hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03474
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | UniProt NCBI |
| PDCD4 | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | UniProt NCBI |
| YWHAQ | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | UniProt NCBI |
| YWHAE | 14-3-3 protein epsilon (14-3-3E) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5615 | 4.01529174297e-10 | 1.0 | PDCD4 IQGAP1 YWHAQ YWHAE | Emerin complex 52 |
| CORUM:5199 | 0.000602576435264 | 0.5 | YWHAE YWHAQ | Kinase maturation complex 1 |
| REAC:R-HSA-75035 | 0.000783559910601 | 0.5 | YWHAE YWHAQ | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| REAC:R-HSA-111447 | 0.00105460323216 | 0.5 | YWHAE YWHAQ | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-114452 | 0.00436320194063 | 0.5 | YWHAE YWHAQ | Activation of BH3-only proteins |
| REAC:R-HSA-195258 | 0.0064749029242 | 0.75 | IQGAP1 YWHAQ YWHAE | RHO GTPase Effectors |
| WP:WP179 | 0.0110921279178 | 0.5 | YWHAE YWHAQ | Cell Cycle |
| KEGG:04114 | 0.0112562119133 | 0.5 | YWHAE YWHAQ | Oocyte meiosis |
| WP:WP536 | 0.0118694610121 | 0.5 | YWHAE YWHAQ | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-109606 | 0.0122651619918 | 0.5 | YWHAE YWHAQ | Intrinsic Pathway for Apoptosis |
| WP:WP706 | 0.0135021805118 | 0.5 | YWHAE YWHAQ | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 0.0141412443784 | 0.5 | YWHAE YWHAQ | Myometrial Relaxation and Contraction Pathways |
| KEGG:04110 | 0.0141554312811 | 0.5 | YWHAE YWHAQ | Cell cycle |
| REAC:R-HSA-194315 | 0.0173883634433 | 0.75 | IQGAP1 YWHAQ YWHAE | Signaling by Rho GTPases |
| KEGG:05160 | 0.0181736572757 | 0.5 | YWHAE YWHAQ | Hepatitis C |
| KEGG:04390 | 0.0198080875546 | 0.5 | YWHAE YWHAQ | Hippo signaling pathway |
| REAC:R-HSA-1445148 | 0.0227713839361 | 0.5 | YWHAE YWHAQ | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| CORUM:6729 | 0.0249595281251 | 0.25 | IQGAP1 | IQGAP1-CXCR2 complex |
| REAC:R-HSA-5628897 | 0.0315540312145 | 0.5 | YWHAE YWHAQ | TP53 Regulates Metabolic Genes |
| KEGG:05205 | 0.03463652866 | 0.5 | IQGAP1 PDCD4 | Proteoglycans in cancer |
| KEGG:05203 | 0.03463652866 | 0.5 | YWHAE YWHAQ | Viral carcinogenesis |
| WP:WP3888 | 0.0393304030404 | 0.5 | IQGAP1 YWHAE | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-5625740 | 0.042667909674 | 0.5 | YWHAE YWHAQ | RHO GTPases activate PKNs |
| REAC:R-HSA-69473 | 0.0435915557177 | 0.5 | YWHAE YWHAQ | G2/M DNA damage checkpoint |
| CORUM:1844 | 0.0499140284799 | 0.25 | IQGAP1 | APC-IQGAP1 complex |
| CORUM:2145 | 0.0499140284799 | 0.25 | YWHAE | HSF1-YWHAE complex |
| CORUM:5189 | 0.0499140284799 | 0.25 | YWHAQ | YWHAQ-CALM1-CABIN1 complex |
| CORUM:6676 | 0.0499140284799 | 0.25 | YWHAQ | WWTR1-YWHAQ complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| YWHAQ | YWHAE | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt (YWHAE) gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAQ | IQGAP1 | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| IQGAP1 | YWHAE | 0.988 | 0.901 | boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PDCD4 | IQGAP1 | 0.988 | 0.901 | youn (PDCD4) youn_WMM fraction |
| PDCD4 | YWHAE | 0.988 | 0.901 | youn (PDCD4) gupta_WMM fraction |
| PDCD4 | YWHAQ | 0.988 | 0.901 | youn (PDCD4) youn_WMM gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_03474 has an average edge precision of 0.909 which is ranked 525 out of all 6965 complexes.
Related Complexes