hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03636
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN2A | Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) | UniProt NCBI |
| CDK4 | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9630791 | 1.67592346237e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| REAC:R-HSA-9632697 | 1.67592346237e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| REAC:R-HSA-9630750 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects |
| REAC:R-HSA-9630747 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | Diseases of Cellular Senescence |
| CORUM:1642 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | p16-cyclin D2-CDK4 complex |
| REAC:R-HSA-9632700 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| REAC:R-HSA-9630794 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| REAC:R-HSA-9632693 | 5.02777038712e-06 | 1.0 | CDK4 CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects |
| KEGG:05219 | 9.71677643943e-05 | 1.0 | CDK4 CDKN2A | Bladder cancer |
| WP:WP4204 | 0.000162072879297 | 1.0 | CDK4 CDKN2A | Tumor suppressor activity of SMARCB1 |
| HP:0012056 | 0.000220402556674 | 1.0 | CDK4 CDKN2A | Cutaneous melanoma |
| WP:WP2828 | 0.000234726238982 | 1.0 | CDK4 CDKN2A | Bladder Cancer |
| KEGG:05218 | 0.00027589225596 | 1.0 | CDK4 CDKN2A | Melanoma |
| KEGG:04115 | 0.000294129448977 | 1.0 | CDK4 CDKN2A | p53 signaling pathway |
| KEGG:05223 | 0.000294129448977 | 1.0 | CDK4 CDKN2A | Non-small cell lung cancer |
| KEGG:05214 | 0.000332354605541 | 1.0 | CDK4 CDKN2A | Glioma |
| WP:WP3998 | 0.000352461939805 | 1.0 | CDK4 CDKN2A | Prader-Willi and Angelman Syndrome |
| KEGG:05212 | 0.000362555397177 | 1.0 | CDK4 CDKN2A | Pancreatic cancer |
| KEGG:05220 | 0.00039406926671 | 1.0 | CDK4 CDKN2A | Chronic myeloid leukemia |
| KEGG:01522 | 0.000584319664263 | 1.0 | CDK4 CDKN2A | Endocrine resistance |
| WP:WP45 | 0.000727651340845 | 1.0 | CDK4 CDKN2A | G1 to S cell cycle control |
| REAC:R-HSA-2559585 | 0.000831258037338 | 1.0 | CDK4 CDKN2A | Oncogene Induced Senescence |
| WP:WP4255 | 0.000899783916099 | 1.0 | CDK4 CDKN2A | Non-small cell lung cancer |
| KEGG:04110 | 0.00104170846513 | 1.0 | CDK4 CDKN2A | Cell cycle |
| WP:WP2261 | 0.00123734260264 | 1.0 | CDK4 CDKN2A | Signaling Pathways in Glioblastoma |
| WP:WP4263 | 0.00126789427184 | 1.0 | CDK4 CDKN2A | Pancreatic adenocarcinoma pathway |
| KEGG:04934 | 0.00144000876062 | 1.0 | CDK4 CDKN2A | Cushing syndrome |
| REAC:R-HSA-69236 | 0.0014429701011 | 1.0 | CDK4 CDKN2A | G1 Phase |
| REAC:R-HSA-69231 | 0.0014429701011 | 1.0 | CDK4 CDKN2A | Cyclin D associated events in G1 |
| KEGG:04218 | 0.00152317036077 | 1.0 | CDK4 CDKN2A | Cellular senescence |
| KEGG:05225 | 0.00183261905189 | 1.0 | CDK4 CDKN2A | Hepatocellular carcinoma |
| WP:WP179 | 0.00248511748256 | 1.0 | CDK4 CDKN2A | Cell Cycle |
| KEGG:05203 | 0.00256458703081 | 1.0 | CDK4 CDKN2A | Viral carcinogenesis |
| HP:0001480 | 0.00273833479504 | 1.0 | CDK4 CDKN2A | Freckling |
| KEGG:05166 | 0.00281669798708 | 1.0 | CDK4 CDKN2A | Human T-cell leukemia virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | CDK4 CDKN2A | Human cytomegalovirus infection |
| HP:0030895 | 0.00409080502918 | 1.0 | CDK4 CDKN2A | Abnormal gastrointestinal motility |
| HP:0002579 | 0.00409080502918 | 1.0 | CDK4 CDKN2A | Gastrointestinal dysmotility |
| HP:0006753 | 0.0053297345523 | 1.0 | CDK4 CDKN2A | Neoplasm of the stomach |
| HP:0002861 | 0.00552008221488 | 1.0 | CDK4 CDKN2A | Melanoma |
| HP:0002894 | 0.0085355899221 | 1.0 | CDK4 CDKN2A | Neoplasm of the pancreas |
| HP:0100013 | 0.00877602907484 | 1.0 | CDK4 CDKN2A | Neoplasm of the breast |
| REAC:R-HSA-2559582 | 0.00932651406811 | 1.0 | CDK4 CDKN2A | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | CDK4 CDKN2A | Oxidative Stress Induced Senescence |
| KEGG:05200 | 0.0157394270613 | 1.0 | CDK4 CDKN2A | Pathways in cancer |
| HP:0000488 | 0.0158723235132 | 1.0 | CDK4 CDKN2A | Retinopathy |
| HP:0003764 | 0.0165301917506 | 1.0 | CDK4 CDKN2A | Nevus |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | CDK4 CDKN2A | Mitotic G1-G1/S phases |
| HP:0000958 | 0.0234461568244 | 1.0 | CDK4 CDKN2A | Dry skin |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | CDK4 CDKN2A | Cellular Senescence |
| HP:0008069 | 0.0383233293999 | 1.0 | CDK4 CDKN2A | Neoplasm of the skin |
| HP:0001062 | 0.0497341708567 | 0.5 | CDK4 | Atypical nevus |
| HP:0001074 | 0.0497341708567 | 0.5 | CDK4 | Atypical nevi in non-sun exposed areas |
| CORUM:5287 | 0.0499173803268 | 0.5 | CDK4 | CCND1-CDK4 complex |
| CORUM:5107 | 0.0499173803268 | 0.5 | CDK4 | p34(SEI-1)-CDK4-CyclinD2 complex |
| CORUM:3086 | 0.0499173803268 | 0.5 | CDK4 | CCND3-CDK4 complex |
| CORUM:3085 | 0.0499173803268 | 0.5 | CDK4 | CCND2-CDK4 complex |
| CORUM:3084 | 0.0499173803268 | 0.5 | CDK4 | CCND1-CDK4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN2A | CDK4 | 0.974 | 0.886 | hein_WMM bioplex (CDK4) bioplex_WMM youn_WMM hein (CDK4) gupta_WMM |
Images
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Complex HuMAP2_03636 has an average edge precision of 0.886 which is ranked 633 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN2A | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |
| CDK4 | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |