hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03661
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Indanol dehydrogenase) (EC 1.1.1.112) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| GDPD2 | Glycerophosphoinositol inositolphosphodiesterase GDPD2 (EC 3.1.4.43) (Glycerophosphodiester phosphodiesterase 3) (Glycerophosphodiester phosphodiesterase domain-containing protein 2) (Osteoblast differentiation promoting factor) | UniProt NCBI |
| PLXDC2 | Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) | UniProt NCBI |
| AKR1C4 | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.357) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP696 | 4.70171748526e-05 | 0.5 | AKR1C4 AKR1C3 | Benzo(a)pyrene metabolism |
| REAC:R-HSA-193775 | 0.000783559910601 | 0.5 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| REAC:R-HSA-193807 | 0.000783559910601 | 0.5 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| KEGG:00140 | 0.00188834163584 | 0.5 | AKR1C4 AKR1C3 | Steroid hormone biosynthesis |
| REAC:R-HSA-193368 | 0.00210807296175 | 0.5 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| REAC:R-HSA-192105 | 0.00436320194063 | 0.5 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts |
| REAC:R-HSA-194068 | 0.00631572211528 | 0.5 | AKR1C4 AKR1C3 | Bile acid and bile salt metabolism |
| REAC:R-HSA-975634 | 0.00821677913545 | 0.5 | AKR1C4 AKR1C3 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00947680746611 | 0.5 | AKR1C4 AKR1C3 | Metabolism of fat-soluble vitamins |
| GO:0009753 | 0.0162267366884 | 0.5 | AKR1C4 AKR1C3 | response to jasmonic acid |
| GO:0071395 | 0.0162267366884 | 0.5 | AKR1C4 AKR1C3 | cellular response to jasmonic acid stimulus |
| WP:WP702 | 0.0208080933183 | 0.5 | AKR1C4 AKR1C3 | Metapathway biotransformation Phase I and II |
| GO:0047086 | 0.0270421395626 | 0.5 | AKR1C4 AKR1C3 | ketosteroid monooxygenase activity |
| REAC:R-HSA-2187338 | 0.0277220764292 | 0.5 | AKR1C4 AKR1C3 | Visual phototransduction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1C3 | AKR1C4 | 0.95 | 0.858 | bioplex (AKR1C3,AKR1C4) bioplex_WMM |
| AKR1C4 | GDPD2 | 0.446 | 0.59 | bioplex (AKR1C4) bioplex_WMM |
| AKR1C4 | PLXDC2 | 0.207 | 0.455 | bioplex (AKR1C4) bioplex_WMM |
| AKR1C3 | GDPD2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PLXDC2 | GDPD2 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| AKR1C3 | PLXDC2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03661 has an average edge precision of 0.334 which is ranked 4191 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C3 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 |
| GDPD2 | HuMAP2_03661 HuMAP2_05598 |
| PLXDC2 | HuMAP2_01018 HuMAP2_03661 HuMAP2_05598 |
| AKR1C4 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 HuMAP2_05598 |