hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03596
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKAP9 | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | UniProt NCBI |
| PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | UniProt NCBI |
| AKAP11 | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | UniProt NCBI |
| AKAP5 | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | UniProt NCBI |
| PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | UniProt NCBI |
| PRKACB | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 1.37772277124e-12 | 1.0 | PRKAR1B AKAP11 PRKAR1A PRKACB AKAP5 AKAP9 | G Protein Signaling Pathways |
| GO:0051018 | 4.17250787048e-08 | 0.833333333333 | PRKAR1B AKAP11 AKAP5 AKAP9 PRKAR1A | protein kinase A binding |
| REAC:R-HSA-381676 | 6.26114845342e-08 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-442720 | 9.81439878764e-07 | 0.5 | PRKAR1B PRKACB PRKAR1A | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| REAC:R-HSA-422356 | 1.02998099357e-06 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Regulation of insulin secretion |
| WP:WP3869 | 2.65048170372e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | Cannabinoid receptor signaling |
| REAC:R-HSA-163615 | 3.32843063241e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | PKA activation |
| WP:WP2012 | 3.88939936433e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | miRs in Muscle Cell Differentiation |
| REAC:R-HSA-164378 | 4.04105473372e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | PKA activation in glucagon signalling |
| REAC:R-HSA-163685 | 4.11561600349e-06 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Integration of energy metabolism |
| REAC:R-HSA-111931 | 4.84853251826e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | PKA-mediated phosphorylation of CREB |
| WP:WP3965 | 4.89916083633e-06 | 0.5 | PRKAR1B PRKACB PRKAR1A | Lipid Metabolism Pathway |
| REAC:R-HSA-180024 | 1.05150257754e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | DARPP-32 events |
| REAC:R-HSA-163359 | 2.6656058306e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111933 | 3.23451507706e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | Calmodulin induced events |
| REAC:R-HSA-111997 | 3.23451507706e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | CaM pathway |
| REAC:R-HSA-111996 | 3.878939824e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | Ca-dependent events |
| REAC:R-HSA-112314 | 4.44669391559e-05 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-432040 | 4.60355113742e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 5.41301437531e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | Aquaporin-mediated transport |
| REAC:R-HSA-1489509 | 5.41301437531e-05 | 0.5 | PRKAR1B PRKACB PRKAR1A | DAG and IP3 signaling |
| REAC:R-HSA-112043 | 0.00012312225834 | 0.5 | PRKAR1B PRKACB PRKAR1A | PLC beta mediated events |
| REAC:R-HSA-112315 | 0.000126179445512 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Transmission across Chemical Synapses |
| REAC:R-HSA-112040 | 0.000130640571844 | 0.5 | PRKAR1B PRKACB PRKAR1A | G-protein mediated events |
| WP:WP4540 | 0.000157102141644 | 0.5 | PRKAR1B PRKACB PRKAR1A | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.000253909359144 | 0.5 | PRKAR1B PRKACB PRKAR1A | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-438064 | 0.00036649373235 | 0.5 | PRKAR1B PRKACB PRKAR1A | Post NMDA receptor activation events |
| WP:WP536 | 0.00041417182098 | 0.5 | PRKAR1B PRKACB PRKAR1A | Calcium Regulation in the Cardiac Cell |
| WP:WP706 | 0.000502836491787 | 0.5 | PRKAR1B PRKACB PRKAR1A | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| KEGG:04910 | 0.000524612840052 | 0.5 | PRKAR1B PRKACB PRKAR1A | Insulin signaling pathway |
| WP:WP289 | 0.000539074693736 | 0.5 | PRKAR1B PRKACB PRKAR1A | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-442755 | 0.000560531240275 | 0.5 | PRKAR1B PRKACB PRKAR1A | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 0.000601857302474 | 0.5 | PRKAR1B PRKACB PRKAR1A | Opioid Signalling |
| REAC:R-HSA-9010642 | 0.000620139265586 | 0.333333333333 | AKAP5 PRKACB | ROBO receptors bind AKAP5 |
| REAC:R-HSA-112316 | 0.00064028821607 | 0.666666666667 | PRKAR1B AKAP5 PRKACB PRKAR1A | Neuronal System |
| GO:0034199 | 0.00123252169378 | 0.5 | PRKAR1B PRKACB PRKAR1A | activation of protein kinase A activity |
| GO:0071377 | 0.00123252169378 | 0.5 | PRKAR1B PRKACB PRKAR1A | cellular response to glucagon stimulus |
| REAC:R-HSA-5610787 | 0.00129954570423 | 0.5 | PRKAR1B PRKACB PRKAR1A | Hedgehog 'off' state |
| GO:0033762 | 0.00175581235783 | 0.5 | PRKAR1B PRKACB PRKAR1A | response to glucagon |
| REAC:R-HSA-5358351 | 0.00272420329871 | 0.5 | PRKAR1B PRKACB PRKAR1A | Signaling by Hedgehog |
| REAC:R-HSA-983231 | 0.00382327070463 | 0.5 | PRKAR1B PRKACB PRKAR1A | Factors involved in megakaryocyte development and platelet production |
| GO:0097546 | 0.00470617323084 | 0.5 | PRKAR1B PRKACB PRKAR1A | ciliary base |
| GO:0003091 | 0.00661098268806 | 0.5 | PRKAR1B PRKACB PRKAR1A | renal water homeostasis |
| REAC:R-HSA-418594 | 0.0167741368829 | 0.5 | PRKAR1B PRKACB PRKAR1A | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 0.0171589759047 | 0.5 | PRKAR1B PRKACB PRKAR1A | Intracellular signaling by second messengers |
| GO:0050891 | 0.0353486827187 | 0.5 | PRKAR1B PRKACB PRKAR1A | multicellular organismal water homeostasis |
| WP:WP4549 | 0.0358990321007 | 0.333333333333 | AKAP5 PRKAR1A | Fragile X Syndrome |
| GO:0030104 | 0.0398453744123 | 0.5 | PRKAR1B PRKACB PRKAR1A | water homeostasis |
| CORUM:668 | 0.0499726005494 | 0.166666666667 | AKAP5 | BKCA-beta2AR-AKAP79 signaling complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKACB | PRKAR1A | 1.0 | 0.949 | hein_WMM bioplex (PRKACB,PRKAR1A) bioplex_WMM Guru hein (PRKACB) fraction |
| PRKAR1A | PRKAR1B | 1.0 | 0.949 | hein_WMM bioplex (PRKAR1A) bioplex_WMM |
| PRKACB | AKAP11 | 0.997 | 0.929 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (PRKACB) |
| PRKACB | AKAP9 | 0.993 | 0.917 | hein_WMM bioplex (PRKACB) bioplex_WMM hein (PRKACB) |
| PRKACB | AKAP5 | 0.982 | 0.898 | hein_WMM bioplex (PRKACB) bioplex_WMM hein (AKAP5) gupta_WMM |
| PRKACB | PRKAR1B | 0.943 | 0.856 | hein_WMM bioplex (PRKACB) bioplex_WMM hein (PRKACB) |
| PRKAR1A | AKAP11 | 0.516 | 0.631 | hein_WMM bioplex (PRKAR1A) bioplex_WMM youn_WMM boldt_WMM |
| AKAP11 | PRKAR1B | 0.017 | 0.164 | hein_WMM bioplex_WMM WMM_only |
| AKAP9 | AKAP5 | 0.011 | 0.139 | bioplex_WMM WMM_only |
| AKAP5 | PRKAR1B | 0.01 | 0.118 | bioplex_WMM WMM_only |
| PRKAR1A | AKAP5 | 0.01 | 0.118 | bioplex_WMM WMM_only |
| PRKAR1A | AKAP9 | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| AKAP9 | PRKAR1B | 0.008 | 0.089 | hein_WMM bioplex_WMM WMM_only |
| AKAP11 | AKAP5 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| AKAP11 | AKAP9 | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03596 has an average edge precision of 0.466 which is ranked 2749 out of all 6965 complexes.
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