hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03506
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) | UniProt NCBI |
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | UniProt NCBI |
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | UniProt NCBI |
| ARL4C | ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK) | UniProt NCBI |
| FBXO33 | F-box only protein 33 | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:258 | 1.3523445861e-08 | 0.428571428571 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:251 | 1.3523445861e-08 | 0.428571428571 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:68 | 1.3523445861e-08 | 0.428571428571 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:261 | 3.38018031602e-08 | 0.428571428571 | XRCC2 RAD51B RAD51D | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| CORUM:262 | 1.007158685e-05 | 0.285714285714 | XRCC2 RAD51D | RAD51L3-XRCC2 complex |
| GO:0033063 | 1.27120391093e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| REAC:R-HSA-5693554 | 2.75125863862e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| CORUM:2228 | 3.02079974644e-05 | 0.285714285714 | XRCC2 RAD51D | BLM-RAD51L3-XRCC2 complex |
| KEGG:03440 | 3.26746785114e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Homologous recombination |
| REAC:R-HSA-5693568 | 5.24220725237e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 5.7652648919e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Resolution of D-Loop Structures |
| GO:0033061 | 6.35345863999e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | DNA recombinase mediator complex |
| REAC:R-HSA-5693616 | 8.90519417624e-05 | 0.428571428571 | XRCC2 RAD51B RAD51D | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 0.000112460791469 | 0.428571428571 | XRCC2 RAD51B RAD51D | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5685942 | 0.000458587574342 | 0.428571428571 | XRCC2 RAD51B RAD51D | HDR through Homologous Recombination (HRR) |
| GO:0000400 | 0.001775386605 | 0.428571428571 | XRCC2 RAD51B RAD51D | four-way junction DNA binding |
| REAC:R-HSA-5693567 | 0.00370699600406 | 0.428571428571 | XRCC2 RAD51B RAD51D | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00424354480889 | 0.428571428571 | XRCC2 RAD51B RAD51D | Homology Directed Repair |
| GO:0000217 | 0.00640641290662 | 0.428571428571 | XRCC2 RAD51B RAD51D | DNA secondary structure binding |
| REAC:R-HSA-5693532 | 0.00742733779262 | 0.428571428571 | XRCC2 RAD51B RAD51D | DNA Double-Strand Break Repair |
| CORUM:256 | 0.0499886427319 | 0.142857142857 | RAD51B | RAD51B-RAD51C complex |
| CORUM:260 | 0.0499886427319 | 0.142857142857 | RAD51B | RAD51B-RAD51C complex |
| CORUM:5683 | 0.0499886427319 | 0.142857142857 | XRCC2 | hRAD51C-hXRCC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC2 | RAD51D | 0.758 | 0.747 | bioplex (XRCC2) bioplex_WMM |
| ARL4C | XRCC2 | 0.116 | 0.387 | bioplex (ARL4C) bioplex_WMM |
| ARL4C | FBXO33 | 0.11 | 0.38 | bioplex (ARL4C) bioplex_WMM |
| ARL4C | GADD45A | 0.055 | 0.311 | bioplex (ARL4C) bioplex_WMM |
| XRCC2 | RAD51B | 0.045 | 0.284 | bioplex (XRCC2) bioplex_WMM |
| ARL4C | RGS12 | 0.021 | 0.187 | bioplex (ARL4C) bioplex_WMM |
| RAD51B | RAD51D | 0.01 | 0.134 | bioplex_WMM WMM_only |
| GADD45A | RGS12 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| GADD45A | FBXO33 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| XRCC2 | GADD45A | 0.008 | 0.085 | bioplex_WMM WMM_only |
| GADD45A | RAD51B | 0.008 | 0.082 | bioplex_WMM WMM_only |
| GADD45A | RAD51D | 0.008 | 0.06 | bioplex_WMM WMM_only |
| FBXO33 | RGS12 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| XRCC2 | RGS12 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| XRCC2 | FBXO33 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| RGS12 | RAD51B | 0.008 | 0.028 | bioplex_WMM WMM_only |
| FBXO33 | RAD51B | 0.008 | 0.028 | bioplex_WMM WMM_only |
| FBXO33 | RAD51D | 0.008 | 0.011 | bioplex_WMM WMM_only |
| RGS12 | RAD51D | 0.008 | 0.011 | bioplex_WMM WMM_only |
| ARL4C | RAD51B | 0.007 | 0.006 | bioplex (ARL4C) bioplex_WMM |
| ARL4C | RAD51D | 0.004 | 0.01 | bioplex (ARL4C) bioplex_WMM |
Images
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Complex HuMAP2_03506 has an average edge precision of 0.146 which is ranked 6731 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GADD45A | HuMAP2_00467 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 |
| RAD51B | HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 |
| RAD51D | HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 HuMAP2_03862 |
| ARL4C | HuMAP2_00467 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 |
| FBXO33 | HuMAP2_00467 HuMAP2_02675 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 |
| RGS12 | HuMAP2_00508 HuMAP2_01804 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 HuMAP2_04946 HuMAP2_05902 |
| XRCC2 | HuMAP2_00467 HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 HuMAP2_03862 |