |
| GO:0071174 | 0.00367721278555 | 0.6 | BUB3 BUB1 BUB1B | mitotic spindle checkpoint |
| GO:0007094 | 0.00367721278555 | 0.6 | BUB3 BUB1 BUB1B | mitotic spindle assembly checkpoint |
| GO:0071173 | 0.00367721278555 | 0.6 | BUB3 BUB1 BUB1B | spindle assembly checkpoint |
| GO:0031577 | 0.00367721278555 | 0.6 | BUB3 BUB1 BUB1B | spindle checkpoint |
| REAC:R-HSA-179409 | 0.00371437175588 | 0.4 | BUB3 BUB1B | APC-Cdc20 mediated degradation of Nek2A |
| HP:0000340 | 0.00387225643734 | 0.6 | BUB3 BUB1 BUB1B | Sloping forehead |
| GO:0045841 | 0.00407078924856 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of mitotic metaphase/anaphase transition |
| HP:0010576 | 0.00413295524356 | 0.6 | BUB3 BUB1 BUB1B | Intracranial cystic lesion |
| HP:0030724 | 0.00413295524356 | 0.6 | BUB3 BUB1 BUB1B | Central nervous system cyst |
| GO:1902100 | 0.0044914523029 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of metaphase/anaphase transition of cell cycle |
| GO:0051754 | 0.00450823411379 | 0.4 | BUB1 BUB1B | meiotic sister chromatid cohesion, centromeric |
| GO:2000816 | 0.0049400991777 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of mitotic sister chromatid separation |
| HP:0007379 | 0.00518810524287 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of the genitourinary tract |
| GO:1905819 | 0.00541762673764 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of chromosome separation |
| GO:0033048 | 0.00646290954968 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of mitotic sister chromatid segregation |
| HP:0002250 | 0.00652760684787 | 0.6 | BUB3 BUB1 BUB1B | Abnormal large intestine morphology |
| HP:0001320 | 0.00652760684787 | 0.6 | BUB3 BUB1 BUB1B | Cerebellar vermis hypoplasia |
| HP:0001561 | 0.00714724895655 | 0.6 | BUB3 BUB1 BUB1B | Polyhydramnios |
| GO:0033046 | 0.00763446836913 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of sister chromatid segregation |
| HP:0002244 | 0.00767012019887 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the small intestine |
| GO:0051985 | 0.00826983957236 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of chromosome segregation |
| HP:0011119 | 0.00879065778809 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the nasal dorsum |
| HP:0006817 | 0.00938943928499 | 0.6 | BUB3 BUB1 BUB1B | Aplasia/Hypoplasia of the cerebellar vermis |
| HP:0000348 | 0.00938943928499 | 0.6 | BUB3 BUB1 BUB1B | High forehead |
| HP:0007378 | 0.0100146377786 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm of the gastrointestinal tract |
| HP:0007957 | 0.0100146377786 | 0.6 | BUB3 BUB1 BUB1B | Corneal opacity |
| REAC:R-HSA-69620 | 0.0103005771752 | 0.6 | BUB3 BUB1 BUB1B | Cell Cycle Checkpoints |
| HP:0000368 | 0.0111739705033 | 0.6 | BUB3 BUB1 BUB1B | Low-set, posteriorly rotated ears |
| HP:0000568 | 0.0118746757518 | 0.6 | BUB3 BUB1 BUB1B | Microphthalmia |
| GO:0030071 | 0.0119783897598 | 0.6 | BUB3 BUB1 BUB1B | regulation of mitotic metaphase/anaphase transition |
| HP:0001679 | 0.0124188738287 | 0.6 | BUB3 BUB1 BUB1B | Abnormal aortic morphology |
| HP:0002104 | 0.0124188738287 | 0.6 | BUB3 BUB1 BUB1B | Apnea |
| GO:0045839 | 0.0128326937391 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of mitotic nuclear division |
| GO:1902099 | 0.0128326937391 | 0.6 | BUB3 BUB1 BUB1B | regulation of metaphase/anaphase transition of cell cycle |
| REAC:R-HSA-195258 | 0.0128363146831 | 0.6 | BUB3 BUB1 BUB1B | RHO GTPase Effectors |
| HP:0000821 | 0.0131698060475 | 0.6 | BUB3 BUB1 BUB1B | Hypothyroidism |
| HP:0000107 | 0.0133621205771 | 0.6 | BUB3 BUB1 BUB1B | Renal cyst |
| GO:0007135 | 0.0135228859698 | 0.4 | BUB1 BUB1B | meiosis II |
| GO:0045144 | 0.0135228859698 | 0.4 | BUB1 BUB1B | meiotic sister chromatid segregation |
| GO:0061983 | 0.0135228859698 | 0.4 | BUB1 BUB1B | meiosis II cell cycle process |
| GO:0051177 | 0.0135228859698 | 0.4 | BUB1 BUB1B | meiotic sister chromatid cohesion |
| HP:0002334 | 0.0135562849022 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the cerebellar vermis |
| HP:0004377 | 0.01395019732 | 0.6 | BUB3 BUB1 BUB1B | Hematological neoplasm |
| HP:0002926 | 0.0145551542008 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of thyroid physiology |
| GO:0007091 | 0.0146610377831 | 0.6 | BUB3 BUB1 BUB1B | metaphase/anaphase transition of mitotic cell cycle |
| GO:0044784 | 0.0156368617465 | 0.6 | BUB3 BUB1 BUB1B | metaphase/anaphase transition of cell cycle |
| HP:0100887 | 0.0160336662282 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of globe size |
| GO:0051784 | 0.0166549756635 | 0.6 | BUB3 BUB1 BUB1B | negative regulation of nuclear division |
| GO:0010965 | 0.0166549756635 | 0.6 | BUB3 BUB1 BUB1B | regulation of mitotic sister chromatid separation |
| HP:0031653 | 0.016696561986 | 0.6 | BUB3 BUB1 BUB1B | Abnormal heart valve physiology |
| HP:0004209 | 0.0178412399264 | 0.6 | BUB3 BUB1 BUB1B | Clinodactyly of the 5th finger |
| HP:0009179 | 0.0183132582526 | 0.6 | BUB3 BUB1 BUB1B | Deviation of the 5th finger |
| GO:0051306 | 0.0188216371551 | 0.6 | BUB3 BUB1 BUB1B | mitotic sister chromatid separation |
| HP:0011792 | 0.0197787034757 | 0.6 | BUB3 BUB1 BUB1B | Neoplasm by histology |
| GO:1905818 | 0.0211681462149 | 0.6 | BUB3 BUB1 BUB1B | regulation of chromosome separation |
| WP:WP179 | 0.0219349325413 | 0.4 | BUB3 BUB1 | Cell Cycle |
| REAC:R-HSA-68886 | 0.0231915667986 | 0.6 | BUB3 BUB1 BUB1B | M Phase |
| HP:0040019 | 0.023494903838 | 0.6 | BUB3 BUB1 BUB1B | Finger clinodactyly |
| HP:0000501 | 0.023494903838 | 0.6 | BUB3 BUB1 BUB1B | Glaucoma |
| MIRNA:hsa-miR-340-5p | 0.0256415227246 | 0.6 | KCTD20 BUB1 BTBD10 | hsa-miR-340-5p |
| HP:0002438 | 0.0258119768497 | 0.6 | BUB3 BUB1 BUB1B | Cerebellar malformation |
| HP:0001560 | 0.0261117985092 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the amniotic fluid |
| HP:0007360 | 0.0261117985092 | 0.6 | BUB3 BUB1 BUB1B | Aplasia/Hypoplasia of the cerebellum |
| HP:0001631 | 0.0292374582023 | 0.6 | BUB3 BUB1 BUB1B | Atrial septal defect |
| HP:0011994 | 0.0295629530581 | 0.6 | BUB3 BUB1 BUB1B | Abnormal atrial septum morphology |
| GO:0033047 | 0.0308999432136 | 0.6 | BUB3 BUB1 BUB1B | regulation of mitotic sister chromatid segregation |
| HP:0005120 | 0.0326006997834 | 0.6 | BUB3 BUB1 BUB1B | Abnormal cardiac atrium morphology |
| REAC:R-HSA-174184 | 0.0332320424718 | 0.4 | BUB3 BUB1B | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| HP:0011218 | 0.0336572505221 | 0.6 | BUB3 BUB1 BUB1B | Abnormal shape of the frontal region |
| HP:0002007 | 0.0336572505221 | 0.6 | BUB3 BUB1 BUB1B | Frontal bossing |
| REAC:R-HSA-179419 | 0.0341769281663 | 0.4 | BUB3 BUB1B | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-194315 | 0.034259108007 | 0.6 | BUB3 BUB1 BUB1B | Signaling by Rho GTPases |
| REAC:R-HSA-176409 | 0.0361060371214 | 0.4 | BUB3 BUB1B | APC/C:Cdc20 mediated degradation of mitotic proteins |
| HP:0000820 | 0.0365846413997 | 0.6 | BUB3 BUB1 BUB1B | Abnormality of the thyroid gland |
| REAC:R-HSA-176814 | 0.0370902496619 | 0.4 | BUB3 BUB1B | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| HP:0002793 | 0.0384968933304 | 0.6 | BUB3 BUB1 BUB1B | Abnormal pattern of respiration |
| HP:0000358 | 0.0400733062151 | 0.6 | BUB3 BUB1 BUB1B | Posteriorly rotated ears |
| REAC:R-HSA-176408 | 0.0411580285567 | 0.4 | BUB3 BUB1B | Regulation of APC/C activators between G1/S and early anaphase |
| MIRNA:hsa-miR-885-5p | 0.0435496282017 | 0.4 | BUB3 BUB1 | hsa-miR-885-5p |
| HP:0004097 | 0.0472480670031 | 0.6 | BUB3 BUB1 BUB1B | Deviation of finger |
| REAC:R-HSA-174143 | 0.0476518941102 | 0.4 | BUB3 BUB1B | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 0.0476518941102 | 0.4 | BUB3 BUB1B | Regulation of mitotic cell cycle |
| HP:0004207 | 0.0485960101036 | 0.6 | BUB3 BUB1 BUB1B | Abnormal 5th finger morphology |
| GO:0033045 | 0.0493791608738 | 0.6 | BUB3 BUB1 BUB1B | regulation of sister chromatid segregation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BUB1B | BUB3 | 1.0 | 0.949 | hein_WMM bioplex (BUB3) bioplex_WMM youn_WMM hein (BUB1B,BUB3) gupta_WMM |
| BUB1 | BUB3 | 0.998 | 0.944 | hein_WMM bioplex (BUB1,BUB3) bioplex_WMM youn_WMM hein (BUB1,BUB3) |
| KCTD20 | BUB3 | 0.659 | 0.696 | bioplex (BUB3) bioplex_WMM |
| BUB1B | BUB1 | 0.179 | 0.438 | hein_WMM bioplex (BUB1) bioplex_WMM youn_WMM |
| BUB3 | BTBD10 | 0.05 | 0.295 | bioplex (BUB3) bioplex_WMM |
| KCTD20 | BTBD10 | 0.014 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| BUB1 | BTBD10 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| BUB1B | BTBD10 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| KCTD20 | BUB1 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| BUB1B | KCTD20 | 0.008 | 0.083 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03465 has an average edge precision of 0.382 which is ranked 3504 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BUB1B | HuMAP2_00635 HuMAP2_03465 HuMAP2_03762 HuMAP2_05264 |
| BUB1 | HuMAP2_03465 HuMAP2_03762 HuMAP2_05264 |
| BTBD10 | HuMAP2_03465 HuMAP2_03762 HuMAP2_03890 HuMAP2_05859 |
| KCTD20 | HuMAP2_00866 HuMAP2_03465 HuMAP2_03890 HuMAP2_05859 |
| BUB3 | HuMAP2_03465 HuMAP2_03762 HuMAP2_05264 HuMAP2_05859 |