hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03540
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYCBP2 | E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) | UniProt NCBI |
| LGALS3BP | Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K) | UniProt NCBI |
| GNE | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)] | UniProt NCBI |
| SPRYD3 | SPRY domain-containing protein 3 | UniProt NCBI |
| HECTD4 | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4085011 | 0.0499190562503 | 0.25 | GNE | Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LGALS3BP | SPRYD3 | 0.558 | 0.649 | hein_WMM bioplex (LGALS3BP) bioplex_WMM hein (LGALS3BP) |
| LGALS3BP | MYCBP2 | 0.402 | 0.561 | hein_WMM bioplex (LGALS3BP) bioplex_WMM youn_WMM hein (LGALS3BP) boldt_WMM |
| GNE | LGALS3BP | 0.373 | 0.546 | bioplex (LGALS3BP) bioplex_WMM |
| LGALS3BP | HECTD4 | 0.052 | 0.301 | bioplex (LGALS3BP) bioplex_WMM |
| SPRYD3 | MYCBP2 | 0.01 | 0.139 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| SPRYD3 | HECTD4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| GNE | HECTD4 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| GNE | SPRYD3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| MYCBP2 | HECTD4 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| GNE | MYCBP2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03540 has an average edge precision of 0.241 which is ranked 5505 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYCBP2 | HuMAP2_02816 HuMAP2_03540 |
| LGALS3BP | HuMAP2_01716 HuMAP2_03540 HuMAP2_03782 |
| GNE | HuMAP2_00770 HuMAP2_03540 HuMAP2_07018 |
| SPRYD3 | HuMAP2_01716 HuMAP2_03540 HuMAP2_03782 HuMAP2_04602 |
| HECTD4 | HuMAP2_03540 HuMAP2_04041 |