hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03676
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2A1 | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | UniProt NCBI |
| CLTB | Clathrin light chain B (Lcb) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5140745 | 0.000130722030065 | 1.0 | CLTB AP2A1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 0.000152509035076 | 1.0 | CLTB AP2A1 | WNT5A-dependent internalization of FZD4 |
| KEGG:04961 | 0.000178724491566 | 1.0 | CLTB AP2A1 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04721 | 0.000322579470084 | 1.0 | CLTB AP2A1 | Synaptic vesicle cycle |
| REAC:R-HSA-3928665 | 0.00173458078356 | 1.0 | CLTB AP2A1 | EPH-ephrin mediated repulsion of cells |
| KEGG:05016 | 0.00224682217969 | 1.0 | CLTB AP2A1 | Huntington disease |
| WP:WP4549 | 0.00244227062941 | 1.0 | CLTB AP2A1 | Fragile X Syndrome |
| KEGG:04144 | 0.00387576825996 | 1.0 | CLTB AP2A1 | Endocytosis |
| REAC:R-HSA-2682334 | 0.00612550025498 | 1.0 | CLTB AP2A1 | EPH-Ephrin signaling |
| REAC:R-HSA-8856825 | 0.00656291627866 | 1.0 | CLTB AP2A1 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-4086400 | 0.00686290657842 | 1.0 | CLTB AP2A1 | PCP/CE pathway |
| REAC:R-HSA-8856828 | 0.0138364241054 | 1.0 | CLTB AP2A1 | Clathrin-mediated endocytosis |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | CLTB AP2A1 | Beta-catenin independent WNT signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CLTB | AP2A1 | 0.688 | 0.713 | hein_WMM bioplex_WMM boldt hein (CLTB) fraction boldt_WMM |
Images
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Complex HuMAP2_03676 has an average edge precision of 0.713 which is ranked 1330 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AP2A1 | HuMAP2_02595 HuMAP2_03676 HuMAP2_06613 HuMAP2_06626 HuMAP2_06848 |
| CLTB | HuMAP2_02565 HuMAP2_03676 HuMAP2_03895 HuMAP2_06848 |