hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03467
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMC1A | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | UniProt NCBI |
| SMC3 | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5241 | 1.67592346237e-06 | 1.0 | SMC1A SMC3 | SMC1-SMC3 complex |
| CORUM:64 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA2 complex |
| CORUM:164 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA1 complex |
| CORUM:165 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA1 complex |
| CORUM:6303 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | DDX11-RAD21-SMC1A-SMC3 complex |
| CORUM:166 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA2 complex |
| CORUM:63 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA1 complex |
| CORUM:163 | 1.00555407742e-05 | 1.0 | SMC1A SMC3 | Cohesin-SA2 complex |
| CORUM:1856 | 2.51388519356e-05 | 1.0 | SMC1A SMC3 | Sororin-cohesin complex |
| CORUM:5432 | 2.51388519356e-05 | 1.0 | SMC1A SMC3 | Sororin-cohesin complex |
| WP:WP4240 | 3.39049011863e-05 | 1.0 | SMC1A SMC3 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| REAC:R-HSA-2470946 | 7.54165558069e-05 | 1.0 | SMC1A SMC3 | Cohesin Loading onto Chromatin |
| REAC:R-HSA-2468052 | 9.21757904306e-05 | 1.0 | SMC1A SMC3 | Establishment of Sister Chromatid Cohesion |
| HP:0000667 | 0.00015027447046 | 1.0 | SMC1A SMC3 | Phthisis bulbi |
| REAC:R-HSA-68884 | 0.000152509035076 | 1.0 | SMC1A SMC3 | Mitotic Telophase/Cytokinesis |
| HP:0002580 | 0.000183668797228 | 1.0 | SMC1A SMC3 | Volvulus |
| CORUM:282 | 0.000201110815485 | 1.0 | SMC1A SMC3 | SNF2h-cohesin-NuRD complex |
| HP:0010300 | 0.000220402556674 | 1.0 | SMC1A SMC3 | Abnormally low-pitched voice |
| HP:0007665 | 0.000260475748797 | 1.0 | SMC1A SMC3 | Curly eyelashes |
| HP:0010034 | 0.000400731921226 | 1.0 | SMC1A SMC3 | Short 1st metacarpal |
| WP:WP3959 | 0.000553283277601 | 1.0 | SMC1A SMC3 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| HP:0010026 | 0.000701280862145 | 1.0 | SMC1A SMC3 | Aplasia/Hypoplasia of the 1st metacarpal |
| HP:0010009 | 0.000771408948359 | 1.0 | SMC1A SMC3 | Abnormality of the 1st metacarpal |
| HP:0009660 | 0.000771408948359 | 1.0 | SMC1A SMC3 | Short phalanx of the thumb |
| KEGG:04114 | 0.000827384972793 | 1.0 | SMC1A SMC3 | Oocyte meiosis |
| HP:0008850 | 0.000844876467251 | 1.0 | SMC1A SMC3 | Severe postnatal growth retardation |
| HP:0002557 | 0.00100182980306 | 1.0 | SMC1A SMC3 | Hypoplastic nipples |
| HP:0012165 | 0.00100182980306 | 1.0 | SMC1A SMC3 | Oligodactyly |
| KEGG:04110 | 0.00104170846513 | 1.0 | SMC1A SMC3 | Cell cycle |
| HP:0010880 | 0.00108531561999 | 1.0 | SMC1A SMC3 | Increased nuchal translucency |
| HP:0009658 | 0.00135580966681 | 1.0 | SMC1A SMC3 | Aplasia/Hypoplasia of the phalanges of the thumb |
| WP:WP2446 | 0.00139382676196 | 1.0 | SMC1A SMC3 | Retinoblastoma Gene in Cancer |
| HP:0009623 | 0.00155283619475 | 1.0 | SMC1A SMC3 | Proximal placement of thumb |
| HP:0000059 | 0.00155283619475 | 1.0 | SMC1A SMC3 | Hypoplastic labia majora |
| HP:0009603 | 0.00187342173173 | 1.0 | SMC1A SMC3 | Deviation of the thumb |
| HP:0012881 | 0.00198696244274 | 1.0 | SMC1A SMC3 | Abnormality of the labia majora |
| HP:0001956 | 0.00210384258643 | 1.0 | SMC1A SMC3 | Truncal obesity |
| HP:0006709 | 0.00247451961357 | 1.0 | SMC1A SMC3 | Aplasia/Hypoplasia of the nipples |
| WP:WP179 | 0.00248511748256 | 1.0 | SMC1A SMC3 | Cell Cycle |
| HP:0000413 | 0.00260475748797 | 1.0 | SMC1A SMC3 | Atresia of the external auditory canal |
| HP:0000498 | 0.00287525153479 | 1.0 | SMC1A SMC3 | Blepharitis |
| HP:0000066 | 0.00315910331233 | 1.0 | SMC1A SMC3 | Labial hypoplasia |
| HP:0012815 | 0.00345631282057 | 1.0 | SMC1A SMC3 | Hypoplastic female external genitalia |
| REAC:R-HSA-3108214 | 0.004164669804 | 1.0 | SMC1A SMC3 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1221632 | 0.00465068760809 | 1.0 | SMC1A SMC3 | Meiotic synapsis |
| HP:0000687 | 0.00552008221488 | 1.0 | SMC1A SMC3 | Widely spaced teeth |
| HP:0000294 | 0.00552008221488 | 1.0 | SMC1A SMC3 | Low anterior hairline |
| HP:0007598 | 0.00571376931014 | 1.0 | SMC1A SMC3 | Bilateral single transverse palmar creases |
| HP:0000372 | 0.00571376931014 | 1.0 | SMC1A SMC3 | Abnormality of the auditory canal |
| HP:0002974 | 0.00571376931014 | 1.0 | SMC1A SMC3 | Radioulnar synostosis |
| HP:0000965 | 0.00591079583808 | 1.0 | SMC1A SMC3 | Cutis marmorata |
| HP:0000058 | 0.00611116179869 | 1.0 | SMC1A SMC3 | Abnormality of the labia |
| HP:0009778 | 0.00631486719198 | 1.0 | SMC1A SMC3 | Short thumb |
| HP:0000776 | 0.00760722763793 | 1.0 | SMC1A SMC3 | Congenital diaphragmatic hernia |
| HP:0003042 | 0.00783430905996 | 1.0 | SMC1A SMC3 | Elbow dislocation |
| HP:0000722 | 0.00783430905996 | 1.0 | SMC1A SMC3 | Obsessive-compulsive behavior |
| HP:0002162 | 0.00829849020205 | 1.0 | SMC1A SMC3 | Low posterior hairline |
| HP:0030141 | 0.00829849020205 | 1.0 | SMC1A SMC3 | Abnormality of the posterior hairline |
| HP:0000527 | 0.0085355899221 | 1.0 | SMC1A SMC3 | Long eyelashes |
| HP:0200055 | 0.00877602907484 | 1.0 | SMC1A SMC3 | Small hand |
| HP:0012368 | 0.00901980766025 | 1.0 | SMC1A SMC3 | Flat face |
| GO:0030893 | 0.00946729163895 | 1.0 | SMC1A SMC3 | meiotic cohesin complex |
| HP:0002566 | 0.00951738312911 | 1.0 | SMC1A SMC3 | Intestinal malrotation |
| HP:0030310 | 0.00977118001255 | 1.0 | SMC1A SMC3 | Upper extremity joint dislocation |
| REAC:R-HSA-1500620 | 0.0107946230212 | 1.0 | SMC1A SMC3 | Meiosis |
| HP:0000775 | 0.0108197618731 | 1.0 | SMC1A SMC3 | Abnormality of the diaphragm |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | SMC1A SMC3 | Resolution of Sister Chromatid Cohesion |
| HP:0010049 | 0.012205626434 | 1.0 | SMC1A SMC3 | Short metacarpal |
| HP:0002714 | 0.012205626434 | 1.0 | SMC1A SMC3 | Downturned corners of mouth |
| HP:0000786 | 0.012205626434 | 1.0 | SMC1A SMC3 | Primary amenorrhea |
| HP:0000599 | 0.0130772183627 | 1.0 | SMC1A SMC3 | Abnormality of the frontal hairline |
| HP:0000574 | 0.0133744278709 | 1.0 | SMC1A SMC3 | Thick eyebrow |
| HP:0009601 | 0.0133744278709 | 1.0 | SMC1A SMC3 | Aplasia/Hypoplasia of the thumb |
| REAC:R-HSA-1474165 | 0.0134090636225 | 1.0 | SMC1A SMC3 | Reproduction |
| HP:0100238 | 0.0136749768118 | 1.0 | SMC1A SMC3 | Synostosis involving bones of the upper limbs |
| HP:0001385 | 0.0139788651854 | 1.0 | SMC1A SMC3 | Hip dysplasia |
| HP:0000319 | 0.0139788651854 | 1.0 | SMC1A SMC3 | Smooth philtrum |
| HP:0000453 | 0.0142860929917 | 1.0 | SMC1A SMC3 | Choanal atresia |
| HP:0000664 | 0.0142860929917 | 1.0 | SMC1A SMC3 | Synophrys |
| HP:0002983 | 0.0145966602306 | 1.0 | SMC1A SMC3 | Micromelia |
| HP:0002996 | 0.0145966602306 | 1.0 | SMC1A SMC3 | Limited elbow movement |
| HP:0005914 | 0.0149105669023 | 1.0 | SMC1A SMC3 | Aplasia/Hypoplasia involving the metacarpal bones |
| HP:0000003 | 0.0149105669023 | 1.0 | SMC1A SMC3 | Multicystic kidney dysplasia |
| HP:0001773 | 0.0155483985436 | 1.0 | SMC1A SMC3 | Short foot |
| HP:0002219 | 0.0158723235132 | 1.0 | SMC1A SMC3 | Facial hypertrichosis |
| HP:0000415 | 0.0158723235132 | 1.0 | SMC1A SMC3 | Abnormality of the choanae |
| HP:0002230 | 0.0161995879155 | 1.0 | SMC1A SMC3 | Generalized hirsutism |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | SMC1A SMC3 | Estrogen-dependent gene expression |
| HP:0000324 | 0.0175420398516 | 1.0 | SMC1A SMC3 | Facial asymmetry |
| HP:0001622 | 0.019295242007 | 1.0 | SMC1A SMC3 | Premature birth |
| HP:0002021 | 0.0203872364924 | 1.0 | SMC1A SMC3 | Pyloric stenosis |
| HP:0000482 | 0.0203872364924 | 1.0 | SMC1A SMC3 | Microcornea |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | SMC1A SMC3 | S Phase |
| HP:0004400 | 0.0215092858718 | 1.0 | SMC1A SMC3 | Abnormality of the pylorus |
| HP:0000055 | 0.0215092858718 | 1.0 | SMC1A SMC3 | Abnormality of female external genitalia |
| HP:0002553 | 0.0218899811969 | 1.0 | SMC1A SMC3 | Highly arched eyebrow |
| HP:0000954 | 0.0222740159548 | 1.0 | SMC1A SMC3 | Single transverse palmar crease |
| HP:0000141 | 0.0222740159548 | 1.0 | SMC1A SMC3 | Amenorrhea |
| HP:0000076 | 0.0226613901453 | 1.0 | SMC1A SMC3 | Vesicoureteral reflux |
| REAC:R-HSA-3108232 | 0.0229517718172 | 1.0 | SMC1A SMC3 | SUMO E3 ligases SUMOylate target proteins |
| HP:0002997 | 0.0234461568244 | 1.0 | SMC1A SMC3 | Abnormality of the ulna |
| REAC:R-HSA-2990846 | 0.0246461304377 | 1.0 | SMC1A SMC3 | SUMOylation |
| HP:0005916 | 0.0250557633746 | 1.0 | SMC1A SMC3 | Abnormal metacarpal morphology |
| HP:0009602 | 0.0267188008477 | 1.0 | SMC1A SMC3 | Abnormality of thumb phalanx |
| HP:0008897 | 0.0271429087977 | 1.0 | SMC1A SMC3 | Postnatal growth retardation |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | SMC1A SMC3 | Separation of Sister Chromatids |
| HP:0009774 | 0.0280011429956 | 1.0 | SMC1A SMC3 | Triangular shaped phalanges of the hand |
| HP:0025634 | 0.0288727349243 | 1.0 | SMC1A SMC3 | Abnormal ureter physiology |
| GO:0008278 | 0.029754345151 | 1.0 | SMC1A SMC3 | cohesin complex |
| HP:0001120 | 0.0302051685624 | 1.0 | SMC1A SMC3 | Abnormality of corneal size |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | SMC1A SMC3 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | SMC1A SMC3 | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | SMC1A SMC3 | Mitotic Metaphase and Anaphase |
| HP:0000684 | 0.0311101548178 | 1.0 | SMC1A SMC3 | Delayed eruption of teeth |
| HP:0009553 | 0.0329602005208 | 1.0 | SMC1A SMC3 | Abnormality of the hairline |
| HP:0010490 | 0.0334310605282 | 1.0 | SMC1A SMC3 | Abnormality of the palmar creases |
| HP:0100240 | 0.0339052599684 | 1.0 | SMC1A SMC3 | Synostosis of joints |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | SMC1A SMC3 | ESR-mediated signaling |
| HP:0004404 | 0.0348636771466 | 1.0 | SMC1A SMC3 | Abnormal nipple morphology |
| HP:0000717 | 0.0348636771466 | 1.0 | SMC1A SMC3 | Autism |
| HP:0001018 | 0.0353478948848 | 1.0 | SMC1A SMC3 | Abnormal palmar dermatoglyphics |
| HP:0100533 | 0.0383233293999 | 1.0 | SMC1A SMC3 | Inflammatory abnormality of the eye |
| HP:0000248 | 0.0383233293999 | 1.0 | SMC1A SMC3 | Brachycephaly |
| HP:0011361 | 0.0388309231668 | 1.0 | SMC1A SMC3 | Congenital abnormal hair pattern |
| HP:0001557 | 0.0388309231668 | 1.0 | SMC1A SMC3 | Prenatal movement abnormality |
| HP:0001387 | 0.0388309231668 | 1.0 | SMC1A SMC3 | Joint stiffness |
| HP:0000823 | 0.0408946925611 | 1.0 | SMC1A SMC3 | Delayed puberty |
| HP:0001007 | 0.0414189834913 | 1.0 | SMC1A SMC3 | Hirsutism |
| HP:0002818 | 0.0424775836499 | 1.0 | SMC1A SMC3 | Abnormality of the radius |
| HP:0000998 | 0.0430118928782 | 1.0 | SMC1A SMC3 | Hypertrichosis |
| HP:0000426 | 0.0430118928782 | 1.0 | SMC1A SMC3 | Prominent nasal bridge |
| HP:0001163 | 0.0430118928782 | 1.0 | SMC1A SMC3 | Abnormality of the metacarpal bones |
| HP:0000400 | 0.0440905296328 | 1.0 | SMC1A SMC3 | Macrotia |
| HP:0000130 | 0.0446348571592 | 1.0 | SMC1A SMC3 | Abnormality of the uterus |
| HP:0001770 | 0.0457335305099 | 1.0 | SMC1A SMC3 | Toe syndactyly |
| HP:0011338 | 0.0468455615913 | 1.0 | SMC1A SMC3 | Abnormality of mouth shape |
| HP:0010720 | 0.047406586281 | 1.0 | SMC1A SMC3 | Abnormal hair pattern |
| HP:0040072 | 0.0485386539584 | 1.0 | SMC1A SMC3 | Abnormality of forearm bone |
| HP:0000140 | 0.0496840793666 | 1.0 | SMC1A SMC3 | Abnormality of the menstrual cycle |
| HP:0002465 | 0.0496840793666 | 1.0 | SMC1A SMC3 | Poor speech |
| HP:0002973 | 0.0496840793666 | 1.0 | SMC1A SMC3 | Abnormality of the forearm |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | SMC1A SMC3 | Signaling by Nuclear Receptors |
| HP:0030820 | 0.0497341708567 | 0.5 | SMC3 | Hooded eyelid |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMC3 | SMC1A | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (SMC1A,SMC3) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_03467 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMC1A | HuMAP2_00301 HuMAP2_01398 HuMAP2_03467 HuMAP2_05244 HuMAP2_06979 |
| SMC3 | HuMAP2_00301 HuMAP2_01398 HuMAP2_03467 HuMAP2_05244 |