hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03685
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6053 | 5.02777038712e-06 | 1.0 | STK11 STRADA | LKB1-STRAD-MO25 complex |
| REAC:R-HSA-380972 | 0.000633499068778 | 1.0 | STK11 STRADA | Energy dependent regulation of mTOR by LKB1-AMPK |
| WP:WP1403 | 0.000751123964743 | 1.0 | STK11 STRADA | AMP-activated Protein Kinase (AMPK) Signaling |
| KEGG:04152 | 0.000906899134346 | 1.0 | STK11 STRADA | AMPK signaling pathway |
| REAC:R-HSA-165159 | 0.00124185928562 | 1.0 | STK11 STRADA | mTOR signalling |
| KEGG:04150 | 0.00150216111442 | 1.0 | STK11 STRADA | mTOR signaling pathway |
| WP:WP3932 | 0.0121610546673 | 1.0 | STK11 STRADA | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP3595 | 0.0332875339197 | 0.5 | STK11 | mir-124 predicted interactions with cell cycle and differentiation |
| HP:0008204 | 0.0497341708567 | 0.5 | STK11 | Precocious puberty with Sertoli cell tumor |
| HP:0012289 | 0.0497341708567 | 0.5 | STK11 | Facial neoplasm |
| HP:0012720 | 0.0497341708567 | 0.5 | STK11 | Neoplasm of the nose |
| HP:0031261 | 0.0497341708567 | 0.5 | STK11 | Bladder polyp |
| HP:0032451 | 0.0497341708567 | 0.5 | STK11 | Oral melanotic macule |
| HP:0032453 | 0.0497341708567 | 0.5 | STK11 | Abnormal lip pigmentation |
| HP:0032454 | 0.0497341708567 | 0.5 | STK11 | Labial melanotic macule |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STRADA | STK11 | 0.976 | 0.889 | bioplex (STK11) bioplex_WMM |
Images
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Complex HuMAP2_03685 has an average edge precision of 0.889 which is ranked 622 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| STRADA | HuMAP2_00480 HuMAP2_01236 HuMAP2_02924 HuMAP2_03685 HuMAP2_03829 HuMAP2_04879 HuMAP2_05382 HuMAP2_06034 HuMAP2_06078 HuMAP2_06088 |
| STK11 | HuMAP2_00480 HuMAP2_03165 HuMAP2_03685 HuMAP2_04879 HuMAP2_06034 |