hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03593
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | UniProt NCBI |
| CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | UniProt NCBI |
| PRMT7 | Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | UniProt NCBI |
| SETD3 | Actin-histidine N-methyltransferase (EC 2.1.1.85) (SET domain-containing protein 3) (hSETD3) | UniProt NCBI |
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0200149 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | CSF lymphocytic pleiocytosis |
| HP:0030356 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Increased serum interferon-gamma level |
| HP:0012229 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | CSF pleocytosis |
| HP:0009710 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Chilblains |
| HP:0009709 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Increased CSF interferon alpha |
| HP:0009704 | 1.35564784896e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Chronic CSF lymphocytosis |
| HP:0040140 | 2.16859950518e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Degeneration of the striatum |
| HP:0005550 | 2.16859950518e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Chronic lymphatic leukemia |
| HP:0001955 | 2.16859950518e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Unexplained fevers |
| GO:0032299 | 3.17865016081e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | ribonuclease H2 complex |
| HP:0030354 | 3.25224378374e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal serum interferon level |
| HP:0030355 | 3.25224378374e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal serum interferon-gamma level |
| HP:0011834 | 4.64512630769e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Moyamoya phenomenon |
| HP:0007052 | 4.64512630769e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Multifocal cerebral white matter abnormalities |
| HP:0003552 | 8.39281054501e-06 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Muscle stiffness |
| HP:0004809 | 8.51263284576e-06 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Neonatal alloimmune thrombocytopenia |
| HP:0007076 | 1.10641924054e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Extrapyramidal muscular rigidity |
| HP:0003683 | 1.10641924054e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Large beaked nose |
| HP:0011112 | 1.40788613268e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormality of serum cytokine level |
| HP:0011111 | 1.75950296076e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormality of immune serum protein physiology |
| HP:0030038 | 1.75950296076e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Enchondroma |
| HP:0005558 | 2.16510561586e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Chronic leukemia |
| HP:0004963 | 2.16510561586e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Calcification of the aorta |
| KEGG:03030 | 2.36321422077e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | DNA replication |
| HP:0030880 | 3.15359643514e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Raynaud phenomenon |
| HP:0012490 | 4.40398359193e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Panniculitis |
| HP:0001063 | 5.13694502998e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Acrocyanosis |
| HP:0003207 | 7.81269866661e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Arterial calcification |
| HP:0004934 | 8.87627654202e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Vascular calcification |
| HP:0002132 | 8.87627654202e-05 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Porencephalic cyst |
| HP:0011915 | 0.0001128375617 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cardiovascular calcification |
| HP:0000625 | 0.0001128375617 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Eyelid coloboma |
| HP:0002139 | 0.000140903306855 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Arrhinencephaly |
| HP:0010994 | 0.000140903306855 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal corpus striatum morphology |
| HP:0025323 | 0.000156527655735 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal arterial physiology |
| HP:0100614 | 0.000156527655735 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Myositis |
| HP:0006579 | 0.000173263524592 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Prolonged neonatal jaundice |
| HP:0011226 | 0.000173263524592 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Aplasia/Hypoplasia of the eyelid |
| HP:0007108 | 0.000210221244229 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Demyelinating peripheral neuropathy |
| HP:0002371 | 0.000230518728837 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Loss of speech |
| HP:0002061 | 0.000266971429668 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Lower limb spasticity |
| HP:0001087 | 0.000299138836936 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Developmental glaucoma |
| HP:0002313 | 0.000324713787646 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Spastic paraparesis |
| HP:0010551 | 0.000437655931958 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Paraplegia/paraparesis |
| HP:0002828 | 0.000707593756353 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Multiple joint contractures |
| HP:0000961 | 0.000799483936187 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cyanosis |
| HP:0002385 | 0.000898974807669 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Paraparesis |
| HP:0002323 | 0.00118290692185 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Anencephaly |
| HP:0001357 | 0.00124602529857 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Plagiocephaly |
| HP:0000965 | 0.00131134073925 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cutis marmorata |
| HP:0001433 | 0.00137889021682 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Hepatosplenomegaly |
| HP:0001609 | 0.00137889021682 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Hoarse voice |
| HP:0010622 | 0.00159531214256 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Neoplasm of the skeletal system |
| HP:0002180 | 0.001833168498 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Neurodegeneration |
| HP:0001640 | 0.00209345261454 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cardiomegaly |
| HP:0002510 | 0.0023771553591 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Spastic tetraplegia |
| HP:0100578 | 0.00257978907368 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Lipoatrophy |
| HP:0007256 | 0.0032828064817 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Abnormal pyramidal sign |
| HP:0004302 | 0.00388487764213 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Functional motor deficit |
| HP:0025454 | 0.00403972366653 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal CSF metabolite level |
| HP:0004942 | 0.00403972366653 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Aortic aneurysm |
| HP:0002415 | 0.00510151282311 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Leukodystrophy |
| HP:0100851 | 0.0057144914168 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Abnormal emotion/affect behavior |
| HP:0002187 | 0.00596340351898 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Intellectual disability, profound |
| HP:0009125 | 0.00652407882332 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Lipodystrophy |
| HP:0010549 | 0.0068379729891 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Weakness due to upper motor neuron dysfunction |
| HP:0009145 | 0.00711858944677 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal cerebral artery morphology |
| HP:0002514 | 0.0073244450141 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cerebral calcification |
| HP:0012447 | 0.00778237757503 | 0.571428571429 | RNASEH2C PRMT7 RNASEH2B RNASEH2A | Abnormal myelination |
| HP:0000958 | 0.0103685612154 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Dry skin |
| HP:0001909 | 0.0109003743403 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Leukemia |
| HP:0002960 | 0.0117314228717 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Autoimmunity |
| HP:0008936 | 0.0117314228717 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Muscular hypotonia of the trunk |
| HP:0000737 | 0.0126033076324 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Irritability |
| HP:0002617 | 0.0154734133885 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Dilatation |
| HP:0030163 | 0.0176082521898 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal vascular physiology |
| HP:0000925 | 0.0194118781335 | 0.714285714286 | RNASEH2C PRMT7 RNASEH2B SPAST RNASEH2A | Abnormality of the vertebral column |
| HP:0000952 | 0.0195289520329 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Jaundice |
| HP:0002063 | 0.0199289601625 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Rigidity |
| HP:0009830 | 0.0222785089839 | 0.571428571429 | RNASEH2A RNASEH2B SPAST RNASEH2C | Peripheral neuropathy |
| HP:0001369 | 0.0261084478552 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Arthritis |
| HP:0002134 | 0.0261084478552 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormality of the basal ganglia |
| HP:0003819 | 0.0290730325003 | 0.285714285714 | RNASEH2A RNASEH2C | Death in childhood |
| HP:0010766 | 0.029622117541 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Ectopic calcification |
| HP:0004374 | 0.0306802712058 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Hemiplegia/hemiparesis |
| HP:0009124 | 0.0317630295579 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal adipose tissue morphology |
| HP:0000054 | 0.0351616198099 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Micropenis |
| HP:0011119 | 0.0357503243224 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormality of the nasal dorsum |
| HP:0011400 | 0.0369471251775 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Abnormal CNS myelination |
| HP:0002355 | 0.0369471251775 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Difficulty walking |
| HP:0000496 | 0.0371139930584 | 0.714285714286 | RNASEH2C PRMT7 RNASEH2B SPAST RNASEH2A | Abnormality of eye movement |
| HP:0002910 | 0.0419977710671 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Elevated hepatic transaminase |
| HP:0001396 | 0.0426592871787 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Cholestasis |
| HP:0001005 | 0.0453738649811 | 0.428571428571 | RNASEH2A RNASEH2B RNASEH2C | Dermatological manifestations of systemic disorders |
| CORUM:6569 | 0.0499886427319 | 0.142857142857 | SPAST | SPG4-SPG33 complex |
| CORUM:6615 | 0.0499886427319 | 0.142857142857 | SPAST | SPG4-SPG12 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A) fraction |
| RNASEH2B | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A,RNASEH2B) fraction |
| RNASEH2C | RNASEH2B | 1.0 | 0.949 | hein_WMM hein (RNASEH2B) fraction |
| CMTR1 | SETD3 | 0.148 | 0.409 | fraction |
| SETD3 | RNASEH2A | 0.108 | 0.373 | fraction |
| RNASEH2B | SETD3 | 0.064 | 0.349 | fraction |
| PRMT7 | RNASEH2B | 0.048 | 0.296 | fraction |
| SPAST | RNASEH2B | 0.043 | 0.269 | fraction |
| CMTR1 | RNASEH2A | 0.041 | 0.27 | youn_WMM fraction |
| PRMT7 | RNASEH2C | 0.038 | 0.261 | fraction |
| RNASEH2C | CMTR1 | 0.017 | 0.172 | fraction |
| RNASEH2C | SETD3 | 0.013 | 0.142 | fraction |
| SPAST | RNASEH2C | 0.012 | 0.15 | fraction |
| PRMT7 | CMTR1 | 0.007 | 0.003 | youn_WMM WMM_only |
| SPAST | CMTR1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| SPAST | RNASEH2A | 0.005 | 0.007 | fraction |
| RNASEH2B | CMTR1 | 0.004 | 0.013 | fraction |
| SPAST | SETD3 | 0.004 | 0.012 | fraction |
| PRMT7 | SETD3 | 0.0 | 0.007 | fraction |
Images
Click to enlarge
Complex HuMAP2_03593 has an average edge precision of 0.294 which is ranked 4686 out of all 6965 complexes.
Related Complexes