hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03627
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EGLN1 | Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) | UniProt NCBI |
| SPART | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | UniProt NCBI |
| POLK | DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2996 | 0.0249595281251 | 0.25 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| MIRNA:hsa-miR-4790-3p | 0.048384308251 | 0.5 | EGLN1 SPART | hsa-miR-4790-3p |
| CORUM:1783 | 0.0499140284799 | 0.25 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLK | SPART | 0.049 | 0.296 | bioplex (SPART) bioplex_WMM youn_WMM |
| SPART | SMURF1 | 0.026 | 0.22 | bioplex (SPART) bioplex_WMM |
| SPART | EGLN1 | 0.021 | 0.188 | bioplex_WMM youn_WMM gupta_WMM fraction |
| POLK | EGLN1 | 0.007 | 0.002 | youn_WMM WMM_only |
Images
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Complex HuMAP2_03627 has an average edge precision of 0.176 which is ranked 6459 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EGLN1 | HuMAP2_03627 HuMAP2_06704 |
| SPART | HuMAP2_00269 HuMAP2_03627 HuMAP2_06193 |
| SMURF1 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_03627 HuMAP2_04429 |
| POLK | HuMAP2_00092 HuMAP2_02264 HuMAP2_03143 HuMAP2_03627 HuMAP2_06193 |