hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03473
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CBR1 | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | UniProt NCBI |
| UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein) | UniProt NCBI |
| CBL | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | UniProt NCBI |
| UBE2G1 | Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed] | UniProt NCBI |
| PPP5C | Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT) | UniProt NCBI |
| TP53I3 | Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) | UniProt NCBI |
| CBR3 | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Short chain dehydrogenase/reductase family 21C member 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00590 | 0.00973038726098 | 0.285714285714 | CBR3 CBR1 | Arachidonic acid metabolism |
| KEGG:00980 | 0.019730410569 | 0.285714285714 | CBR3 CBR1 | Metabolism of xenobiotics by cytochrome P450 |
| CORUM:2756 | 0.0499886427319 | 0.142857142857 | UBE2V2 | Ubiquitin ligase (UBE2N, UBE2V2) |
| CORUM:2956 | 0.0499886427319 | 0.142857142857 | CBL | PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated |
| CORUM:3175 | 0.0499886427319 | 0.142857142857 | CBL | CIN85-CBL complex |
| CORUM:5720 | 0.0499886427319 | 0.142857142857 | CBL | CIN85-CBL complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CBR3 | CBR1 | 0.997 | 0.935 | hein_WMM bioplex (CBR3) bioplex_WMM hein (CBR3) fraction |
| CBR3 | UBE2G1 | 0.091 | 0.354 | fraction |
| UBE2G1 | PPP5C | 0.056 | 0.315 | fraction |
| CBR1 | UBE2V2 | 0.041 | 0.271 | bioplex_WMM fraction |
| CBR3 | PPP5C | 0.028 | 0.232 | bioplex_WMM fraction |
| CBL | PPP5C | 0.028 | 0.231 | fraction |
| TP53I3 | PPP5C | 0.025 | 0.215 | fraction |
| CBR3 | UBE2V2 | 0.013 | 0.141 | bioplex_WMM fraction |
| PPP5C | UBE2V2 | 0.008 | 0.087 | bioplex_WMM fraction |
| CBR1 | CBL | 0.007 | 0.001 | gupta_WMM WMM_only |
| CBR3 | CBL | 0.007 | 0.0 | youn_WMM WMM_only |
| UBE2G1 | UBE2V2 | 0.006 | 0.004 | bioplex (UBE2G1) |
| CBR1 | PPP5C | 0.0 | 0.012 | bioplex_WMM fraction |
| UBE2G1 | TP53I3 | 0.0 | 0.001 | fraction |
| CBR3 | TP53I3 | 0.0 | 0.001 | fraction |
Images
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Complex HuMAP2_03473 has an average edge precision of 0.187 which is ranked 6352 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CBR1 | HuMAP2_00317 HuMAP2_03473 HuMAP2_04263 HuMAP2_06771 |
| UBE2V2 | HuMAP2_03473 HuMAP2_04263 HuMAP2_05809 HuMAP2_05915 |
| CBL | HuMAP2_01205 HuMAP2_03473 HuMAP2_04106 |
| UBE2G1 | HuMAP2_00079 HuMAP2_01205 HuMAP2_03473 HuMAP2_06892 |
| PPP5C | HuMAP2_01205 HuMAP2_03473 |
| TP53I3 | HuMAP2_00480 HuMAP2_01205 HuMAP2_03473 |
| CBR3 | HuMAP2_00009 HuMAP2_00079 HuMAP2_01205 HuMAP2_03473 HuMAP2_04263 HuMAP2_06771 HuMAP2_06892 |