hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03645

Confidence: Very High

Genename	Protein Name	Links
KDM1A	Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)	UniProt NCBI
MTA2	Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)	UniProt NCBI
HDAC1	Histone deacetylase 1 (HD1) (EC 3.5.1.98)	UniProt NCBI
RBBP4	Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)	UniProt NCBI
HDAC2	Histone deacetylase 2 (HD2) (EC 3.5.1.98)	UniProt NCBI
MBD2	Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)	UniProt NCBI
ZNF219	Zinc finger protein 219	UniProt NCBI
CHD4	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	UniProt NCBI
GATAD2A	Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)	UniProt NCBI
MBD3	Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:62	2.21696531037e-21	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	MeCP1 complex
CORUM:659	9.97458468438e-21	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	MeCP1 complex
CORUM:685	9.97458468438e-21	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	MeCP1 complex
WP:WP4320	1.80288654716e-18	0.8	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	The effect of progerin on the involved genes in Hutchinson-Gilford Progeria Syndrome
CORUM:61	7.21971209041e-18	0.6	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3	Mi2/NuRD complex
CORUM:778	1.39364867603e-17	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	LARC complex (LCR-associated remodeling complex)
CORUM:888	2.88721974657e-17	0.6	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3	MTA2 complex
CORUM:646	8.65966432277e-17	0.6	RBBP4 MTA2 MBD3 MBD2 HDAC1 KDM1A	HDAC1-associated protein complex
CORUM:649	8.65966432277e-17	0.6	RBBP4 GATAD2A MBD3 MBD2 HDAC1 MTA2	HDAC1-associated core complex cII
REAC:R-HSA-8943724	2.57990634693e-16	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	Regulation of PTEN gene transcription
GO:0090545	1.19687974277e-15	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	CHD-type complex
GO:0016581	1.19687974277e-15	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	NuRD complex
REAC:R-HSA-6804758	1.58011761716e-15	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	Regulation of TP53 Activity through Acetylation
CORUM:1495	3.07197297078e-15	0.5	CHD4 HDAC1 MBD3 MTA2 RBBP4	PID complex
CORUM:282	8.24224329717e-15	0.6	RBBP4 MTA2 MBD3 MBD2 HDAC1 HDAC2	SNF2h-cohesin-NuRD complex
CORUM:632	1.27350773356e-14	0.6	CHD4 MTA2 RBBP4 HDAC1 HDAC2 KDM1A	Anti-HDAC2 complex
REAC:R-HSA-3214815	1.58319945618e-14	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	HDACs deacetylate histones
GO:0090568	4.55337250611e-14	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	nuclear transcriptional repressor complex
REAC:R-HSA-73762	4.86678322205e-14	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	RNA Polymerase I Transcription Initiation
REAC:R-HSA-73854	5.89462313079e-14	0.8	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 GATAD2A HDAC2	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	6.35618277977e-14	0.8	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 GATAD2A HDAC2	RNA Polymerase I Transcription
CORUM:614	6.44753296685e-14	0.5	CHD4 HDAC1 RBBP4 HDAC2 KDM1A	NRD complex (Nucleosome remodeling and deacetylation complex)
CORUM:650	6.44753296685e-14	0.5	MBD3 RBBP4 GATAD2A MTA2 HDAC2	HDAC2-asscociated core complex
CORUM:587	1.7188609212e-13	0.5	CHD4 HDAC1 MBD3 HDAC2 RBBP4	NuRD.1 complex
REAC:R-HSA-6807070	3.42591744486e-13	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	PTEN Regulation
CORUM:1257	3.86688972128e-13	0.6	RBBP4 MTA2 MBD3 HDAC2 HDAC1 KDM1A	ALL-1 supercomplex
REAC:R-HSA-212165	6.50718374228e-13	0.8	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 GATAD2A HDAC2	Epigenetic regulation of gene expression
GO:0031492	9.97233166896e-13	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	nucleosomal DNA binding
REAC:R-HSA-427389	1.52834853396e-12	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
REAC:R-HSA-5250913	1.62738602737e-11	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-1257604	2.19779122676e-11	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	PIP3 activates AKT signaling
REAC:R-HSA-9006925	7.76510206345e-11	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	Intracellular signaling by second messengers
GO:0031491	9.07154427883e-11	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	nucleosome binding
REAC:R-HSA-4839726	9.31653702691e-11	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	Chromatin organization
REAC:R-HSA-3247509	9.31653702691e-11	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	Chromatin modifying enzymes
GO:0000118	1.02036821475e-10	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	histone deacetylase complex
CORUM:886	1.14280476802e-10	0.4	MBD3 HDAC1 HDAC2 RBBP4	MTA1 complex
GO:0017053	1.60271216282e-10	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	transcriptional repressor complex
REAC:R-HSA-5633007	3.09127907346e-10	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	Regulation of TP53 Activity
GO:0070603	4.42408764981e-10	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	SWI/SNF superfamily-type complex
GO:0031490	4.85940487579e-10	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	chromatin DNA binding
GO:1904949	5.84105116833e-10	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	ATPase complex
GO:0043044	9.06754491968e-10	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	ATP-dependent chromatin remodeling
GO:0006338	5.59970612159e-08	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	chromatin remodeling
GO:0000980	6.8216822631e-08	0.6	CHD4 RBBP4 HDAC1 HDAC2 MBD3 MBD2	RNA polymerase II distal enhancer sequence-specific DNA binding
REAC:R-HSA-3700989	8.46442586525e-08	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	Transcriptional Regulation by TP53
GO:1901796	8.83475466036e-08	0.7	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A	regulation of signal transduction by p53 class mediator
GO:0001158	1.61694792199e-07	0.6	CHD4 RBBP4 HDAC1 HDAC2 MBD3 MBD2	enhancer sequence-specific DNA binding
CORUM:634	1.62061692851e-07	0.3	HDAC1 HDAC2 KDM1A	XFIM complex
CORUM:7225	1.62061692851e-07	0.3	CHD4 MTA2 HDAC2	CDH4-HDAC2-MTA2-RBBP7-TWIST1 complex
CORUM:585	1.62061692851e-07	0.3	MBD3 HDAC1 CHD4	Mi2/NuRD-BCL6-MTA3 complex
CORUM:41	1.62061692851e-07	0.3	HDAC1 MTA2 MBD3	Mi-2/NuRD-MTA3 complex
CORUM:3048	1.62061692851e-07	0.3	HDAC1 HDAC2 RBBP4	mSin3A complex
CORUM:889	1.62061692851e-07	0.3	HDAC1 HDAC2 RBBP4	MTA1-HDAC core complex
GO:0003682	1.69202530865e-07	0.8	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	chromatin binding
GO:0044212	2.58097823292e-07	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	transcription regulatory region DNA binding
GO:0001067	2.58097823292e-07	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	regulatory region nucleic acid binding
CORUM:636	3.24009105225e-07	0.3	HDAC1 HDAC2 KDM1A	BHC complex
GO:0035326	3.43595041806e-07	0.6	CHD4 RBBP4 HDAC1 HDAC2 MBD3 MBD2	enhancer binding
CORUM:871	5.66816007784e-07	0.3	HDAC1 HDAC2 KDM1A	BRAF53-BRCA2 complex
CORUM:732	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	SIN3 complex
CORUM:698	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	SIN3-HDAC-SAP30-ARID4 complex
CORUM:283	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	Sin3 complex
CORUM:620	5.66816007784e-07	0.3	HDAC1 HDAC2 KDM1A	CoREST-HDAC complex
CORUM:596	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	SIN3-HDAC-SAP30-ARID4 complex
CORUM:54	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	SIN3 complex
CORUM:695	5.66816007784e-07	0.3	HDAC1 HDAC2 RBBP4	SIN3-HDAC-SAP30-ARID4 complex
CORUM:591	9.06585833412e-07	0.3	HDAC1 HDAC2 RBBP4	SAP complex (Sin3-associated protein complex)
CORUM:696	9.06585833412e-07	0.3	HDAC1 HDAC2 RBBP4	BRMS1-SIN3-HDAC complex
GO:0000790	1.08279984617e-06	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	nuclear chromatin
GO:0072331	1.13722487717e-06	0.7	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A	signal transduction by p53 class mediator
GO:0043565	1.20364126583e-06	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	sequence-specific DNA binding
CORUM:592	1.35939923621e-06	0.3	HDAC1 HDAC2 RBBP4	SAP complex (Sin3-associated protein complex)
CORUM:738	1.35939923621e-06	0.3	HDAC1 HDAC2 RBBP4	SIN3-ING1b complex I
CORUM:643	1.35939923621e-06	0.3	HDAC1 HDAC2 KDM1A	CtBP core complex
CORUM:1492	1.94131410987e-06	0.3	HDAC1 HDAC2 KDM1A	BHC110 complex
CORUM:743	1.94131410987e-06	0.3	HDAC1 HDAC2 RBBP4	SIN3-SAP25 complex
CORUM:691	2.66836560606e-06	0.3	HDAC1 HDAC2 RBBP4	SIN3-SAP25 complex
CORUM:633	2.66836560606e-06	0.3	HDAC1 HDAC2 KDM1A	anti-BHC110 complex
CORUM:2851	4.62190547268e-06	0.3	HDAC1 HDAC2 RBBP4	ING2 complex
GO:0000785	4.79671681544e-06	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	chromatin
GO:0044454	6.44350061995e-06	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	nuclear chromosome part
GO:0000976	6.73591455624e-06	0.8	RBBP4 ZNF219 CHD4 HDAC1 HDAC2 MBD2 MBD3 MTA2	transcription regulatory region sequence-specific DNA binding
CORUM:714	7.34784590616e-06	0.3	HDAC1 HDAC2 RBBP4	BRM-SIN3A complex
GO:0000122	7.56212675801e-06	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of transcription by RNA polymerase II
GO:0000228	8.18041212093e-06	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	nuclear chromosome
CORUM:739	9.04031310346e-06	0.3	HDAC1 HDAC2 RBBP4	SIN3-ING1b complex II
GO:0006325	1.0889816169e-05	0.8	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	chromatin organization
CORUM:642	1.0973651278e-05	0.3	HDAC1 HDAC2 KDM1A	CtBP complex
GO:0000978	1.20020192824e-05	0.7	CHD4 ZNF219 RBBP4 HDAC1 HDAC2 MBD3 MBD2	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:1990837	1.24746765786e-05	0.8	RBBP4 ZNF219 CHD4 HDAC1 HDAC2 MBD2 MBD3 MTA2	sequence-specific double-stranded DNA binding
CORUM:2721	1.31637369008e-05	0.3	HDAC1 HDAC2 RBBP4	HCF-1 complex
GO:0000987	1.61563178019e-05	0.7	CHD4 ZNF219 RBBP4 HDAC1 HDAC2 MBD3 MBD2	proximal promoter sequence-specific DNA binding
REAC:R-HSA-74160	2.43247356738e-05	0.8	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 GATAD2A HDAC2	Gene expression (Transcription)
GO:0003690	3.30447024813e-05	0.8	RBBP4 ZNF219 CHD4 HDAC1 HDAC2 MBD2 MBD3 MTA2	double-stranded DNA binding
GO:0042826	5.8640833427e-05	0.5	CHD4 HDAC1 RBBP4 MTA2 HDAC2	histone deacetylase binding
GO:0044427	7.653029207e-05	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	chromosomal part
CORUM:648	9.0534767973e-05	0.2	HDAC1 KDM1A	HDAC1-associated core complex cI
CORUM:3053	9.0534767973e-05	0.2	HDAC1 HDAC2	mSin3A-HDAC1-HDAC2 complex
CORUM:1134	9.0534767973e-05	0.2	CHD4 HDAC2	ATR-HDAC2-CHD4 complex
CORUM:2814	9.0534767973e-05	0.2	HDAC1 HDAC2	BRCA1-HDAC1-HDAC2 complex
GO:0003677	0.000102069759412	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	DNA binding
GO:0005694	0.000105741912425	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	chromosome
GO:0001103	0.000120700657529	0.4	CHD4 HDAC1 MTA2 HDAC2	RNA polymerase II repressing transcription factor binding
REAC:R-HSA-212436	0.000158873773892	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	Generic Transcription Pathway
CORUM:749	0.000181004688405	0.2	HDAC1 HDAC2	MeCP2-SIN3A-HDAC complex
CORUM:6421	0.000181004688405	0.2	HDAC1 HDAC2	DNTTIP1-ZNF541-HDAC1-HDAC2 complex
CORUM:6373	0.000181004688405	0.2	HDAC1 HDAC2	MiDAC complex
GO:0006357	0.000243495701416	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of transcription by RNA polymerase II
REAC:R-HSA-193670	0.000254558008694	0.2	HDAC1 HDAC2	p75NTR negatively regulates cell cycle via SC1
GO:0045892	0.000256626613347	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of transcription, DNA-templated
GO:0000977	0.000256975378466	0.7	CHD4 ZNF219 RBBP4 HDAC1 HDAC2 MBD3 MBD2	RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903507	0.000261360308446	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of nucleic acid-templated transcription
GO:1902679	0.000263755558421	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of RNA biosynthetic process
GO:0045814	0.00026875022533	0.5	MBD3 HDAC1 RBBP4 HDAC2 MBD2	negative regulation of gene expression, epigenetic
GO:0001012	0.000275339461294	0.7	CHD4 ZNF219 RBBP4 HDAC1 HDAC2 MBD3 MBD2	RNA polymerase II regulatory region DNA binding
GO:0010629	0.000280109253013	0.9	RBBP4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of gene expression
REAC:R-HSA-73857	0.00033374524047	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	RNA Polymerase II Transcription
GO:0051276	0.000443702834808	0.8	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	chromosome organization
CORUM:3149	0.000452187654768	0.2	HDAC1 RBBP4	NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex
CORUM:3167	0.000452187654768	0.2	HDAC1 HDAC2	NCOR-SIN3-HDAC-HESX1 complex
GO:0051253	0.000512232431813	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of RNA metabolic process
CORUM:1505	0.000632835990272	0.2	HDAC1 HDAC2	NCOR2 complex
GO:0006366	0.000635801489067	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	transcription by RNA polymerase II
REAC:R-HSA-162582	0.000665835207032	0.8	CHD4 MTA2 RBBP4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A	Signal Transduction
GO:0045934	0.000922370846405	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of nucleobase-containing compound metabolic process
GO:2000113	0.00092955147594	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of cellular macromolecule biosynthetic process
CORUM:0000000	0.00104233586959	0.9	RBBP4 MTA2 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	CORUM root
GO:0010558	0.00105929444246	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of macromolecule biosynthetic process
GO:0016569	0.00131660595849	0.6	MTA2 MBD3 HDAC2 HDAC1 KDM1A MBD2	covalent chromatin modification
GO:0031327	0.00135675206274	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of cellular biosynthetic process
GO:0009890	0.00149250127988	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of biosynthetic process
CORUM:626	0.00234548715066	0.2	HDAC1 KDM1A	LSD1 complex
GO:0070491	0.00262475703672	0.4	CHD4 HDAC1 MTA2 HDAC2	repressing transcription factor binding
CORUM:713	0.00273542161733	0.2	RBBP4 HDAC2	BRG1-SIN3A complex
GO:0016580	0.00310592047764	0.3	HDAC1 HDAC2 RBBP4	Sin3 complex
GO:0010468	0.00340054649612	1.0	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of gene expression
GO:0010605	0.00441769028739	0.9	RBBP4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of macromolecule metabolic process
GO:0044877	0.00535257010113	0.7	CHD4 MTA2 RBBP4 HDAC1 MBD2 MBD3 HDAC2	protein-containing complex binding
CORUM:5614	0.00569905735237	0.2	HDAC1 CHD4	Emerin complex 32
GO:0070822	0.00607509040552	0.3	HDAC1 HDAC2 RBBP4	Sin3-type complex
REAC:R-HSA-427413	0.00824560095622	0.3	HDAC1 HDAC2 MBD2	NoRC negatively regulates rRNA expression
GO:0061629	0.00872089947131	0.5	CHD4 HDAC1 HDAC2 MTA2 KDM1A	RNA polymerase II-specific DNA-binding transcription factor binding
REAC:R-HSA-9022699	0.00887131457927	0.2	HDAC1 HDAC2	MECP2 regulates neuronal receptors and channels
REAC:R-HSA-5250941	0.00897046582916	0.3	HDAC1 HDAC2 MBD2	Negative epigenetic regulation of rRNA expression
GO:0006355	0.00928003113255	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of transcription, DNA-templated
GO:1903506	0.00951850402238	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of nucleic acid-templated transcription
GO:2001141	0.00963976154175	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of RNA biosynthetic process
GO:0009892	0.00968048338812	0.9	RBBP4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of metabolic process
REAC:R-HSA-1362300	0.010135013978	0.2	HDAC1 RBBP4	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
WP:WP3996	0.0101838495911	0.2	HDAC1 HDAC2	Ethanol effects on histone modifications
GO:0006346	0.0105009568253	0.3	HDAC1 MBD2 MBD3	methylation-dependent chromatin silencing
KEGG:05203	0.0106972943022	0.3	HDAC1 HDAC2 CHD4	Viral carcinogenesis
WP:WP3414	0.0109073591456	0.2	HDAC1 HDAC2	Initiation of transcription and translation elongation at the HIV-1 LTR
REAC:R-HSA-1362277	0.0144268822495	0.2	HDAC1 RBBP4	Transcription of E2F targets under negative control by DREAM complex
GO:0044451	0.0169522143685	0.7	CHD4 GATAD2A RBBP4 HDAC1 HDAC2 MBD3 MTA2	nucleoplasm part
GO:0006342	0.0172252527059	0.4	MBD3 HDAC1 HDAC2 MBD2	chromatin silencing
GO:0097549	0.0172252527059	0.4	MBD3 HDAC1 HDAC2 MBD2	chromatin organization involved in negative regulation of transcription
WP:WP268	0.018520309875	0.2	HDAC1 HDAC2	Notch Signaling
GO:0006351	0.0190458137046	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	transcription, DNA-templated
GO:0097659	0.0194959170749	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	nucleic acid-templated transcription
GO:0032774	0.0199554036818	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	RNA biosynthetic process
GO:0061198	0.020287053512	0.2	HDAC1 HDAC2	fungiform papilla formation
KEGG:04330	0.0207496192065	0.2	HDAC1 HDAC2	Notch signaling pathway
REAC:R-HSA-9615017	0.0213144720828	0.2	HDAC1 HDAC2	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
HPA:003010_13	0.0221455781376	0.4	MBD3 KDM1A HDAC2 CHD4	bone marrow; hematopoietic cells[Supported,High]
WP:WP4312	0.0236016950948	0.2	HDAC1 CHD4	Rett syndrome causing genes
GO:0034401	0.0237031691842	0.4	MBD3 HDAC1 HDAC2 MBD2	chromatin organization involved in regulation of transcription
GO:0051252	0.0239899782338	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of RNA metabolic process
REAC:R-HSA-983231	0.0283670812811	0.3	HDAC1 HDAC2 KDM1A	Factors involved in megakaryocyte development and platelet production
GO:0051172	0.028453980944	0.8	MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	negative regulation of nitrogen compound metabolic process
GO:0140297	0.0288561454392	0.5	CHD4 HDAC1 HDAC2 MTA2 KDM1A	DNA-binding transcription factor binding
KEGG:04213	0.0294648827991	0.2	HDAC1 HDAC2	Longevity regulating pathway - multiple species
REAC:R-HSA-350054	0.0295283272229	0.2	HDAC1 HDAC2	Notch-HLH transcription pathway
REAC:R-HSA-1538133	0.0295283272229	0.2	HDAC1 RBBP4	G0 and Early G1
REAC:R-HSA-69205	0.0317883468809	0.2	HDAC1 RBBP4	G1/S-Specific Transcription
GO:0040029	0.0330968228393	0.5	MBD3 HDAC1 RBBP4 HDAC2 MBD2	regulation of gene expression, epigenetic
REAC:R-HSA-9022692	0.0341308097173	0.2	HDAC1 HDAC2	Regulation of MECP2 expression and activity
GO:2000112	0.0342794665629	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of cellular macromolecule biosynthetic process
WP:WP61	0.0382565269801	0.2	HDAC1 HDAC2	Notch Signaling Pathway
WP:000000	0.0400621463691	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	WIKIPATHWAYS
GO:0010556	0.0407565971491	0.9	CHD4 MTA2 ZNF219 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	regulation of macromolecule biosynthetic process
GO:0010467	0.0416663694824	1.0	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A GATAD2A MBD2	gene expression
KEGG:05165	0.047087803646	0.3	HDAC1 HDAC2 CHD4	Human papillomavirus infection
GO:0003676	0.0486319481008	0.9	RBBP4 MTA2 ZNF219 CHD4 HDAC1 HDAC2 MBD3 KDM1A MBD2	nucleic acid binding

Edges

Protein 1	Protein 2	Score	Precision	Evidence
MTA2	HDAC1	1.0	0.949	hein_WMM bioplex (HDAC1) bioplex_WMM Guru boldt youn_WMM hein (HDAC1,MTA2) gupta_WMM fraction boldt_WMM
HDAC2	HDAC1	1.0	0.949	hein_WMM bioplex (HDAC1) bioplex_WMM boldt youn_WMM hein (HDAC1) Malo gupta_WMM fraction boldt_WMM treiber_WMM
MTA2	HDAC2	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (MTA2) gupta_WMM fraction boldt_WMM treiber_WMM
CHD4	HDAC1	1.0	0.949	hein_WMM bioplex (HDAC1) bioplex_WMM youn_WMM hein (HDAC1) gupta_WMM fraction boldt_WMM
MTA2	GATAD2A	1.0	0.949	hein_WMM bioplex (GATAD2A) bioplex_WMM Guru youn_WMM hein (MTA2) Malo gupta_WMM fraction boldt_WMM
MTA2	RBBP4	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (MTA2) gupta_WMM fraction boldt_WMM
MTA2	MBD3	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM hein (MTA2) Malo gupta_WMM fraction boldt_WMM
MTA2	CHD4	1.0	0.949	hein_WMM bioplex_WMM youn_WMM hein (MTA2) gupta_WMM fraction boldt_WMM
RBBP4	HDAC1	1.0	0.949	hein_WMM bioplex (HDAC1) bioplex_WMM Guru boldt youn_WMM hein (HDAC1) gupta_WMM fraction boldt_WMM treiber_WMM
GATAD2A	CHD4	1.0	0.949	hein_WMM bioplex (GATAD2A) bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
RBBP4	CHD4	1.0	0.949	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
MBD3	HDAC1	1.0	0.949	hein_WMM bioplex (HDAC1) bioplex_WMM Guru youn_WMM hein (HDAC1) gupta_WMM fraction boldt_WMM
MTA2	MBD2	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (MBD2,MTA2) Malo fraction boldt_WMM
MBD2	GATAD2A	1.0	0.949	hein_WMM bioplex (GATAD2A) bioplex_WMM Guru youn_WMM hein (MBD2) Malo fraction boldt_WMM
MBD3	GATAD2A	0.998	0.937	hein_WMM bioplex (GATAD2A) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM
MBD2	HDAC1	0.994	0.923	hein_WMM bioplex (HDAC1) bioplex_WMM boldt youn_WMM hein (HDAC1,MBD2) boldt_WMM
RBBP4	GATAD2A	0.994	0.919	hein_WMM bioplex (GATAD2A) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM
HDAC2	RBBP4	0.992	0.914	hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
KDM1A	RBBP4	0.988	0.901	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
MBD3	RBBP4	0.988	0.901	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM
MBD3	CHD4	0.988	0.901	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
KDM1A	HDAC1	0.985	0.899	hein_WMM bioplex (HDAC1) bioplex_WMM Guru youn_WMM hein (HDAC1) gupta_WMM fraction
HDAC2	CHD4	0.984	0.899	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
GATAD2A	HDAC1	0.982	0.898	hein_WMM bioplex (GATAD2A,HDAC1) bioplex_WMM Guru youn_WMM hein (HDAC1) gupta_WMM fraction boldt_WMM
MBD3	ZNF219	0.976	0.892	hein_WMM bioplex (ZNF219) bioplex_WMM
HDAC2	MBD2	0.964	0.871	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (MBD2) fraction boldt_WMM
ZNF219	CHD4	0.953	0.86	hein_WMM bioplex (ZNF219) bioplex_WMM
ZNF219	GATAD2A	0.885	0.817	hein_WMM bioplex (ZNF219) bioplex_WMM
ZNF219	RBBP4	0.883	0.818	hein_WMM bioplex (ZNF219) bioplex_WMM
MTA2	KDM1A	0.872	0.804	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
ZNF219	MBD2	0.861	0.797	hein_WMM bioplex (ZNF219) bioplex_WMM
HDAC2	KDM1A	0.837	0.78	hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
ZNF219	HDAC1	0.819	0.773	hein_WMM bioplex (HDAC1,ZNF219) bioplex_WMM
RBBP4	MBD2	0.78	0.753	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (MBD2) fraction boldt_WMM
HDAC2	MBD3	0.693	0.717	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM
HDAC2	GATAD2A	0.605	0.672	hein_WMM bioplex (GATAD2A) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM
MTA2	ZNF219	0.489	0.617	hein_WMM bioplex (ZNF219) bioplex_WMM
KDM1A	CHD4	0.474	0.609	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
MBD2	CHD4	0.455	0.595	hein_WMM bioplex_WMM youn_WMM hein (MBD2) fraction boldt_WMM
KDM1A	GATAD2A	0.287	0.489	hein_WMM bioplex_WMM youn_WMM fraction
HDAC2	ZNF219	0.21	0.457	hein_WMM bioplex (ZNF219) bioplex_WMM
MBD3	MBD2	0.034	0.263	hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM
MBD3	KDM1A	0.024	0.21	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
KDM1A	MBD2	0.008	0.028	hein_WMM bioplex_WMM youn_WMM WMM_only
ZNF219	KDM1A	0.004	0.009	bioplex (ZNF219) bioplex_WMM

Images

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Complex HuMAP2_03645 has an average edge precision of 0.782 which is ranked 996 out of all 6965 complexes.

Related Complexes

Genename	Complexes
KDM1A	HuMAP2_01592 HuMAP2_03645 HuMAP2_03931 HuMAP2_04159 HuMAP2_05698 HuMAP2_05708 HuMAP2_06991
MTA2	HuMAP2_00089 HuMAP2_02937 HuMAP2_03645 HuMAP2_05156 HuMAP2_06754 HuMAP2_06969
HDAC1	HuMAP2_03645 HuMAP2_06754 HuMAP2_06969
RBBP4	HuMAP2_01771 HuMAP2_02289 HuMAP2_02937 HuMAP2_03645 HuMAP2_04544 HuMAP2_06754
HDAC2	HuMAP2_00822 HuMAP2_03645 HuMAP2_06754 HuMAP2_06969
MBD2	HuMAP2_02937 HuMAP2_03645 HuMAP2_06754
ZNF219	HuMAP2_01364 HuMAP2_02937 HuMAP2_03645 HuMAP2_04619 HuMAP2_06142 HuMAP2_06754
CHD4	HuMAP2_02937 HuMAP2_03645 HuMAP2_06754
GATAD2A	HuMAP2_02937 HuMAP2_03645 HuMAP2_06754
MBD3	HuMAP2_00929 HuMAP2_02937 HuMAP2_03645 HuMAP2_06754

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03645