hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03623
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | UniProt NCBI |
| NECAP2 | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | UniProt NCBI |
| NECAP1 | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 5.10580236014e-05 | 1.0 | NECAP2 AP2A2 NECAP1 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0030125 | 7.41079580349e-05 | 1.0 | NECAP2 AP2A2 NECAP1 | clathrin vesicle coat |
| REAC:R-HSA-8856828 | 0.000157135918784 | 1.0 | NECAP2 AP2A2 NECAP1 | Clathrin-mediated endocytosis |
| GO:0030118 | 0.000208882724853 | 1.0 | NECAP2 AP2A2 NECAP1 | clathrin coat |
| GO:0030120 | 0.00147262321021 | 1.0 | NECAP2 AP2A2 NECAP1 | vesicle coat |
| GO:0030117 | 0.00564855215433 | 1.0 | NECAP2 AP2A2 NECAP1 | membrane coat |
| GO:0048475 | 0.00564855215433 | 1.0 | NECAP2 AP2A2 NECAP1 | coated membrane |
| GO:0030665 | 0.00638454589443 | 1.0 | NECAP2 AP2A2 NECAP1 | clathrin-coated vesicle membrane |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | NECAP2 AP2A2 NECAP1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | NECAP2 AP2A2 NECAP1 | Vesicle-mediated transport |
| GO:0030136 | 0.0310032822085 | 1.0 | NECAP2 AP2A2 NECAP1 | clathrin-coated vesicle |
| GO:0030662 | 0.033252767518 | 1.0 | NECAP2 AP2A2 NECAP1 | coated vesicle membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NECAP2 | AP2A2 | 0.963 | 0.871 | bioplex (NECAP2) bioplex_WMM youn_WMM gupta_WMM |
| NECAP2 | NECAP1 | 0.958 | 0.863 | bioplex (NECAP2) bioplex_WMM |
| AP2A2 | NECAP1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03623 has an average edge precision of 0.61 which is ranked 1892 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AP2A2 | HuMAP2_01005 HuMAP2_02595 HuMAP2_03002 HuMAP2_03623 HuMAP2_04081 HuMAP2_06613 HuMAP2_06848 |
| NECAP2 | HuMAP2_01005 HuMAP2_01015 HuMAP2_02529 HuMAP2_03623 HuMAP2_05052 |
| NECAP1 | HuMAP2_01015 HuMAP2_02529 HuMAP2_03623 HuMAP2_05052 HuMAP2_06862 |