hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03650

Confidence: Medium

Genename	Protein Name	Links
H4C1	Histone H4	UniProt NCBI
H2AC11	Histone H2A type 1 (H2A.1) (Histone H2A/ptl)	UniProt NCBI
HLTF	Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)	UniProt NCBI
RPA2	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	UniProt NCBI
APLF	Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)	UniProt NCBI
MSH3	DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)	UniProt NCBI
PARP2	Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)	UniProt NCBI
CHD1L	Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1)	UniProt NCBI
XRCC1	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	UniProt NCBI
H3-2		NCBI
POLB	DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-)	UniProt NCBI
LIG3	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	UniProt NCBI
PNKP	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	UniProt NCBI
RNF146	E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-73933	1.07674183987e-11	0.545454545455	PNKP PARP2 LIG3 XRCC1 POLB RPA2	Resolution of Abasic Sites (AP sites)
CORUM:362	1.08938230665e-11	0.363636363636	POLB XRCC1 PNKP LIG3	DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
REAC:R-HSA-5649702	5.29242157224e-10	0.363636363636	POLB XRCC1 PNKP LIG3	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
REAC:R-HSA-73894	1.46058585279e-09	0.727272727273	PNKP PARP2 MSH3 LIG3 XRCC1 POLB CHD1L RPA2	DNA Repair
REAC:R-HSA-73884	3.29993220395e-09	0.545454545455	PNKP PARP2 LIG3 XRCC1 POLB RPA2	Base Excision Repair
GO:0006281	5.58551594454e-08	0.818181818182	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB CHD1L APLF	DNA repair
CORUM:1086	8.10772781726e-08	0.272727272727	POLB XRCC1 LIG3	DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
CORUM:5243	8.10772781726e-08	0.272727272727	PNKP XRCC1 LIG3	XRCC1-LIG3-PNK-TDP1 complex
CORUM:1085	2.02611522486e-07	0.272727272727	POLB XRCC1 LIG3	DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
KEGG:03410	2.5807429411e-07	0.363636363636	POLB LIG3 XRCC1 PARP2	Base excision repair
REAC:R-HSA-110381	2.62789949866e-07	0.272727272727	POLB XRCC1 LIG3	Resolution of AP sites via the single-nucleotide replacement pathway
REAC:R-HSA-5696399	4.99014338822e-07	0.454545454545	PARP2 LIG3 XRCC1 CHD1L RPA2	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-5696398	1.9610564103e-06	0.454545454545	PARP2 LIG3 XRCC1 CHD1L RPA2	Nucleotide Excision Repair
GO:0006259	3.09288420706e-06	0.818181818182	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB CHD1L APLF	DNA metabolic process
GO:0006974	3.13208475642e-06	0.818181818182	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB CHD1L APLF	cellular response to DNA damage stimulus
REAC:R-HSA-5685939	7.86465652313e-06	0.272727272727	LIG3 XRCC1 PARP2	HDR through MMEJ (alt-NHEJ)
GO:0006266	1.45859703988e-05	0.363636363636	POLB LIG3 XRCC1 APLF	DNA ligation
GO:0006288	1.49850650438e-05	0.272727272727	POLB XRCC1 LIG3	base-excision repair, DNA ligation
CORUM:212	3.35524866385e-05	0.181818181818	XRCC1 LIG3	DNA ligase III-XRCC1 complex
CORUM:365	3.35524866385e-05	0.181818181818	XRCC1 LIG3	DNA ligase III-XRCC1 complex
CORUM:363	3.35524866385e-05	0.181818181818	XRCC1 LIG3	DNA ligase III-XRCC1 complex
REAC:R-HSA-5696397	0.000149830419159	0.272727272727	LIG3 XRCC1 RPA2	Gap-filling DNA repair synthesis and ligation in GG-NER
REAC:R-HSA-110373	0.000149830419159	0.272727272727	POLB RPA2 PARP2	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
GO:0006302	0.000268082879719	0.545454545455	PARP2 LIG3 XRCC1 POLB RPA2 APLF	double-strand break repair
GO:0006289	0.000353351292924	0.454545454545	PNKP LIG3 XRCC1 CHD1L RPA2	nucleotide-excision repair
REAC:R-HSA-5693538	0.000458022310575	0.363636363636	PARP2 LIG3 XRCC1 RPA2	Homology Directed Repair
GO:0006284	0.000586693494072	0.363636363636	POLB LIG3 XRCC1 RPA2	base-excision repair
REAC:R-HSA-5696400	0.000689964514024	0.272727272727	RPA2 CHD1L PARP2	Dual Incision in GG-NER
REAC:R-HSA-5696395	0.000798122385996	0.272727272727	RPA2 CHD1L PARP2	Formation of Incision Complex in GG-NER
GO:0051103	0.000837474301274	0.272727272727	POLB XRCC1 LIG3	DNA ligation involved in DNA repair
GO:0006261	0.000923443156188	0.454545454545	MSH3 LIG3 RPA2 PNKP POLB	DNA-dependent DNA replication
REAC:R-HSA-5693532	0.000965670107827	0.363636363636	PARP2 LIG3 XRCC1 RPA2	DNA Double-Strand Break Repair
GO:0005654	0.0021313263302	1.0	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB HLTF CHD1L RNF146 APLF	nucleoplasm
REAC:R-HSA-6782210	0.00267177367643	0.272727272727	LIG3 XRCC1 RPA2	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-110362	0.00303768164914	0.181818181818	POLB PARP2	POLB-Dependent Long Patch Base Excision Repair
GO:0033554	0.00343302886669	0.818181818182	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB CHD1L APLF	cellular response to stress
REAC:R-HSA-6781827	0.00485100371951	0.272727272727	LIG3 XRCC1 RPA2	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
KEGG:03430	0.00560391353404	0.181818181818	MSH3 RPA2	Mismatch repair
REAC:R-HSA-5358606	0.00984862364944	0.181818181818	MSH3 RPA2	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
GO:0006260	0.0109238650085	0.454545454545	MSH3 LIG3 RPA2 PNKP POLB	DNA replication
HPA:035010_13	0.0109999394382	0.363636363636	PNKP LIG3 XRCC1 RPA2	placenta; decidual cells[Supported,High]
REAC:R-HSA-5358508	0.0113592180397	0.181818181818	MSH3 RPA2	Mismatch Repair
HPA:014020_13	0.0121490352329	0.363636363636	PNKP LIG3 XRCC1 RPA2	endometrium 2; glandular cells[Supported,High]
HPA:007030_13	0.0140347128076	0.363636363636	PNKP LIG3 XRCC1 RPA2	cerebellum; cells in molecular layer[Supported,High]
HPA:004020_13	0.015944127193	0.363636363636	PNKP LIG3 XRCC1 RPA2	breast; glandular cells[Supported,High]
GO:0031981	0.0170336395485	1.0	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB HLTF CHD1L RNF146 APLF	nuclear lumen
HPA:013020_13	0.0170624163486	0.363636363636	PNKP LIG3 XRCC1 RPA2	endometrium 1; glandular cells[Supported,High]
REAC:R-HSA-5651801	0.02266357179	0.181818181818	POLB RPA2	PCNA-Dependent Long Patch Base Excision Repair
HPA:044010_13	0.0240222808154	0.363636363636	PNKP LIG3 XRCC1 RPA2	skin 2; epidermal cells[Supported,High]
HPA:053020_03	0.026042651636	0.454545454545	PNKP LIG3 XRCC1 HLTF RPA2	testis; cells in seminiferous ducts[Uncertain,High]
GO:0006297	0.0263254502884	0.272727272727	LIG3 XRCC1 RPA2	nucleotide-excision repair, DNA gap filling
HPA:003010_13	0.0304584298787	0.363636363636	PNKP LIG3 XRCC1 RPA2	bone marrow; hematopoietic cells[Supported,High]
HPA:008030_13	0.0334799429924	0.363636363636	PNKP LIG3 XRCC1 RPA2	cerebral cortex; neuronal cells[Supported,High]
GO:0044428	0.0345199601716	1.0	PNKP LIG3 PARP2 MSH3 XRCC1 RPA2 POLB HLTF CHD1L RNF146 APLF	nuclear part
GO:0051052	0.0350066109779	0.454545454545	MSH3 PNKP XRCC1 APLF RPA2	regulation of DNA metabolic process
HPA:015010_13	0.0353944334695	0.363636363636	PNKP LIG3 XRCC1 RPA2	epididymis; glandular cells[Supported,High]
HPA:007030_03	0.045790560885	0.363636363636	PNKP LIG3 XRCC1 RPA2	cerebellum; cells in molecular layer[Uncertain,High]
HPA:055010_13	0.0477847920692	0.363636363636	PNKP LIG3 XRCC1 RPA2	thyroid gland; glandular cells[Supported,High]
HPA:053020_13	0.0481910856418	0.363636363636	PNKP LIG3 XRCC1 RPA2	testis; cells in seminiferous ducts[Supported,High]

Edges

Protein 1	Protein 2	Score	Precision	Evidence
XRCC1	POLB	1.0	0.949	hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1)
POLB	LIG3	0.999	0.949	hein_WMM bioplex (POLB) bioplex_WMM
APLF	LIG3	0.938	0.85	bioplex (APLF) bioplex_WMM
POLB	PNKP	0.882	0.818	hein_WMM bioplex (POLB) bioplex_WMM
PARP2	APLF	0.543	0.644	bioplex (APLF) bioplex_WMM
PARP2	RNF146	0.404	0.563	bioplex (RNF146) bioplex_WMM
APLF	H3-2	0.392	0.554	bioplex (APLF) bioplex_WMM
XRCC1	LIG3	0.186	0.441	hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM
PARP2	RPA2	0.167	0.423	bioplex (RPA2) bioplex_WMM boldt_WMM
XRCC1	APLF	0.157	0.416	bioplex (APLF) bioplex_WMM
POLB	PARP2	0.092	0.355	bioplex (POLB) bioplex_WMM
CHD1L	RNF146	0.077	0.352	bioplex (CHD1L,RNF146) bioplex_WMM
HLTF	APLF	0.056	0.313	bioplex (APLF) bioplex_WMM
PARP2	CHD1L	0.047	0.291	bioplex (CHD1L) bioplex_WMM
MSH3	APLF	0.036	0.263	bioplex (APLF) bioplex_WMM
HLTF	CHD1L	0.032	0.245	bioplex (CHD1L) bioplex_WMM
H2AC11	APLF	0.03	0.235	bioplex (APLF) bioplex_WMM
APLF	RPA2	0.027	0.231	bioplex (APLF) bioplex_WMM
APLF	H4C1	0.026	0.217	bioplex (APLF) bioplex_WMM
POLB	APLF	0.02	0.185	bioplex (APLF,POLB) bioplex_WMM
XRCC1	PNKP	0.012	0.15	hein_WMM bioplex_WMM hein (XRCC1)
CHD1L	RPA2	0.012	0.15	bioplex (CHD1L) bioplex_WMM
PARP2	LIG3	0.012	0.147	bioplex_WMM WMM_only
HLTF	LIG3	0.011	0.14	hein_WMM bioplex_WMM youn_WMM WMM_only
PARP2	H4C1	0.01	0.139	bioplex_WMM WMM_only
HLTF	XRCC1	0.01	0.13	bioplex_WMM youn_WMM WMM_only
LIG3	H4C1	0.01	0.102	bioplex_WMM WMM_only
H3-2	H4C1	0.009	0.107	bioplex_WMM WMM_only
XRCC1	PARP2	0.009	0.108	bioplex_WMM WMM_only
XRCC1	CHD1L	0.009	0.107	bioplex (CHD1L) bioplex_WMM
RPA2	H4C1	0.009	0.106	bioplex (RPA2) bioplex_WMM
HLTF	PARP2	0.009	0.098	bioplex_WMM WMM_only
XRCC1	MSH3	0.009	0.097	bioplex_WMM youn_WMM WMM_only
POLB	RPA2	0.009	0.092	bioplex (POLB) bioplex_WMM
MSH3	POLB	0.008	0.091	bioplex_WMM WMM_only
MSH3	LIG3	0.008	0.088	bioplex_WMM youn_WMM WMM_only
RNF146	RPA2	0.008	0.087	bioplex (RNF146) bioplex_WMM
LIG3	PNKP	0.008	0.081	hein_WMM bioplex_WMM WMM_only
MSH3	RPA2	0.008	0.071	bioplex_WMM youn_WMM WMM_only
PARP2	H3-2	0.008	0.066	bioplex_WMM WMM_only
APLF	PNKP	0.008	0.067	bioplex_WMM WMM_only
XRCC1	RNF146	0.008	0.062	bioplex_WMM WMM_only
MSH3	CHD1L	0.008	0.059	bioplex_WMM WMM_only
HLTF	MSH3	0.008	0.041	bioplex_WMM youn_WMM WMM_only
LIG3	CHD1L	0.008	0.042	bioplex_WMM WMM_only
POLB	CHD1L	0.008	0.029	bioplex_WMM WMM_only
LIG3	RPA2	0.008	0.028	bioplex (RPA2) bioplex_WMM youn_WMM gupta_WMM
XRCC1	H4C1	0.008	0.028	bioplex_WMM WMM_only
MSH3	H3-2	0.008	0.024	bioplex_WMM WMM_only
H2AC11	PARP2	0.008	0.025	bioplex_WMM WMM_only
LIG3	H3-2	0.008	0.012	bioplex_WMM WMM_only
MSH3	PARP2	0.007	0.009	bioplex_WMM WMM_only
POLB	H3-2	0.007	0.01	bioplex_WMM WMM_only
MSH3	H4C1	0.007	0.007	bioplex_WMM WMM_only
XRCC1	H3-2	0.007	0.006	bioplex_WMM WMM_only
PARP2	PNKP	0.007	0.007	bioplex_WMM WMM_only
CHD1L	H4C1	0.007	0.003	bioplex (CHD1L) bioplex_WMM
CHD1L	H3-2	0.007	0.0	bioplex_WMM WMM_only
HLTF	PNKP	0.007	0.001	bioplex_WMM WMM_only
MSH3	PNKP	0.007	0.002	youn_WMM WMM_only
MSH3	H2AC11	0.007	0.002	bioplex_WMM WMM_only
PNKP	H4C1	0.007	0.001	bioplex (PNKP) bioplex_WMM
H2AC11	LIG3	0.007	0.004	bioplex_WMM WMM_only
H3-2	RPA2	0.007	0.002	bioplex_WMM WMM_only
XRCC1	H2AC11	0.007	0.002	bioplex_WMM WMM_only
H2AC11	PNKP	0.007	0.004	bioplex_WMM WMM_only
HLTF	H3-2	0.006	0.002	bioplex_WMM WMM_only
RNF146	H4C1	0.006	0.004	bioplex (RNF146) bioplex_WMM
HLTF	H4C1	0.006	0.005	bioplex_WMM WMM_only
H2AC11	CHD1L	0.006	0.005	bioplex_WMM WMM_only
H2AC11	H3-2	0.005	0.005	bioplex_WMM WMM_only
H2AC11	RPA2	0.005	0.009	bioplex_WMM WMM_only
H2AC11	H4C1	0.005	0.007	bioplex_WMM WMM_only
HLTF	H2AC11	0.005	0.009	bioplex_WMM WMM_only
HLTF	RPA2	0.005	0.009	bioplex (RPA2) bioplex_WMM youn_WMM
POLB	H2AC11	0.004	0.009	bioplex (POLB) bioplex_WMM
PNKP	RPA2	0.004	0.011	bioplex (PNKP) bioplex_WMM youn_WMM fraction
APLF	CHD1L	0.0	0.014	bioplex (APLF) bioplex_WMM
POLB	H4C1	0.0	0.017	bioplex (POLB) bioplex_WMM
LIG3	RNF146	0.0	0.011	bioplex (RNF146) bioplex_WMM
HLTF	RNF146	0.0	0.0	bioplex (RNF146) bioplex_WMM
XRCC1	RPA2	0.0	0.003	bioplex (RPA2) bioplex_WMM youn_WMM gupta_WMM
HLTF	POLB	0.0	0.0	hein_WMM bioplex (POLB) bioplex_WMM

Images

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Complex HuMAP2_03650 has an average edge precision of 0.145 which is ranked 6740 out of all 6965 complexes.

Related Complexes

Genename	Complexes
H4C1	HuMAP2_02284 HuMAP2_03650 HuMAP2_04079
H2AC11	HuMAP2_00315 HuMAP2_02284 HuMAP2_03650
HLTF	HuMAP2_00030 HuMAP2_00315 HuMAP2_01256 HuMAP2_01412 HuMAP2_02284 HuMAP2_03650 HuMAP2_04196 HuMAP2_05037
RPA2	HuMAP2_00586 HuMAP2_02745 HuMAP2_03624 HuMAP2_03648 HuMAP2_03650 HuMAP2_05012 HuMAP2_05034
APLF	HuMAP2_00315 HuMAP2_01256 HuMAP2_02284 HuMAP2_03086 HuMAP2_03650 HuMAP2_04827 HuMAP2_05224 HuMAP2_05863
MSH3	HuMAP2_00315 HuMAP2_02284 HuMAP2_03650 HuMAP2_06931
PARP2	HuMAP2_00315 HuMAP2_01256 HuMAP2_02284 HuMAP2_03086 HuMAP2_03650 HuMAP2_04196 HuMAP2_04827 HuMAP2_05224 HuMAP2_06136
CHD1L	HuMAP2_00315 HuMAP2_02284 HuMAP2_03650 HuMAP2_03978 HuMAP2_04196 HuMAP2_06136
XRCC1	HuMAP2_00315 HuMAP2_00825 HuMAP2_02820 HuMAP2_03650 HuMAP2_05623 HuMAP2_05733
H3-2	HuMAP2_00547 HuMAP2_01240 HuMAP2_01256 HuMAP2_02646 HuMAP2_03647 HuMAP2_03650 HuMAP2_04079
POLB	HuMAP2_00315 HuMAP2_00825 HuMAP2_02820 HuMAP2_03650 HuMAP2_04311 HuMAP2_04453 HuMAP2_05623 HuMAP2_05733
LIG3	HuMAP2_00315 HuMAP2_00825 HuMAP2_02820 HuMAP2_03650 HuMAP2_03932 HuMAP2_04827 HuMAP2_05623 HuMAP2_05733
PNKP	HuMAP2_00315 HuMAP2_00825 HuMAP2_02820 HuMAP2_03650 HuMAP2_04311 HuMAP2_04453 HuMAP2_05623
RNF146	HuMAP2_00315 HuMAP2_02284 HuMAP2_03650 HuMAP2_03978 HuMAP2_04196 HuMAP2_06136

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03650