hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03501
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | UniProt NCBI |
| NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit) | UniProt NCBI |
| NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2920 | 1.26199510107e-07 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Respiratory chain complex I (lambda subunit) mitochondrial |
| WP:WP4324 | 1.50887656874e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Mitochondrial complex I assembly model OXPHOS system |
| WP:WP623 | 1.68980520707e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Oxidative phosphorylation |
| CORUM:178 | 2.22651992831e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Respiratory chain complex I (holoenzyme), mitochondrial |
| HP:0002928 | 2.94418390245e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Decreased activity of the pyruvate dehydrogenase complex |
| HP:0007183 | 4.23820021441e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Focal T2 hyperintense basal ganglia lesion |
| HP:0012751 | 5.86462438633e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal basal ganglia MRI signal intensity |
| KEGG:00190 | 8.02679835688e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Oxidative phosphorylation |
| WP:WP111 | 8.35827186966e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Electron Transport Chain (OXPHOS system in mitochondria) |
| KEGG:05012 | 9.78855844223e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Parkinson disease |
| REAC:R-HSA-6799198 | 9.93609173322e-06 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Complex I biogenesis |
| KEGG:04723 | 1.12669164546e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Non-alcoholic fatty liver disease (NAFLD) |
| HP:0007020 | 1.73683106826e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Progressive spastic paraplegia |
| KEGG:05010 | 1.79503216233e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Alzheimer disease |
| HP:0008972 | 2.13631408567e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 2.24494022562e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal activity of mitochondrial respiratory chain |
| KEGG:05016 | 2.6860646392e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Huntington disease |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Nonalcoholic fatty liver disease |
| HP:0002490 | 3.69186415316e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Increased CSF lactate |
| HP:0030085 | 3.69186415316e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal CSF lactate level |
| HP:0002073 | 4.00818584703e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Progressive cerebellar ataxia |
| KEGG:04714 | 4.51020686166e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Thermogenesis |
| REAC:R-HSA-611105 | 6.02657683388e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Respiratory electron transport |
| HP:0025454 | 6.29170912782e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal CSF metabolite level |
| HP:0002415 | 7.95665699637e-05 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Leukodystrophy |
| HP:0000712 | 0.00010497618293 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Emotional lability |
| REAC:R-HSA-163200 | 0.000113954833063 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| CORUM:2904 | 0.000150966163965 | 0.666666666667 | NDUFA2 NDUFV2 | Respiratory chain complex I (intermediate VII/650kD), mitochondrial |
| HP:0001258 | 0.000154409386803 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Spastic paraplegia |
| HP:0003287 | 0.000162534978223 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of mitochondrial metabolism |
| CORUM:2905 | 0.000184505937338 | 0.666666666667 | NDUFA2 NDUFV2 | Respiratory chain complex I (intermediate), mitochondrial |
| CORUM:2948 | 0.000184505937338 | 0.666666666667 | NDUFV2 NDUFS1 | Respiratory chain complex I (incomplete intermediate), mitochondrial |
| HP:0010550 | 0.000265676982068 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Paraplegia |
| HP:0000580 | 0.000271452568635 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Pigmentary retinopathy |
| HP:0012103 | 0.000277311257167 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the mitochondrion |
| HP:0002151 | 0.000314241770407 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Increased serum lactate |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0002061 | 0.000397654774179 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Lower limb spasticity |
| HP:0000998 | 0.000405205181284 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Hypertrichosis |
| HP:0002134 | 0.000412850562063 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the basal ganglia |
| HP:0010551 | 0.000576947263642 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Paraplegia/paraparesis |
| HP:0011400 | 0.000586616770854 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal CNS myelination |
| GO:0003954 | 0.000766145507331 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | NADH dehydrogenase activity |
| GO:0008137 | 0.000766145507331 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 0.000766145507331 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | NADH dehydrogenase (quinone) activity |
| HP:0002104 | 0.000803358567253 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Apnea |
| HP:0000602 | 0.000852281881213 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Ophthalmoplegia |
| HP:0001639 | 0.00101088554291 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Hypertrophic cardiomyopathy |
| HP:0000597 | 0.00118803756318 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Ophthalmoparesis |
| GO:0005747 | 0.00120280122085 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial respiratory chain complex I |
| GO:0045271 | 0.00120280122085 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | respiratory chain complex I |
| GO:0030964 | 0.00120280122085 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | NADH dehydrogenase complex |
| GO:0006120 | 0.00128871559377 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial electron transport, NADH to ubiquinone |
| HP:0007703 | 0.00196894672818 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of retinal pigmentation |
| GO:0016655 | 0.00200709053011 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| HP:0010864 | 0.00207995314584 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Intellectual disability, severe |
| HP:0001941 | 0.00226611341913 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Acidosis |
| HP:0001629 | 0.00233868873949 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Ventricular septal defect |
| HP:0002793 | 0.00251402142032 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal pattern of respiration |
| HP:0010438 | 0.00251402142032 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal ventricular septum morphology |
| HP:0004360 | 0.0029472200921 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of acid-base homeostasis |
| GO:0032981 | 0.00326856055107 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial respiratory chain complex I assembly |
| GO:0010257 | 0.00326856055107 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | NADH dehydrogenase complex assembly |
| HP:0012748 | 0.00384043859485 | 0.666666666667 | NDUFV2 NDUFS1 | Focal T2 hyperintense brainstem lesion |
| HP:0008316 | 0.00410511241748 | 0.666666666667 | NDUFV2 NDUFS1 | Abnormal mitochondria in muscle tissue |
| HP:0001332 | 0.00435163677096 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Dystonia |
| GO:0098803 | 0.00455146375597 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | respiratory chain complex |
| HP:0010549 | 0.00461568495452 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Weakness due to upper motor neuron dysfunction |
| GO:0005746 | 0.00475834847216 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial respirasome |
| HP:0012747 | 0.00495195349433 | 0.666666666667 | NDUFV2 NDUFS1 | Abnormal brainstem MRI signal intensity |
| HP:0012447 | 0.00509281251216 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal myelination |
| HP:0011923 | 0.00525183643236 | 0.666666666667 | NDUFV2 NDUFS1 | Decreased activity of mitochondrial complex I |
| HP:0007704 | 0.00525183643236 | 0.666666666667 | NDUFV2 NDUFS1 | Paroxysmal involuntary eye movements |
| HP:0025116 | 0.00525183643236 | 0.666666666667 | NDUFV2 NDUFS1 | Fetal distress |
| GO:0070469 | 0.00564855215433 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | respirasome |
| HP:0002921 | 0.00586844410879 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the cerebrospinal fluid |
| HP:0000114 | 0.00587799905401 | 0.666666666667 | NDUFV2 NDUFS1 | Proximal tubulopathy |
| HP:0001638 | 0.00633153871247 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Cardiomyopathy |
| HP:0011017 | 0.0063791442667 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal cellular physiology |
| HP:0001260 | 0.00686838927801 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Dysarthria |
| HP:0025354 | 0.00686838927801 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal cellular phenotype |
| HP:0001713 | 0.00686838927801 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal cardiac ventricle morphology |
| HP:0004366 | 0.0068832170429 | 0.666666666667 | NDUFV2 NDUFS1 | Abnormality of glycolysis |
| HP:0003542 | 0.0068832170429 | 0.666666666667 | NDUFV2 NDUFS1 | Increased serum pyruvate |
| GO:0042775 | 0.00690911398953 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00718184217333 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | ATP synthesis coupled electron transport |
| HP:0001637 | 0.007329551761 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal myocardium morphology |
| HP:0001903 | 0.00825608287359 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Anemia |
| HP:0031466 | 0.00865921881594 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Impairment in personality functioning |
| HP:0001671 | 0.00895506774716 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal cardiac septum morphology |
| HP:0011013 | 0.00913104209388 | 0.666666666667 | NDUFV2 NDUFS1 | Abnormal circulating carbohydrate concentration |
| GO:0016651 | 0.00929437307021 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | oxidoreductase activity, acting on NAD(P)H |
| GO:1990204 | 0.00996606725847 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | oxidoreductase complex |
| HP:0011362 | 0.0100758259595 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal hair quantity |
| HP:0001877 | 0.0100758259595 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal erythrocyte morphology |
| HP:0000648 | 0.0101406917918 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Optic atrophy |
| KEGG:01100 | 0.0105851300972 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Metabolic pathways |
| GO:0033108 | 0.0106693663112 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 0.0110330947082 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | respiratory electron transport chain |
| HP:0009830 | 0.0113563554161 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Peripheral neuropathy |
| GO:0022900 | 0.011404996777 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | electron transport chain |
| HP:0003737 | 0.0116951722183 | 0.666666666667 | NDUFV2 NDUFS1 | Mitochondrial myopathy |
| HP:0001138 | 0.0116951722183 | 0.666666666667 | NDUFV2 NDUFS1 | Optic neuropathy |
| HP:0000508 | 0.0135130087077 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Ptosis |
| HP:0012795 | 0.0140715494797 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the optic disc |
| HP:0001347 | 0.0171883112328 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Hyperreflexia |
| HP:0000817 | 0.0172167410086 | 0.666666666667 | NDUFV2 NDUFS1 | Poor eye contact |
| HP:0003800 | 0.0183346678183 | 0.666666666667 | NDUFV2 NDUFS1 | Muscle abnormality related to mitochondrial dysfunction |
| GO:0098800 | 0.0218385980648 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | inner mitochondrial membrane protein complex |
| HP:0000587 | 0.0229000256292 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the optic nerve |
| GO:0006119 | 0.0248678516681 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | oxidative phosphorylation |
| HP:0001257 | 0.0255710895815 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Spasticity |
| HP:0000124 | 0.0292514239306 | 0.666666666667 | NDUFV2 NDUFS1 | Renal tubular dysfunction |
| HP:0000735 | 0.029972334664 | 0.666666666667 | NDUFV2 NDUFS1 | Impaired social interactions |
| HP:0000479 | 0.0301561740182 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal retinal morphology |
| HP:0000486 | 0.0336432066673 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Strabismus |
| HP:0000759 | 0.0348133037034 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal peripheral nervous system morphology |
| HP:0001251 | 0.0351100068041 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Ataxia |
| HP:0001508 | 0.036313677034 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Failure to thrive |
| HP:0000549 | 0.0372342633882 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal conjugate eye movement |
| HP:0010993 | 0.0409072271866 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of the cerebral subcortex |
| HP:0000639 | 0.04291596551 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Nystagmus |
| GO:0045333 | 0.0442598881134 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | cellular respiration |
| HP:0012547 | 0.0446392984448 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormal involuntary eye movements |
| HP:0001276 | 0.0448141259844 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Hypertonia |
| HP:0000543 | 0.0453293273008 | 0.666666666667 | NDUFV2 NDUFS1 | Optic disc pallor |
| HP:0011443 | 0.0493345167285 | 1.0 | NDUFA2 NDUFV2 NDUFS1 | Abnormality of coordination |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFA2 | NDUFS1 | 0.988 | 0.901 | hein_WMM bioplex_WMM youn_WMM fraction |
| NDUFS1 | NDUFV2 | 0.896 | 0.821 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFA2 | NDUFV2 | 0.774 | 0.752 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_03501 has an average edge precision of 0.825 which is ranked 858 out of all 6965 complexes.
Related Complexes