hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03697
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | UniProt NCBI |
| MAPK3 | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | UniProt NCBI |
| SUSD4 | Sushi domain-containing protein 4 | UniProt NCBI |
| DHPS | Deoxyhypusine synthase (DHS) (EC 2.5.1.46) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2868 | 1.67963599768e-05 | 0.5 | MAPK3 MAPK1 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| CORUM:6937 | 3.01612206104e-05 | 0.5 | MAPK3 MAPK1 | ARHGEF2-MAPK1-MAPK3-PXN complex |
| CORUM:7504 | 3.01612206104e-05 | 0.5 | MAPK3 MAPK1 | CD44-ERK1-ERK2-RHAMM complex |
| CORUM:6802 | 5.02641999304e-05 | 0.5 | MAPK3 MAPK1 | VEGFR2-S1PR5-ERK1/2-PKC-alpha complex |
| CORUM:6801 | 5.02641999304e-05 | 0.5 | MAPK3 MAPK1 | VEGFR2-S1PR3-ERK1/2-PKC-alpha complex |
| CORUM:6800 | 5.02641999304e-05 | 0.5 | MAPK3 MAPK1 | VEGFR2-S1PR2-ERK1/2-PKC-alpha complex |
| CORUM:6799 | 5.02641999304e-05 | 0.5 | MAPK3 MAPK1 | VEGFR2-S1PR1-ERK1/2-PKC-alpha complex |
| WP:WP4389 | 7.55497829866e-05 | 0.5 | MAPK3 MAPK1 | Bile Acids synthesis and enterohepatic circulation |
| WP:WP3301 | 0.000110786500894 | 0.5 | MAPK3 MAPK1 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| WP:WP1434 | 0.000130917773883 | 0.5 | MAPK3 MAPK1 | Osteopontin Signaling |
| REAC:R-HSA-5674499 | 0.000150779097211 | 0.5 | MAPK3 MAPK1 | Negative feedback regulation of MAPK pathway |
| WP:WP3859 | 0.000176203894069 | 0.5 | MAPK3 MAPK1 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| WP:WP22 | 0.000201357839858 | 0.5 | MAPK3 MAPK1 | IL-9 Signaling Pathway |
| WP:WP734 | 0.000201357839858 | 0.5 | MAPK3 MAPK1 | Serotonin Receptor 4/6/7 and NR3C Signaling |
| REAC:R-HSA-444257 | 0.000211071833435 | 0.5 | MAPK3 MAPK1 | RSK activation |
| WP:WP4560 | 0.000228185108581 | 0.5 | MAPK3 MAPK1 | MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement |
| WP:WP4301 | 0.000256685249648 | 0.5 | MAPK3 MAPK1 | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| WP:WP3879 | 0.000256685249648 | 0.5 | MAPK3 MAPK1 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| REAC:R-HSA-74749 | 0.000281403908969 | 0.5 | MAPK3 MAPK1 | Signal attenuation |
| REAC:R-HSA-170968 | 0.000281403908969 | 0.5 | MAPK3 MAPK1 | Frs2-mediated activation |
| WP:WP4331 | 0.000318702346676 | 0.5 | MAPK3 MAPK1 | Neovascularisation processes |
| WP:WP732 | 0.000318702346676 | 0.5 | MAPK3 MAPK1 | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |
| WP:WP205 | 0.000387405527127 | 0.5 | MAPK3 MAPK1 | IL-7 Signaling Pathway |
| WP:WP3869 | 0.000424263272643 | 0.5 | MAPK3 MAPK1 | Cannabinoid receptor signaling |
| REAC:R-HSA-450341 | 0.000452175281072 | 0.5 | MAPK3 MAPK1 | Activation of the AP-1 family of transcription factors |
| WP:WP2035 | 0.000462791187914 | 0.5 | MAPK3 MAPK1 | Follicle Stimulating Hormone (FSH) signaling pathway |
| WP:WP3668 | 0.000502988822667 | 0.5 | MAPK3 MAPK1 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| WP:WP26 | 0.000502988822667 | 0.5 | MAPK3 MAPK1 | Signal Transduction of S1P Receptor |
| WP:WP581 | 0.000544855726676 | 0.5 | MAPK3 MAPK1 | EPO Receptor Signaling |
| REAC:R-HSA-879415 | 0.000552609179875 | 0.5 | MAPK3 MAPK1 | Advanced glycosylation endproduct receptor signaling |
| REAC:R-HSA-169893 | 0.000552609179875 | 0.5 | MAPK3 MAPK1 | Prolonged ERK activation events |
| WP:WP3995 | 0.000633595541779 | 0.5 | MAPK3 MAPK1 | Prion disease pathway |
| WP:WP2112 | 0.000633595541779 | 0.5 | MAPK3 MAPK1 | IL17 signaling pathway |
| REAC:R-HSA-9627069 | 0.000663071622452 | 0.5 | MAPK3 MAPK1 | Regulation of the apoptosome activity |
| REAC:R-HSA-111458 | 0.000663071622452 | 0.5 | MAPK3 MAPK1 | Formation of apoptosome |
| WP:WP4481 | 0.000729007032317 | 0.5 | MAPK3 MAPK1 | Resistin as a regulator of inflammation |
| REAC:R-HSA-202670 | 0.000783559910601 | 0.5 | MAPK3 MAPK1 | ERKs are inactivated |
| KEGG:05020 | 0.000811520562786 | 0.5 | MAPK3 MAPK1 | Prion diseases |
| WP:WP244 | 0.000884625784373 | 0.5 | MAPK3 MAPK1 | Alpha 6 Beta 4 signaling pathway |
| WP:WP422 | 0.000884625784373 | 0.5 | MAPK3 MAPK1 | MAPK Cascade |
| REAC:R-HSA-1295596 | 0.000914071346391 | 0.5 | MAPK3 MAPK1 | Spry regulation of FGF signaling |
| REAC:R-HSA-111461 | 0.000914071346391 | 0.5 | MAPK3 MAPK1 | Cytochrome c-mediated apoptotic response |
| KEGG:04960 | 0.000929284284868 | 0.5 | MAPK3 MAPK1 | Aldosterone-regulated sodium reabsorption |
| WP:WP313 | 0.000939830639711 | 0.5 | MAPK3 MAPK1 | Signaling of Hepatocyte Growth Factor Receptor |
| WP:WP4553 | 0.000939830639711 | 0.5 | MAPK3 MAPK1 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| WP:WP127 | 0.00117729775616 | 0.5 | MAPK3 MAPK1 | IL-5 Signaling Pathway |
| WP:WP2636 | 0.00117729775616 | 0.5 | MAPK3 MAPK1 | Common Pathways Underlying Drug Addiction |
| REAC:R-HSA-881907 | 0.00120515287053 | 0.5 | MAPK3 MAPK1 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-111471 | 0.00120515287053 | 0.5 | MAPK3 MAPK1 | Apoptotic factor-mediated response |
| WP:WP2332 | 0.00124082421052 | 0.5 | MAPK3 MAPK1 | Interleukin-11 Signaling Pathway |
| WP:WP2526 | 0.00130601363574 | 0.5 | MAPK3 MAPK1 | PDGF Pathway |
| WP:WP49 | 0.00130601363574 | 0.5 | MAPK3 MAPK1 | IL-2 Signaling Pathway |
| WP:WP2036 | 0.00130601363574 | 0.5 | MAPK3 MAPK1 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| KEGG:05219 | 0.00133025918726 | 0.5 | MAPK3 MAPK1 | Bladder cancer |
| KEGG:05216 | 0.00133025918726 | 0.5 | MAPK3 MAPK1 | Thyroid cancer |
| WP:WP2203 | 0.00137286558226 | 0.5 | MAPK3 MAPK1 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| WP:WP364 | 0.00144137960059 | 0.5 | MAPK3 MAPK1 | IL-6 signaling pathway |
| WP:WP286 | 0.00144137960059 | 0.5 | MAPK3 MAPK1 | IL-3 Signaling Pathway |
| WP:WP4535 | 0.0015833920549 | 0.5 | MAPK3 MAPK1 | Envelope proteins and their potential roles in EDMD physiopathology |
| REAC:R-HSA-9634638 | 0.00171688133139 | 0.5 | MAPK3 MAPK1 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| REAC:R-HSA-5654732 | 0.00171688133139 | 0.5 | MAPK3 MAPK1 | Negative regulation of FGFR3 signaling |
| REAC:R-HSA-112409 | 0.00171688133139 | 0.5 | MAPK3 MAPK1 | RAF-independent MAPK1/3 activation |
| REAC:R-HSA-5668599 | 0.00171688133139 | 0.5 | MAPK3 MAPK1 | RHO GTPases Activate NADPH Oxidases |
| REAC:R-HSA-8940973 | 0.00171688133139 | 0.5 | MAPK3 MAPK1 | RUNX2 regulates osteoblast differentiation |
| WP:WP4566 | 0.00173204740358 | 0.5 | MAPK3 MAPK1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP4539 | 0.00180886504004 | 0.5 | MAPK3 MAPK1 | Synaptic signaling pathways associated with autism spectrum disorder |
| WP:WP2795 | 0.00188734205227 | 0.5 | MAPK3 MAPK1 | Cardiac Hypertrophic Response |
| KEGG:04930 | 0.00188834163584 | 0.5 | MAPK3 MAPK1 | Type II diabetes mellitus |
| REAC:R-HSA-982772 | 0.0019074750117 | 0.5 | MAPK3 MAPK1 | Growth hormone receptor signaling |
| REAC:R-HSA-445144 | 0.0019074750117 | 0.5 | MAPK3 MAPK1 | Signal transduction by L1 |
| WP:WP2637 | 0.00196747799108 | 0.5 | MAPK3 MAPK1 | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP195 | 0.00213272485195 | 0.5 | MAPK3 MAPK1 | IL-1 signaling pathway |
| WP:WP2018 | 0.00221783487587 | 0.5 | MAPK3 MAPK1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| WP:WP395 | 0.00221783487587 | 0.5 | MAPK3 MAPK1 | IL-4 Signaling Pathway |
| REAC:R-HSA-198753 | 0.00231867248578 | 0.5 | MAPK3 MAPK1 | ERK/MAPK targets |
| REAC:R-HSA-5654733 | 0.00231867248578 | 0.5 | MAPK3 MAPK1 | Negative regulation of FGFR4 signaling |
| REAC:R-HSA-5654726 | 0.00231867248578 | 0.5 | MAPK3 MAPK1 | Negative regulation of FGFR1 signaling |
| REAC:R-HSA-5654727 | 0.00253927088831 | 0.5 | MAPK3 MAPK1 | Negative regulation of FGFR2 signaling |
| WP:WP4538 | 0.00257484178538 | 0.5 | MAPK3 MAPK1 | Regulatory circuits of the STAT3 signaling pathway |
| WP:WP304 | 0.00257484178538 | 0.5 | MAPK3 MAPK1 | Kit receptor signaling pathway |
| WP:WP4205 | 0.00266823297178 | 0.5 | MAPK3 MAPK1 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04730 | 0.00274845130998 | 0.5 | MAPK3 MAPK1 | Long-term depression |
| REAC:R-HSA-8941326 | 0.00276986547413 | 0.5 | MAPK3 MAPK1 | RUNX2 regulates bone development |
| KEGG:04929 | 0.00285390492132 | 0.5 | MAPK3 MAPK1 | GnRH secretion |
| KEGG:04370 | 0.00296133374321 | 0.5 | MAPK3 MAPK1 | VEGF signaling pathway |
| KEGG:04664 | 0.00296133374321 | 0.5 | MAPK3 MAPK1 | Fc epsilon RI signaling pathway |
| REAC:R-HSA-198725 | 0.00301045354831 | 0.5 | MAPK3 MAPK1 | Nuclear Events (kinase and transcription factor activation) |
| WP:WP4155 | 0.00316000321986 | 0.5 | MAPK3 MAPK1 | Endometrial cancer |
| KEGG:05140 | 0.00318211487745 | 0.5 | MAPK3 MAPK1 | Leishmaniasis |
| KEGG:05213 | 0.00318211487745 | 0.5 | MAPK3 MAPK1 | Endometrial cancer |
| REAC:R-HSA-442742 | 0.00326103241616 | 0.5 | MAPK3 MAPK1 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-2871796 | 0.00326103241616 | 0.5 | MAPK3 MAPK1 | FCERI mediated MAPK activation |
| WP:WP4341 | 0.00326331699224 | 0.5 | MAPK3 MAPK1 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| WP:WP2374 | 0.00336828295894 | 0.5 | MAPK3 MAPK1 | Oncostatin M Signaling Pathway |
| WP:WP3303 | 0.0034749006715 | 0.5 | MAPK3 MAPK1 | RAC1/PAK1/p38/MMP2 Pathway |
| WP:WP2032 | 0.0034749006715 | 0.5 | MAPK3 MAPK1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| WP:WP2324 | 0.0034749006715 | 0.5 | MAPK3 MAPK1 | AGE/RAGE pathway |
| KEGG:05133 | 0.00352808727693 | 0.5 | MAPK3 MAPK1 | Pertussis |
| KEGG:05221 | 0.00352808727693 | 0.5 | MAPK3 MAPK1 | Acute myeloid leukemia |
| KEGG:04720 | 0.00376859643257 | 0.5 | MAPK3 MAPK1 | Long-term potentiation |
| KEGG:05218 | 0.00376859643257 | 0.5 | MAPK3 MAPK1 | Melanoma |
| KEGG:04917 | 0.00376859643257 | 0.5 | MAPK3 MAPK1 | Prolactin signaling pathway |
| REAC:R-HSA-456926 | 0.00379215175563 | 0.5 | MAPK3 MAPK1 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-5654741 | 0.00379215175563 | 0.5 | MAPK3 MAPK1 | Signaling by FGFR3 |
| KEGG:05211 | 0.00389180767222 | 0.5 | MAPK3 MAPK1 | Renal cell carcinoma |
| KEGG:05131 | 0.00401698930658 | 0.5 | MAPK3 MAPK1 | Shigellosis |
| KEGG:05223 | 0.00401698930658 | 0.5 | MAPK3 MAPK1 | Non-small cell lung cancer |
| WP:WP4255 | 0.00403274972955 | 0.5 | MAPK3 MAPK1 | Non-small cell lung cancer |
| REAC:R-HSA-187687 | 0.00407268683926 | 0.5 | MAPK3 MAPK1 | Signalling to ERKs |
| WP:WP4216 | 0.0041492685023 | 0.5 | MAPK3 MAPK1 | Chromosomal and microsatellite instability in colorectal cancer |
| REAC:R-HSA-5654743 | 0.00436320194063 | 0.5 | MAPK3 MAPK1 | Signaling by FGFR4 |
| KEGG:05230 | 0.00440435122993 | 0.5 | MAPK3 MAPK1 | Central carbon metabolism in cancer |
| KEGG:05132 | 0.00440435122993 | 0.5 | MAPK3 MAPK1 | Salmonella infection |
| KEGG:04662 | 0.00440435122993 | 0.5 | MAPK3 MAPK1 | B cell receptor signaling pathway |
| WP:WP2034 | 0.00450871467598 | 0.5 | MAPK3 MAPK1 | Leptin signaling pathway |
| WP:WP2037 | 0.00450871467598 | 0.5 | MAPK3 MAPK1 | Prolactin Signaling Pathway |
| KEGG:05214 | 0.00453740909542 | 0.5 | MAPK3 MAPK1 | Glioma |
| WP:WP4298 | 0.0046318251922 | 0.5 | MAPK3 MAPK1 | Viral Acute Myocarditis |
| REAC:R-HSA-450282 | 0.00466369436644 | 0.5 | MAPK3 MAPK1 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04520 | 0.00467243468204 | 0.5 | MAPK3 MAPK1 | Adherens junction |
| WP:WP1544 | 0.00475658252429 | 0.5 | MAPK3 MAPK1 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04657 | 0.00480942745524 | 0.5 | MAPK3 MAPK1 | IL-17 signaling pathway |
| WP:WP69 | 0.00488298622434 | 0.5 | MAPK3 MAPK1 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04658 | 0.00494838688052 | 0.5 | MAPK3 MAPK1 | Th1 and Th2 cell differentiation |
| KEGG:05212 | 0.00494838688052 | 0.5 | MAPK3 MAPK1 | Pancreatic cancer |
| REAC:R-HSA-2559585 | 0.00497416142364 | 0.5 | MAPK3 MAPK1 | Oncogene Induced Senescence |
| KEGG:01524 | 0.00508931242344 | 0.5 | MAPK3 MAPK1 | Platinum drug resistance |
| WP:WP2059 | 0.00527207105384 | 0.5 | MAPK3 MAPK1 | Alzheimers Disease |
| KEGG:05220 | 0.00537705972469 | 0.5 | MAPK3 MAPK1 | Chronic myeloid leukemia |
| KEGG:01521 | 0.00537705972469 | 0.5 | MAPK3 MAPK1 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP2261 | 0.00553968457037 | 0.5 | MAPK3 MAPK1 | Signaling Pathways in Glioblastoma |
| WP:WP4263 | 0.00567595707464 | 0.5 | MAPK3 MAPK1 | Pancreatic adenocarcinoma pathway |
| WP:WP2355 | 0.00581387281279 | 0.5 | MAPK3 MAPK1 | Corticotropin-releasing hormone signaling pathway |
| WP:WP673 | 0.00595343133727 | 0.5 | MAPK3 MAPK1 | ErbB Signaling Pathway |
| REAC:R-HSA-5663213 | 0.00596538345738 | 0.5 | MAPK3 MAPK1 | RHO GTPases Activate WASPs and WAVEs |
| KEGG:04350 | 0.00597612422935 | 0.5 | MAPK3 MAPK1 | TGF-beta signaling pathway |
| KEGG:04012 | 0.00613079763587 | 0.5 | MAPK3 MAPK1 | ErbB signaling pathway |
| KEGG:05235 | 0.00628743288644 | 0.5 | MAPK3 MAPK1 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-5654736 | 0.00631572211528 | 0.5 | MAPK3 MAPK1 | Signaling by FGFR1 |
| REAC:R-HSA-74751 | 0.00631572211528 | 0.5 | MAPK3 MAPK1 | Insulin receptor signalling cascade |
| REAC:R-HSA-6802948 | 0.00631572211528 | 0.5 | MAPK3 MAPK1 | Signaling by high-kinase activity BRAF mutants |
| WP:WP231 | 0.0063819591539 | 0.5 | MAPK3 MAPK1 | TNF alpha Signaling Pathway |
| WP:WP75 | 0.0063819591539 | 0.5 | MAPK3 MAPK1 | Toll-like Receptor Signaling Pathway |
| KEGG:04912 | 0.00644602944709 | 0.5 | MAPK3 MAPK1 | GnRH signaling pathway |
| KEGG:04914 | 0.00644602944709 | 0.5 | MAPK3 MAPK1 | Progesterone-mediated oocyte maturation |
| WP:WP2431 | 0.00652808434915 | 0.5 | MAPK3 MAPK1 | Spinal Cord Injury |
| KEGG:05210 | 0.00660658678392 | 0.5 | MAPK3 MAPK1 | Colorectal cancer |
| REAC:R-HSA-5675221 | 0.00667602194349 | 0.5 | MAPK3 MAPK1 | Negative regulation of MAPK pathway |
| KEGG:04540 | 0.00693358165081 | 0.5 | MAPK3 MAPK1 | Gap junction |
| KEGG:04620 | 0.00726841321698 | 0.5 | MAPK3 MAPK1 | Toll-like receptor signaling pathway |
| KEGG:04659 | 0.00726841321698 | 0.5 | MAPK3 MAPK1 | Th17 cell differentiation |
| KEGG:04625 | 0.00761107721317 | 0.5 | MAPK3 MAPK1 | C-type lectin receptor signaling pathway |
| KEGG:04713 | 0.00761107721317 | 0.5 | MAPK3 MAPK1 | Circadian entrainment |
| KEGG:05142 | 0.00761107721317 | 0.5 | MAPK3 MAPK1 | Chagas disease (American trypanosomiasis) |
| KEGG:04666 | 0.00761107721317 | 0.5 | MAPK3 MAPK1 | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.00778534503861 | 0.5 | MAPK3 MAPK1 | Choline metabolism in cancer |
| KEGG:04916 | 0.00778534503861 | 0.5 | MAPK3 MAPK1 | Melanogenesis |
| REAC:R-HSA-5674135 | 0.0078166615373 | 0.5 | MAPK3 MAPK1 | MAP2K and MAPK activation |
| KEGG:01522 | 0.00796156937098 | 0.5 | MAPK3 MAPK1 | Endocrine resistance |
| KEGG:04660 | 0.00796156937098 | 0.5 | MAPK3 MAPK1 | T cell receptor signaling pathway |
| KEGG:05215 | 0.00796156937098 | 0.5 | MAPK3 MAPK1 | Prostate cancer |
| KEGG:04933 | 0.00813974967686 | 0.5 | MAPK3 MAPK1 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04668 | 0.00850197607578 | 0.5 | MAPK3 MAPK1 | TNF signaling pathway |
| KEGG:05145 | 0.00868602110226 | 0.5 | MAPK3 MAPK1 | Toxoplasmosis |
| KEGG:04726 | 0.00887201996914 | 0.5 | MAPK3 MAPK1 | Serotonergic synapse |
| KEGG:04725 | 0.00905997214328 | 0.5 | MAPK3 MAPK1 | Cholinergic synapse |
| KEGG:04928 | 0.00924987709158 | 0.5 | MAPK3 MAPK1 | Parathyroid hormone synthesis, secretion and action |
| REAC:R-HSA-6802946 | 0.00947680746611 | 0.5 | MAPK3 MAPK1 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-6802955 | 0.00947680746611 | 0.5 | MAPK3 MAPK1 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| KEGG:04270 | 0.00963554317862 | 0.5 | MAPK3 MAPK1 | Vascular smooth muscle contraction |
| KEGG:04650 | 0.00963554317862 | 0.5 | MAPK3 MAPK1 | Natural killer cell mediated cytotoxicity |
| KEGG:04066 | 0.00983130325145 | 0.5 | MAPK3 MAPK1 | HIF-1 signaling pathway |
| KEGG:04724 | 0.00983130325145 | 0.5 | MAPK3 MAPK1 | Glutamatergic synapse |
| KEGG:04380 | 0.0104302851929 | 0.5 | MAPK3 MAPK1 | Osteoclast differentiation |
| KEGG:04722 | 0.0112562119133 | 0.5 | MAPK3 MAPK1 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.0112562119133 | 0.5 | MAPK3 MAPK1 | Oocyte meiosis |
| WP:WP1449 | 0.0114775392713 | 0.5 | MAPK3 MAPK1 | Regulation of toll-like receptor signaling pathway |
| WP:WP4217 | 0.0114775392713 | 0.5 | MAPK3 MAPK1 | Ebola Virus Pathway on Host |
| KEGG:04071 | 0.0116808588864 | 0.5 | MAPK3 MAPK1 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.0121132892553 | 0.5 | MAPK3 MAPK1 | Platelet activation |
| REAC:R-HSA-375165 | 0.0122651619918 | 0.5 | MAPK3 MAPK1 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-109606 | 0.0122651619918 | 0.5 | MAPK3 MAPK1 | Intrinsic Pathway for Apoptosis |
| KEGG:05135 | 0.0123324218825 | 0.5 | MAPK3 MAPK1 | Yersinia infection |
| KEGG:04919 | 0.0125534987617 | 0.5 | MAPK3 MAPK1 | Thyroid hormone signaling pathway |
| WP:WP3929 | 0.012672821387 | 0.5 | MAPK3 MAPK1 | Chemokine signaling pathway |
| WP:WP3915 | 0.012672821387 | 0.5 | MAPK3 MAPK1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04068 | 0.012776519361 | 0.5 | MAPK3 MAPK1 | FoxO signaling pathway |
| KEGG:04926 | 0.0141554312811 | 0.5 | MAPK3 MAPK1 | Relaxin signaling pathway |
| WP:WP51 | 0.0143575098671 | 0.5 | MAPK3 MAPK1 | Regulation of Actin Cytoskeleton |
| KEGG:04915 | 0.0146305942314 | 0.5 | MAPK3 MAPK1 | Estrogen signaling pathway |
| MIRNA:hsa-miR-550a-3p | 0.0148076193911 | 0.5 | MAPK3 MAPK1 | hsa-miR-550a-3p |
| KEGG:04550 | 0.0148710843718 | 0.5 | MAPK3 MAPK1 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4239 | 0.015016032698 | 0.5 | MAPK3 MAPK1 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04371 | 0.0151135129134 | 0.5 | MAPK3 MAPK1 | Apelin signaling pathway |
| WP:WP2380 | 0.0152387809455 | 0.5 | MAPK3 MAPK1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:04910 | 0.0153578793248 | 0.5 | MAPK3 MAPK1 | Insulin signaling pathway |
| KEGG:04210 | 0.0153578793248 | 0.5 | MAPK3 MAPK1 | Apoptosis |
| REAC:R-HSA-6802949 | 0.0154107631021 | 0.5 | MAPK3 MAPK1 | Signaling by RAS mutants |
| KEGG:04072 | 0.0156041830743 | 0.5 | MAPK3 MAPK1 | Phospholipase D signaling pathway |
| WP:WP4262 | 0.0159167413674 | 0.5 | MAPK3 MAPK1 | Breast cancer pathway |
| REAC:R-HSA-8943724 | 0.0159697215039 | 0.5 | MAPK3 MAPK1 | Regulation of PTEN gene transcription |
| GO:0090170 | 0.0162267366884 | 0.5 | MAPK3 MAPK1 | regulation of Golgi inheritance |
| KEGG:04261 | 0.0163547130378 | 0.5 | MAPK3 MAPK1 | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-5654738 | 0.0165385846138 | 0.5 | MAPK3 MAPK1 | Signaling by FGFR2 |
| KEGG:04062 | 0.016608760826 | 0.5 | MAPK3 MAPK1 | Chemokine signaling pathway |
| KEGG:05224 | 0.016608760826 | 0.5 | MAPK3 MAPK1 | Breast cancer |
| KEGG:05226 | 0.0168647432957 | 0.5 | MAPK3 MAPK1 | Gastric cancer |
| REAC:R-HSA-2029482 | 0.017117349746 | 0.5 | MAPK3 MAPK1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-74752 | 0.017117349746 | 0.5 | MAPK3 MAPK1 | Signaling by Insulin receptor |
| KEGG:04723 | 0.0171226599156 | 0.5 | MAPK3 MAPK1 | Retrograde endocannabinoid signaling |
| WP:WP4666 | 0.0173163427152 | 0.5 | MAPK3 MAPK1 | Hepatitis B infection |
| KEGG:04140 | 0.0173825101547 | 0.5 | MAPK3 MAPK1 | Autophagy - animal |
| KEGG:04921 | 0.0179080093657 | 0.5 | MAPK3 MAPK1 | Oxytocin signaling pathway |
| KEGG:05160 | 0.0181736572757 | 0.5 | MAPK3 MAPK1 | Hepatitis C |
| WP:WP481 | 0.0195247658454 | 0.5 | MAPK3 MAPK1 | Insulin Signaling |
| KEGG:04022 | 0.0195308586359 | 0.5 | MAPK3 MAPK1 | cGMP-PKG signaling pathway |
| KEGG:04934 | 0.0195308586359 | 0.5 | MAPK3 MAPK1 | Cushing syndrome |
| REAC:R-HSA-450294 | 0.0195313767937 | 0.5 | MAPK3 MAPK1 | MAP kinase activation |
| REAC:R-HSA-6802952 | 0.0195313767937 | 0.5 | MAPK3 MAPK1 | Signaling by BRAF and RAF fusions |
| WP:WP4223 | 0.0197782099748 | 0.5 | MAPK3 MAPK1 | Ras Signaling |
| KEGG:04150 | 0.0203683297936 | 0.5 | MAPK3 MAPK1 | mTOR signaling pathway |
| KEGG:04218 | 0.0206513420529 | 0.5 | MAPK3 MAPK1 | Cellular senescence |
| REAC:R-HSA-3371453 | 0.0207977326435 | 0.5 | MAPK3 MAPK1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-9009391 | 0.0214457367555 | 0.5 | MAPK3 MAPK1 | Extra-nuclear estrogen signaling |
| KEGG:05164 | 0.0215119370249 | 0.5 | MAPK3 MAPK1 | Influenza A |
| KEGG:05152 | 0.0220952935316 | 0.5 | MAPK3 MAPK1 | Tuberculosis |
| REAC:R-HSA-190236 | 0.0221036214141 | 0.5 | MAPK3 MAPK1 | Signaling by FGFR |
| KEGG:05010 | 0.0232850911193 | 0.5 | MAPK3 MAPK1 | Alzheimer disease |
| REAC:R-HSA-448424 | 0.0234490216385 | 0.5 | MAPK3 MAPK1 | Interleukin-17 signaling |
| REAC:R-HSA-6811558 | 0.0234490216385 | 0.5 | MAPK3 MAPK1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:05161 | 0.0235873467107 | 0.5 | MAPK3 MAPK1 | Hepatitis B |
| KEGG:05206 | 0.0241976216174 | 0.5 | MAPK3 MAPK1 | MicroRNAs in cancer |
| KEGG:04621 | 0.0245056398731 | 0.5 | MAPK3 MAPK1 | NOD-like receptor signaling pathway |
| KEGG:05225 | 0.0248155779574 | 0.5 | MAPK3 MAPK1 | Hepatocellular carcinoma |
| REAC:R-HSA-438064 | 0.0262582706021 | 0.5 | MAPK3 MAPK1 | Post NMDA receptor activation events |
| REAC:R-HSA-187037 | 0.0262582706021 | 0.5 | MAPK3 MAPK1 | Signaling by NTRK1 (TRKA) |
| KEGG:04360 | 0.0267154932054 | 0.5 | MAPK3 MAPK1 | Axon guidance |
| KEGG:05167 | 0.0267154932054 | 0.5 | MAPK3 MAPK1 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05034 | 0.027038855262 | 0.5 | MAPK3 MAPK1 | Alcoholism |
| KEGG:04024 | 0.0283514541231 | 0.5 | MAPK3 MAPK1 | cAMP signaling pathway |
| REAC:R-HSA-199418 | 0.0284687652941 | 0.5 | MAPK3 MAPK1 | Negative regulation of the PI3K/AKT network |
| WP:WP306 | 0.0290430519819 | 0.5 | MAPK3 MAPK1 | Focal Adhesion |
| KEGG:04015 | 0.0293559966201 | 0.5 | MAPK3 MAPK1 | Rap1 signaling pathway |
| REAC:R-HSA-6802957 | 0.0299917015228 | 0.5 | MAPK3 MAPK1 | Oncogenic MAPK signaling |
| KEGG:05130 | 0.0307221505972 | 0.5 | MAPK3 MAPK1 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2029480 | 0.0315540312145 | 0.5 | MAPK3 MAPK1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-168176 | 0.0331557329305 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0331557329305 | 0.5 | MAPK3 MAPK1 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0331557329305 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 10 (TLR10) Cascade |
| KEGG:04014 | 0.0331864260111 | 0.5 | MAPK3 MAPK1 | Ras signaling pathway |
| KEGG:04810 | 0.0342711457345 | 0.5 | MAPK3 MAPK1 | Regulation of actin cytoskeleton |
| KEGG:05203 | 0.03463652866 | 0.5 | MAPK3 MAPK1 | Viral carcinogenesis |
| KEGG:05205 | 0.03463652866 | 0.5 | MAPK3 MAPK1 | Proteoglycans in cancer |
| REAC:R-HSA-442755 | 0.0347967852364 | 0.5 | MAPK3 MAPK1 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-975138 | 0.0347967852364 | 0.5 | MAPK3 MAPK1 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| KEGG:04510 | 0.0350038155474 | 0.5 | MAPK3 MAPK1 | Focal adhesion |
| REAC:R-HSA-168181 | 0.0356320611636 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-3371556 | 0.0356320611636 | 0.5 | MAPK3 MAPK1 | Cellular response to heat stress |
| REAC:R-HSA-975155 | 0.0356320611636 | 0.5 | MAPK3 MAPK1 | MyD88 dependent cascade initiated on endosome |
| KEGG:05166 | 0.0380105899241 | 0.5 | MAPK3 MAPK1 | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 0.0387812861874 | 0.5 | MAPK3 MAPK1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-168188 | 0.0390714342086 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.0390714342086 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.0390714342086 | 0.5 | MAPK3 MAPK1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| WP:WP3888 | 0.0393304030404 | 0.5 | MAPK3 MAPK1 | VEGFA-VEGFR2 Signaling Pathway |
| WP:WP382 | 0.0393304030404 | 0.5 | MAPK3 MAPK1 | MAPK Signaling Pathway |
| KEGG:05163 | 0.0399515654372 | 0.5 | MAPK3 MAPK1 | Human cytomegalovirus infection |
| REAC:R-HSA-168164 | 0.0399558314157 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | MAPK3 MAPK1 | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.041754071825 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.041754071825 | 0.5 | MAPK3 MAPK1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-166166 | 0.042667909674 | 0.5 | MAPK3 MAPK1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.042667909674 | 0.5 | MAPK3 MAPK1 | TRIF(TICAM1)-mediated TLR4 signaling |
| CORUM:57 | 0.0499140284799 | 0.25 | MAPK1 | HDAC4-ERK2 complex |
| CORUM:55 | 0.0499140284799 | 0.25 | MAPK3 | HDAC4-ERK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK3 | MAPK1 | 0.968 | 0.88 | bioplex_WMM boldt fraction boldt_WMM |
| DHPS | MAPK3 | 0.342 | 0.531 | hein_WMM bioplex_WMM hein (MAPK3) |
| SUSD4 | DHPS | 0.246 | 0.469 | bioplex (SUSD4) bioplex_WMM |
| DHPS | MAPK1 | 0.006 | 0.011 | bioplex_WMM youn_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03697 has an average edge precision of 0.473 which is ranked 2673 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK1 | HuMAP2_01496 HuMAP2_02168 HuMAP2_03697 |
| MAPK3 | HuMAP2_01496 HuMAP2_03697 HuMAP2_06898 |
| SUSD4 | HuMAP2_01255 HuMAP2_02156 HuMAP2_03697 HuMAP2_06898 |
| DHPS | HuMAP2_01255 HuMAP2_02156 HuMAP2_03697 HuMAP2_06898 |