hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03619
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TP63 | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | UniProt NCBI |
| CHEK2 | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | UniProt NCBI |
| ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | UniProt NCBI |
| TP73 | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1742 | 0.000228185108581 | 0.5 | TP63 TP73 | TP53 Network |
| REAC:R-HSA-139915 | 0.000361772624521 | 0.5 | TP63 TP73 | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-6803211 | 0.000452175281072 | 0.5 | TP63 TP73 | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-6803207 | 0.000552609179875 | 0.5 | TP63 TP73 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| REAC:R-HSA-6804759 | 0.000783559910601 | 0.5 | TP63 TP73 | Regulation of TP53 Activity through Association with Co-factors |
| REAC:R-HSA-6803205 | 0.000783559910601 | 0.5 | TP63 TP73 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | TP63 CHEK2 TP73 | Regulation of TP53 Activity |
| WP:WP2516 | 0.00124082421052 | 0.5 | CHEK2 TP73 | ATM Signaling Pathway |
| REAC:R-HSA-6803204 | 0.0019074750117 | 0.5 | TP63 TP73 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| WP:WP3959 | 0.00248310593375 | 0.5 | CHEK2 TP73 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| KEGG:04115 | 0.00401698930658 | 0.5 | CHEK2 TP73 | p53 signaling pathway |
| REAC:R-HSA-114452 | 0.00436320194063 | 0.5 | TP63 TP73 | Activation of BH3-only proteins |
| WP:WP254 | 0.00438725142358 | 0.5 | TP63 TP73 | Apoptosis |
| REAC:R-HSA-5633008 | 0.0078166615373 | 0.5 | TP63 TP73 | TP53 Regulates Transcription of Cell Death Genes |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | TP63 CHEK2 TP73 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-109606 | 0.0122651619918 | 0.5 | TP63 TP73 | Intrinsic Pathway for Apoptosis |
| GO:0097371 | 0.0405595771497 | 0.5 | TP63 TP73 | MDM2/MDM4 family protein binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHEK2 | TP63 | 0.227 | 0.468 | bioplex (TP63) bioplex_WMM |
| TP63 | TP73 | 0.142 | 0.406 | bioplex (TP63) bioplex_WMM |
| CHEK2 | ACAP2 | 0.072 | 0.353 | fraction |
| CHEK2 | TP73 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03619 has an average edge precision of 0.308 which is ranked 4475 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TP63 | HuMAP2_03619 |
| CHEK2 | HuMAP2_03619 |
| ACAP2 | HuMAP2_03619 |
| TP73 | HuMAP2_03619 HuMAP2_06789 |