hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03511
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | UniProt NCBI |
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | UniProt NCBI |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | UniProt NCBI |
| ZNF2 | Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661) | UniProt NCBI |
| CCND2 | G1/S-specific cyclin-D2 | UniProt NCBI |
| CCND3 | G1/S-specific cyclin-D3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69231 | 4.04583533895e-13 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 4.04583533895e-13 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | G1 Phase |
| WP:WP45 | 1.66485079619e-12 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | G1 to S cell cycle control |
| WP:WP179 | 7.2482059599e-11 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Cell Cycle |
| KEGG:04110 | 8.78984306893e-11 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Cell cycle |
| REAC:R-HSA-453279 | 9.68838483071e-10 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Mitotic G1-G1/S phases |
| WP:WP1545 | 1.23769432954e-09 | 0.571428571429 | CDKN1B CCND3 CCND1 CDKN1A | miRNAs involved in DNA damage response |
| WP:WP707 | 1.75521227176e-09 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | DNA Damage Response |
| WP:WP1530 | 2.19889988477e-09 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | miRNA Regulation of DNA Damage Response |
| GO:0000079 | 3.29717683142e-09 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:1904029 | 4.26409003356e-09 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of cyclin-dependent protein kinase activity |
| WP:WP710 | 1.66441812025e-08 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | DNA Damage Response (only ATM dependent) |
| CORUM:313 | 3.38018031602e-08 | 0.428571428571 | CDKN1A CCND3 CCND1 | Cell cycle kinase complex CDK5 |
| GO:0016538 | 7.47192024193e-08 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | cyclin-dependent protein serine/threonine kinase regulator activity |
| GO:0019887 | 1.8023911526e-07 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | protein kinase regulator activity |
| KEGG:05169 | 2.8609257174e-07 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | Epstein-Barr virus infection |
| KEGG:05203 | 3.27669829759e-07 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | Viral carcinogenesis |
| GO:0019207 | 4.49619679719e-07 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | kinase regulator activity |
| KEGG:04115 | 5.63189841402e-07 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | p53 signaling pathway |
| HP:0003072 | 1.04822205573e-06 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Hypercalcemia |
| WP:WP2261 | 1.5688624246e-06 | 0.571428571429 | CDKN1B CCND2 CCND1 CDKN1A | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-69278 | 1.91008072332e-06 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Cell Cycle, Mitotic |
| WP:WP2446 | 1.99495642073e-06 | 0.571428571429 | CDKN1B CCND3 CCND1 CDKN1A | Retinoblastoma Gene in Cancer |
| WP:WP4172 | 2.77765299142e-06 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | PI3K-Akt Signaling Pathway |
| WP:WP4658 | 2.84955660529e-06 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Small cell lung cancer |
| KEGG:04151 | 3.41566047287e-06 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | PI3K-Akt signaling pathway |
| KEGG:05165 | 4.15537865589e-06 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | Human papillomavirus infection |
| HP:0006744 | 4.64512630769e-06 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Adrenocortical carcinoma |
| REAC:R-HSA-1640170 | 5.63049101506e-06 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | Cell Cycle |
| KEGG:04068 | 5.86708166493e-06 | 0.571428571429 | CDKN1B CCND2 CCND1 CDKN1A | FoxO signaling pathway |
| REAC:R-HSA-8934593 | 7.20866903966e-06 | 0.428571428571 | CCND2 CCND1 CCND3 | Regulation of RUNX1 Expression and Activity |
| KEGG:04630 | 7.46106182314e-06 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | JAK-STAT signaling pathway |
| KEGG:05162 | 9.35850222973e-06 | 0.571428571429 | CDKN1B CCND2 CCND1 CCND3 | Measles |
| KEGG:04218 | 1.54550028729e-05 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | Cellular senescence |
| WP:WP3981 | 1.83384489647e-05 | 0.428571428571 | CDKN1B CCND1 CDKN1A | miRNA regulation of prostate cancer signaling pathways |
| KEGG:05206 | 2.12688843743e-05 | 0.571428571429 | CDKN1B CCND2 CCND1 CDKN1A | MicroRNAs in cancer |
| WP:WP3941 | 2.60950900306e-05 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Oxidative Damage |
| HP:0004363 | 2.74414392248e-05 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Abnormal circulating calcium concentration |
| CORUM:1634 | 3.02079974644e-05 | 0.285714285714 | CDKN1A CCND1 | CyclinD1-CDK4-p21 complex |
| KEGG:05200 | 3.03475025714e-05 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | Pathways in cancer |
| GO:2000045 | 3.10195398683e-05 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | regulation of G1/S transition of mitotic cell cycle |
| HP:0100568 | 3.1295319835e-05 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Neoplasm of the endocrine system |
| HP:0100641 | 3.15359643514e-05 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Neoplasm of the adrenal cortex |
| GO:0071900 | 3.74611219186e-05 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of protein serine/threonine kinase activity |
| HP:0010927 | 4.0202255485e-05 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Abnormal blood inorganic cation concentration |
| GO:0000307 | 4.44842942078e-05 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | cyclin-dependent protein kinase holoenzyme complex |
| GO:1902806 | 4.85560909241e-05 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | regulation of cell cycle G1/S phase transition |
| KEGG:05166 | 5.27961755709e-05 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | Human T-cell leukemia virus 1 infection |
| CORUM:5101 | 6.04024714829e-05 | 0.285714285714 | CDKN1A CCND3 | CyclinD3-CDK4-CDK6-p21 complex |
| CORUM:311 | 6.04024714829e-05 | 0.285714285714 | CDKN1A CCND1 | Cell cycle kinase complex CDK2 |
| CORUM:312 | 6.04024714829e-05 | 0.285714285714 | CDKN1A CCND1 | Cell cycle kinase complex CDK4 |
| HP:0100634 | 0.0001128375617 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Neuroendocrine neoplasm |
| REAC:R-HSA-212436 | 0.00012164166601 | 0.857142857143 | CCND1 CDKN1B CCND2 ZNF2 CDKN1A CCND3 | Generic Transcription Pathway |
| WP:WP2572 | 0.000132668935945 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Primary Focal Segmental Glomerulosclerosis FSGS |
| HP:0100631 | 0.000140903306855 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Neoplasm of the adrenal gland |
| CORUM:310 | 0.000150938581911 | 0.285714285714 | CDKN1A CCND1 | Cell cycle kinase complex CDC2 |
| KEGG:05220 | 0.000212916179135 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Chronic myeloid leukemia |
| REAC:R-HSA-73857 | 0.00023249479605 | 0.857142857143 | CCND1 CDKN1B CCND2 ZNF2 CDKN1A CCND3 | RNA Polymerase II Transcription |
| WP:WP4336 | 0.000253390302973 | 0.428571428571 | CCND2 CCND1 CCND3 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| REAC:R-HSA-8849470 | 0.000316419251483 | 0.285714285714 | CDKN1B CCND1 | PTK6 Regulates Cell Cycle |
| WP:WP673 | 0.000328513273506 | 0.428571428571 | CDKN1B CCND1 CDKN1A | ErbB Signaling Pathway |
| REAC:R-HSA-187577 | 0.000341719312652 | 0.428571428571 | CDKN1B CCND1 CDKN1A | SCF(Skp2)-mediated degradation of p27/p21 |
| WP:WP4258 | 0.000352401426229 | 0.428571428571 | CCND2 CCND1 CCND3 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:01522 | 0.000384620372076 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Endocrine resistance |
| KEGG:05215 | 0.000384620372076 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Prostate cancer |
| HP:0010929 | 0.000391208089721 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Abnormal blood cation concentration |
| HP:0100007 | 0.000410070446942 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Neoplasm of the peripheral nervous system |
| KEGG:05222 | 0.000410972913564 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Small cell lung cancer |
| GO:0000082 | 0.000437577354195 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | G1/S transition of mitotic cell cycle |
| REAC:R-HSA-74160 | 0.000444522787502 | 0.857142857143 | CCND1 CDKN1B CCND2 ZNF2 CDKN1A CCND3 | Gene expression (Transcription) |
| WP:WP399 | 0.000489203368595 | 0.428571428571 | CCND2 CCND1 CCND3 | Wnt Signaling Pathway and Pluripotency |
| MIRNA:hsa-miR-503-5p | 0.00052189876614 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | hsa-miR-503-5p |
| GO:0007346 | 0.000571114136273 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of mitotic cell cycle |
| GO:0090068 | 0.000571940466567 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | positive regulation of cell cycle process |
| GO:0044843 | 0.000585622727758 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | cell cycle G1/S phase transition |
| HP:0003111 | 0.00062680112878 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Abnormal blood ion concentration |
| GO:0045859 | 0.000633529120773 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of protein kinase activity |
| WP:WP428 | 0.000657238949319 | 0.428571428571 | CCND2 CCND1 CCND3 | Wnt Signaling |
| REAC:R-HSA-69202 | 0.000926585499379 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Cyclin E associated events during G1/S transition |
| HP:0001732 | 0.000937641310515 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Abnormality of the pancreas |
| MIRNA:hsa-miR-203a-5p | 0.00096670188468 | 0.428571428571 | CDKN1B CCND2 CDKN1A | hsa-miR-203a-5p |
| GO:1902554 | 0.000971413809773 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | serine/threonine protein kinase complex |
| REAC:R-HSA-69656 | 0.00099653441927 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Cyclin A:Cdk2-associated events at S phase entry |
| WP:WP2877 | 0.00109943747432 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Vitamin D Receptor Pathway |
| GO:0043549 | 0.00112760001095 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of kinase activity |
| HP:0030687 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Abnormal glucagon level |
| HP:0008291 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Pituitary corticotropic cell adenoma |
| HP:0100522 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Thymoma |
| HP:0030688 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Increased glucagon level |
| HP:0012197 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Insulinoma |
| HP:0030404 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Glucagonoma |
| HP:0011761 | 0.0011537726365 | 0.285714285714 | CDKN1B CDKN1A | Pituitary null cell adenoma |
| KEGG:05226 | 0.00118882602816 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Gastric cancer |
| MIRNA:hsa-miR-196a-5p | 0.00122097703197 | 0.571428571429 | CDKN1B CCND2 CCND1 CDKN1A | hsa-miR-196a-5p |
| HP:0011792 | 0.00126348759091 | 0.571428571429 | CDKN1B CDKN1C CCND1 CDKN1A | Neoplasm by histology |
| KEGG:04934 | 0.0014818224657 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Cushing syndrome |
| KEGG:04390 | 0.00151349756768 | 0.428571428571 | CCND2 CCND1 CCND3 | Hippo signaling pathway |
| KEGG:04310 | 0.00167858916845 | 0.428571428571 | CCND2 CCND1 CCND3 | Wnt signaling pathway |
| HP:0008208 | 0.00173027154874 | 0.285714285714 | CDKN1B CDKN1A | Parathyroid hyperplasia |
| HP:0008261 | 0.00173027154874 | 0.285714285714 | CDKN1B CDKN1A | Pancreatic islet cell adenoma |
| HP:0030405 | 0.00173027154874 | 0.285714285714 | CDKN1B CDKN1A | Pancreatic endocrine tumor |
| GO:0045737 | 0.001775386605 | 0.428571428571 | CCND2 CCND1 CCND3 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0045787 | 0.00181883639121 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | positive regulation of cell cycle |
| GO:1902911 | 0.00196423913453 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | protein kinase complex |
| HP:0011732 | 0.0020041380536 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Abnormality of adrenal morphology |
| KEGG:05202 | 0.00204353407792 | 0.428571428571 | CDKN1B CCND2 CDKN1A | Transcriptional misregulation in cancer |
| HP:0002894 | 0.0022799246445 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Neoplasm of the pancreas |
| MIRNA:hsa-miR-708-5p | 0.00230628329141 | 0.428571428571 | CDKN1A CCND3 CCND1 | hsa-miR-708-5p |
| WP:WP205 | 0.00231614132512 | 0.285714285714 | CDKN1B CCND1 | IL-7 Signaling Pathway |
| MIRNA:hsa-miR-3616-3p | 0.00238267755536 | 0.428571428571 | CDKN1B CCND2 CDKN1A | hsa-miR-3616-3p |
| HP:0011760 | 0.0024218379091 | 0.285714285714 | CDKN1B CDKN1A | Pituitary growth hormone cell adenoma |
| HP:0007449 | 0.0024218379091 | 0.285714285714 | CDKN1B CDKN1A | Confetti-like hypopigmented macules |
| HP:0006767 | 0.0024218379091 | 0.285714285714 | CDKN1B CDKN1A | Pituitary prolactin cell adenoma |
| HP:0100521 | 0.0024218379091 | 0.285714285714 | CDKN1B CDKN1A | Neoplasm of the thymus |
| GO:0051338 | 0.00265796142203 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of transferase activity |
| REAC:R-HSA-198323 | 0.00287361887808 | 0.285714285714 | CDKN1B CDKN1A | AKT phosphorylates targets in the cytosol |
| REAC:R-HSA-6804116 | 0.00287361887808 | 0.285714285714 | CDKN1B CDKN1A | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| WP:WP34 | 0.00300595539129 | 0.285714285714 | CDKN1B CCND2 | Ovarian Infertility Genes |
| GO:1904030 | 0.00307019549622 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | negative regulation of cyclin-dependent protein kinase activity |
| GO:1904031 | 0.00307019549622 | 0.428571428571 | CCND2 CCND1 CCND3 | positive regulation of cyclin-dependent protein kinase activity |
| HP:0012030 | 0.00322839434563 | 0.285714285714 | CDKN1B CDKN1A | Increased urinary cortisol level |
| HP:0008256 | 0.00322839434563 | 0.285714285714 | CDKN1B CDKN1A | Adrenocortical adenoma |
| HP:0012029 | 0.00322839434563 | 0.285714285714 | CDKN1B CDKN1A | Abnormal urine hormone level |
| HP:0002044 | 0.00322839434563 | 0.285714285714 | CDKN1B CDKN1A | Zollinger-Ellison syndrome |
| HP:0032367 | 0.00337864712578 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Abnormal growth hormone level |
| HP:0010785 | 0.00350463794031 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Gonadal neoplasm |
| WP:WP306 | 0.00354999471684 | 0.428571428571 | CCND2 CCND1 CCND3 | Focal Adhesion |
| KEGG:04510 | 0.00355359464803 | 0.428571428571 | CCND2 CCND1 CCND3 | Focal adhesion |
| MIRNA:hsa-miR-95-3p | 0.00366731711479 | 0.285714285714 | CDKN1A CCND1 | hsa-miR-95-3p |
| GO:0030234 | 0.0036709874671 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | enzyme regulator activity |
| REAC:R-HSA-69206 | 0.00370699600406 | 0.428571428571 | CDKN1B CCND1 CDKN1A | G1/S Transition |
| HP:0100570 | 0.00414986351758 | 0.285714285714 | CDKN1B CDKN1A | Carcinoid tumor |
| HP:0009726 | 0.00418145670879 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Renal neoplasm |
| MIRNA:hsa-let-7a-3p | 0.0042816922466 | 0.428571428571 | CDKN1B CCND2 CCND1 | hsa-let-7a-3p |
| REAC:R-HSA-9617828 | 0.00429175515342 | 0.285714285714 | CDKN1B CDKN1A | FOXO-mediated transcription of cell cycle genes |
| HP:0001031 | 0.0051861681154 | 0.285714285714 | CDKN1B CDKN1A | Subcutaneous lipoma |
| HP:0008283 | 0.0051861681154 | 0.285714285714 | CDKN1B CDKN1A | Fasting hyperinsulinemia |
| REAC:R-HSA-9634638 | 0.00539383467143 | 0.285714285714 | CDKN1B CCND1 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| WP:WP2828 | 0.00629697152788 | 0.285714285714 | CDKN1A CCND1 | Bladder Cancer |
| HP:0020073 | 0.0063372308607 | 0.285714285714 | CDKN1B CDKN1A | Hypopigmented macule |
| KEGG:05219 | 0.00655764034054 | 0.285714285714 | CDKN1A CCND1 | Bladder cancer |
| KEGG:05216 | 0.00655764034054 | 0.285714285714 | CDKN1A CCND1 | Thyroid cancer |
| REAC:R-HSA-69242 | 0.0067714376714 | 0.428571428571 | CDKN1B CCND1 CDKN1A | S Phase |
| GO:1901990 | 0.006838389231 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | regulation of mitotic cell cycle phase transition |
| HP:0010786 | 0.00691660030561 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Urinary tract neoplasm |
| WP:WP4249 | 0.00702347294811 | 0.285714285714 | CCND2 CCND1 | Hedgehog Signaling Pathway |
| HP:0010787 | 0.00818724273911 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Genital neoplasm |
| GO:1900087 | 0.00822626332948 | 0.428571428571 | CCND2 CCND1 CCND3 | positive regulation of G1/S transition of mitotic cell cycle |
| WP:WP2586 | 0.00859430044807 | 0.285714285714 | CDKN1B CDKN1A | Aryl Hydrocarbon Receptor |
| HP:0012334 | 0.00898332183607 | 0.285714285714 | CDKN1B CDKN1A | Extrahepatic cholestasis |
| HP:0003118 | 0.00898332183607 | 0.285714285714 | CDKN1B CDKN1A | Increased circulating cortisol level |
| WP:WP1971 | 0.00901151528078 | 0.285714285714 | CDKN1B CDKN1A | Integrated Cancer Pathway |
| WP:WP2882 | 0.0090850728984 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Nuclear Receptors Meta-Pathway |
| KEGG:04340 | 0.0093000092131 | 0.285714285714 | CCND2 CCND1 | Hedgehog signaling pathway |
| MIRNA:hsa-miR-152-3p | 0.00941984745118 | 0.428571428571 | CDKN1B CCND1 CDKN1A | hsa-miR-152-3p |
| WP:WP3998 | 0.00943851998861 | 0.285714285714 | CCND2 CCND1 | Prader-Willi and Angelman Syndrome |
| REAC:R-HSA-5674400 | 0.00945016076191 | 0.285714285714 | CDKN1B CDKN1A | Constitutive Signaling by AKT1 E17K in Cancer |
| GO:1905179 | 0.00946729163895 | 0.285714285714 | CDKN1B CDKN1A | negative regulation of cardiac muscle tissue regeneration |
| GO:1905178 | 0.00946729163895 | 0.285714285714 | CDKN1B CDKN1A | regulation of cardiac muscle tissue regeneration |
| GO:1901987 | 0.0096650897179 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | regulation of cell cycle phase transition |
| WP:WP3646 | 0.00987530792231 | 0.285714285714 | CDKN1A CCND1 | Hepatitis C and Hepatocellular Carcinoma |
| GO:0000278 | 0.00995795310122 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | mitotic cell cycle |
| WP:WP2864 | 0.0103218724353 | 0.285714285714 | CDKN1B CDKN1A | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| WP:WP3611 | 0.0107782068837 | 0.285714285714 | CDKN1A CCND1 | Photodynamic therapy-induced AP-1 survival signaling. |
| HP:0100733 | 0.0120875188399 | 0.285714285714 | CDKN1B CDKN1A | Neoplasm of the parathyroid gland |
| HP:0002897 | 0.0120875188399 | 0.285714285714 | CDKN1B CDKN1A | Parathyroid adenoma |
| HP:0000854 | 0.0138112142376 | 0.285714285714 | CDKN1B CDKN1A | Thyroid adenoma |
| HP:0003165 | 0.0138112142376 | 0.285714285714 | CDKN1B CDKN1A | Elevated circulating parathyroid hormone level |
| MIRNA:hsa-miR-182-5p | 0.0145420418846 | 0.428571428571 | CDKN1B CCND2 CDKN1A | hsa-miR-182-5p |
| MIRNA:hsa-let-7b-5p | 0.0147928173185 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | hsa-let-7b-5p |
| MIRNA:hsa-miR-146a-5p | 0.0153209907279 | 0.428571428571 | CDKN1A CCND2 CCND1 | hsa-miR-146a-5p |
| WP:WP61 | 0.0153237691065 | 0.285714285714 | CDKN1A CCND1 | Notch Signaling Pathway |
| KEGG:05213 | 0.015644435852 | 0.285714285714 | CDKN1A CCND1 | Endometrial cancer |
| GO:0051726 | 0.0159107434364 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of cell cycle |
| HP:0004375 | 0.017239739418 | 0.428571428571 | CDKN1B CCND1 CDKN1A | Neoplasm of the nervous system |
| REAC:R-HSA-8878171 | 0.0175710513735 | 0.428571428571 | CCND2 CCND1 CCND3 | Transcriptional regulation by RUNX1 |
| HP:0000845 | 0.017601413367 | 0.285714285714 | CDKN1B CDKN1A | Growth hormone excess |
| HP:0011766 | 0.017601413367 | 0.285714285714 | CDKN1B CDKN1A | Abnormality of the parathyroid morphology |
| KEGG:04917 | 0.0185153457906 | 0.285714285714 | CCND2 CCND1 | Prolactin signaling pathway |
| KEGG:05218 | 0.0185153457906 | 0.285714285714 | CDKN1A CCND1 | Melanoma |
| WP:WP4155 | 0.0187911062599 | 0.285714285714 | CDKN1A CCND1 | Endometrial cancer |
| GO:1902808 | 0.0189025357646 | 0.428571428571 | CCND2 CCND1 CCND3 | positive regulation of cell cycle G1/S phase transition |
| WP:WP3680 | 0.0194028583033 | 0.285714285714 | CDKN1B CDKN1A | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| HP:0000843 | 0.0196677630092 | 0.285714285714 | CDKN1B CDKN1A | Hyperparathyroidism |
| KEGG:05223 | 0.019730410569 | 0.285714285714 | CDKN1A CCND1 | Non-small cell lung cancer |
| MIRNA:hsa-miR-96-5p | 0.0199419370248 | 0.428571428571 | CDKN1A CCND2 CCND1 | hsa-miR-96-5p |
| HP:0000834 | 0.0203343378628 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Abnormality of the adrenal glands |
| WP:WP2032 | 0.0206553279975 | 0.285714285714 | CDKN1B CCND3 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| HP:0007379 | 0.0211613391692 | 0.428571428571 | CDKN1B CDKN1C CCND1 | Neoplasm of the genitourinary tract |
| HP:0004398 | 0.0218481766952 | 0.285714285714 | CDKN1B CDKN1A | Peptic ulcer |
| KEGG:05214 | 0.0222745983281 | 0.285714285714 | CDKN1A CCND1 | Glioma |
| GO:0001932 | 0.0238124818355 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of protein phosphorylation |
| WP:WP4255 | 0.0239551606733 | 0.285714285714 | CDKN1A CCND1 | Non-small cell lung cancer |
| MIRNA:hsa-miR-195-5p | 0.0240411900324 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | hsa-miR-195-5p |
| KEGG:05212 | 0.0242823355935 | 0.285714285714 | CDKN1A CCND1 | Pancreatic cancer |
| WP:WP4216 | 0.0246439874002 | 0.285714285714 | CDKN1A CCND1 | Chromosomal and microsatellite instability in colorectal cancer |
| HP:0006476 | 0.0265508883611 | 0.285714285714 | CDKN1B CDKN1A | Abnormality of the pancreatic islet cells |
| HP:0010615 | 0.0265508883611 | 0.285714285714 | CDKN1B CDKN1A | Angiofibromas |
| HP:0100633 | 0.0265508883611 | 0.285714285714 | CDKN1B CDKN1A | Esophagitis |
| HP:0000825 | 0.0265508883611 | 0.285714285714 | CDKN1B CDKN1A | Hyperinsulinemic hypoglycemia |
| HP:0012093 | 0.0290730325003 | 0.285714285714 | CDKN1B CDKN1A | Abnormality of endocrine pancreas physiology |
| GO:0019901 | 0.0298914161514 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | protein kinase binding |
| KEGG:04012 | 0.030052232514 | 0.285714285714 | CDKN1B CDKN1A | ErbB signaling pathway |
| GO:0044772 | 0.0302100525789 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | mitotic cell cycle phase transition |
| KEGG:05210 | 0.0323714198719 | 0.285714285714 | CDKN1A CCND1 | Colorectal cancer |
| REAC:R-HSA-9006927 | 0.0324500337431 | 0.285714285714 | CDKN1B CCND1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.0324500337431 | 0.285714285714 | CDKN1B CCND1 | Signaling by PTK6 |
| WP:WP4263 | 0.033657197369 | 0.285714285714 | CDKN1A CCND1 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-6791312 | 0.0353499877886 | 0.285714285714 | CDKN1B CDKN1A | TP53 Regulates Transcription of Cell Cycle Genes |
| HP:0002717 | 0.0373216957502 | 0.285714285714 | CDKN1B CDKN1A | Adrenal overactivity |
| WP:WP138 | 0.0378182063894 | 0.285714285714 | CDKN1A CCND1 | Androgen receptor signaling pathway |
| WP:WP2431 | 0.0386789142735 | 0.285714285714 | CDKN1B CCND1 | Spinal Cord Injury |
| WP:WP615 | 0.0386789142735 | 0.285714285714 | CDKN1B CDKN1A | Senescence and Autophagy in Cancer |
| KEGG:04933 | 0.0398354893533 | 0.285714285714 | CDKN1B CCND1 | AGE-RAGE signaling pathway in diabetic complications |
| HP:0002893 | 0.0402984044053 | 0.285714285714 | CDKN1B CDKN1A | Pituitary adenoma |
| HP:0007378 | 0.0406950613881 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Neoplasm of the gastrointestinal tract |
| HP:0011747 | 0.0413430401734 | 0.428571428571 | CDKN1B CDKN1C CDKN1A | Abnormality of the anterior pituitary |
| GO:0044770 | 0.0415114195377 | 0.714285714286 | CDKN1B CCND3 CCND2 CCND1 CDKN1A | cell cycle phase transition |
| HP:0032148 | 0.0433885622377 | 0.285714285714 | CDKN1B CDKN1A | Episodic pain |
| HP:0002574 | 0.0433885622377 | 0.285714285714 | CDKN1B CDKN1A | Episodic abdominal pain |
| MIRNA:hsa-miR-98-5p | 0.0454398201407 | 0.571428571429 | CDKN1B CCND2 CCND1 CDKN1A | hsa-miR-98-5p |
| MIRNA:hsa-miR-15b-5p | 0.0464525947268 | 0.571428571429 | CDKN1A CCND2 CCND1 CCND3 | hsa-miR-15b-5p |
| GO:0042325 | 0.0476427474477 | 0.857142857143 | CCND1 CDKN1B CCND2 CDKN1C CDKN1A CCND3 | regulation of phosphorylation |
| KEGG:04066 | 0.048055671732 | 0.285714285714 | CDKN1B CDKN1A | HIF-1 signaling pathway |
| HP:0011731 | 0.0499089185913 | 0.285714285714 | CDKN1B CDKN1A | Abnormality of circulating cortisol level |
| HP:0100530 | 0.0499089185913 | 0.285714285714 | CDKN1B CDKN1A | Abnormal calcium-phosphate regulating hormone level |
| CORUM:314 | 0.0499886427319 | 0.142857142857 | CDKN1A | PCNA-p21 complex |
| CORUM:3085 | 0.0499886427319 | 0.142857142857 | CCND2 | CCND2-CDK4 complex |
| CORUM:3086 | 0.0499886427319 | 0.142857142857 | CCND3 | CCND3-CDK4 complex |
| CORUM:3087 | 0.0499886427319 | 0.142857142857 | CCND1 | CCND1-CDK6 complex |
| CORUM:3088 | 0.0499886427319 | 0.142857142857 | CCND2 | CCND2-CDK6 complex |
| CORUM:3089 | 0.0499886427319 | 0.142857142857 | CCND3 | CCND3-CDK6 complex |
| CORUM:5107 | 0.0499886427319 | 0.142857142857 | CCND2 | p34(SEI-1)-CDK4-CyclinD2 complex |
| CORUM:5287 | 0.0499886427319 | 0.142857142857 | CCND1 | CCND1-CDK4 complex |
| CORUM:3084 | 0.0499886427319 | 0.142857142857 | CCND1 | CCND1-CDK4 complex |
| CORUM:2635 | 0.0499886427319 | 0.142857142857 | CCND1 | BETA2-Cyclin D1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN1A | CCND3 | 0.999 | 0.949 | hein_WMM bioplex (CCND3) bioplex_WMM hein (CDKN1A) |
| CDKN1B | CCND3 | 0.93 | 0.846 | hein_WMM bioplex (CCND3) bioplex_WMM |
| CCND3 | CDKN1C | 0.747 | 0.741 | hein_WMM bioplex (CCND3) bioplex_WMM |
| CDKN1A | CCND2 | 0.463 | 0.6 | bioplex (CCND2) bioplex_WMM |
| CCND3 | ZNF2 | 0.445 | 0.589 | bioplex (CCND3) bioplex_WMM |
| CDKN1B | CCND1 | 0.133 | 0.406 | hein_WMM bioplex (CCND1) bioplex_WMM hein (CCND1) |
| CDKN1B | CCND2 | 0.119 | 0.393 | bioplex (CCND2) bioplex_WMM |
| CCND2 | CDKN1C | 0.111 | 0.381 | bioplex (CCND2) bioplex_WMM |
| CCND1 | CDKN1C | 0.099 | 0.359 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CCND1 | CDKN1A | 0.065 | 0.347 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CDKN1B | CDKN1C | 0.036 | 0.267 | hein_WMM bioplex_WMM WMM_only |
| CDKN1B | CDKN1A | 0.029 | 0.232 | hein_WMM bioplex_WMM WMM_only |
| CDKN1A | CDKN1C | 0.029 | 0.233 | hein_WMM bioplex_WMM WMM_only |
| CCND2 | CCND3 | 0.008 | 0.096 | bioplex_WMM WMM_only |
| CDKN1C | ZNF2 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CDKN1B | ZNF2 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| CDKN1A | ZNF2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CCND1 | CCND3 | 0.007 | 0.002 | hein_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03511 has an average edge precision of 0.367 which is ranked 3674 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN1A | HuMAP2_03511 HuMAP2_04287 HuMAP2_05212 HuMAP2_06056 |
| CCND1 | HuMAP2_02228 HuMAP2_03511 HuMAP2_03854 HuMAP2_05212 HuMAP2_06056 |
| CDKN1B | HuMAP2_01003 HuMAP2_03511 HuMAP2_05212 HuMAP2_06056 |
| CDKN1C | HuMAP2_03511 HuMAP2_04287 HuMAP2_05212 HuMAP2_06056 |
| ZNF2 | HuMAP2_03511 HuMAP2_05212 HuMAP2_06056 HuMAP2_06719 |
| CCND2 | HuMAP2_03511 HuMAP2_05212 HuMAP2_06056 |
| CCND3 | HuMAP2_03511 HuMAP2_05212 HuMAP2_06056 HuMAP2_06719 |