hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_03683

Confidence: Medium

Genename	Protein Name	Links
ACD	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein)	UniProt NCBI
TERF1	Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)	UniProt NCBI
TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)	UniProt NCBI
TERF2	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)	UniProt NCBI
DCLRE1B	5' exonuclease Apollo (EC 3.1.-.-) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B)	UniProt NCBI
ARL4D	ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L)	UniProt NCBI
TINF2	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)	UniProt NCBI
CCDC106	Coiled-coil domain-containing protein 106	UniProt NCBI
POT1	Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:138	2.29174218292e-19	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Telomere-associated protein complex
CORUM:1197	2.29174218292e-19	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Telomere-associated protein complex
CORUM:1204	1.60394245013e-18	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Rap1 complex
GO:0070187	2.77300804133e-16	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	shelterin complex
CORUM:1206	5.11711653312e-15	0.555555555556	TINF2 TERF1 TERF2 POT1 TERF2IP	TRF-Rap1 complex I, 2MD
GO:0000782	2.55960491743e-13	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	telomere cap complex
GO:0000783	2.55960491743e-13	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	nuclear telomere cap complex
CORUM:1207	2.54036423996e-12	0.444444444444	TINF2 TERF2 POT1 TERF2IP	TRF2-Rap1 complex II
CORUM:1201	2.54036423996e-12	0.444444444444	TINF2 TERF1 ACD POT1	TRF1-TIN2 complex
CORUM:1198	2.54036423996e-12	0.444444444444	TINF2 TERF2 ACD POT1	TIN2 complex
GO:0016233	8.56659925401e-12	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	telomere capping
REAC:R-HSA-171306	1.97423218389e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Packaging Of Telomere Ends
REAC:R-HSA-110331	2.82975378725e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cleavage of the damaged purine
REAC:R-HSA-110330	2.82975378725e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Recognition and association of DNA glycosylase with site containing an affected purine
REAC:R-HSA-73927	2.82975378725e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Depurination
REAC:R-HSA-110329	4.43161191762e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cleavage of the damaged pyrimidine
REAC:R-HSA-110328	4.43161191762e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-73928	4.43161191762e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Depyrimidination
REAC:R-HSA-73929	4.93244931022e-11	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Base-Excision Repair, AP Site Formation
GO:0070198	1.31200830559e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	protein localization to chromosome, telomeric region
GO:0010833	1.46393051314e-10	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	telomere maintenance via telomere lengthening
REAC:R-HSA-1221632	2.19818241748e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Meiotic synapsis
REAC:R-HSA-2559586	3.03233204985e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-157579	3.53922468215e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Telomere Maintenance
GO:0032205	4.4785279023e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	negative regulation of telomere maintenance
GO:0042162	5.37330376739e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	telomeric DNA binding
REAC:R-HSA-73884	5.50126976973e-10	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Base Excision Repair
REAC:R-HSA-73886	2.07704084707e-09	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Chromosome Maintenance
REAC:R-HSA-1500620	2.89176198029e-09	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Meiosis
GO:0000784	2.90767097061e-09	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	nuclear chromosome, telomeric region
REAC:R-HSA-1474165	5.59253328752e-09	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Reproduction
GO:0000781	9.38607665938e-09	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	chromosome, telomeric region
REAC:R-HSA-73894	1.3992110943e-08	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	DNA Repair
GO:0032211	1.59492880088e-08	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	negative regulation of telomere maintenance via telomerase
GO:0000723	1.61589955315e-08	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	telomere maintenance
GO:0007004	2.73828917822e-08	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	telomere maintenance via telomerase
GO:0032200	2.92016429281e-08	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	telomere organization
GO:0006278	3.00276443181e-08	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	RNA-dependent DNA biosynthetic process
GO:0032204	5.98932251623e-08	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	regulation of telomere maintenance
REAC:R-HSA-2559583	6.05586574879e-08	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cellular Senescence
GO:0034502	7.03431095625e-08	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	protein localization to chromosome
GO:1904357	8.29184516585e-08	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	negative regulation of telomere maintenance via telomere lengthening
GO:2000279	1.46270692304e-07	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	negative regulation of DNA biosynthetic process
CORUM:2766	2.20399991956e-07	0.333333333333	TINF2 TERF2 TERF2IP	TERF2-RAP1 complex
GO:0051053	2.37318717686e-07	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	negative regulation of DNA metabolic process
GO:0031848	3.86783944726e-07	0.444444444444	TERF2IP TERF2 DCLRE1B ACD	protection from non-homologous end joining at telomere
GO:0098505	6.4446669519e-07	0.444444444444	TERF2IP TERF1 POT1 TERF2	G-rich strand telomeric DNA binding
GO:2001251	1.04472952245e-06	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	negative regulation of chromosome organization
GO:0098687	1.1235245653e-06	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	chromosomal region
GO:0060249	1.41190070396e-06	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	anatomical structure homeostasis
GO:0043247	1.51828376741e-06	0.444444444444	TERF2IP TERF2 DCLRE1B ACD	telomere maintenance in response to DNA damage
GO:0098847	1.51828376741e-06	0.444444444444	TERF2IP TERF1 POT1 TERF2	sequence-specific single stranded DNA binding
GO:0043047	1.51828376741e-06	0.444444444444	TERF2IP TERF1 POT1 TERF2	single-stranded telomeric DNA binding
GO:0032993	2.22781748377e-06	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	protein-DNA complex
GO:0032210	2.39978628803e-06	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	regulation of telomere maintenance via telomerase
GO:0071897	2.89179810718e-06	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	DNA biosynthetic process
GO:1904356	5.10531909805e-06	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	regulation of telomere maintenance via telomere lengthening
REAC:R-HSA-2262752	6.26634545565e-06	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cellular responses to stress
CORUM:1205	1.34129279418e-05	0.222222222222	TERF2IP TERF2	TRF2-Rap1 complex III
REAC:R-HSA-8953897	1.84679185574e-05	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cellular responses to external stimuli
GO:0032202	3.05058200216e-05	0.333333333333	TINF2 ACD POT1	telomere assembly
GO:2000278	3.96904562425e-05	0.555555555556	TINF2 TERF1 TERF2 ACD POT1	regulation of DNA biosynthetic process
CORUM:1202	4.02261743042e-05	0.222222222222	TINF2 TERF1	TRF1 telomere length regulation complex
HP:0002894	4.31250122602e-05	0.444444444444	TINF2 TERF2IP ACD POT1	Neoplasm of the pancreas
REAC:R-HSA-1640170	7.49207314556e-05	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	Cell Cycle
GO:0051052	0.00011507797834	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	regulation of DNA metabolic process
HP:0000488	0.000150362377198	0.444444444444	TINF2 TERF2IP ACD POT1	Retinopathy
GO:0033044	0.000153781987065	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	regulation of chromosome organization
GO:0010639	0.000157159195074	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	negative regulation of organelle organization
CORUM:1193	0.0002812304202	0.222222222222	TERF2IP TERF2	Rap1 complex
HP:0000958	0.00032866810835	0.444444444444	TINF2 TERF2IP ACD POT1	Dry skin
GO:0061820	0.00063965474072	0.333333333333	TERF1 POT1 TERF2	telomeric D-loop disassembly
GO:0006259	0.000908515472699	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	DNA metabolic process
HP:0001480	0.00111657431676	0.333333333333	TERF2IP ACD POT1	Freckling
GO:0090657	0.00125570522129	0.333333333333	TERF1 POT1 TERF2	telomeric loop disassembly
HP:0006753	0.00305001064113	0.333333333333	TERF2IP ACD POT1	Neoplasm of the stomach
HP:0002861	0.00321540112157	0.333333333333	TERF2IP ACD POT1	Melanoma
HP:0001732	0.00375616074684	0.444444444444	TINF2 TERF2IP ACD POT1	Abnormality of the pancreas
GO:0051129	0.00414979324147	0.666666666667	ACD TERF2IP TERF2 POT1 TINF2 TERF1	negative regulation of cellular component organization
GO:0051276	0.00574740693261	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	chromosome organization
GO:0044454	0.00574740693261	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	nuclear chromosome part
GO:0070200	0.00619690362803	0.333333333333	TERF1 ACD POT1	establishment of protein localization to telomere
HP:0100013	0.00645186043433	0.333333333333	TERF2IP ACD POT1	Neoplasm of the breast
GO:0000228	0.00690551858738	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	nuclear chromosome
GO:0003697	0.00954888715776	0.444444444444	TERF2IP TERF1 POT1 TERF2	single-stranded DNA binding
GO:1904534	0.0162296428096	0.222222222222	TERF2 TERF1	negative regulation of telomeric loop disassembly
GO:1905838	0.0162296428096	0.222222222222	TERF2 TERF1	regulation of telomeric D-loop disassembly
GO:0031627	0.0162296428096	0.222222222222	DCLRE1B TERF2	telomeric loop formation
GO:0032213	0.0162296428096	0.222222222222	TERF2 TERF1	regulation of telomere maintenance via semi-conservative replication
GO:1905839	0.0162296428096	0.222222222222	TERF2 TERF1	negative regulation of telomeric D-loop disassembly
GO:0048239	0.0162296428096	0.222222222222	TERF2IP TERF2	negative regulation of DNA recombination at telomere
GO:0032214	0.0162296428096	0.222222222222	TERF2 TERF1	negative regulation of telomere maintenance via semi-conservative replication
GO:1905778	0.0162296428096	0.222222222222	TERF2 TERF1	negative regulation of exonuclease activity
GO:0072695	0.0162296428096	0.222222222222	TERF2IP TERF2	regulation of DNA recombination at telomere
GO:1905777	0.0162296428096	0.222222222222	TERF2 TERF1	regulation of exonuclease activity
HP:0003764	0.0166371369698	0.333333333333	TERF2IP ACD POT1	Nevus
GO:0016604	0.0169098023253	0.666666666667	DCLRE1B TERF2IP TERF2 TINF2 TERF1 ACD	nuclear body
HP:0001000	0.0198839923879	0.444444444444	TINF2 TERF2IP ACD POT1	Abnormality of skin pigmentation
GO:0070199	0.0221527855631	0.333333333333	TERF1 ACD POT1	establishment of protein localization to chromosome
CORUM:2219	0.0249698419797	0.111111111111	TERF1	TERF1 homodimer complex
GO:0042592	0.0265853417471	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	homeostatic process
HP:0002745	0.0383405566315	0.222222222222	TINF2 ACD	Oral leukoplakia
HP:0025125	0.0383405566315	0.222222222222	TINF2 ACD	White lesion of the oral mucosa
GO:0044427	0.0384546907947	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	chromosomal part
HP:0001915	0.0425872663121	0.222222222222	TINF2 ACD	Aplastic anemia
HP:0010450	0.0425872663121	0.222222222222	TINF2 ACD	Esophageal stenosis
GO:0003677	0.0479540615773	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	DNA binding
GO:1904533	0.0486736709081	0.222222222222	TERF2 TERF1	regulation of telomeric loop disassembly
GO:0005694	0.049270844601	0.777777777778	DCLRE1B TERF2IP TERF2 POT1 TINF2 TERF1 ACD	chromosome
CORUM:1218	0.0499262710315	0.111111111111	TERF2	BLM-TRF2 complex
CORUM:1217	0.0499262710315	0.111111111111	TERF2	WRN-TRF2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TINF2	TERF1	1.0	0.949	hein_WMM bioplex (TERF1,TINF2) bioplex_WMM hein (TERF1)
TERF2IP	TERF2	1.0	0.949	hein_WMM bioplex_WMM hein (TERF2,TERF2IP) Malo fraction
ACD	POT1	1.0	0.949	hein_WMM bioplex (ACD,POT1) bioplex_WMM hein (POT1)
TINF2	POT1	0.999	0.949	hein_WMM bioplex (POT1,TINF2) bioplex_WMM hein (POT1)
TERF1	POT1	0.999	0.949	hein_WMM bioplex (POT1,TERF1) bioplex_WMM hein (POT1,TERF1)
TERF1	ACD	0.972	0.886	hein_WMM bioplex (TERF1) bioplex_WMM hein (TERF1)
POT1	TERF2	0.839	0.783	hein_WMM bioplex (POT1) bioplex_WMM hein (POT1)
TINF2	ACD	0.709	0.728	hein_WMM bioplex (ACD,TINF2) bioplex_WMM
POT1	TERF2IP	0.651	0.69	hein_WMM bioplex (POT1) bioplex_WMM hein (POT1,TERF2IP)
ACD	TERF2IP	0.154	0.414	hein_WMM bioplex (ACD) bioplex_WMM hein (TERF2IP)
TINF2	TERF2IP	0.113	0.383	hein_WMM bioplex (TINF2) bioplex_WMM
TINF2	TERF2	0.088	0.353	hein_WMM bioplex (TINF2) bioplex_WMM
TERF1	TERF2	0.083	0.35	hein_WMM bioplex_WMM hein (TERF1)
TERF1	TERF2IP	0.047	0.293	hein_WMM bioplex (TERF1) bioplex_WMM hein (TERF1)
ARL4D	TERF2	0.038	0.264	bioplex (ARL4D) bioplex_WMM
DCLRE1B	TERF2	0.031	0.239	hein_WMM hein (DCLRE1B,TERF2)
TINF2	DCLRE1B	0.029	0.231	hein_WMM hein (DCLRE1B)
DCLRE1B	TERF2IP	0.026	0.22	hein_WMM hein (DCLRE1B,TERF2IP)
CCDC106	TERF2IP	0.023	0.209	bioplex (CCDC106) bioplex_WMM
ARL4D	TERF2IP	0.018	0.177	bioplex (ARL4D) bioplex_WMM
DCLRE1B	POT1	0.012	0.147	hein_WMM hein (DCLRE1B)
TERF1	DCLRE1B	0.011	0.145	hein_WMM hein (DCLRE1B,TERF1)
ACD	TERF2	0.011	0.144	hein_WMM bioplex_WMM WMM_only
ACD	DCLRE1B	0.008	0.082	hein_WMM WMM_only
CCDC106	TERF2	0.008	0.024	bioplex (CCDC106) bioplex_WMM

Images

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Complex HuMAP2_03683 has an average edge precision of 0.46 which is ranked 2799 out of all 6965 complexes.

Related Complexes

Genename	Complexes
ACD	HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271
TERF1	HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271
TERF2IP	HuMAP2_01336 HuMAP2_03683 HuMAP2_04123 HuMAP2_06271 HuMAP2_06523
TERF2	HuMAP2_01336 HuMAP2_03683 HuMAP2_04123 HuMAP2_06271 HuMAP2_06523
DCLRE1B	HuMAP2_01336 HuMAP2_03683
ARL4D	HuMAP2_01336 HuMAP2_03683
TINF2	HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271
CCDC106	HuMAP2_01336 HuMAP2_03683
POT1	HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271

hu.MAP 2.0: Complex View

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Complex: HuMAP2_03683