hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03572
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NBN | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) | UniProt NCBI |
| RFC1 | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | UniProt NCBI |
| FAM219A | Protein FAM219A | UniProt NCBI |
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:433 | 1.48483493479e-07 | 0.75 | RFC1 RAD50 NBN | BASC complex (BRCA1-associated genome surveillance complex) |
| WP:WP707 | 1.07742605018e-05 | 0.75 | RFC1 RAD50 NBN | DNA Damage Response |
| WP:WP1530 | 1.23096465226e-05 | 0.75 | RFC1 RAD50 NBN | miRNA Regulation of DNA Damage Response |
| CORUM:618 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:173 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:331 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:972 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 1.50819606993e-05 | 0.5 | RAD50 NBN | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:1081 | 1.50819606993e-05 | 0.5 | RAD50 NBN | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:627 | 3.01612206104e-05 | 0.5 | RAD50 NBN | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| CORUM:619 | 3.01612206104e-05 | 0.5 | RAD50 NBN | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:202 | 3.01612206104e-05 | 0.5 | RAD50 NBN | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:2218 | 3.01612206104e-05 | 0.5 | RAD50 NBN | MDC1-MRE11-RAD50-NBS1 complex |
| CORUM:964 | 3.01612206104e-05 | 0.5 | RAD50 NBN | BRCA1-RAD50-MRE11-NBS1 complex |
| WP:WP2942 | 3.52660392509e-05 | 0.5 | RAD50 NBN | DDX1 as a regulatory component of the Drosha microprocessor |
| REAC:R-HSA-5685942 | 5.88039824914e-05 | 0.75 | RFC1 RAD50 NBN | HDR through Homologous Recombination (HRR) |
| CORUM:2217 | 7.53895486054e-05 | 0.5 | RAD50 NBN | MDC1-MRN-ATM-FANCD2 complex |
| CORUM:5197 | 7.53895486054e-05 | 0.5 | RAD50 NBN | PTIP-DNA damage response complex |
| CORUM:1189 | 0.000105535916717 | 0.5 | RAD50 NBN | DNA double-strand break end-joining complex |
| WP:WP186 | 0.000110786500894 | 0.5 | RAD50 NBN | Homologous recombination |
| CORUM:2815 | 0.000140701954484 | 0.5 | RAD50 NBN | BRCA1-BARD1-BACH1-DNA damage complex II |
| REAC:R-HSA-5693548 | 0.000150779097211 | 0.5 | RAD50 NBN | Sensing of DNA Double Strand Breaks |
| REAC:R-HSA-5685939 | 0.000452175281072 | 0.5 | RAD50 NBN | HDR through MMEJ (alt-NHEJ) |
| REAC:R-HSA-5693567 | 0.000480050915503 | 0.75 | RFC1 RAD50 NBN | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000550034129522 | 0.75 | RFC1 RAD50 NBN | Homology Directed Repair |
| REAC:R-HSA-5693532 | 0.000966811034897 | 0.75 | RFC1 RAD50 NBN | DNA Double-Strand Break Repair |
| WP:WP2516 | 0.00124082421052 | 0.5 | RAD50 NBN | ATM Signaling Pathway |
| KEGG:03440 | 0.0015575421878 | 0.5 | RAD50 NBN | Homologous recombination |
| WP:WP3878 | 0.0015833920549 | 0.5 | RAD50 NBN | ATM Signaling Network in Development and Disease |
| HP:0030406 | 0.00206626211915 | 0.5 | RAD50 NBN | Primary peritoneal carcinoma |
| WP:WP3959 | 0.00248310593375 | 0.5 | RAD50 NBN | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| REAC:R-HSA-5693554 | 0.00326103241616 | 0.5 | RAD50 NBN | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5693568 | 0.00497416142364 | 0.5 | RAD50 NBN | Resolution of D-loop Structures through Holliday Junction Intermediates |
| WP:WP4016 | 0.00501103584449 | 0.5 | RAD50 NBN | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-5693537 | 0.00529460041948 | 0.5 | RAD50 NBN | Resolution of D-Loop Structures |
| REAC:R-HSA-5685938 | 0.00631572211528 | 0.5 | RAD50 NBN | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 0.0070462802506 | 0.5 | RAD50 NBN | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-73894 | 0.00725712676591 | 0.75 | RFC1 RAD50 NBN | DNA Repair |
| HP:0011027 | 0.00737157747856 | 0.5 | RAD50 NBN | Abnormality of the fallopian tube |
| HP:0012125 | 0.00796059020261 | 0.5 | RAD50 NBN | Prostate cancer |
| HP:0100787 | 0.00796059020261 | 0.5 | RAD50 NBN | Prostate neoplasm |
| REAC:R-HSA-5693579 | 0.00821677913545 | 0.5 | RAD50 NBN | Homologous DNA Pairing and Strand Exchange |
| HP:0008775 | 0.0119684664945 | 0.5 | RAD50 NBN | Abnormal prostate morphology |
| WP:WP4262 | 0.0159167413674 | 0.5 | RAD50 NBN | Breast cancer pathway |
| HP:0003220 | 0.0159281461127 | 0.5 | RAD50 NBN | Abnormality of chromosome stability |
| GO:0031860 | 0.0162267366884 | 0.5 | RAD50 NBN | telomeric 3' overhang formation |
| KEGG:04218 | 0.0206513420529 | 0.5 | RAD50 NBN | Cellular senescence |
| HP:0000022 | 0.023433582519 | 0.5 | RAD50 NBN | Abnormality of male internal genitalia |
| REAC:R-HSA-5693571 | 0.0234490216385 | 0.5 | RAD50 NBN | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 0.0284687652941 | 0.5 | RAD50 NBN | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0292253078855 | 0.5 | RAD50 NBN | DNA Double Strand Break Response |
| REAC:R-HSA-2559586 | 0.0307679435258 | 0.5 | RAD50 NBN | DNA Damage/Telomere Stress Induced Senescence |
| HP:0003002 | 0.0335949626331 | 0.5 | RAD50 NBN | Breast carcinoma |
| REAC:R-HSA-912446 | 0.0356320611636 | 0.5 | RAD50 NBN | Meiotic recombination |
| HP:0100615 | 0.0360996225593 | 0.5 | RAD50 NBN | Ovarian neoplasm |
| HP:0002861 | 0.0373855400094 | 0.5 | RAD50 NBN | Melanoma |
| REAC:R-HSA-6804756 | 0.0408500448467 | 0.5 | RAD50 NBN | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.0435915557177 | 0.5 | RAD50 NBN | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.0464213162589 | 0.5 | RAD50 NBN | Processing of DNA double-strand break ends |
| CORUM:72 | 0.0499140284799 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:263 | 0.0499140284799 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:264 | 0.0499140284799 | 0.25 | RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:7103 | 0.0499140284799 | 0.25 | NBN | NBS1-VRK1 complex |
| CORUM:2776 | 0.0499140284799 | 0.25 | RAD50 | RAD50-BRCA1 complex |
| CORUM:2723 | 0.0499140284799 | 0.25 | NBN | ATM-NBN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NBN | RAD50 | 0.999 | 0.948 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| NBN | FAM219A | 0.78 | 0.754 | bioplex (FAM219A) bioplex_WMM |
| RAD50 | FAM219A | 0.423 | 0.573 | bioplex (FAM219A) bioplex_WMM |
| RFC1 | NBN | 0.02 | 0.184 | youn_WMM fraction |
| RFC1 | RAD50 | 0.0 | 0.002 | youn_WMM fraction treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_03572 has an average edge precision of 0.492 which is ranked 2542 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NBN | HuMAP2_01080 HuMAP2_03572 HuMAP2_03801 HuMAP2_05113 |
| RFC1 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02847 HuMAP2_03572 |
| FAM219A | HuMAP2_01080 HuMAP2_03572 HuMAP2_03801 HuMAP2_05113 |
| RAD50 | HuMAP2_01080 HuMAP2_02474 HuMAP2_03572 HuMAP2_05113 |