hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03617
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | UniProt NCBI |
| NRBP1 | Nuclear receptor-binding protein | UniProt NCBI |
| GINS1 | DNA replication complex GINS protein PSF1 (GINS complex subunit 1) | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | UniProt NCBI |
| RANBP3 | Ran-binding protein 3 (RanBP3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:678 | 4.54011687692e-13 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | GINS complex |
| REAC:R-HSA-176974 | 5.93381512707e-10 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | Unwinding of DNA |
| REAC:R-HSA-69190 | 4.30144390958e-08 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA strand elongation |
| GO:0006271 | 8.69705349223e-07 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA strand elongation involved in DNA replication |
| GO:0000811 | 1.81637152046e-06 | 0.5 | GINS1 GINS2 GINS4 | GINS complex |
| GO:0022616 | 3.88005641427e-06 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA strand elongation |
| REAC:R-HSA-69239 | 9.09450019206e-06 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | Synthesis of DNA |
| REAC:R-HSA-69306 | 1.18518696073e-05 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA Replication |
| GO:0031261 | 1.81582264982e-05 | 0.5 | GINS1 GINS2 GINS4 | DNA replication preinitiation complex |
| REAC:R-HSA-69242 | 3.02487101892e-05 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | S Phase |
| GO:0043138 | 0.000660060925697 | 0.5 | GINS1 GINS2 GINS4 | 3'-5' DNA helicase activity |
| REAC:R-HSA-69278 | 0.00331294271573 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | Cell Cycle, Mitotic |
| GO:0006261 | 0.00373197176408 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA-dependent DNA replication |
| REAC:R-HSA-1640170 | 0.00675311119139 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | Cell Cycle |
| GO:0006260 | 0.0271190786656 | 0.666666666667 | GINS2 GINS3 GINS4 GINS1 | DNA replication |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GINS1 | GINS4 | 1.0 | 0.949 | bioplex_WMM Malo fraction |
| GINS1 | GINS2 | 1.0 | 0.949 | bioplex_WMM youn_WMM Malo fraction |
| GINS3 | GINS1 | 0.997 | 0.931 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS3 | GINS2 | 0.929 | 0.845 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS4 | GINS2 | 0.66 | 0.697 | bioplex_WMM Malo fraction |
| GINS3 | GINS4 | 0.434 | 0.578 | hein_WMM bioplex (GINS3) bioplex_WMM Guru Malo fraction |
| GINS3 | RANBP3 | 0.021 | 0.189 | bioplex_WMM youn_WMM fraction |
| GINS3 | NRBP1 | 0.02 | 0.188 | bioplex_WMM fraction |
| GINS4 | NRBP1 | 0.008 | 0.009 | bioplex_WMM fraction |
| NRBP1 | RANBP3 | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GINS1 | RANBP3 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| GINS1 | NRBP1 | 0.0 | 0.012 | fraction |
| GINS2 | RANBP3 | 0.0 | 0.009 | youn_WMM fraction |
| GINS4 | RANBP3 | 0.0 | 0.003 | bioplex_WMM fraction |
Images
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Complex HuMAP2_03617 has an average edge precision of 0.383 which is ranked 3500 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GINS2 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| NRBP1 | HuMAP2_01926 HuMAP2_03617 HuMAP2_03960 |
| GINS1 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS3 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 |
| GINS4 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| RANBP3 | HuMAP2_03617 |