hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03578
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | UniProt NCBI |
| EZH2 | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7375 | 5.02777038712e-06 | 1.0 | EZH2 SUZ12 | BRD7-EZH2-SUZ12 complex |
| CORUM:974 | 1.67592346237e-05 | 1.0 | EZH2 SUZ12 | EED-EZH2 complex |
| CORUM:105 | 1.67592346237e-05 | 1.0 | EZH2 SUZ12 | Polycomb repressive complex 2 (PRC 2) |
| CORUM:7304 | 1.67592346237e-05 | 1.0 | EZH2 SUZ12 | HIC1-PCL3L-PCR2 complex |
| HP:0001814 | 3.33943267688e-05 | 1.0 | EZH2 SUZ12 | Deep-set nails |
| WP:WP2916 | 4.47097598062e-05 | 1.0 | EZH2 SUZ12 | Interactome of polycomb repressive complex 2 (PRC2) |
| WP:WP4204 | 0.000162072879297 | 1.0 | EZH2 SUZ12 | Tumor suppressor activity of SMARCB1 |
| WP:WP4553 | 0.000209018127094 | 1.0 | EZH2 SUZ12 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| HP:0010300 | 0.000220402556674 | 1.0 | EZH2 SUZ12 | Abnormally low-pitched voice |
| HP:0001816 | 0.000303888373596 | 1.0 | EZH2 SUZ12 | Thin nail |
| REAC:R-HSA-8953750 | 0.000940193062392 | 1.0 | EZH2 SUZ12 | Transcriptional Regulation by E2F6 |
| HP:0001176 | 0.00126230555186 | 1.0 | EZH2 SUZ12 | Large hands |
| HP:0001769 | 0.00135580966681 | 1.0 | EZH2 SUZ12 | Broad foot |
| HP:0002002 | 0.0022240621628 | 1.0 | EZH2 SUZ12 | Deep philtrum |
| REAC:R-HSA-8943724 | 0.00267477384595 | 1.0 | EZH2 SUZ12 | Regulation of PTEN gene transcription |
| HP:0001800 | 0.00315910331233 | 1.0 | EZH2 SUZ12 | Hypoplastic toenails |
| WP:WP4239 | 0.00336999814539 | 1.0 | EZH2 SUZ12 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-3214841 | 0.004164669804 | 1.0 | EZH2 SUZ12 | PKMTs methylate histone lysines |
| REAC:R-HSA-212300 | 0.00428366036983 | 1.0 | EZH2 SUZ12 | PRC2 methylates histones and DNA |
| GO:0046976 | 0.00450823411379 | 1.0 | EZH2 SUZ12 | histone methyltransferase activity (H3-K27 specific) |
| HP:0005616 | 0.00477872816061 | 1.0 | EZH2 SUZ12 | Accelerated skeletal maturation |
| HP:0001582 | 0.00495905752517 | 1.0 | EZH2 SUZ12 | Redundant skin |
| HP:0001852 | 0.00552008221488 | 1.0 | EZH2 SUZ12 | Sandal gap |
| HP:0011304 | 0.00571376931014 | 1.0 | EZH2 SUZ12 | Broad thumb |
| HP:0001609 | 0.00611116179869 | 1.0 | EZH2 SUZ12 | Hoarse voice |
| HP:0002213 | 0.00631486719198 | 1.0 | EZH2 SUZ12 | Fine hair |
| HP:0009768 | 0.00806472991466 | 1.0 | EZH2 SUZ12 | Broad phalanges of the hand |
| HP:0010624 | 0.00829849020205 | 1.0 | EZH2 SUZ12 | Aplastic/hypoplastic toenail |
| HP:0000311 | 0.00877602907484 | 1.0 | EZH2 SUZ12 | Round face |
| HP:0000973 | 0.00901980766025 | 1.0 | EZH2 SUZ12 | Cutis laxa |
| REAC:R-HSA-5619507 | 0.0109856782959 | 1.0 | EZH2 SUZ12 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0109856782959 | 1.0 | EZH2 SUZ12 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | EZH2 SUZ12 | Oxidative Stress Induced Senescence |
| HP:0001500 | 0.0124928176442 | 1.0 | EZH2 SUZ12 | Broad finger |
| HP:0006009 | 0.0142860929917 | 1.0 | EZH2 SUZ12 | Broad phalanx |
| HP:0001792 | 0.0145966602306 | 1.0 | EZH2 SUZ12 | Small nail |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | EZH2 SUZ12 | PTEN Regulation |
| HP:0005622 | 0.0165301917506 | 1.0 | EZH2 SUZ12 | Broad long bones |
| MIRNA:hsa-miR-138-5p | 0.0165799814847 | 1.0 | EZH2 SUZ12 | hsa-miR-138-5p |
| REAC:R-HSA-212165 | 0.0177396498492 | 1.0 | EZH2 SUZ12 | Epigenetic regulation of gene expression |
| HP:0008388 | 0.0189379227106 | 1.0 | EZH2 SUZ12 | Abnormal toenail morphology |
| HP:0000337 | 0.0196559007361 | 1.0 | EZH2 SUZ12 | Broad forehead |
| HP:0008067 | 0.0196559007361 | 1.0 | EZH2 SUZ12 | Abnormally lax or hyperextensible skin |
| HP:0000098 | 0.0211319299793 | 1.0 | EZH2 SUZ12 | Tall stature |
| HP:0002164 | 0.0238435493129 | 1.0 | EZH2 SUZ12 | Nail dysplasia |
| HP:0009602 | 0.0267188008477 | 1.0 | EZH2 SUZ12 | Abnormality of thumb phalanx |
| HP:0009774 | 0.0280011429956 | 1.0 | EZH2 SUZ12 | Triangular shaped phalanges of the hand |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | EZH2 SUZ12 | Cellular Senescence |
| HP:0010719 | 0.032028498804 | 1.0 | EZH2 SUZ12 | Abnormality of hair texture |
| HP:0001231 | 0.0339052599684 | 1.0 | EZH2 SUZ12 | Abnormal fingernail morphology |
| HP:0010647 | 0.0368205846953 | 1.0 | EZH2 SUZ12 | Abnormal elasticity of skin |
| HP:0001387 | 0.0388309231668 | 1.0 | EZH2 SUZ12 | Joint stiffness |
| HP:0008386 | 0.0398561289986 | 1.0 | EZH2 SUZ12 | Aplasia/Hypoplasia of the nails |
| HP:0100490 | 0.0408946925611 | 1.0 | EZH2 SUZ12 | Camptodactyly of finger |
| MIRNA:hsa-miR-200b-3p | 0.0413481110737 | 1.0 | EZH2 SUZ12 | hsa-miR-200b-3p |
| HP:0001220 | 0.0419466138543 | 1.0 | EZH2 SUZ12 | Interphalangeal joint contracture of finger |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | EZH2 SUZ12 | PIP3 activates AKT signaling |
| HP:0006101 | 0.0435495415392 | 1.0 | EZH2 SUZ12 | Finger syndactyly |
| HP:0000400 | 0.0440905296328 | 1.0 | EZH2 SUZ12 | Macrotia |
| HP:0000944 | 0.0451825241182 | 1.0 | EZH2 SUZ12 | Abnormality of the metaphysis |
| HP:0006261 | 0.0457335305099 | 1.0 | EZH2 SUZ12 | Abnormal phalangeal joint morphology of the hand |
| HP:0005692 | 0.0462878763342 | 1.0 | EZH2 SUZ12 | Joint hyperflexibility |
| HP:0012785 | 0.0491096969462 | 1.0 | EZH2 SUZ12 | Flexion contracture of finger |
| HP:0003856 | 0.0497341708567 | 0.5 | EZH2 | Upper limb metaphyseal widening |
| HP:0003849 | 0.0497341708567 | 0.5 | EZH2 | Flared upper limb metaphysis |
| HP:0200000 | 0.0497341708567 | 0.5 | EZH2 | Dysharmonic bone age |
| HP:0003911 | 0.0497341708567 | 0.5 | EZH2 | Flared humeral metaphysis |
| CORUM:5521 | 0.0499173803268 | 0.5 | EZH2 | EED-EZH polycomb complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUZ12 | EZH2 | 1.0 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM hein (EZH2) Malo fraction |
Images
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Complex HuMAP2_03578 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUZ12 | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| EZH2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |