hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03537
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PMS1 | PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) | UniProt NCBI |
| MLH1 | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:380 | 1.67592346237e-06 | 1.0 | PMS1 MLH1 | MutL-beta complex |
| CORUM:285 | 5.02777038712e-06 | 1.0 | PMS1 MLH1 | PCNA-MLH1-PMS1 complex |
| CORUM:370 | 1.00555407742e-05 | 1.0 | PMS1 MLH1 | MSH2-MSH6-PMS1-MLH1 complex |
| HP:0100571 | 0.000303888373596 | 1.0 | PMS1 MLH1 | Cardiac diverticulum |
| HP:0012174 | 0.000571042987746 | 1.0 | PMS1 MLH1 | Glioblastoma multiforme |
| HP:0006725 | 0.00100182980306 | 1.0 | PMS1 MLH1 | Pancreatic adenocarcinoma |
| HP:0010524 | 0.00117214086958 | 1.0 | PMS1 MLH1 | Agnosia |
| HP:0002893 | 0.00117214086958 | 1.0 | PMS1 MLH1 | Pituitary adenoma |
| GO:0032389 | 0.00135247023414 | 1.0 | PMS1 MLH1 | MutLalpha complex |
| HP:0100576 | 0.00165635860773 | 1.0 | PMS1 MLH1 | Amaurosis fugax |
| HP:0040277 | 0.00176322045339 | 1.0 | PMS1 MLH1 | Neoplasm of the pituitary gland |
| HP:0100743 | 0.00176322045339 | 1.0 | PMS1 MLH1 | Neoplasm of the rectum |
| HP:0011750 | 0.00176322045339 | 1.0 | PMS1 MLH1 | Neoplasm of the anterior pituitary |
| HP:0009733 | 0.00187342173173 | 1.0 | PMS1 MLH1 | Glioma |
| HP:0004376 | 0.00210384258643 | 1.0 | PMS1 MLH1 | Neuroblastic tumor |
| HP:0003006 | 0.00210384258643 | 1.0 | PMS1 MLH1 | Neuroblastoma |
| HP:0100613 | 0.00210384258643 | 1.0 | PMS1 MLH1 | Death in early adulthood |
| HP:0030067 | 0.00210384258643 | 1.0 | PMS1 MLH1 | Peripheral primitive neuroectodermal neoplasm |
| HP:0010526 | 0.0022240621628 | 1.0 | PMS1 MLH1 | Dysgraphia |
| HP:0003003 | 0.0022240621628 | 1.0 | PMS1 MLH1 | Colon cancer |
| HP:0030065 | 0.00234762117185 | 1.0 | PMS1 MLH1 | Primitive neuroectodermal tumor |
| HP:0200008 | 0.00345631282057 | 1.0 | PMS1 MLH1 | Intestinal polyposis |
| HP:0002671 | 0.00345631282057 | 1.0 | PMS1 MLH1 | Basal cell carcinoma |
| HP:0001402 | 0.00392717282801 | 1.0 | PMS1 MLH1 | Hepatocellular carcinoma |
| HP:0005266 | 0.00425777666302 | 1.0 | PMS1 MLH1 | Intestinal polyp |
| HP:0100273 | 0.00425777666302 | 1.0 | PMS1 MLH1 | Neoplasm of the colon |
| HP:0100031 | 0.0053297345523 | 1.0 | PMS1 MLH1 | Neoplasm of the thyroid gland |
| HP:0100615 | 0.0053297345523 | 1.0 | PMS1 MLH1 | Ovarian neoplasm |
| HP:0030063 | 0.00552008221488 | 1.0 | PMS1 MLH1 | Neuroepithelial neoplasm |
| HP:0030061 | 0.00571376931014 | 1.0 | PMS1 MLH1 | Neuroectodermal neoplasm |
| HP:0030060 | 0.00571376931014 | 1.0 | PMS1 MLH1 | Nervous tissue neoplasm |
| HP:0100836 | 0.00631486719198 | 1.0 | PMS1 MLH1 | Malignant neoplasm of the central nervous system |
| HP:0010622 | 0.00673229627659 | 1.0 | PMS1 MLH1 | Neoplasm of the skeletal system |
| HP:0002516 | 0.00694601996791 | 1.0 | PMS1 MLH1 | Increased intracranial pressure |
| HP:0100834 | 0.00694601996791 | 1.0 | PMS1 MLH1 | Neoplasm of the large intestine |
| HP:0012640 | 0.00694601996791 | 1.0 | PMS1 MLH1 | Abnormality of intracranial pressure |
| HP:0100835 | 0.00829849020205 | 1.0 | PMS1 MLH1 | Benign neoplasm of the central nervous system |
| HP:0002894 | 0.0085355899221 | 1.0 | PMS1 MLH1 | Neoplasm of the pancreas |
| GO:0032300 | 0.00946729163895 | 1.0 | PMS1 MLH1 | mismatch repair complex |
| HP:0002034 | 0.0102887920775 | 1.0 | PMS1 MLH1 | Abnormality of the rectum |
| HP:0010785 | 0.0113640893994 | 1.0 | PMS1 MLH1 | Gonadal neoplasm |
| HP:0002896 | 0.0113640893994 | 1.0 | PMS1 MLH1 | Neoplasm of the liver |
| HP:0003401 | 0.0136749768118 | 1.0 | PMS1 MLH1 | Paresthesia |
| HP:0100568 | 0.0145966602306 | 1.0 | PMS1 MLH1 | Neoplasm of the endocrine system |
| HP:0002354 | 0.0175420398516 | 1.0 | PMS1 MLH1 | Memory impairment |
| HP:0010786 | 0.0178860014174 | 1.0 | PMS1 MLH1 | Urinary tract neoplasm |
| HP:0010787 | 0.0200198988979 | 1.0 | PMS1 MLH1 | Genital neoplasm |
| HP:0002239 | 0.0203872364924 | 1.0 | PMS1 MLH1 | Gastrointestinal hemorrhage |
| HP:0100006 | 0.0211319299793 | 1.0 | PMS1 MLH1 | Neoplasm of the central nervous system |
| HP:0011772 | 0.0226613901453 | 1.0 | PMS1 MLH1 | Abnormality of thyroid morphology |
| HP:0002076 | 0.0226613901453 | 1.0 | PMS1 MLH1 | Migraine |
| HP:0100705 | 0.0242442812341 | 1.0 | PMS1 MLH1 | Abnormality of the glial cells |
| HP:0000737 | 0.0267188008477 | 1.0 | PMS1 MLH1 | Irritability |
| HP:0000738 | 0.0271429087977 | 1.0 | PMS1 MLH1 | Hallucinations |
| HP:0001522 | 0.0297576845837 | 1.0 | PMS1 MLH1 | Death in infancy |
| HP:0004375 | 0.0329602005208 | 1.0 | PMS1 MLH1 | Neoplasm of the nervous system |
| HP:0007379 | 0.0378190750657 | 1.0 | PMS1 MLH1 | Neoplasm of the genitourinary tract |
| HP:0000763 | 0.0383233293999 | 1.0 | PMS1 MLH1 | Sensory neuropathy |
| HP:0008069 | 0.0383233293999 | 1.0 | PMS1 MLH1 | Neoplasm of the skin |
| HP:0001123 | 0.0403737410635 | 1.0 | PMS1 MLH1 | Visual field defect |
| HP:0002250 | 0.0440905296328 | 1.0 | PMS1 MLH1 | Abnormal large intestine morphology |
| HP:0004374 | 0.0485386539584 | 1.0 | PMS1 MLH1 | Hemiplegia/hemiparesis |
| HP:0100660 | 0.0491096969462 | 1.0 | PMS1 MLH1 | Dyskinesia |
| CORUM:379 | 0.0499173803268 | 0.5 | MLH1 | MutL-alpha complex |
| CORUM:292 | 0.0499173803268 | 0.5 | MLH1 | MutL-alpha complex |
| REAC:R-HSA-5632987 | 0.0499173803268 | 0.5 | MLH1 | Defective Mismatch Repair Associated With PMS2 |
| REAC:R-HSA-5545483 | 0.0499173803268 | 0.5 | MLH1 | Defective Mismatch Repair Associated With MLH1 |
| WP:WP531 | 0.0499262710315 | 0.5 | MLH1 | DNA Mismatch Repair |
| KEGG:03430 | 0.049938686792 | 0.5 | MLH1 | Mismatch repair |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PMS1 | MLH1 | 0.042 | 0.269 | hein_WMM youn_WMM hein (MLH1) gupta_WMM |
Images
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Complex HuMAP2_03537 has an average edge precision of 0.269 which is ranked 5042 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PMS1 | HuMAP2_00483 HuMAP2_03537 |
| MLH1 | HuMAP2_00483 HuMAP2_03537 |