hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03703
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF4 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | UniProt NCBI |
| ALKBH7 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11) | UniProt NCBI |
| NDUFAF3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | UniProt NCBI |
| NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit) | UniProt NCBI |
| CHDH | Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012748 | 3.79094101603e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Focal T2 hyperintense brainstem lesion |
| HP:0008316 | 4.19668994697e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 5.58518220376e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal brainstem MRI signal intensity |
| REAC:R-HSA-6799198 | 5.97963045475e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Complex I biogenesis |
| HP:0025116 | 6.1081767866e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Fetal distress |
| HP:0011923 | 6.1081767866e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Decreased activity of mitochondrial complex I |
| HP:0007704 | 6.1081767866e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Paroxysmal involuntary eye movements |
| HP:0000114 | 7.24995537039e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Proximal tubulopathy |
| HP:0004366 | 9.21594329683e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormality of glycolysis |
| HP:0003542 | 9.21594329683e-05 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Increased serum pyruvate |
| HP:0011013 | 0.00014151146773 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal circulating carbohydrate concentration |
| HP:0001138 | 0.000205896553803 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Optic neuropathy |
| HP:0003737 | 0.000205896553803 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Mitochondrial myopathy |
| HP:0008972 | 0.000334999316862 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.000351997622505 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal activity of mitochondrial respiratory chain |
| REAC:R-HSA-611105 | 0.000361148609859 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Respiratory electron transport |
| HP:0000817 | 0.000369560169821 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Poor eye contact |
| HP:0003800 | 0.000406414519902 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Muscle abnormality related to mitochondrial dysfunction |
| HP:0002490 | 0.000578226462924 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Increased CSF lactate |
| HP:0030085 | 0.000578226462924 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal CSF lactate level |
| REAC:R-HSA-163200 | 0.000681366686347 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0000124 | 0.000822579716856 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Renal tubular dysfunction |
| HP:0000735 | 0.000853340168558 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Impaired social interactions |
| HP:0025454 | 0.00098402511782 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal CSF metabolite level |
| HP:0002415 | 0.00124354263601 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Leukodystrophy |
| KEGG:04714 | 0.00127045127527 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Thermogenesis |
| HP:0000543 | 0.00159159306632 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Optic disc pallor |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0003287 | 0.00253383203522 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormality of mitochondrial metabolism |
| HP:0012433 | 0.00286833354554 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal social behavior |
| HP:0002421 | 0.00354196137083 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Poor head control |
| HP:0001254 | 0.00354196137083 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Lethargy |
| HP:0002352 | 0.00413295524356 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Leukoencephalopathy |
| HP:0012103 | 0.00431306699981 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormality of the mitochondrion |
| WP:WP4324 | 0.00457029877776 | 0.4 | NDUFAF3 NDUFAF4 | Mitochondrial complex I assembly model OXPHOS system |
| HP:0002363 | 0.00478595596144 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormality of brainstem morphology |
| HP:0003128 | 0.00508554614389 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Lactic acidosis |
| HP:0001943 | 0.00780468270807 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Hypoglycemia |
| HP:0011400 | 0.0090867811499 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal CNS myelination |
| HP:0011015 | 0.00985583118217 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormal blood glucose concentration |
| HP:0002013 | 0.0100146377786 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Vomiting |
| HP:0001298 | 0.0151772229235 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Encephalopathy |
| HP:0001639 | 0.0156015562715 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Hypertrophic cardiomyopathy |
| HP:0000618 | 0.0164736212267 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Blindness |
| GO:0044429 | 0.0210056852384 | 1.0 | ALKBH7 CHDH NDUFAF4 NDUFAF3 NDUFS7 | mitochondrial part |
| HP:0004372 | 0.0295629530581 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Reduced consciousness/confusion |
| GO:0032981 | 0.0324949337356 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | mitochondrial respiratory chain complex I assembly |
| GO:0010257 | 0.0324949337356 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | NADH dehydrogenase complex assembly |
| HP:0001941 | 0.0347361605983 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Acidosis |
| HP:0000819 | 0.0441992691151 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Diabetes mellitus |
| HP:0004360 | 0.0450566918732 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Abnormality of acid-base homeostasis |
| HP:0001952 | 0.0476946051304 | 0.6 | NDUFS7 NDUFAF3 NDUFAF4 | Glucose intolerance |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFS7 | ALKBH7 | 0.087 | 0.353 | bioplex (NDUFS7) bioplex_WMM |
| NDUFS7 | NDUFAF3 | 0.058 | 0.325 | bioplex (NDUFS7) bioplex_WMM boldt youn_WMM boldt_WMM |
| NDUFS7 | CHDH | 0.048 | 0.294 | bioplex (NDUFS7) bioplex_WMM |
| NDUFAF4 | NDUFS7 | 0.03 | 0.235 | bioplex (NDUFS7) bioplex_WMM youn_WMM boldt_WMM |
| NDUFAF4 | NDUFAF3 | 0.011 | 0.148 | bioplex_WMM boldt youn_WMM boldt_WMM |
| CHDH | ALKBH7 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| NDUFAF3 | CHDH | 0.008 | 0.081 | bioplex_WMM WMM_only boldt_WMM |
| NDUFAF3 | ALKBH7 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| NDUFAF4 | ALKBH7 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| NDUFAF4 | CHDH | 0.007 | 0.005 | bioplex_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_03703 has an average edge precision of 0.157 which is ranked 6653 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFAF4 | HuMAP2_00408 HuMAP2_01573 HuMAP2_03703 HuMAP2_04606 HuMAP2_04892 HuMAP2_05273 |
| ALKBH7 | HuMAP2_03301 HuMAP2_03703 |
| NDUFAF3 | HuMAP2_01573 HuMAP2_03301 HuMAP2_03703 HuMAP2_06566 |
| NDUFS7 | HuMAP2_01573 HuMAP2_03301 HuMAP2_03703 HuMAP2_06566 |
| CHDH | HuMAP2_03301 HuMAP2_03703 |