hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03681
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| H4C1 | Histone H4 | UniProt NCBI |
| DAXX | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | UniProt NCBI |
| CHAF1A | Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) | UniProt NCBI |
| ATRX | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | UniProt NCBI |
| ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2839 | 5.02777038712e-06 | 0.5 | DAXX ATRX | ATRX-DAXX complex |
| CORUM:2843 | 5.02777038712e-06 | 0.5 | DAXX ATRX | ATRX-DAXX complex |
| HP:0030446 | 2.27305921704e-05 | 0.5 | DAXX ATRX | Atypical pulmonary carcinoid tumor |
| HP:0030145 | 2.27305921704e-05 | 0.5 | DAXX ATRX | Lack of bowel sounds |
| HP:0012701 | 6.81856710606e-05 | 0.5 | DAXX ATRX | Bowel urgency |
| HP:0030149 | 6.81856710606e-05 | 0.5 | DAXX ATRX | Cardiogenic shock |
| HP:0030445 | 0.000136359131835 | 0.5 | DAXX ATRX | Pulmonary carcinoid tumor |
| HP:0031273 | 0.000136359131835 | 0.5 | DAXX ATRX | Shock |
| HP:0031566 | 0.000227244870274 | 0.5 | DAXX ATRX | Abnormal pulmonary valve cusp morphology |
| HP:0001708 | 0.000340836782771 | 0.5 | DAXX ATRX | Right ventricular failure |
| HP:0030142 | 0.000477128766336 | 0.5 | DAXX ATRX | Abnormal bowel sounds |
| HP:0003144 | 0.000477128766336 | 0.5 | DAXX ATRX | Increased serum serotonin |
| HP:0002248 | 0.000477128766336 | 0.5 | DAXX ATRX | Hematemesis |
| HP:0002044 | 0.000636114718594 | 0.5 | DAXX ATRX | Zollinger-Ellison syndrome |
| HP:0003154 | 0.000636114718594 | 0.5 | DAXX ATRX | Increased circulating ACTH level |
| HP:0004385 | 0.000636114718594 | 0.5 | DAXX ATRX | Protracted diarrhea |
| HP:0007380 | 0.000636114718594 | 0.5 | DAXX ATRX | Facial telangiectasia |
| HP:0025428 | 0.000817788537784 | 0.5 | DAXX ATRX | Bronchospasm |
| HP:0100570 | 0.000817788537784 | 0.5 | DAXX ATRX | Carcinoid tumor |
| HP:0002730 | 0.00102214412276 | 0.5 | DAXX ATRX | Chronic noninfectious lymphadenopathy |
| HP:0025427 | 0.00102214412276 | 0.5 | DAXX ATRX | Abnormal bronchus physiology |
| HP:0002249 | 0.00206626211915 | 0.5 | DAXX ATRX | Melena |
| HP:0002668 | 0.00238393503741 | 0.5 | DAXX ATRX | Paraganglioma |
| HP:0002254 | 0.00238393503741 | 0.5 | DAXX ATRX | Intermittent diarrhea |
| HP:0001891 | 0.00272425312749 | 0.5 | DAXX ATRX | Iron deficiency anemia |
| HP:0025085 | 0.00476530778748 | 0.5 | DAXX ATRX | Bloody diarrhea |
| HP:0011043 | 0.00680514289491 | 0.5 | DAXX ATRX | Abnormality of circulating adrenocorticotropin level |
| HP:0005180 | 0.00680514289491 | 0.5 | DAXX ATRX | Tricuspid regurgitation |
| HP:0031651 | 0.00737157747856 | 0.5 | DAXX ATRX | Abnormal tricuspid valve physiology |
| HP:0100634 | 0.00796059020261 | 0.5 | DAXX ATRX | Neuroendocrine neoplasm |
| HP:0004396 | 0.00796059020261 | 0.5 | DAXX ATRX | Poor appetite |
| HP:0002574 | 0.00857217497701 | 0.5 | DAXX ATRX | Episodic abdominal pain |
| HP:0032148 | 0.00857217497701 | 0.5 | DAXX ATRX | Episodic pain |
| HP:0001931 | 0.00986303631958 | 0.5 | DAXX ATRX | Hypochromic anemia |
| HP:0100007 | 0.01857406376 | 0.5 | DAXX ATRX | Neoplasm of the peripheral nervous system |
| HP:0012700 | 0.0214223630957 | 0.5 | DAXX ATRX | Abnormal large intestine physiology |
| HP:0001641 | 0.0244728799535 | 0.5 | DAXX ATRX | Abnormal pulmonary valve morphology |
| HP:0001962 | 0.0348360947433 | 0.5 | DAXX ATRX | Palpitations |
| HP:0100585 | 0.0400245195282 | 0.5 | DAXX ATRX | Telangiectasia of the skin |
| HP:0030872 | 0.0400245195282 | 0.5 | DAXX ATRX | Abnormal cardiac ventricular function |
| GO:0070087 | 0.0405595771497 | 0.5 | CHAF1A ATRX | chromo shadow domain binding |
| CORUM:3168 | 0.0499140284799 | 0.25 | DAXX | DAXX-AXIN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| H4C1 | ATRX | 0.357 | 0.539 | bioplex (H4C1) boldt |
| DAXX | H4C1 | 0.059 | 0.328 | bioplex (H4C1) |
| CHAF1A | H4C1 | 0.048 | 0.295 | bioplex (H4C1) |
| ATP1A4 | H4C1 | 0.043 | 0.269 | bioplex (H4C1) |
| DAXX | ATRX | 0.023 | 0.207 | hein_WMM bioplex_WMM youn_WMM hein (ATRX,DAXX) |
| CHAF1A | DAXX | 0.009 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| ATP1A4 | ATRX | 0.008 | 0.034 | bioplex_WMM WMM_only |
| ATP1A4 | CHAF1A | 0.008 | 0.015 | bioplex_WMM WMM_only |
| CHAF1A | ATRX | 0.008 | 0.012 | hein_WMM bioplex_WMM youn_WMM hein (CHAF1A) |
| ATP1A4 | DAXX | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_03681 has an average edge precision of 0.181 which is ranked 6424 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| H4C1 | HuMAP2_03681 HuMAP2_06126 |
| DAXX | HuMAP2_03681 HuMAP2_05546 HuMAP2_06126 |
| CHAF1A | HuMAP2_01408 HuMAP2_01768 HuMAP2_02289 HuMAP2_03681 HuMAP2_04079 HuMAP2_06126 |
| ATRX | HuMAP2_03681 HuMAP2_06126 |
| ATP1A4 | HuMAP2_00711 HuMAP2_02155 HuMAP2_02677 HuMAP2_03681 HuMAP2_04770 HuMAP2_06535 HuMAP2_06635 |