hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03654
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPHB2 | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | UniProt NCBI |
| EPHA5 | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | UniProt NCBI |
| EPHB4 | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | UniProt NCBI |
| EFNB2 | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | UniProt NCBI |
| EFNB1 | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | UniProt NCBI |
| EPHB3 | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | UniProt NCBI |
| SDC3 | Syndecan-3 (SYND3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928665 | 7.22253289646e-13 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-3928664 | 3.5555021893e-12 | 0.714285714286 | EPHB4 EFNB1 EPHB3 EFNB2 EPHB2 | Ephrin signaling |
| REAC:R-HSA-2682334 | 3.61688684949e-11 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | EPH-Ephrin signaling |
| REAC:R-HSA-3928662 | 3.30003828923e-10 | 0.714285714286 | EPHB4 EFNB1 EPHB3 EFNB2 EPHB2 | EPHB-mediated forward signaling |
| KEGG:04360 | 6.13580309067e-10 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | Axon guidance |
| GO:0048013 | 5.4564622564e-09 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | ephrin receptor signaling pathway |
| GO:0005003 | 1.16343266976e-06 | 0.571428571429 | EPHB4 EPHB3 EPHB2 EPHA5 | ephrin receptor activity |
| REAC:R-HSA-422475 | 1.84442336635e-06 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | Axon guidance |
| WP:WP4564 | 2.01090806007e-05 | 0.428571428571 | EPHB4 EPHB2 EPHB3 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 2.60950900306e-05 | 0.428571428571 | EPHB4 EPHB2 EPHB3 | Neural Crest Cell Migration in Cancer |
| REAC:R-HSA-1266738 | 6.10567662343e-05 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | Developmental Biology |
| GO:0007411 | 0.000217910906533 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | axon guidance |
| GO:0097485 | 0.000224257230247 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | neuron projection guidance |
| GO:0004714 | 0.000310987597034 | 0.571428571429 | EPHB4 EPHB3 EPHB2 EPHA5 | transmembrane receptor protein tyrosine kinase activity |
| GO:0007169 | 0.000545064820292 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0019199 | 0.000820699113124 | 0.571428571429 | EPHB4 EPHB3 EPHB2 EPHA5 | transmembrane receptor protein kinase activity |
| GO:0040011 | 0.000886250502029 | 1.0 | EPHB3 EFNB1 SDC3 EFNB2 EPHB4 EPHA5 EPHB2 | locomotion |
| WP:WP4331 | 0.00190590477553 | 0.285714285714 | EPHB4 EPHB2 | Neovascularisation processes |
| GO:0007409 | 0.00218643526384 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | axonogenesis |
| GO:0061564 | 0.00289568484403 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | axon development |
| WP:WP4561 | 0.00300595539129 | 0.285714285714 | EFNB2 EFNB1 | Cell migration and invasion through p75NTR |
| GO:0006928 | 0.00305651191569 | 1.0 | EPHB3 EFNB1 SDC3 EFNB2 EPHB4 EPHA5 EPHB2 | movement of cell or subcellular component |
| GO:0007167 | 0.00386206265228 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | enzyme linked receptor protein signaling pathway |
| GO:0004713 | 0.00433362278423 | 0.571428571429 | EPHB4 EPHB3 EPHB2 EPHA5 | protein tyrosine kinase activity |
| GO:0048667 | 0.00654925967096 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | cell morphogenesis involved in neuron differentiation |
| GO:0006935 | 0.00979493405468 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | chemotaxis |
| GO:0042330 | 0.00979493405468 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | taxis |
| GO:0048812 | 0.0133528244508 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | neuron projection morphogenesis |
| GO:0120039 | 0.0152940808592 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | plasma membrane bounded cell projection morphogenesis |
| GO:0048858 | 0.0158606753809 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | cell projection morphogenesis |
| GO:0032990 | 0.0180828342295 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | cell part morphogenesis |
| GO:0000904 | 0.0257043347096 | 0.714285714286 | EPHA5 EFNB1 EPHB3 EFNB2 EPHB2 | cell morphogenesis involved in differentiation |
| GO:0005887 | 0.0349297821312 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | integral component of plasma membrane |
| GO:0031226 | 0.0443376193359 | 0.857142857143 | EPHB3 EFNB1 EPHB4 EFNB2 EPHA5 EPHB2 | intrinsic component of plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EFNB2 | EFNB1 | 1.0 | 0.949 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | SDC3 | 0.903 | 0.827 | bioplex (EFNB2) bioplex_WMM |
| EPHB4 | EFNB2 | 0.679 | 0.708 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | EPHB2 | 0.096 | 0.359 | bioplex (EFNB2) bioplex_WMM |
| EFNB2 | EPHB3 | 0.051 | 0.295 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | EPHA5 | 0.03 | 0.231 | bioplex (EFNB2) bioplex_WMM |
| SDC3 | EPHA5 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| EPHB3 | EPHA5 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SDC3 | EPHB3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SDC3 | EPHB2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| EPHB2 | EPHA5 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| EPHB3 | EPHB2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| EPHB4 | EPHB2 | 0.008 | 0.09 | bioplex_WMM WMM_only |
| EPHB4 | EPHB3 | 0.008 | 0.044 | bioplex_WMM gupta_WMM WMM_only |
| EPHB4 | EPHA5 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| EPHB4 | SDC3 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| EFNB1 | EPHB3 | 0.008 | 0.031 | bioplex_WMM gupta_WMM WMM_only |
| EFNB1 | SDC3 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| EFNB1 | EPHA5 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| EFNB1 | EPHB2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| EPHB4 | EFNB1 | 0.007 | 0.0 | bioplex_WMM gupta_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03654 has an average edge precision of 0.202 which is ranked 6159 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPHB2 | HuMAP2_00438 HuMAP2_03393 HuMAP2_03654 |
| EPHA5 | HuMAP2_03654 HuMAP2_03886 HuMAP2_04818 |
| EPHB4 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 |
| EFNB2 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| EFNB1 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| EPHB3 | HuMAP2_00251 HuMAP2_03654 |
| SDC3 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |