hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03499
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ABRAXAS1 | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | UniProt NCBI |
| BABAM1 | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UniProt NCBI |
| ABRAXAS2 | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | UniProt NCBI |
| BRCC3 | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | UniProt NCBI |
| BABAM2 | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | UniProt NCBI |
| UIMC1 | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | UniProt NCBI |
| PYROXD2 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5689901 | 7.592971223e-13 | 0.75 | ABRAXAS2 UIMC1 BABAM1 ABRAXAS1 BABAM2 BRCC3 | Metalloprotease DUBs |
| GO:0070531 | 9.63047224659e-12 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | BRCA1-A complex |
| GO:0070536 | 5.47331906216e-11 | 0.75 | ABRAXAS2 UIMC1 BABAM1 ABRAXAS1 BABAM2 BRCC3 | protein K63-linked deubiquitination |
| KEGG:03440 | 2.88547426816e-10 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Homologous recombination |
| GO:0072425 | 5.89615868482e-10 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | signal transduction involved in G2 DNA damage checkpoint |
| GO:0070552 | 8.53661148134e-09 | 0.5 | BABAM2 ABRAXAS2 BABAM1 BRCC3 | BRISC complex |
| REAC:R-HSA-5693571 | 1.80866742192e-08 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 2.96973872106e-08 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 3.17543529708e-08 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | DNA Double Strand Break Response |
| GO:0031572 | 3.68980820905e-08 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | G2 DNA damage checkpoint |
| REAC:R-HSA-69473 | 8.79671668475e-08 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 1.03227550056e-07 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Processing of DNA double-strand break ends |
| REAC:R-HSA-5688426 | 1.4783553325e-07 | 0.75 | ABRAXAS2 UIMC1 BABAM1 ABRAXAS1 BABAM2 BRCC3 | Deubiquitination |
| REAC:R-HSA-5693567 | 4.55947799744e-07 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 5.72743727546e-07 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Homology Directed Repair |
| GO:0031593 | 6.98740534742e-07 | 0.625 | ABRAXAS1 UIMC1 ABRAXAS2 BABAM2 BRCC3 | polyubiquitin modification-dependent protein binding |
| REAC:R-HSA-5693532 | 1.47228520714e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 1.61294267391e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | G2/M Checkpoints |
| GO:0045739 | 2.70357819404e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | positive regulation of DNA repair |
| GO:0072401 | 5.10044212982e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | signal transduction involved in DNA integrity checkpoint |
| GO:0072422 | 5.10044212982e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | signal transduction involved in DNA damage checkpoint |
| GO:0072395 | 5.49185841861e-06 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | signal transduction involved in cell cycle checkpoint |
| GO:0006303 | 1.31457982206e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | double-strand break repair via nonhomologous end joining |
| GO:0010212 | 1.57602037409e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | response to ionizing radiation |
| GO:2001022 | 1.87742584898e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | positive regulation of response to DNA damage stimulus |
| GO:0000726 | 2.10272659881e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | non-recombinational repair |
| REAC:R-HSA-69620 | 2.43008641553e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Cell Cycle Checkpoints |
| GO:0016579 | 2.53904235984e-05 | 0.75 | ABRAXAS2 UIMC1 BABAM1 ABRAXAS1 BABAM2 BRCC3 | protein deubiquitination |
| GO:1902750 | 2.6180475908e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | negative regulation of cell cycle G2/M phase transition |
| GO:0070646 | 3.71842558349e-05 | 0.75 | ABRAXAS2 UIMC1 BABAM1 ABRAXAS1 BABAM2 BRCC3 | protein modification by small protein removal |
| REAC:R-HSA-597592 | 3.99090878717e-05 | 0.875 | BRCC3 UIMC1 BABAM1 ABRAXAS1 BABAM2 UBA2 ABRAXAS2 | Post-translational protein modification |
| REAC:R-HSA-73894 | 4.24460256581e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | DNA Repair |
| GO:0006282 | 5.51628812838e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | regulation of DNA repair |
| CORUM:2786 | 7.00904180673e-05 | 0.25 | ABRAXAS1 UIMC1 | BRCA1 A complex |
| GO:0042770 | 7.5426841969e-05 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | signal transduction in response to DNA damage |
| CORUM:5400 | 0.00011678598518 | 0.25 | BABAM2 BRCC3 | BRCC complex |
| GO:0000077 | 0.000118880242109 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | DNA damage checkpoint |
| GO:0140030 | 0.00013365695753 | 0.625 | ABRAXAS1 UIMC1 ABRAXAS2 BABAM2 BRCC3 | modification-dependent protein binding |
| GO:0031570 | 0.000186979517477 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | DNA integrity checkpoint |
| GO:0051054 | 0.00028313316466 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | positive regulation of DNA metabolic process |
| WP:WP4016 | 0.000384271844534 | 0.375 | ABRAXAS1 BRCC3 UIMC1 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-392499 | 0.000489491604102 | 0.875 | BRCC3 UIMC1 BABAM1 ABRAXAS1 BABAM2 UBA2 ABRAXAS2 | Metabolism of proteins |
| GO:0070647 | 0.000532319978735 | 0.875 | BRCC3 UIMC1 BABAM1 ABRAXAS1 BABAM2 UBA2 ABRAXAS2 | protein modification by small protein conjugation or removal |
| GO:2001020 | 0.000681860159317 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | regulation of response to DNA damage stimulus |
| GO:0000075 | 0.000847334457479 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | cell cycle checkpoint |
| GO:1902749 | 0.000917055976279 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | regulation of cell cycle G2/M phase transition |
| REAC:R-HSA-1640170 | 0.00108292913925 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | Cell Cycle |
| GO:1901988 | 0.00147220946451 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | negative regulation of cell cycle phase transition |
| GO:0006302 | 0.00221843806518 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | double-strand break repair |
| GO:0044839 | 0.00292428009786 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | cell cycle G2/M phase transition |
| GO:0051052 | 0.0044322007313 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | regulation of DNA metabolic process |
| GO:0009314 | 0.0050532976353 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | response to radiation |
| GO:0010948 | 0.00673460397389 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | negative regulation of cell cycle process |
| GO:1901987 | 0.0252432963787 | 0.625 | ABRAXAS1 UIMC1 BRCC3 BABAM1 BABAM2 | regulation of cell cycle phase transition |
| GO:0070537 | 0.0378589948753 | 0.25 | UIMC1 BRCC3 | histone H2A K63-linked deubiquitination |
| CORUM:7114 | 0.0497224828424 | 0.125 | ABRAXAS2 | ABRAXAS2-SHMT2 complex |
| CORUM:5756 | 0.0497224828424 | 0.125 | UBA2 | SUA1-UBA2 complex |
| CORUM:7113 | 0.0497224828424 | 0.125 | ABRAXAS2 | ABRAXAS2-SHMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BABAM1 | BABAM2 | 1.0 | 0.949 | hein_WMM bioplex (BABAM1) bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM |
| BABAM1 | ABRAXAS1 | 0.998 | 0.939 | bioplex (BABAM1) bioplex_WMM |
| BABAM1 | BRCC3 | 0.996 | 0.926 | hein_WMM bioplex (BABAM1) bioplex_WMM boldt youn_WMM boldt_WMM |
| BABAM1 | ABRAXAS2 | 0.976 | 0.892 | bioplex (BABAM1) bioplex_WMM boldt fraction boldt_WMM |
| BABAM1 | UIMC1 | 0.973 | 0.886 | bioplex (BABAM1) bioplex_WMM youn_WMM |
| ABRAXAS2 | BRCC3 | 0.681 | 0.708 | bioplex (ABRAXAS2) bioplex_WMM boldt gupta_WMM boldt_WMM |
| UBA2 | ABRAXAS2 | 0.037 | 0.264 | bioplex_WMM fraction |
| PYROXD2 | UBA2 | 0.023 | 0.21 | fraction |
| BRCC3 | BABAM2 | 0.016 | 0.165 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ABRAXAS1 | UIMC1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| BABAM2 | UIMC1 | 0.008 | 0.081 | bioplex_WMM youn_WMM WMM_only |
| ABRAXAS1 | BABAM2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| BRCC3 | UIMC1 | 0.008 | 0.027 | bioplex_WMM youn_WMM WMM_only |
| ABRAXAS1 | ABRAXAS2 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| ABRAXAS2 | UIMC1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| UBA2 | UIMC1 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| UBA2 | BABAM2 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| UBA2 | BRCC3 | 0.007 | 0.006 | youn_WMM WMM_only |
| BABAM1 | UBA2 | 0.006 | 0.006 | bioplex_WMM youn_WMM fraction |
| ABRAXAS1 | UBA2 | 0.005 | 0.009 | bioplex (ABRAXAS1) |
| ABRAXAS2 | BABAM2 | 0.003 | 0.012 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| ABRAXAS1 | BRCC3 | 0.0 | 0.01 | bioplex (ABRAXAS1) bioplex_WMM |
Images
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Complex HuMAP2_03499 has an average edge precision of 0.282 which is ranked 4850 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ABRAXAS1 | HuMAP2_02106 HuMAP2_03499 HuMAP2_04891 |
| BABAM1 | HuMAP2_02106 HuMAP2_03499 HuMAP2_04873 HuMAP2_04891 |
| UBA2 | HuMAP2_02320 HuMAP2_03004 HuMAP2_03428 HuMAP2_03499 HuMAP2_04667 HuMAP2_05199 HuMAP2_06870 |
| ABRAXAS2 | HuMAP2_03499 HuMAP2_04891 |
| BRCC3 | HuMAP2_03499 HuMAP2_04891 |
| BABAM2 | HuMAP2_03499 HuMAP2_04873 HuMAP2_04891 |
| UIMC1 | HuMAP2_03499 HuMAP2_04891 HuMAP2_06842 |
| PYROXD2 | HuMAP2_02320 HuMAP2_03499 |