hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03679
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 3.17414367033e-12 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | RUNX3 regulates YAP1-mediated transcription |
| WP:WP3967 | 2.75775910936e-11 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | miR-509-3p alteration of YAP1/ECM axis |
| REAC:R-HSA-2032785 | 9.07805089715e-11 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| KEGG:04392 | 2.70158253491e-10 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Hippo signaling pathway - multiple species |
| WP:WP4542 | 4.15254881274e-10 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4533 | 1.8398005024e-07 | 0.75 | TEAD2 TEAD4 TEAD1 | Transcription co-factors SKI and SKIL protein partners |
| REAC:R-HSA-8878159 | 2.53401411634e-07 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Transcriptional regulation by RUNX3 |
| WP:WP4537 | 2.57005041727e-07 | 0.75 | TEAD2 TEAD4 TEAD1 | Hippo-Yap signaling pathway |
| KEGG:04390 | 2.93370268701e-07 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Hippo signaling pathway |
| GO:0035329 | 1.61120484949e-06 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | hippo signaling |
| WP:WP4534 | 2.40067855039e-06 | 0.75 | TEAD2 TEAD4 TEAD1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP4540 | 2.38151267007e-05 | 0.75 | TEAD2 TEAD4 TEAD1 | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | TEAD2 TEAD4 TEAD1 | Hippo-Merlin Signaling Dysregulation |
| WP:WP2857 | 7.83602997854e-05 | 0.75 | YAP1 TEAD2 TEAD1 | Mesodermal Commitment Pathway |
| GO:0006367 | 0.000819333954364 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | transcription initiation from RNA polymerase II promoter |
| GO:0006352 | 0.00188428573822 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | DNA-templated transcription, initiation |
| GO:0071149 | 0.00270494046827 | 0.5 | YAP1 TEAD2 | TEAD-2-YAP complex |
| GO:0071148 | 0.00270494046827 | 0.5 | YAP1 TEAD1 | TEAD-1-YAP complex |
| GO:0005667 | 0.00406662724791 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | transcription factor complex |
| REAC:R-HSA-212436 | 0.00429443977897 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | RNA Polymerase II Transcription |
| GO:0001085 | 0.0080085486554 | 0.75 | TEAD2 TEAD4 TEAD1 | RNA polymerase II transcription factor binding |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | YAP1 TEAD2 TEAD4 TEAD1 | Gene expression (Transcription) |
| GO:0001134 | 0.0270421395626 | 0.5 | TEAD2 TEAD1 | transcription regulator recruiting activity |
| CORUM:6651 | 0.0499140284799 | 0.25 | YAP1 | WWTR1-YAP1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEAD2 | TEAD4 | 1.0 | 0.949 | bioplex (TEAD2,TEAD4) bioplex_WMM |
| TEAD4 | YAP1 | 1.0 | 0.949 | hein_WMM bioplex (TEAD4) bioplex_WMM hein (YAP1) |
| TEAD4 | TEAD1 | 0.998 | 0.944 | hein_WMM bioplex (TEAD4) bioplex_WMM |
| TEAD2 | TEAD1 | 0.819 | 0.773 | bioplex (TEAD2) bioplex_WMM |
| TEAD2 | YAP1 | 0.169 | 0.426 | bioplex (TEAD2) bioplex_WMM |
| TEAD1 | YAP1 | 0.044 | 0.279 | hein_WMM bioplex_WMM hein (YAP1) |
Images
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Complex HuMAP2_03679 has an average edge precision of 0.72 which is ranked 1310 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TEAD4 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| TEAD2 | HuMAP2_01219 HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 |
| YAP1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 HuMAP2_04805 |