hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03674
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | UniProt NCBI |
| ATG10 | Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like) | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | UniProt NCBI |
| ATG7 | Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2509 | 2.03563999398e-16 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 2.25056562354e-15 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Autophagy - other |
| WP:WP4577 | 1.66327390452e-14 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| WP:WP615 | 1.58541356808e-12 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Senescence and Autophagy in Cancer |
| REAC:R-HSA-1632852 | 5.46571984656e-12 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Macroautophagy |
| REAC:R-HSA-9612973 | 1.54760294566e-11 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Autophagy |
| KEGG:04140 | 2.09582729009e-11 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Autophagy - animal |
| REAC:R-HSA-8953897 | 1.96860593734e-07 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | Cellular responses to external stimuli |
| GO:0000045 | 1.10316613839e-06 | 0.833333333333 | ATG16L1 ATG12 ATG5 ATG7 ATG3 | autophagosome assembly |
| GO:1905037 | 1.17664441353e-06 | 0.833333333333 | ATG16L1 ATG12 ATG5 ATG7 ATG3 | autophagosome organization |
| GO:0016236 | 1.21660050468e-06 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | macroautophagy |
| GO:0019776 | 1.81637152046e-06 | 0.5 | ATG12 ATG3 ATG5 | Atg8 ligase activity |
| GO:0006501 | 7.26438828159e-06 | 0.5 | ATG12 ATG7 ATG5 | C-terminal protein lipidation |
| GO:0007033 | 1.45244802245e-05 | 0.833333333333 | ATG16L1 ATG12 ATG5 ATG7 ATG3 | vacuole organization |
| GO:0061919 | 1.67630347668e-05 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | process utilizing autophagic mechanism |
| GO:0006914 | 1.67630347668e-05 | 1.0 | ATG16L1 ATG5 ATG10 ATG7 ATG12 ATG3 | autophagy |
| GO:0061726 | 0.000154355035659 | 0.666666666667 | ATG5 ATG12 ATG7 ATG3 | mitochondrion disassembly |
| GO:0000422 | 0.000154355035659 | 0.666666666667 | ATG5 ATG12 ATG7 ATG3 | autophagy of mitochondrion |
| GO:0018410 | 0.000299339163023 | 0.5 | ATG12 ATG7 ATG5 | C-terminal protein amino acid modification |
| GO:0006497 | 0.000373722975929 | 0.666666666667 | ATG10 ATG12 ATG7 ATG5 | protein lipidation |
| GO:0042158 | 0.000395345440439 | 0.666666666667 | ATG10 ATG12 ATG7 ATG5 | lipoprotein biosynthetic process |
| GO:1903008 | 0.000666750687757 | 0.666666666667 | ATG5 ATG12 ATG7 ATG3 | organelle disassembly |
| GO:0042157 | 0.000700012687215 | 0.666666666667 | ATG10 ATG12 ATG7 ATG5 | lipoprotein metabolic process |
| REAC:R-HSA-8934903 | 0.000797179114843 | 0.333333333333 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| KEGG:04621 | 0.00105950907114 | 0.5 | ATG16L1 ATG5 ATG12 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5205685 | 0.00377982352449 | 0.333333333333 | ATG12 ATG5 | Pink/Parkin Mediated Mitophagy |
| WP:WP4313 | 0.00390360990759 | 0.333333333333 | ATG7 ATG5 | Ferroptosis |
| KEGG:04216 | 0.00437348887795 | 0.333333333333 | ATG7 ATG5 | Ferroptosis |
| GO:0000407 | 0.00470617323084 | 0.5 | ATG12 ATG7 ATG5 | phagophore assembly site |
| REAC:R-HSA-5205647 | 0.0060953046166 | 0.333333333333 | ATG12 ATG5 | Mitophagy |
| GO:0019777 | 0.00676235117068 | 0.333333333333 | ATG10 ATG3 | Atg12 transferase activity |
| WP:WP3865 | 0.00792327646772 | 0.333333333333 | ATG12 ATG5 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| REAC:R-HSA-936440 | 0.0102563889288 | 0.333333333333 | ATG12 ATG5 | Negative regulators of DDX58/IFIH1 signaling |
| KEGG:04622 | 0.0124835568261 | 0.333333333333 | ATG12 ATG5 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 0.0125813796702 | 0.333333333333 | ATG12 ATG5 | Cytosolic DNA-sensing pathway |
| GO:0034274 | 0.020283420769 | 0.333333333333 | ATG12 ATG5 | Atg12-Atg5-Atg16 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATG16L1 | ATG5 | 0.993 | 0.918 | bioplex_WMM Guru Malo fraction |
| ATG5 | ATG3 | 0.543 | 0.644 | bioplex (ATG3) bioplex_WMM |
| ATG16L1 | ATG3 | 0.482 | 0.612 | bioplex (ATG3) bioplex_WMM |
| ATG3 | ATG12 | 0.47 | 0.605 | bioplex (ATG3) bioplex_WMM |
| ATG10 | ATG12 | 0.232 | 0.47 | bioplex (ATG10) bioplex_WMM |
| ATG7 | ATG10 | 0.042 | 0.27 | bioplex (ATG10) bioplex_WMM |
| ATG7 | ATG3 | 0.015 | 0.142 | bioplex (ATG3,ATG7) bioplex_WMM |
| ATG7 | ATG12 | 0.009 | 0.113 | bioplex_WMM WMM_only |
| ATG16L1 | ATG12 | 0.008 | 0.048 | bioplex_WMM WMM_only |
| ATG5 | ATG7 | 0.008 | 0.01 | bioplex_WMM WMM_only |
| ATG16L1 | ATG7 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| ATG5 | ATG12 | 0.006 | 0.007 | bioplex_WMM fraction |
Images
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Complex HuMAP2_03674 has an average edge precision of 0.321 which is ranked 4336 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATG3 | HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG16L1 | HuMAP2_02085 HuMAP2_02846 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG5 | HuMAP2_02085 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG10 | HuMAP2_03674 HuMAP2_06023 HuMAP2_06855 |
| ATG12 | HuMAP2_03674 HuMAP2_06023 HuMAP2_06855 |
| ATG7 | HuMAP2_03674 HuMAP2_05157 |