hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03608
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | UniProt NCBI |
| PDK2 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 0.000201110815485 | 1.0 | PDK2 PDK1 | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 0.000680424925724 | 1.0 | PDK2 PDK1 | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 0.00130722030065 | 1.0 | PDK2 PDK1 | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 0.00222227451111 | 1.0 | PDK2 PDK1 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004740 | 0.00270494046827 | 1.0 | PDK2 PDK1 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| GO:0010510 | 0.0126230555186 | 1.0 | PDK2 PDK1 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| GO:0050812 | 0.0126230555186 | 1.0 | PDK2 PDK1 | regulation of acyl-CoA biosynthetic process |
| GO:0042762 | 0.020287053512 | 1.0 | PDK2 PDK1 | regulation of sulfur metabolic process |
| GO:0051196 | 0.020287053512 | 1.0 | PDK2 PDK1 | regulation of coenzyme metabolic process |
| REAC:R-HSA-1428517 | 0.0226752444459 | 1.0 | PDK2 PDK1 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006086 | 0.029754345151 | 1.0 | PDK2 PDK1 | acetyl-CoA biosynthetic process from pyruvate |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | PDK2 PDK1 | Signaling by Nuclear Receptors |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDK1 | PDK2 | 1.0 | 0.949 | hein_WMM bioplex (PDK1) bioplex_WMM hein (PDK1) |
Images
Click to enlarge
Complex HuMAP2_03608 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDK1 | HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_03608 |
| PDK2 | HuMAP2_01188 HuMAP2_02908 HuMAP2_03608 |