hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03509
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS26C | Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) | UniProt NCBI |
| VIPAS39 | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | UniProt NCBI |
| COMMD10 | COMM domain-containing protein 10 | UniProt NCBI |
| VPS35L | VPS35 endosomal protein sorting factor-like (Esophageal cancer-associated protein) | UniProt NCBI |
| COMMD3 | COMM domain-containing protein 3 (Protein Bup) (Protein PIL) | UniProt NCBI |
| CCDC22 | Coiled-coil domain-containing protein 22 | UniProt NCBI |
| COMMD2 | COMM domain-containing protein 2 | UniProt NCBI |
| COMMD8 | COMM domain-containing protein 8 | UniProt NCBI |
| MTMR2 | Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | UniProt NCBI |
| COMMD7 | COMM domain-containing protein 7 | UniProt NCBI |
| DENND10 | Protein FAM45A | UniProt NCBI |
| COMMD9 | COMM domain-containing protein 9 | UniProt NCBI |
| COMMD4 | COMM domain-containing protein 4 | UniProt NCBI |
| VPS33B | Vacuolar protein sorting-associated protein 33B (hVPS33B) | UniProt NCBI |
| CCDC93 | Coiled-coil domain-containing protein 93 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6645 | 2.87828632499e-28 | 0.666666666667 | COMMD3 VPS35L COMMD8 COMMD7 COMMD2 COMMD10 CCDC22 COMMD9 CCDC93 COMMD4 | CCC complex |
| CORUM:6639 | 3.02035462989e-27 | 0.666666666667 | COMMD3 VPS35L COMMD8 COMMD7 COMMD2 COMMD10 CCDC22 COMMD9 CCDC93 COMMD4 | CCC-Wash (WASH1, FAM21C) complex |
| REAC:R-HSA-8951664 | 3.39676785622e-09 | 0.533333333333 | COMMD3 COMMD7 COMMD8 COMMD2 COMMD10 CCDC22 COMMD9 COMMD4 | Neddylation |
| CORUM:7132 | 4.09133189015e-08 | 0.2 | VPS35L CCDC93 CCDC22 | CCDC22-CCDC93-C16orf62 complex |
| CORUM:7131 | 1.63554364889e-07 | 0.2 | VPS35L CCDC93 CCDC22 | COMMD1-CCDC22-CCDC93-C16orf62 complex |
| CORUM:7135 | 4.08638781573e-07 | 0.2 | VPS35L CCDC93 CCDC22 | CCDC22-CCDC93-C16orf62-FAM21-WASH1 complex |
| CORUM:6390 | 4.68677803909e-05 | 0.133333333333 | VPS33B VIPAS39 | Endosomal targeting complex (VIPAS39-VPS33B) |
| CORUM:7134 | 0.000140521514535 | 0.133333333333 | VPS35L CCDC93 | COMMD1-CCDC93-C16orf62 complex |
| CORUM:6658 | 0.000140521514535 | 0.133333333333 | CCDC22 COMMD8 | CCDC22-COMMD8-CUL1 complex |
| CORUM:6659 | 0.000140521514535 | 0.133333333333 | CCDC22 COMMD8 | Ubiquitin E3 ligase (CCDC22, COMMD8, CUL3) |
| CORUM:0000000 | 0.000234925829667 | 0.8 | CCDC22 COMMD3 COMMD2 VPS35L COMMD8 COMMD7 VIPAS39 COMMD10 COMMD9 VPS33B CCDC93 COMMD4 | CORUM root |
| GO:1990126 | 0.00041604535388 | 0.266666666667 | VPS35L CCDC93 VPS26C CCDC22 | retrograde transport, endosome to plasma membrane |
| REAC:R-HSA-597592 | 0.00257009388199 | 0.533333333333 | COMMD3 COMMD7 COMMD8 COMMD2 COMMD10 CCDC22 COMMD9 COMMD4 | Post-translational protein modification |
| GO:0032456 | 0.00297916318359 | 0.266666666667 | VPS35L CCDC93 VPS26C CCDC22 | endocytic recycling |
| HP:0200084 | 0.004502988404 | 0.133333333333 | VPS33B VIPAS39 | Giant cell hepatitis |
| HP:0009806 | 0.004502988404 | 0.133333333333 | VPS33B VIPAS39 | Nephrogenic diabetes insipidus |
| GO:0016192 | 0.0130698235791 | 0.666666666667 | CCDC22 COMMD3 VPS35L DENND10 VPS26C VIPAS39 VPS33B COMMD9 CCDC93 MTMR2 | vesicle-mediated transport |
| HP:0001884 | 0.0157329610297 | 0.133333333333 | VPS33B VIPAS39 | Talipes calcaneovalgus |
| REAC:R-HSA-392499 | 0.036581544761 | 0.533333333333 | COMMD3 COMMD7 COMMD8 COMMD2 COMMD10 CCDC22 COMMD9 COMMD4 | Metabolism of proteins |
| GO:0098876 | 0.0388089410914 | 0.266666666667 | VPS35L CCDC93 VPS26C CCDC22 | vesicle-mediated transport to the plasma membrane |
| HP:0002611 | 0.0411095510007 | 0.133333333333 | VPS33B VIPAS39 | Cholestatic liver disease |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COMMD3 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM youn_WMM hein (CCDC93) gupta_WMM fraction |
| COMMD3 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD3) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| CCDC22 | COMMD2 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD2) bioplex_WMM Guru youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD2 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (COMMD2) bioplex_WMM Guru youn_WMM hein (CCDC93) gupta_WMM fraction |
| CCDC22 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22) bioplex_WMM Guru youn_WMM hein (CCDC22,CCDC93) gupta_WMM fraction |
| COMMD4 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD4) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| DENND10 | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3,DENND10) bioplex_WMM |
| VPS35L | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD10 | CCDC22 | 0.999 | 0.949 | hein_WMM bioplex (CCDC22,COMMD10) bioplex_WMM Guru hein (CCDC22) fraction |
| COMMD4 | COMMD3 | 0.999 | 0.948 | hein_WMM bioplex (COMMD3,COMMD4) bioplex_WMM youn_WMM gupta_WMM |
| COMMD10 | CCDC93 | 0.998 | 0.939 | hein_WMM bioplex (COMMD10) bioplex_WMM Guru hein (CCDC93) fraction |
| COMMD3 | COMMD2 | 0.997 | 0.932 | hein_WMM bioplex (COMMD2,COMMD3) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD7 | CCDC22 | 0.988 | 0.902 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| COMMD4 | COMMD7 | 0.987 | 0.901 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD10 | COMMD4 | 0.987 | 0.901 | hein_WMM bioplex (COMMD10,COMMD4) bioplex_WMM fraction |
| COMMD4 | COMMD2 | 0.986 | 0.9 | hein_WMM bioplex (COMMD2,COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD4 | COMMD9 | 0.983 | 0.899 | hein_WMM bioplex (COMMD4) bioplex_WMM |
| DENND10 | COMMD4 | 0.982 | 0.898 | hein_WMM bioplex (COMMD4,DENND10) bioplex_WMM fraction |
| VPS26C | CCDC93 | 0.968 | 0.88 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD10 | COMMD3 | 0.939 | 0.851 | hein_WMM bioplex (COMMD10,COMMD3) bioplex_WMM fraction |
| DENND10 | CCDC93 | 0.921 | 0.844 | hein_WMM bioplex (DENND10) bioplex_WMM hein (CCDC93) fraction |
| COMMD8 | CCDC22 | 0.911 | 0.834 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD9 | COMMD3 | 0.903 | 0.827 | hein_WMM bioplex (COMMD3) bioplex_WMM fraction |
| COMMD9 | CCDC22 | 0.901 | 0.826 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| CCDC22 | MTMR2 | 0.893 | 0.819 | bioplex (CCDC22) bioplex_WMM |
| VPS26C | COMMD3 | 0.889 | 0.818 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD8 | COMMD3 | 0.855 | 0.793 | hein_WMM bioplex (COMMD3,COMMD8) bioplex_WMM youn_WMM gupta_WMM |
| COMMD7 | COMMD3 | 0.817 | 0.773 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| CCDC22 | VIPAS39 | 0.775 | 0.752 | bioplex (CCDC22) bioplex_WMM youn_WMM gupta_WMM |
| VPS26C | CCDC22 | 0.75 | 0.743 | hein_WMM bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD4 | 0.713 | 0.728 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD7 | COMMD2 | 0.673 | 0.706 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| COMMD8 | VPS35L | 0.641 | 0.688 | hein_WMM bioplex (COMMD8) bioplex_WMM fraction |
| CCDC22 | VPS33B | 0.638 | 0.686 | bioplex (CCDC22) bioplex_WMM youn_WMM gupta_WMM |
| COMMD10 | COMMD7 | 0.631 | 0.681 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| COMMD7 | CCDC93 | 0.623 | 0.678 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD8 | COMMD9 | 0.62 | 0.676 | hein_WMM bioplex (COMMD8) bioplex_WMM |
| COMMD10 | COMMD9 | 0.608 | 0.674 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| COMMD8 | COMMD10 | 0.605 | 0.672 | hein_WMM bioplex (COMMD10,COMMD8) bioplex_WMM |
| DENND10 | CCDC22 | 0.515 | 0.632 | hein_WMM bioplex (CCDC22,DENND10) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD2 | 0.508 | 0.628 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| DENND10 | COMMD7 | 0.479 | 0.612 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| DENND10 | COMMD9 | 0.443 | 0.586 | hein_WMM bioplex (DENND10) bioplex_WMM |
| COMMD9 | COMMD2 | 0.415 | 0.571 | hein_WMM bioplex (COMMD2) bioplex_WMM |
| COMMD8 | COMMD4 | 0.381 | 0.549 | hein_WMM bioplex (COMMD4,COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD8 | VPS26C | 0.349 | 0.536 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD10 | COMMD2 | 0.348 | 0.536 | hein_WMM bioplex (COMMD10,COMMD2) bioplex_WMM Guru fraction |
| COMMD9 | CCDC93 | 0.322 | 0.512 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD8 | COMMD7 | 0.293 | 0.493 | hein_WMM bioplex (COMMD8) bioplex_WMM fraction |
| COMMD8 | COMMD2 | 0.235 | 0.469 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD10 | VPS35L | 0.153 | 0.411 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| DENND10 | COMMD10 | 0.125 | 0.399 | hein_WMM bioplex (COMMD10,DENND10) bioplex_WMM fraction |
| DENND10 | VPS26C | 0.113 | 0.38 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| DENND10 | COMMD8 | 0.096 | 0.358 | hein_WMM bioplex (COMMD8,DENND10) bioplex_WMM fraction |
| DENND10 | COMMD2 | 0.079 | 0.352 | hein_WMM bioplex (COMMD2,DENND10) bioplex_WMM fraction |
| VPS35L | CCDC93 | 0.079 | 0.353 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| VPS35L | COMMD7 | 0.072 | 0.353 | hein_WMM bioplex_WMM fraction |
| COMMD8 | CCDC93 | 0.059 | 0.328 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM hein (CCDC93) gupta_WMM fraction |
| VPS35L | COMMD9 | 0.057 | 0.324 | hein_WMM bioplex_WMM WMM_only |
| DENND10 | VPS35L | 0.054 | 0.303 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD7 | COMMD9 | 0.047 | 0.293 | hein_WMM bioplex_WMM WMM_only |
| COMMD4 | CCDC93 | 0.043 | 0.268 | hein_WMM bioplex (COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| VPS26C | COMMD9 | 0.034 | 0.261 | hein_WMM bioplex_WMM WMM_only |
| VPS33B | VIPAS39 | 0.015 | 0.139 | bioplex_WMM youn_WMM WMM_only |
| VPS26C | COMMD7 | 0.011 | 0.141 | hein_WMM bioplex_WMM fraction |
| CCDC93 | VPS33B | 0.009 | 0.096 | bioplex_WMM gupta_WMM WMM_only |
| COMMD2 | VPS33B | 0.009 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| VPS35L | VPS33B | 0.009 | 0.093 | bioplex_WMM WMM_only |
| COMMD10 | VPS33B | 0.009 | 0.093 | bioplex_WMM WMM_only |
| COMMD7 | VPS33B | 0.009 | 0.093 | bioplex_WMM WMM_only |
| COMMD9 | VPS33B | 0.008 | 0.088 | bioplex_WMM WMM_only |
| DENND10 | VPS33B | 0.008 | 0.086 | bioplex_WMM WMM_only |
| COMMD4 | VPS33B | 0.008 | 0.081 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MTMR2 | VIPAS39 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COMMD8 | VPS33B | 0.008 | 0.061 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MTMR2 | VPS33B | 0.008 | 0.06 | bioplex_WMM WMM_only |
| COMMD3 | VPS33B | 0.008 | 0.06 | bioplex_WMM gupta_WMM WMM_only |
| CCDC93 | MTMR2 | 0.008 | 0.047 | bioplex_WMM WMM_only |
| VPS35L | MTMR2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| COMMD10 | MTMR2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| COMMD2 | MTMR2 | 0.008 | 0.041 | bioplex_WMM WMM_only |
| COMMD9 | MTMR2 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| DENND10 | MTMR2 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| COMMD4 | MTMR2 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| VPS26C | VPS33B | 0.008 | 0.026 | bioplex_WMM WMM_only |
| COMMD3 | MTMR2 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| COMMD2 | VIPAS39 | 0.008 | 0.023 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC93 | VIPAS39 | 0.008 | 0.011 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| COMMD4 | VIPAS39 | 0.007 | 0.011 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| COMMD10 | VIPAS39 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| COMMD7 | VIPAS39 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| VPS35L | VIPAS39 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| COMMD9 | VIPAS39 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| DENND10 | VIPAS39 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| COMMD3 | VIPAS39 | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| COMMD8 | VIPAS39 | 0.007 | 0.002 | youn_WMM gupta_WMM WMM_only |
| COMMD10 | VPS26C | 0.004 | 0.007 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| VPS26C | COMMD2 | 0.003 | 0.014 | hein_WMM bioplex_WMM youn_WMM fraction |
| COMMD7 | MTMR2 | 0.0 | 0.012 | bioplex_WMM fraction |
| VPS26C | COMMD4 | 0.0 | 0.015 | hein_WMM bioplex (COMMD4) bioplex_WMM gupta_WMM fraction |
| VPS26C | VPS35L | 0.0 | 0.001 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_03509 has an average edge precision of 0.45 which is ranked 2873 out of all 6965 complexes.
Related Complexes