hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03652
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016903 | 6.13901440096e-09 | 1.0 | MRPS36 OGDHL PDHX PDHA1 DLD | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:1990204 | 3.20924936678e-07 | 1.0 | MRPS36 OGDHL PDHX PDHA1 DLD | oxidoreductase complex |
| REAC:R-HSA-204174 | 1.5207132982e-06 | 0.6 | PDHX PDHA1 DLD | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | OGDHL PDHA1 DLD | Citrate cycle (TCA cycle) |
| REAC:R-HSA-70268 | 9.90965664735e-06 | 0.6 | PDHX PDHA1 DLD | Pyruvate metabolism |
| REAC:R-HSA-389661 | 1.10096191184e-05 | 0.6 | PDHX PDHA1 DLD | Glyoxylate metabolism and glycine degradation |
| GO:0004738 | 1.81582264982e-05 | 0.6 | PDHX PDHA1 DLD | pyruvate dehydrogenase activity |
| GO:0045254 | 1.81582264982e-05 | 0.6 | PDHX PDHA1 DLD | pyruvate dehydrogenase complex |
| REAC:R-HSA-5362517 | 2.67648652633e-05 | 0.6 | PDHX PDHA1 DLD | Signaling by Retinoic Acid |
| GO:0045252 | 3.17736949706e-05 | 0.6 | MRPS36 DLD OGDHL | oxoglutarate dehydrogenase complex |
| REAC:R-HSA-71406 | 5.97963045475e-05 | 0.6 | PDHX PDHA1 DLD | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP3925 | 7.31920604822e-05 | 0.6 | PDHX PDHA1 DLD | Amino Acid metabolism |
| GO:0045240 | 0.000149729915117 | 0.6 | MRPS36 DLD OGDHL | dihydrolipoyl dehydrogenase complex |
| GO:0006086 | 0.000199619769136 | 0.6 | PDHX PDHA1 DLD | acetyl-CoA biosynthetic process from pyruvate |
| KEGG:01200 | 0.000205667969449 | 0.6 | OGDHL PDHA1 DLD | Carbon metabolism |
| GO:0045239 | 0.000259479548289 | 0.6 | MRPS36 DLD OGDHL | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 0.000399978956636 | 0.4 | PDHA1 DLD | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:0006085 | 0.000616695699567 | 0.6 | PDHX PDHA1 DLD | acetyl-CoA biosynthetic process |
| HP:0003112 | 0.00141044232307 | 0.6 | PDHX PDHA1 DLD | Abnormality of serum amino acid level |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | PDHX PDHA1 DLD | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0004354 | 0.00234614920866 | 0.6 | PDHX PDHA1 DLD | Abnormal circulating carboxylic acid concentration |
| GO:0006084 | 0.00235581550516 | 0.6 | PDHX PDHA1 DLD | acetyl-CoA metabolic process |
| HP:0003287 | 0.00253383203522 | 0.6 | PDHX PDHA1 DLD | Abnormality of mitochondrial metabolism |
| WP:WP534 | 0.00314132080553 | 0.4 | PDHA1 DLD | Glycolysis and Gluconeogenesis |
| KEGG:00620 | 0.00316574451287 | 0.4 | PDHA1 DLD | Pyruvate metabolism |
| GO:0006099 | 0.00367721278555 | 0.6 | OGDHL PDHA1 DLD | tricarboxylic acid cycle |
| GO:0016491 | 0.00382718608595 | 1.0 | MRPS36 OGDHL PDHX PDHA1 DLD | oxidoreductase activity |
| HP:0012103 | 0.00431306699981 | 0.6 | PDHX PDHA1 DLD | Abnormality of the mitochondrion |
| HP:0003128 | 0.00508554614389 | 0.6 | PDHX PDHA1 DLD | Lactic acidosis |
| REAC:R-HSA-9006931 | 0.00634577840696 | 0.6 | PDHX PDHA1 DLD | Signaling by Nuclear Receptors |
| KEGG:00010 | 0.00831682765542 | 0.4 | PDHA1 DLD | Glycolysis / Gluconeogenesis |
| GO:0035384 | 0.0103850554114 | 0.6 | PDHX PDHA1 DLD | thioester biosynthetic process |
| GO:0071616 | 0.0103850554114 | 0.6 | PDHX PDHA1 DLD | acyl-CoA biosynthetic process |
| KEGG:01100 | 0.0121945453342 | 0.8 | OGDHL PDHX PDHA1 DLD | Metabolic pathways |
| GO:0061732 | 0.0135228859698 | 0.4 | DLD PDHX | mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| HP:0010916 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating alanine concentration |
| HP:0010915 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Abnormal circulating pyruvate family amino acid concentration |
| HP:0003348 | 0.0175069025895 | 0.4 | PDHA1 PDHX | Hyperalaninemia |
| REAC:R-HSA-71291 | 0.0184395275066 | 0.6 | PDHX PDHA1 DLD | Metabolism of amino acids and derivatives |
| HP:0002928 | 0.0229596708254 | 0.4 | PDHA1 PDHX | Decreased activity of the pyruvate dehydrogenase complex |
| GO:0034033 | 0.0250406933376 | 0.6 | PDHX PDHA1 DLD | purine nucleoside bisphosphate biosynthetic process |
| GO:0033866 | 0.0250406933376 | 0.6 | PDHX PDHA1 DLD | nucleoside bisphosphate biosynthetic process |
| GO:0034030 | 0.0250406933376 | 0.6 | PDHX PDHA1 DLD | ribonucleoside bisphosphate biosynthetic process |
| GO:0034604 | 0.0270421395626 | 0.4 | DLD PDHX | pyruvate dehydrogenase (NAD+) activity |
| GO:0034603 | 0.0270421395626 | 0.4 | DLD PDHX | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0004591 | 0.0270421395626 | 0.4 | OGDHL MRPS36 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| HP:0001941 | 0.0347361605983 | 0.6 | PDHX PDHA1 DLD | Acidosis |
| HP:0004360 | 0.0450566918732 | 0.6 | PDHX PDHA1 DLD | Abnormality of acid-base homeostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLD | PDHA1 | 0.974 | 0.886 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| DLD | PDHX | 0.909 | 0.832 | hein_WMM bioplex (DLD,PDHX) bioplex_WMM youn_WMM |
| PDHA1 | PDHX | 0.054 | 0.304 | hein_WMM bioplex (PDHX) bioplex_WMM |
| MRPS36 | PDHA1 | 0.009 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| MRPS36 | PDHX | 0.008 | 0.083 | hein_WMM bioplex_WMM WMM_only |
| OGDHL | PDHA1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| OGDHL | PDHX | 0.008 | 0.028 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03652 has an average edge precision of 0.428 which is ranked 3043 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| PDHA1 | HuMAP2_03652 HuMAP2_04771 HuMAP2_06086 |
| PDHX | HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |