hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03533
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | UniProt NCBI |
| UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | UniProt NCBI |
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-983168 | 4.19201259121e-07 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 1.02822402968e-06 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | Class I MHC mediated antigen processing & presentation |
| KEGG:04120 | 1.31062068202e-06 | 0.8 | UBE2E1 UBE2E2 UBE2D3 UBE2D4 | Ubiquitin mediated proteolysis |
| GO:0061631 | 6.37612051417e-06 | 0.8 | UBE2E1 UBE2E2 UBE2D3 UBE2D4 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 8.98734431525e-06 | 0.8 | UBE2E1 UBE2E2 UBE2D3 UBE2D4 | ubiquitin-like protein conjugating enzyme activity |
| REAC:R-HSA-1280218 | 2.29940671928e-05 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | Adaptive Immune System |
| GO:0070936 | 2.36783333556e-05 | 0.8 | UBE2E1 UBE2E2 UBE2D3 UBE2D4 | protein K48-linked ubiquitination |
| GO:0004842 | 0.000174338926072 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | ubiquitin-protein transferase activity |
| GO:0019787 | 0.000259151609636 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | ubiquitin-like protein transferase activity |
| GO:0070979 | 0.00265002518516 | 0.6 | UBE2E2 UBE2D3 UBE2D4 | protein K11-linked ubiquitination |
| REAC:R-HSA-168256 | 0.00339317023665 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | Immune System |
| GO:0016567 | 0.00400049209339 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | protein ubiquitination |
| GO:0032446 | 0.00732992354676 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | protein modification by small protein conjugation |
| KEGG:05131 | 0.00858395707223 | 0.4 | UBE2D4 UBE2D3 | Shigellosis |
| REAC:R-HSA-8866654 | 0.0206361227401 | 0.4 | UBE2E1 UBE2D3 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0070647 | 0.023802724014 | 1.0 | UBE2E1 UBE2D3 UBE2E2 RNF25 UBE2D4 | protein modification by small protein conjugation or removal |
| GO:0000209 | 0.0264249728386 | 0.8 | UBE2E1 UBE2E2 UBE2D3 UBE2D4 | protein polyubiquitination |
| GO:0042296 | 0.0270421395626 | 0.4 | UBE2E1 UBE2E2 | ISG15 transferase activity |
| REAC:R-HSA-8852135 | 0.0370902496619 | 0.4 | UBE2E1 UBE2D3 | Protein ubiquitination |
| GO:0032020 | 0.0450641792523 | 0.4 | UBE2E1 UBE2E2 | ISG15-protein conjugation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBE2D4 | RNF25 | 1.0 | 0.949 | bioplex (RNF25) bioplex_WMM |
| RNF25 | UBE2E1 | 0.226 | 0.467 | bioplex (RNF25) bioplex_WMM |
| RNF25 | UBE2E2 | 0.171 | 0.429 | bioplex (RNF25,UBE2E2) bioplex_WMM |
| RNF25 | UBE2D3 | 0.058 | 0.328 | bioplex (RNF25) bioplex_WMM |
| UBE2E2 | UBE2E1 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2E2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2E1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| UBE2D4 | UBE2D3 | 0.008 | 0.009 | bioplex_WMM WMM_only |
| UBE2D3 | UBE2E2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| UBE2D3 | UBE2E1 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_03533 has an average edge precision of 0.243 which is ranked 5480 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBE2D3 | HuMAP2_00448 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 |
| UBE2E1 | HuMAP2_01572 HuMAP2_03533 HuMAP2_04182 HuMAP2_04498 |
| UBE2E2 | HuMAP2_01154 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 HuMAP2_03702 |
| UBE2D4 | HuMAP2_00448 HuMAP2_00522 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 HuMAP2_06009 |
| RNF25 | HuMAP2_00448 HuMAP2_00522 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 HuMAP2_03702 HuMAP2_06009 |