hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03510
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SARAF | Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66) | UniProt NCBI |
| TMEM30A | Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) | UniProt NCBI |
| APP | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | UniProt NCBI |
| LSR | Lipolysis-stimulated lipoprotein receptor | UniProt NCBI |
| CNNM1 | Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2711 | 0.0249780992026 | 0.2 | APP | Amyloid beta protein homo-oligomer complex |
| CORUM:6056 | 0.0249780992026 | 0.2 | APP | APP-TNFRSF21 complex |
| CORUM:3092 | 0.0499494897235 | 0.2 | APP | APP-TOM40 complex |
| CORUM:3093 | 0.0499494897235 | 0.2 | APP | APP-TIM23 complex |
| CORUM:7529 | 0.0499494897235 | 0.2 | APP | APP-Abeta42-VDAC1 complex |
| CORUM:7574 | 0.0499494897235 | 0.2 | APP | APP-PSEN1 complex |
| CORUM:7575 | 0.0499494897235 | 0.2 | APP | APP-PSEN2 complex |
| CORUM:7579 | 0.0499494897235 | 0.2 | APP | APP(AICD)-MED12 complex |
| CORUM:7587 | 0.0499494897235 | 0.2 | APP | APP(AICD)-FOXO3 complex |
| CORUM:7588 | 0.0499494897235 | 0.2 | APP | APP(AICD)-FOXO1 complex |
| CORUM:7589 | 0.0499494897235 | 0.2 | APP | APP(AICD)-FOXO4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSR | TMEM30A | 0.169 | 0.426 | bioplex (TMEM30A) bioplex_WMM gupta_WMM |
| APP | TMEM30A | 0.092 | 0.355 | bioplex (TMEM30A) bioplex_WMM gupta_WMM |
| SARAF | TMEM30A | 0.075 | 0.357 | bioplex (TMEM30A) bioplex_WMM |
| TMEM30A | CNNM1 | 0.067 | 0.351 | bioplex (TMEM30A) bioplex_WMM |
| SARAF | CNNM1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| SARAF | APP | 0.007 | 0.006 | bioplex_WMM WMM_only |
| APP | CNNM1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| SARAF | LSR | 0.006 | 0.011 | bioplex_WMM WMM_only |
| LSR | CNNM1 | 0.006 | 0.007 | bioplex_WMM WMM_only |
| APP | LSR | 0.005 | 0.006 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03510 has an average edge precision of 0.153 which is ranked 6685 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SARAF | HuMAP2_01801 HuMAP2_02408 HuMAP2_02715 HuMAP2_03510 |
| TMEM30A | HuMAP2_02715 HuMAP2_03510 |
| APP | HuMAP2_01871 HuMAP2_03510 HuMAP2_03599 HuMAP2_04491 |
| LSR | HuMAP2_02715 HuMAP2_03510 HuMAP2_05149 |
| CNNM1 | HuMAP2_03510 HuMAP2_04301 HuMAP2_05281 HuMAP2_06103 HuMAP2_07000 |