hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03490
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC44A2 | Choline transporter-like protein 2 (Solute carrier family 44 member 2) | UniProt NCBI |
| PER2 | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | UniProt NCBI |
| FAM110B | Protein FAM110B | UniProt NCBI |
| ZNF618 | Zinc finger protein 618 | UniProt NCBI |
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | UniProt NCBI |
| RP2 | Protein XRP2 | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 1.21111857045e-05 | 0.428571428571 | CSNK1E PER2 CSNK1D | Circadian rhythm |
| WP:WP3298 | 1.51144776771e-05 | 0.428571428571 | CSNK1E PER2 CSNK1D | Melatonin metabolism and effects |
| HP:0031873 | 0.000346286800202 | 0.285714285714 | CSNK1D PER2 | Early chronotype |
| REAC:R-HSA-400253 | 0.000458587574342 | 0.428571428571 | CSNK1E PER2 CSNK1D | Circadian Clock |
| WP:WP3594 | 0.0022775454512 | 0.428571428571 | CSNK1E PER2 CSNK1D | Circadian rhythm related genes |
| HP:0006979 | 0.00414986351758 | 0.285714285714 | CSNK1D PER2 | Sleep-wake cycle disturbance |
| WP:WP4249 | 0.00702347294811 | 0.285714285714 | CSNK1E CSNK1D | Hedgehog Signaling Pathway |
| KEGG:04340 | 0.0093000092131 | 0.285714285714 | CSNK1E CSNK1D | Hedgehog signaling pathway |
| GO:1904956 | 0.00946729163895 | 0.285714285714 | CSNK1E CSNK1D | regulation of midbrain dopaminergic neuron differentiation |
| GO:1904958 | 0.00946729163895 | 0.285714285714 | CSNK1E CSNK1D | positive regulation of midbrain dopaminergic neuron differentiation |
| GO:1905424 | 0.00946729163895 | 0.285714285714 | CSNK1E CSNK1D | regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1905426 | 0.00946729163895 | 0.285714285714 | CSNK1E CSNK1D | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| REAC:R-HSA-5617833 | 0.0116992025039 | 0.428571428571 | CSNK1E RP2 CSNK1D | Cilium Assembly |
| WP:WP363 | 0.0117201590248 | 0.285714285714 | CSNK1E CSNK1D | Wnt Signaling Pathway |
| GO:1904340 | 0.0283955176165 | 0.285714285714 | CSNK1E CSNK1D | positive regulation of dopaminergic neuron differentiation |
| REAC:R-HSA-1852241 | 0.0359967876154 | 0.428571428571 | CSNK1E RP2 CSNK1D | Organelle biogenesis and maintenance |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK1E | CSNK1D | 0.975 | 0.887 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1D) |
| FAM110B | CSNK1D | 0.448 | 0.592 | bioplex (CSNK1D) bioplex_WMM |
| RP2 | SLC44A2 | 0.168 | 0.426 | bioplex (RP2) bioplex_WMM |
| CSNK1D | RP2 | 0.155 | 0.416 | bioplex (RP2) bioplex_WMM |
| PER2 | CSNK1E | 0.136 | 0.407 | bioplex (CSNK1E) bioplex_WMM |
| PER2 | CSNK1D | 0.092 | 0.356 | bioplex (CSNK1D) bioplex_WMM |
| FAM110B | CSNK1E | 0.089 | 0.356 | bioplex (CSNK1E) bioplex_WMM |
| ZNF618 | CSNK1E | 0.038 | 0.265 | bioplex (CSNK1E) bioplex_WMM |
| ZNF618 | CSNK1D | 0.028 | 0.231 | bioplex (CSNK1D) bioplex_WMM |
| CSNK1E | RP2 | 0.021 | 0.186 | bioplex (RP2) bioplex_WMM |
| FAM110B | PER2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| FAM110B | ZNF618 | 0.01 | 0.106 | bioplex_WMM WMM_only |
| ZNF618 | PER2 | 0.01 | 0.106 | bioplex_WMM WMM_only |
| CSNK1D | SLC44A2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CSNK1E | SLC44A2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03490 has an average edge precision of 0.303 which is ranked 4533 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC44A2 | HuMAP2_03490 HuMAP2_06740 |
| PER2 | HuMAP2_00180 HuMAP2_01754 HuMAP2_03490 |
| FAM110B | HuMAP2_00180 HuMAP2_01754 HuMAP2_03490 |
| ZNF618 | HuMAP2_00180 HuMAP2_00673 HuMAP2_00796 HuMAP2_03490 |
| CSNK1D | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |
| RP2 | HuMAP2_01576 HuMAP2_03490 HuMAP2_06740 |
| CSNK1E | HuMAP2_00180 HuMAP2_01354 HuMAP2_01754 HuMAP2_03029 HuMAP2_03490 HuMAP2_04369 |