hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03699
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS36 | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) | UniProt NCBI |
| VPS25 | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) | UniProt NCBI |
| SNF8 | Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1187 | 2.25356268047e-10 | 1.0 | VPS25 VPS36 SNF8 | ESCRT-II complex |
| GO:0000814 | 9.08185760231e-08 | 1.0 | VPS25 VPS36 SNF8 | ESCRT II complex |
| GO:0043328 | 3.63274304092e-07 | 1.0 | VPS25 VPS36 SNF8 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0032511 | 9.08185760231e-07 | 1.0 | VPS25 VPS36 SNF8 | late endosome to vacuole transport via multivesicular body sorting pathway |
| REAC:R-HSA-917729 | 2.02093811497e-06 | 1.0 | VPS25 VPS36 SNF8 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0045324 | 2.59741127426e-05 | 1.0 | VPS25 VPS36 SNF8 | late endosome to vacuole transport |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | VPS25 VPS36 SNF8 | Endocytosis |
| GO:0032509 | 8.80032001664e-05 | 1.0 | VPS25 VPS36 SNF8 | endosome transport via multivesicular body sorting pathway |
| GO:0043162 | 0.000103533176666 | 1.0 | VPS25 VPS36 SNF8 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0036452 | 0.000208882724853 | 1.0 | VPS25 VPS36 SNF8 | ESCRT complex |
| GO:0071985 | 0.000265644334868 | 1.0 | VPS25 VPS36 SNF8 | multivesicular body sorting pathway |
| GO:0036258 | 0.000368723418654 | 1.0 | VPS25 VPS36 SNF8 | multivesicular body assembly |
| GO:0036257 | 0.000408229499224 | 1.0 | VPS25 VPS36 SNF8 | multivesicular body organization |
| GO:0072666 | 0.000897287531108 | 1.0 | VPS25 VPS36 SNF8 | establishment of protein localization to vacuole |
| GO:0072665 | 0.00225266395968 | 1.0 | VPS25 VPS36 SNF8 | protein localization to vacuole |
| GO:0007032 | 0.00497140885151 | 1.0 | VPS25 VPS36 SNF8 | endosome organization |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | VPS25 VPS36 SNF8 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | VPS25 VPS36 SNF8 | Vesicle-mediated transport |
| GO:0007034 | 0.0206993698472 | 1.0 | VPS25 VPS36 SNF8 | vacuolar transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS36 | VPS25 | 1.0 | 0.949 | hein_WMM bioplex (VPS36) bioplex_WMM Guru hein (VPS25) fraction |
| VPS36 | SNF8 | 0.999 | 0.949 | hein_WMM bioplex (VPS36) bioplex_WMM hein (SNF8) fraction |
| VPS25 | SNF8 | 0.999 | 0.948 | hein_WMM bioplex_WMM hein (VPS25) fraction |
Images
Click to enlarge
Complex HuMAP2_03699 has an average edge precision of 0.949 which is ranked 347 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS36 | HuMAP2_00588 HuMAP2_03699 HuMAP2_03998 HuMAP2_04660 HuMAP2_05450 HuMAP2_05663 |
| VPS25 | HuMAP2_03699 HuMAP2_03998 HuMAP2_05450 HuMAP2_05663 |
| SNF8 | HuMAP2_03699 HuMAP2_03998 HuMAP2_05450 HuMAP2_05663 |