hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03624
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| NT5C3B | 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) | UniProt NCBI |
| TP53BP1 | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5231 | 6.75163031135e-09 | 0.75 | TP53BP1 RPA1 RPA2 | 53BP1-containing complex |
| CORUM:5229 | 1.50819606993e-05 | 0.5 | RPA1 RPA2 | RPA complex |
| WP:WP4016 | 1.71006587841e-05 | 0.75 | TP53BP1 RPA1 RPA2 | DNA IR-damage and cellular response via ATR |
| CORUM:2738 | 7.53895486054e-05 | 0.5 | RPA1 RPA2 | BLM complex II |
| CORUM:2222 | 7.53895486054e-05 | 0.5 | RPA1 RPA2 | BLM complex II |
| REAC:R-HSA-69473 | 0.000180191665247 | 0.75 | TP53BP1 RPA1 RPA2 | G2/M DNA damage checkpoint |
| CORUM:248 | 0.000180886312261 | 0.5 | RPA1 RPA2 | BRAFT complex |
| REAC:R-HSA-5693607 | 0.000198169454442 | 0.75 | TP53BP1 RPA1 RPA2 | Processing of DNA double-strand break ends |
| CORUM:244 | 0.000276304589937 | 0.5 | RPA1 RPA2 | BRAFT complex |
| CORUM:1005 | 0.000391779955301 | 0.5 | RPA1 RPA2 | RC complex during G2/M-phase of cell cycle |
| CORUM:1004 | 0.000391779955301 | 0.5 | RPA1 RPA2 | RC complex during S-phase of cell cycle |
| REAC:R-HSA-174437 | 0.000452175281072 | 0.5 | RPA1 RPA2 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5693567 | 0.000480050915503 | 0.75 | TP53BP1 RPA1 RPA2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| KEGG:03430 | 0.000505973236264 | 0.5 | RPA1 RPA2 | Mismatch repair |
| REAC:R-HSA-5693538 | 0.000550034129522 | 0.75 | TP53BP1 RPA1 RPA2 | Homology Directed Repair |
| REAC:R-HSA-174414 | 0.000552609179875 | 0.5 | RPA1 RPA2 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-3371511 | 0.000663071622452 | 0.5 | RPA1 RPA2 | HSF1 activation |
| REAC:R-HSA-5358606 | 0.000914071346391 | 0.5 | RPA1 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 0.000914071346391 | 0.5 | RPA1 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-69166 | 0.000914071346391 | 0.5 | RPA1 RPA2 | Removal of the Flap Intermediate |
| REAC:R-HSA-5693532 | 0.000966811034897 | 0.75 | TP53BP1 RPA1 RPA2 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.001021027578 | 0.75 | TP53BP1 RPA1 RPA2 | G2/M Checkpoints |
| REAC:R-HSA-5358508 | 0.00105460323216 | 0.5 | RPA1 RPA2 | Mismatch Repair |
| REAC:R-HSA-69183 | 0.00105460323216 | 0.5 | RPA1 RPA2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-110312 | 0.00120515287053 | 0.5 | RPA1 RPA2 | Translesion synthesis by REV1 |
| KEGG:03030 | 0.00125846611038 | 0.5 | RPA1 RPA2 | DNA replication |
| REAC:R-HSA-5655862 | 0.00136571756437 | 0.5 | RPA1 RPA2 | Translesion synthesis by POLK |
| REAC:R-HSA-5656121 | 0.00136571756437 | 0.5 | RPA1 RPA2 | Translesion synthesis by POLI |
| WP:WP466 | 0.00144137960059 | 0.5 | RPA1 RPA2 | DNA Replication |
| KEGG:03440 | 0.0015575421878 | 0.5 | RPA1 RPA2 | Homologous recombination |
| REAC:R-HSA-110320 | 0.00171688133139 | 0.5 | RPA1 RPA2 | Translesion Synthesis by POLH |
| HPA:022010_13 | 0.00175863305766 | 0.75 | TP53BP1 RPA1 RPA2 | hippocampus; glial cells[Supported,High] |
| KEGG:03420 | 0.00188834163584 | 0.5 | RPA1 RPA2 | Nucleotide excision repair |
| REAC:R-HSA-69186 | 0.0019074750117 | 0.5 | RPA1 RPA2 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 0.00210807296175 | 0.5 | RPA1 RPA2 | PCNA-Dependent Long Patch Base Excision Repair |
| KEGG:03460 | 0.00234639967825 | 0.5 | RPA1 RPA2 | Fanconi anemia pathway |
| REAC:R-HSA-174417 | 0.00276986547413 | 0.5 | RPA1 RPA2 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-110373 | 0.00301045354831 | 0.5 | RPA1 RPA2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 0.00301045354831 | 0.5 | RPA1 RPA2 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| WP:WP45 | 0.00326331699224 | 0.5 | RPA1 RPA2 | G1 to S cell cycle control |
| HPA:006010_13 | 0.00347435083739 | 0.75 | TP53BP1 RPA1 RPA2 | caudate; glial cells[Supported,High] |
| HPA:022010_03 | 0.00359313936294 | 0.75 | TP53BP1 RPA1 RPA2 | hippocampus; glial cells[Uncertain,High] |
| HPA:021010_13 | 0.00400850778369 | 0.75 | TP53BP1 RPA1 RPA2 | heart muscle; myocytes[Supported,High] |
| REAC:R-HSA-110314 | 0.00436320194063 | 0.5 | RPA1 RPA2 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 0.00436320194063 | 0.5 | RPA1 RPA2 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 0.00466369436644 | 0.5 | RPA1 RPA2 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 0.00497416142364 | 0.5 | RPA1 RPA2 | DNA strand elongation |
| REAC:R-HSA-69620 | 0.00518999523011 | 0.75 | TP53BP1 RPA1 RPA2 | Cell Cycle Checkpoints |
| REAC:R-HSA-68962 | 0.00529460041948 | 0.5 | RPA1 RPA2 | Activation of the pre-replicative complex |
| HPA:035010_13 | 0.005495872704 | 0.75 | TP53BP1 RPA1 RPA2 | placenta; decidual cells[Supported,High] |
| REAC:R-HSA-73933 | 0.00596538345738 | 0.5 | RPA1 RPA2 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-6783310 | 0.00596538345738 | 0.5 | RPA1 RPA2 | Fanconi Anemia Pathway |
| WP:WP2446 | 0.00623747495525 | 0.5 | RPA1 RPA2 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-5685938 | 0.00631572211528 | 0.5 | RPA1 RPA2 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.00667602194349 | 0.5 | RPA1 RPA2 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 0.0070462802506 | 0.5 | RPA1 RPA2 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-110313 | 0.0070462802506 | 0.5 | RPA1 RPA2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| HPA:007010_13 | 0.00718236211525 | 0.75 | TP53BP1 RPA1 RPA2 | cerebellum; Purkinje cells[Supported,High] |
| REAC:R-HSA-73894 | 0.00725712676591 | 0.75 | TP53BP1 RPA1 RPA2 | DNA Repair |
| HPA:006010_03 | 0.00743886355825 | 0.75 | TP53BP1 RPA1 RPA2 | caudate; glial cells[Uncertain,High] |
| HPA:048040_12 | 0.00770136360784 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 2; peripheral nerve[Supported,Medium] |
| REAC:R-HSA-5693579 | 0.00821677913545 | 0.5 | RPA1 RPA2 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5696400 | 0.00821677913545 | 0.5 | RPA1 RPA2 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.00904685478976 | 0.5 | RPA1 RPA2 | Formation of Incision Complex in GG-NER |
| HPA:047010_12 | 0.0101843487884 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 1; adipocytes[Supported,Medium] |
| REAC:R-HSA-73893 | 0.0108262926188 | 0.5 | RPA1 RPA2 | DNA Damage Bypass |
| HPA:026010_12 | 0.011690427788 | 0.75 | TP53BP1 RPA1 RPA2 | liver; bile duct cells[Supported,Medium] |
| HPA:004010_12 | 0.0117781632296 | 0.75 | TP53BP1 RPA1 RPA2 | breast; adipocytes[Supported,Medium] |
| HPA:008030_13 | 0.0129586703655 | 0.75 | TP53BP1 RPA1 RPA2 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:048010_12 | 0.0148209572751 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 2; adipocytes[Supported,Medium] |
| HPA:055010_13 | 0.0170761600268 | 0.75 | TP53BP1 RPA1 RPA2 | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.017188862818 | 0.75 | TP53BP1 RPA1 RPA2 | testis; cells in seminiferous ducts[Supported,High] |
| HPA:014010_12 | 0.0185798771417 | 0.75 | TP53BP1 RPA1 RPA2 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| HPA:035010_03 | 0.0186990413257 | 0.75 | TP53BP1 RPA1 RPA2 | placenta; decidual cells[Uncertain,High] |
| HPA:001040_13 | 0.0188187097484 | 0.75 | TP53BP1 RPA1 RPA2 | adrenal gland; glandular cells[Supported,High] |
| REAC:R-HSA-6782210 | 0.0201596117617 | 0.5 | RPA1 RPA2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| HPA:022010_12 | 0.0205475883704 | 0.75 | TP53BP1 RPA1 RPA2 | hippocampus; glial cells[Supported,Medium] |
| REAC:R-HSA-6782135 | 0.0207977326435 | 0.5 | RPA1 RPA2 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 0.0207977326435 | 0.5 | RPA1 RPA2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-3371453 | 0.0207977326435 | 0.5 | RPA1 RPA2 | Regulation of HSF1-mediated heat shock response |
| HPA:018010_13 | 0.0209312173501 | 0.75 | TP53BP1 RPA1 RPA2 | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | TP53BP1 RPA1 RPA2 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0211895818928 | 0.75 | TP53BP1 RPA1 RPA2 | bronchus; respiratory epithelial cells[Supported,High] |
| HPA:021010_03 | 0.0218446946143 | 0.75 | TP53BP1 RPA1 RPA2 | heart muscle; myocytes[Uncertain,High] |
| GO:0090734 | 0.0225145500348 | 0.75 | TP53BP1 RPA1 RPA2 | site of DNA damage |
| HPA:035020_13 | 0.025175887812 | 0.75 | TP53BP1 RPA1 RPA2 | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | TP53BP1 RPA1 RPA2 | caudate; glial cells[Supported,Medium] |
| HPA:013010_12 | 0.02561445023 | 0.75 | TP53BP1 RPA1 RPA2 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:031020_12 | 0.0259096106078 | 0.75 | TP53BP1 RPA1 RPA2 | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:050020_12 | 0.0296284087039 | 0.75 | TP53BP1 RPA1 RPA2 | spleen; cells in white pulp[Supported,Medium] |
| REAC:R-HSA-6781827 | 0.0299917015228 | 0.5 | RPA1 RPA2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:048040_11 | 0.0306101023554 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 2; peripheral nerve[Supported,Low] |
| HPA:011030_12 | 0.0312763482879 | 0.75 | TP53BP1 RPA1 RPA2 | colon; peripheral nerve/ganglion[Supported,Medium] |
| HPA:046010_12 | 0.0316130305275 | 0.75 | TP53BP1 RPA1 RPA2 | smooth muscle; smooth muscle cells[Supported,Medium] |
| REAC:R-HSA-157579 | 0.0323499619092 | 0.5 | RPA1 RPA2 | Telomere Maintenance |
| HPA:019010_13 | 0.0338599256539 | 0.75 | TP53BP1 RPA1 RPA2 | gallbladder; glandular cells[Supported,High] |
| HPA:008020_12 | 0.0340369984952 | 0.75 | TP53BP1 RPA1 RPA2 | cerebral cortex; glial cells[Supported,Medium] |
| HPA:004010_11 | 0.0342146813303 | 0.75 | TP53BP1 RPA1 RPA2 | breast; adipocytes[Supported,Low] |
| HPA:035010_12 | 0.0347513998463 | 0.75 | TP53BP1 RPA1 RPA2 | placenta; decidual cells[Supported,Medium] |
| REAC:R-HSA-5696399 | 0.0347967852364 | 0.5 | RPA1 RPA2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-3371556 | 0.0356320611636 | 0.5 | RPA1 RPA2 | Cellular response to heat stress |
| REAC:R-HSA-69002 | 0.0356320611636 | 0.5 | RPA1 RPA2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-912446 | 0.0356320611636 | 0.5 | RPA1 RPA2 | Meiotic recombination |
| HPA:007020_12 | 0.0365805245307 | 0.75 | TP53BP1 RPA1 RPA2 | cerebellum; cells in granular layer[Supported,Medium] |
| REAC:R-HSA-73884 | 0.0373320991746 | 0.5 | RPA1 RPA2 | Base Excision Repair |
| HPA:047010_11 | 0.0382800635721 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 1; adipocytes[Supported,Low] |
| HPA:024010_12 | 0.038664676769 | 0.75 | TP53BP1 RPA1 RPA2 | kidney; cells in glomeruli[Supported,Medium] |
| REAC:R-HSA-6804756 | 0.0408500448467 | 0.5 | RPA1 RPA2 | Regulation of TP53 Activity through Phosphorylation |
| HPA:050010_12 | 0.0410259794916 | 0.75 | TP53BP1 RPA1 RPA2 | spleen; cells in red pulp[Supported,Medium] |
| HPA:027020_12 | 0.0418336999884 | 0.75 | TP53BP1 RPA1 RPA2 | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.0438987109299 | 0.75 | TP53BP1 RPA1 RPA2 | skeletal muscle; myocytes[Supported,Medium] |
| HPA:011010_12 | 0.0447431662559 | 0.75 | TP53BP1 RPA1 RPA2 | colon; endothelial cells[Supported,Medium] |
| HPA:007030_12 | 0.0447431662559 | 0.75 | TP53BP1 RPA1 RPA2 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:007010_03 | 0.0451693794799 | 0.75 | TP53BP1 RPA1 RPA2 | cerebellum; Purkinje cells[Uncertain,High] |
| HPA:048010_11 | 0.0458137035926 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 2; adipocytes[Supported,Low] |
| HPA:032020_12 | 0.0460298167372 | 0.75 | TP53BP1 RPA1 RPA2 | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | TP53BP1 RPA1 RPA2 | skin 1; Langerhans[Supported,Medium] |
| HPA:028010_12 | 0.0466821853682 | 0.75 | TP53BP1 RPA1 RPA2 | lymph node; germinal center cells[Supported,Medium] |
| HPA:048040_02 | 0.0471204653595 | 0.75 | TP53BP1 RPA1 RPA2 | soft tissue 2; peripheral nerve[Uncertain,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | TP53BP1 | 0.312 | 0.505 | bioplex_WMM youn_WMM fraction |
| RPA1 | TP53BP1 | 0.076 | 0.355 | youn_WMM gupta_WMM fraction |
| NT5C3B | TP53BP1 | 0.06 | 0.337 | fraction |
Images
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Complex HuMAP2_03624 has an average edge precision of 0.536 which is ranked 2296 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPA2 | HuMAP2_00586 HuMAP2_02745 HuMAP2_03624 HuMAP2_03648 HuMAP2_03650 HuMAP2_05012 HuMAP2_05034 |
| RPA1 | HuMAP2_00586 HuMAP2_02745 HuMAP2_03624 HuMAP2_03648 HuMAP2_05012 HuMAP2_05034 |
| NT5C3B | HuMAP2_01823 HuMAP2_03624 HuMAP2_05034 HuMAP2_06161 |
| TP53BP1 | HuMAP2_01823 HuMAP2_03624 HuMAP2_05034 HuMAP2_06161 |