hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_03709
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HIST1H2BO | Histone H2B type 1-O (Histone H2B.2) (Histone H2B.n) (H2B/n) | UniProt NCBI |
| H2AFX | Histone H2AX (H2a/x) (Histone H2A.X) | UniProt NCBI |
| HIST2H2AB | Histone H2A type 2-B | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05322 | 7.04102586614e-06 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | Systemic lupus erythematosus |
| KEGG:05034 | 2.25139851409e-05 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | Alcoholism |
| HPA:022010_13 | 0.00035282228038 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; glial cells[Supported,High] |
| HPA:006010_13 | 0.000698955986725 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; glial cells[Supported,High] |
| HPA:022010_03 | 0.000722964091385 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; glial cells[Uncertain,High] |
| HPA:007020_13 | 0.000772617063281 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in granular layer[Supported,High] |
| HPA:008020_13 | 0.000789659631052 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; glial cells[Supported,High] |
| HPA:027010_13 | 0.000916024778015 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; macrophages[Supported,High] |
| HPA:027020_13 | 0.000954454782405 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; pneumocytes[Supported,High] |
| HPA:047040_12 | 0.001097402545 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; peripheral nerve[Supported,Medium] |
| HPA:022020_13 | 0.00123073367956 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; neuronal cells[Supported,High] |
| HPA:007030_13 | 0.00133752550786 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in molecular layer[Supported,High] |
| REAC:R-HSA-3247509 | 0.00144234915262 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.00144234915262 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | Chromatin organization |
| HPA:006010_03 | 0.00150242567524 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; glial cells[Uncertain,High] |
| HPA:048040_12 | 0.00155576164462 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; peripheral nerve[Supported,Medium] |
| HPA:008020_03 | 0.00170891173618 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; glial cells[Uncertain,High] |
| HPA:027020_03 | 0.00216011757715 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; pneumocytes[Uncertain,High] |
| HPA:007020_03 | 0.00221087569618 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in granular layer[Uncertain,High] |
| HPA:003010_13 | 0.00244002268201 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bone marrow; hematopoietic cells[Supported,High] |
| HPA:007030_03 | 0.00335458489785 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:055010_13 | 0.00346841910953 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.00349149063354 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | testis; cells in seminiferous ducts[Supported,High] |
| HPA:047040_11 | 0.00380079233679 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; peripheral nerve[Supported,Low] |
| HPA:032010_13 | 0.00410204273665 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; exocrine glandular cells[Supported,High] |
| HPA:022010_12 | 0.00417976383173 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; glial cells[Supported,Medium] |
| HPA:018010_13 | 0.0042584604941 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | fallopian tube; glandular cells[Supported,High] |
| HPA:022020_03 | 0.00436491744299 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; neuronal cells[Uncertain,High] |
| HPA:052010_13 | 0.00450046473109 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 2; glandular cells[Supported,High] |
| HPA:051010_13 | 0.00483716412263 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 1; glandular cells[Supported,High] |
| KEGG:04217 | 0.00510487583083 | 0.666666666667 | H2AFX HIST2H2AB | Necroptosis |
| HPA:035020_13 | 0.00513024896348 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.00519025142198 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; glial cells[Supported,Medium] |
| HPA:031020_12 | 0.00528112949206 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:048030_12 | 0.00540394189746 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; fibroblasts[Supported,Medium] |
| HPA:027010_03 | 0.00556011604478 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; macrophages[Uncertain,High] |
| HPA:047030_12 | 0.00575146154485 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; fibroblasts[Supported,Medium] |
| HPA:012010_13 | 0.00578377312656 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | duodenum; glandular cells[Supported,High] |
| HPA:048040_11 | 0.00624892085841 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; peripheral nerve[Supported,Low] |
| HPA:046010_12 | 0.00645567058618 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | smooth muscle; smooth muscle cells[Supported,Medium] |
| HPA:008020_12 | 0.00695571248257 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; glial cells[Supported,Medium] |
| HPA:007020_12 | 0.00748093118123 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in granular layer[Supported,Medium] |
| HPA:047010_11 | 0.00783215433353 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; adipocytes[Supported,Low] |
| HPA:024010_12 | 0.00791166813772 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | kidney; cells in glomeruli[Supported,Medium] |
| HPA:047040_02 | 0.00799171828983 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; peripheral nerve[Uncertain,Medium] |
| HPA:050010_12 | 0.00840007736891 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | spleen; cells in red pulp[Supported,Medium] |
| REAC:R-HSA-171306 | 0.00851790571699 | 0.666666666667 | HIST1H2BO H2AFX | Packaging Of Telomere Ends |
| HPA:027020_12 | 0.00856723853572 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.00899481149022 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skeletal muscle; myocytes[Supported,Medium] |
| HPA:003010_03 | 0.00912580207458 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bone marrow; hematopoietic cells[Uncertain,High] |
| HPA:007030_12 | 0.00916974654685 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:043020_12 | 0.00939158613034 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; fibroblasts[Supported,Medium] |
| HPA:032020_12 | 0.00943637906895 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:043010_12 | 0.00948131420738 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.00948131420738 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; neuronal cells[Supported,Medium] |
| REAC:R-HSA-110331 | 0.00955880978777 | 0.666666666667 | HIST1H2BO H2AFX | Cleavage of the damaged purine |
| REAC:R-HSA-110330 | 0.00955880978777 | 0.666666666667 | HIST1H2BO H2AFX | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-73927 | 0.00955880978777 | 0.666666666667 | HIST1H2BO H2AFX | Depurination |
| HPA:028010_12 | 0.00957161198506 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lymph node; germinal center cells[Supported,Medium] |
| HPA:002020_12 | 0.00961697507504 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | appendix; lymphoid tissue[Supported,Medium] |
| HPA:048040_02 | 0.00966248126625 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; peripheral nerve[Uncertain,Medium] |
| HPA:021010_12 | 0.0104581993752 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | heart muscle; myocytes[Supported,Medium] |
| HPA:009020_12 | 0.0107002782051 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cervix, uterine; squamous epithelial cells[Supported,Medium] |
| HPA:022020_12 | 0.0109460641457 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; neuronal cells[Supported,Medium] |
| REAC:R-HSA-110329 | 0.0110397460449 | 0.666666666667 | HIST1H2BO H2AFX | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-110328 | 0.0110397460449 | 0.666666666667 | HIST1H2BO H2AFX | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73928 | 0.0110397460449 | 0.666666666667 | HIST1H2BO H2AFX | Depyrimidination |
| HPA:004030_12 | 0.011296446043 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | breast; myoepithelial cells[Supported,Medium] |
| MIRNA:hsa-miR-5004-3p | 0.0113615285666 | 0.666666666667 | HIST1H2BO H2AFX | hsa-miR-5004-3p |
| REAC:R-HSA-73929 | 0.011426592715 | 0.666666666667 | HIST1H2BO H2AFX | Base-Excision Repair, AP Site Formation |
| HPA:043040_12 | 0.0116542263866 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; melanocytes[Supported,Medium] |
| HPA:035010_11 | 0.0120194824738 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; decidual cells[Supported,Low] |
| HPA:009010_12 | 0.0121252252686 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cervix, uterine; glandular cells[Supported,Medium] |
| HPA:022010_11 | 0.0124461711303 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; glial cells[Supported,Low] |
| HPA:048030_11 | 0.0125543982526 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; fibroblasts[Supported,Low] |
| REAC:R-HSA-73728 | 0.0126269885924 | 0.666666666667 | HIST1H2BO H2AFX | RNA Polymerase I Promoter Opening |
| HPA:028020_12 | 0.0127727310672 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lymph node; non-germinal center cells[Supported,Medium] |
| HPA:047030_11 | 0.013160878168 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; fibroblasts[Supported,Low] |
| HPA:058010_12 | 0.0133861668291 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | vagina; squamous epithelial cells[Supported,Medium] |
| HPA:027010_12 | 0.013442887875 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; macrophages[Supported,Medium] |
| REAC:R-HSA-5334118 | 0.0134604567412 | 0.666666666667 | HIST1H2BO H2AFX | DNA methylation |
| HPA:003010_12 | 0.013556810201 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bone marrow; hematopoietic cells[Supported,Medium] |
| HPA:056010_12 | 0.0137865820998 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | tonsil; germinal center cells[Supported,Medium] |
| HPA:056020_12 | 0.0137865820998 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | tonsil; non-germinal center cells[Supported,Medium] |
| HPA:043030_12 | 0.0139606044635 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; keratinocytes[Supported,Medium] |
| HPA:031020_11 | 0.0142538853643 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | ovary; ovarian stroma cells[Supported,Low] |
| REAC:R-HSA-5625886 | 0.0143204798819 | 0.666666666667 | HIST1H2BO H2AFX | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| HPA:006010_11 | 0.0146713375688 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; glial cells[Supported,Low] |
| REAC:R-HSA-427359 | 0.0147604473263 | 0.666666666667 | HIST1H2BO H2AFX | SIRT1 negatively regulates rRNA expression |
| HPA:030010_12 | 0.0155305353835 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | oral mucosa; squamous epithelial cells[Supported,Medium] |
| REAC:R-HSA-5693571 | 0.015660289467 | 0.666666666667 | HIST1H2BO H2AFX | Nonhomologous End-Joining (NHEJ) |
| HPA:013010_11 | 0.0157189093358 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | endometrium 1; cells in endometrial stroma[Supported,Low] |
| HPA:008030_12 | 0.0157820374858 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; neuronal cells[Supported,Medium] |
| HPA:007020_11 | 0.0164876369753 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in granular layer[Supported,Low] |
| HPA:043010_11 | 0.0166181455226 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; Langerhans[Supported,Low] |
| HPA:008020_11 | 0.0166836572658 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; glial cells[Supported,Low] |
| HPA:053020_03 | 0.0169474259604 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | testis; cells in seminiferous ducts[Uncertain,High] |
| HPA:055010_03 | 0.0169474259604 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | thyroid gland; glandular cells[Uncertain,High] |
| REAC:R-HSA-606279 | 0.0170598073203 | 0.666666666667 | HIST1H2BO H2AFX | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-774815 | 0.0170598073203 | 0.666666666667 | HIST1H2BO H2AFX | Nucleosome assembly |
| REAC:R-HSA-212300 | 0.0170598073203 | 0.666666666667 | HIST1H2BO H2AFX | PRC2 methylates histones and DNA |
| REAC:R-HSA-2299718 | 0.0170598073203 | 0.666666666667 | HIST1H2BO H2AFX | Condensation of Prophase Chromosomes |
| HPA:043020_11 | 0.0171470665994 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; fibroblasts[Supported,Low] |
| HPA:013020_12 | 0.0171470665994 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | endometrium 1; glandular cells[Supported,Medium] |
| HPA:028010_11 | 0.0176189786249 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lymph node; germinal center cells[Supported,Low] |
| HPA:040010_12 | 0.018238340806 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | seminal vesicle; glandular cells[Supported,Medium] |
| HPA:024010_11 | 0.0183080414715 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | kidney; cells in glomeruli[Supported,Low] |
| HPA:002020_11 | 0.0183080414715 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | appendix; lymphoid tissue[Supported,Low] |
| HPA:018010_03 | 0.0185182085017 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | fallopian tube; glandular cells[Uncertain,High] |
| HPA:007030_11 | 0.0185182085017 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; cells in molecular layer[Supported,Low] |
| REAC:R-HSA-1221632 | 0.0185190091635 | 0.666666666667 | HIST1H2BO H2AFX | Meiotic synapsis |
| REAC:R-HSA-427389 | 0.0185190091635 | 0.666666666667 | HIST1H2BO H2AFX | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| HPA:006020_11 | 0.0185886199409 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; neuronal cells[Supported,Low] |
| HPA:016010_12 | 0.0185886199409 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | esophagus; squamous epithelial cells[Supported,Medium] |
| HPA:032020_11 | 0.0186592096369 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; islets of Langerhans[Supported,Low] |
| HPA:044010_12 | 0.018729977815 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 2; epidermal cells[Supported,Medium] |
| HPA:032010_03 | 0.0188009247007 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; exocrine glandular cells[Uncertain,High] |
| REAC:R-HSA-5693565 | 0.0190186686906 | 0.666666666667 | HIST1H2BO H2AFX | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| HPA:009020_11 | 0.0191583476293 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cervix, uterine; squamous epithelial cells[Supported,Low] |
| HPA:004020_12 | 0.0193025756408 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | breast; glandular cells[Supported,Medium] |
| HPA:022010_02 | 0.0193025756408 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; glial cells[Uncertain,Medium] |
| HPA:009010_11 | 0.0194475256939 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cervix, uterine; glandular cells[Supported,Low] |
| REAC:R-HSA-5693606 | 0.0195249561753 | 0.666666666667 | HIST1H2BO H2AFX | DNA Double Strand Break Response |
| HPA:041010_11 | 0.0196663085449 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skeletal muscle; myocytes[Supported,Low] |
| HPA:046010_11 | 0.0199605629848 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | smooth muscle; smooth muscle cells[Supported,Low] |
| REAC:R-HSA-3214858 | 0.0200378707185 | 0.666666666667 | H2AFX HIST2H2AB | RMTs methylate histone arginines |
| HPA:015010_12 | 0.020183169681 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | epididymis; glandular cells[Supported,Medium] |
| HPA:055010_12 | 0.0202577380419 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | thyroid gland; glandular cells[Supported,Medium] |
| HPA:050010_11 | 0.0202577380419 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | spleen; cells in red pulp[Supported,Low] |
| HPA:053020_12 | 0.0202577380419 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | testis; cells in seminiferous ducts[Supported,Medium] |
| HPA:004030_11 | 0.0203324898428 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | breast; myoepithelial cells[Supported,Low] |
| HPA:032010_12 | 0.0204074253091 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; exocrine glandular cells[Supported,Medium] |
| HPA:026020_11 | 0.0204074253091 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | liver; hepatocytes[Supported,Low] |
| HPA:043040_11 | 0.020482544666 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; melanocytes[Supported,Low] |
| HPA:001040_12 | 0.020482544666 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | adrenal gland; glandular cells[Supported,Medium] |
| HPA:027020_11 | 0.020482544666 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; pneumocytes[Supported,Low] |
| REAC:R-HSA-2559586 | 0.0205574114209 | 0.666666666667 | HIST1H2BO H2AFX | DNA Damage/Telomere Stress Induced Senescence |
| HPA:002010_12 | 0.0207090083348 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | appendix; glandular cells[Supported,Medium] |
| HPA:035020_12 | 0.0207090083348 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; trophoblastic cells[Supported,Medium] |
| HPA:007010_11 | 0.0209371351328 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebellum; Purkinje cells[Supported,Low] |
| HPA:047040_10 | 0.0210135480347 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; peripheral nerve[Supported,Not detected] |
| HPA:029010_12 | 0.0210135480347 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | nasopharynx; respiratory epithelial cells[Supported,Medium] |
| HPA:033010_11 | 0.0210135480347 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | parathyroid gland; glandular cells[Supported,Low] |
| HPA:022020_11 | 0.0212439018034 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | hippocampus; neuronal cells[Supported,Low] |
| REAC:R-HSA-157579 | 0.0216163677069 | 0.666666666667 | HIST1H2BO H2AFX | Telomere Maintenance |
| REAC:R-HSA-9616222 | 0.0227018178396 | 0.666666666667 | HIST1H2BO H2AFX | Transcriptional regulation of granulopoiesis |
| HPA:021010_11 | 0.0228227523244 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | heart muscle; myocytes[Supported,Low] |
| HPA:056010_11 | 0.0229036840703 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | tonsil; germinal center cells[Supported,Low] |
| HPA:028020_11 | 0.0232293243283 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lymph node; non-germinal center cells[Supported,Low] |
| HPA:005010_12 | 0.0233932955771 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bronchus; respiratory epithelial cells[Supported,Medium] |
| HPA:057010_12 | 0.0233932955771 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | urinary bladder; urothelial cells[Supported,Medium] |
| HPA:052010_12 | 0.0233932955771 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 2; glandular cells[Supported,Medium] |
| HPA:011020_12 | 0.0233932955771 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | colon; glandular cells[Supported,Medium] |
| HPA:056030_11 | 0.0234755697703 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | tonsil; squamous epithelial cells[Supported,Low] |
| HPA:018010_12 | 0.0234755697703 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | fallopian tube; glandular cells[Supported,Medium] |
| REAC:R-HSA-912446 | 0.0238137546255 | 0.666666666667 | HIST1H2BO H2AFX | Meiotic recombination |
| HPA:058010_11 | 0.0238898354371 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | vagina; squamous epithelial cells[Supported,Low] |
| HPA:051010_12 | 0.0238898354371 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 1; glandular cells[Supported,Medium] |
| HPA:024020_12 | 0.0240568967711 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | kidney; cells in tubules[Supported,Medium] |
| HPA:045010_12 | 0.0243089462638 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | small intestine; glandular cells[Supported,Medium] |
| HPA:008030_11 | 0.0243089462638 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; neuronal cells[Supported,Low] |
| HPA:043030_11 | 0.0244779535491 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 1; keratinocytes[Supported,Low] |
| HPA:056020_11 | 0.0245627501549 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | tonsil; non-germinal center cells[Supported,Low] |
| HPA:035020_03 | 0.0245627501549 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; trophoblastic cells[Uncertain,High] |
| HPA:037010_12 | 0.02464774237 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | rectum; glandular cells[Supported,Medium] |
| REAC:R-HSA-73884 | 0.0249521708712 | 0.666666666667 | HIST1H2BO H2AFX | Base Excision Repair |
| HPA:030010_11 | 0.0249896718298 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | oral mucosa; squamous epithelial cells[Supported,Low] |
| HPA:012010_12 | 0.0252481838642 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | duodenum; glandular cells[Supported,Medium] |
| HPA:019010_12 | 0.0252481838642 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | gallbladder; glandular cells[Supported,Medium] |
| HPA:014020_11 | 0.0252481838642 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | endometrium 2; glandular cells[Supported,Low] |
| HPA:027010_11 | 0.0254215119053 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | lung; macrophages[Supported,Low] |
| HPA:003010_11 | 0.0254215119053 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bone marrow; hematopoietic cells[Supported,Low] |
| HPA:031020_02 | 0.0255956313976 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | ovary; ovarian stroma cells[Uncertain,Medium] |
| HPA:036010_11 | 0.0255956313976 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | prostate; glandular cells[Supported,Low] |
| HPA:039010_11 | 0.0259462519472 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | salivary gland; glandular cells[Supported,Low] |
| REAC:R-HSA-201722 | 0.0261170593829 | 0.666666666667 | HIST1H2BO H2AFX | Formation of the beta-catenin:TCF transactivating complex |
| REAC:R-HSA-5250924 | 0.0261170593829 | 0.666666666667 | HIST1H2BO H2AFX | B-WICH complex positively regulates rRNA expression |
| HPA:040010_11 | 0.0261227566102 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | seminal vesicle; glandular cells[Supported,Low] |
| HPA:013020_11 | 0.0263890116606 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | endometrium 1; glandular cells[Supported,Low] |
| REAC:R-HSA-73772 | 0.0267094284906 | 0.666666666667 | HIST1H2BO H2AFX | RNA Polymerase I Promoter Escape |
| HPA:004020_11 | 0.0267468242302 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | breast; glandular cells[Supported,Low] |
| HPA:029010_11 | 0.0267468242302 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | nasopharynx; respiratory epithelial cells[Supported,Low] |
| HPA:055010_11 | 0.0267468242302 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | thyroid gland; glandular cells[Supported,Low] |
| HPA:016010_11 | 0.026836779917 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | esophagus; squamous epithelial cells[Supported,Low] |
| HPA:044010_11 | 0.0269269370724 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | skin 2; epidermal cells[Supported,Low] |
| HPA:002010_11 | 0.0272895848861 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | appendix; glandular cells[Supported,Low] |
| REAC:R-HSA-1912408 | 0.0273084129672 | 0.666666666667 | HIST1H2BO H2AFX | Pre-NOTCH Transcription and Translation |
| HPA:032010_11 | 0.0275636972081 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | pancreas; exocrine glandular cells[Supported,Low] |
| HPA:001040_11 | 0.0278396389723 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | adrenal gland; glandular cells[Supported,Low] |
| REAC:R-HSA-8936459 | 0.0279140119136 | 0.666666666667 | HIST1H2BO H2AFX | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| HPA:035020_11 | 0.0282104176401 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; trophoblastic cells[Supported,Low] |
| HPA:052010_03 | 0.0282104176401 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 2; glandular cells[Uncertain,High] |
| HPA:018010_11 | 0.0283036238658 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | fallopian tube; glandular cells[Supported,Low] |
| HPA:053010_11 | 0.0283036238658 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | testis; Leydig cells[Supported,Low] |
| REAC:R-HSA-3214815 | 0.0285262244305 | 0.666666666667 | HIST1H2BO HIST2H2AB | HDACs deacetylate histones |
| REAC:R-HSA-5625740 | 0.0285262244305 | 0.666666666667 | HIST1H2BO H2AFX | RHO GTPases activate PKNs |
| HPA:015010_11 | 0.0286785017641 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | epididymis; glandular cells[Supported,Low] |
| HPA:006010_02 | 0.0289618221432 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | caudate; glial cells[Uncertain,Medium] |
| HPA:011020_11 | 0.0289618221432 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | colon; glandular cells[Supported,Low] |
| REAC:R-HSA-69473 | 0.0291450496188 | 0.666666666667 | HIST1H2BO H2AFX | G2/M DNA damage checkpoint |
| HPA:019010_11 | 0.0292470023876 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | gallbladder; glandular cells[Supported,Low] |
| HPA:057010_11 | 0.0292470023876 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | urinary bladder; urothelial cells[Supported,Low] |
| HPA:053020_11 | 0.0292470023876 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | testis; cells in seminiferous ducts[Supported,Low] |
| HPA:005010_11 | 0.0293424768241 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | bronchus; respiratory epithelial cells[Supported,Low] |
| HPA:037010_11 | 0.0294381588138 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | rectum; glandular cells[Supported,Low] |
| HPA:051010_11 | 0.0298229668107 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 1; glandular cells[Supported,Low] |
| HPA:052010_11 | 0.0306026138628 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 2; glandular cells[Supported,Low] |
| HPA:012010_11 | 0.0307010145504 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | duodenum; glandular cells[Supported,Low] |
| HPA:045010_11 | 0.0308984482754 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | small intestine; glandular cells[Supported,Low] |
| REAC:R-HSA-5693607 | 0.03104119222 | 0.666666666667 | HIST1H2BO H2AFX | Processing of DNA double-strand break ends |
| HPA:024020_11 | 0.0321008510664 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | kidney; cells in tubules[Supported,Low] |
| HPA:051010_03 | 0.0321008510664 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | stomach 1; glandular cells[Uncertain,High] |
| REAC:R-HSA-977225 | 0.033661905203 | 0.666666666667 | HIST1H2BO H2AFX | Amyloid fiber formation |
| HPA:035010_10 | 0.0339623199818 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | placenta; decidual cells[Supported,Not detected] |
| REAC:R-HSA-5578749 | 0.0343335993912 | 0.666666666667 | HIST1H2BO H2AFX | Transcriptional regulation by small RNAs |
| HPA:048020_12 | 0.0348124052904 | 0.666666666667 | H2AFX HIST2H2AB | soft tissue 2; chondrocytes[Supported,Medium] |
| MIRNA:hsa-miR-6822-3p | 0.0350552546403 | 0.666666666667 | HIST1H2BO HIST2H2AB | hsa-miR-6822-3p |
| HPA:048040_10 | 0.0355674233813 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; peripheral nerve[Supported,Not detected] |
| REAC:R-HSA-5250913 | 0.0356968006044 | 0.666666666667 | HIST1H2BO H2AFX | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 0.036388305831 | 0.666666666667 | HIST1H2BO H2AFX | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-2559582 | 0.0370864129386 | 0.666666666667 | HIST1H2BO H2AFX | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-1912422 | 0.037791121028 | 0.666666666667 | HIST1H2BO H2AFX | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-5250941 | 0.0385024292001 | 0.666666666667 | HIST1H2BO H2AFX | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73886 | 0.0385024292001 | 0.666666666667 | HIST1H2BO H2AFX | Chromosome Maintenance |
| REAC:R-HSA-73854 | 0.0392203365557 | 0.666666666667 | HIST1H2BO H2AFX | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 0.0399448421955 | 0.666666666667 | HIST1H2BO H2AFX | RNA Polymerase I Transcription |
| REAC:R-HSA-1500620 | 0.0429088296136 | 0.666666666667 | HIST1H2BO H2AFX | Meiosis |
| REAC:R-HSA-5617472 | 0.0436663131868 | 0.666666666667 | HIST1H2BO H2AFX | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-5619507 | 0.0436663131868 | 0.666666666667 | HIST1H2BO H2AFX | Activation of HOX genes during differentiation |
| HPA:008020_02 | 0.0439784413463 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | cerebral cortex; glial cells[Uncertain,Medium] |
| HPA:012010_03 | 0.0461409386857 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | duodenum; glandular cells[Uncertain,High] |
| HPA:048030_02 | 0.0469207696284 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 2; fibroblasts[Uncertain,Medium] |
| HPA:047010_10 | 0.0475773011709 | 1.0 | HIST2H2AB HIST1H2BO H2AFX | soft tissue 1; adipocytes[Supported,Not detected] |
| REAC:R-HSA-2559580 | 0.0491532487396 | 0.666666666667 | HIST1H2BO H2AFX | Oxidative Stress Induced Senescence |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| H2AFX | HIST1H2BO | 0.978 | 0.894 | bioplex (H2AFX) bioplex_WMM youn_WMM |
| HIST2H2AB | H2AFX | 0.057 | 0.321 | bioplex (H2AFX) bioplex_WMM youn_WMM |
| HIST2H2AB | HIST1H2BO | 0.008 | 0.025 | bioplex_WMM youn_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_03709 has an average edge precision of 0.413 which is ranked 3168 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HIST1H2BO | HuMAP2_00547 HuMAP2_02284 HuMAP2_02818 HuMAP2_03709 HuMAP2_03913 HuMAP2_04053 HuMAP2_06596 |
| H2AFX | HuMAP2_00547 HuMAP2_01156 HuMAP2_02818 HuMAP2_03709 HuMAP2_06596 |
| HIST2H2AB | HuMAP2_00219 HuMAP2_00547 HuMAP2_03607 HuMAP2_03709 HuMAP2_06596 |