hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03488
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6167 | 3.17414367033e-12 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Exocyst complex |
| CORUM:89 | 3.17414367033e-12 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Exocyst Sec6/8 complex |
| REAC:R-HSA-5620916 | 3.51513739035e-10 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | VxPx cargo-targeting to cilium |
| CORUM:6169 | 6.75231048499e-10 | 0.75 | EXOC7 EXOC6 EXOC5 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| REAC:R-HSA-264876 | 9.63670018313e-10 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Insulin processing |
| REAC:R-HSA-5620920 | 1.61758895931e-08 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Cargo trafficking to the periciliary membrane |
| REAC:R-HSA-1445148 | 7.38564283704e-08 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-2980736 | 7.84014393471e-08 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Peptide hormone metabolism |
| WP:WP4352 | 1.2395315779e-06 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Ciliary landscape |
| REAC:R-HSA-5617833 | 4.87252320159e-06 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Cilium Assembly |
| CORUM:6168 | 5.02777038712e-06 | 0.5 | EXOC5 EXOC6 | Exocyst EXOC5-EXOC6 subcomplex |
| REAC:R-HSA-1852241 | 2.24070737955e-05 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Organelle biogenesis and maintenance |
| GO:0000145 | 0.000103844122491 | 0.75 | EXOC8 EXOC6 EXOC5 | exocyst |
| REAC:R-HSA-199991 | 0.000426145417081 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000528360370521 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Vesicle-mediated transport |
| GO:0006893 | 0.00710332146687 | 0.75 | EXOC8 EXOC6 EXOC5 | Golgi to plasma membrane transport |
| GO:0099023 | 0.0100430829723 | 0.75 | EXOC8 EXOC6 EXOC5 | vesicle tethering complex |
| GO:0098876 | 0.0244411426287 | 0.75 | EXOC8 EXOC6 EXOC5 | vesicle-mediated transport to the plasma membrane |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | EXOC8 EXOC5 EXOC6 EXOC7 | Metabolism of proteins |
| GO:0006892 | 0.0469269676219 | 0.75 | EXOC8 EXOC6 EXOC5 | post-Golgi vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOC7 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6,EXOC7) Malo fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6,EXOC8) bioplex_WMM boldt (EXOC6,EXOC8) Malo fraction boldt_WMM |
| EXOC8 | EXOC7 | 1.0 | 0.949 | bioplex (EXOC8) bioplex_WMM boldt (EXOC8) Malo fraction boldt_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC5,EXOC6) Malo fraction boldt_WMM |
| EXOC5 | EXOC7 | 0.979 | 0.895 | bioplex_WMM boldt (EXOC5,EXOC7) Malo fraction boldt_WMM |
| EXOC8 | EXOC5 | 0.708 | 0.729 | bioplex (EXOC8) bioplex_WMM boldt (EXOC5,EXOC8) Malo fraction boldt_WMM |
Images
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Complex HuMAP2_03488 has an average edge precision of 0.903 which is ranked 537 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EXOC6 | HuMAP2_00862 HuMAP2_01433 HuMAP2_01602 HuMAP2_03022 HuMAP2_03488 |
| EXOC7 | HuMAP2_00862 HuMAP2_01433 HuMAP2_01602 HuMAP2_03022 HuMAP2_03488 |
| EXOC5 | HuMAP2_00862 HuMAP2_01602 HuMAP2_03022 HuMAP2_03488 |
| EXOC8 | HuMAP2_00862 HuMAP2_01602 HuMAP2_03022 HuMAP2_03488 |