hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03710
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | UniProt NCBI |
| GINS1 | DNA replication complex GINS protein PSF1 (GINS complex subunit 1) | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:678 | 4.53449095762e-14 | 1.0 | GINS4 GINS1 GINS2 GINS3 | GINS complex |
| REAC:R-HSA-176974 | 4.48914604804e-11 | 1.0 | GINS4 GINS1 GINS2 GINS3 | Unwinding of DNA |
| REAC:R-HSA-69190 | 3.26120589672e-09 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA strand elongation |
| GO:0006271 | 5.80614360177e-08 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA strand elongation involved in DNA replication |
| GO:0022616 | 2.59227234926e-07 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA strand elongation |
| GO:0000811 | 3.63274304092e-07 | 0.75 | GINS4 GINS2 GINS1 | GINS complex |
| REAC:R-HSA-69239 | 6.95938708355e-07 | 1.0 | GINS4 GINS1 GINS2 GINS3 | Synthesis of DNA |
| REAC:R-HSA-69306 | 9.07725736124e-07 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA Replication |
| REAC:R-HSA-69242 | 2.3250149843e-06 | 1.0 | GINS4 GINS1 GINS2 GINS3 | S Phase |
| GO:0031261 | 3.6323771075e-06 | 0.75 | GINS4 GINS2 GINS1 | DNA replication preinitiation complex |
| GO:0043138 | 0.000132158586819 | 0.75 | GINS4 GINS2 GINS1 | 3'-5' DNA helicase activity |
| GO:0006261 | 0.000252118978237 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA-dependent DNA replication |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | GINS4 GINS1 GINS2 GINS3 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | GINS4 GINS1 GINS2 GINS3 | Cell Cycle |
| GO:0006260 | 0.00184822285327 | 1.0 | GINS4 GINS1 GINS2 GINS3 | DNA replication |
| GO:0003678 | 0.0106004966657 | 0.75 | GINS4 GINS2 GINS1 | DNA helicase activity |
| GO:0004386 | 0.0424904593616 | 0.75 | GINS4 GINS2 GINS1 | helicase activity |
| GO:0008094 | 0.0454154921687 | 0.75 | GINS4 GINS2 GINS1 | DNA-dependent ATPase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GINS1 | GINS4 | 1.0 | 0.949 | bioplex_WMM Malo fraction |
| GINS1 | GINS2 | 1.0 | 0.949 | bioplex_WMM youn_WMM Malo fraction |
| GINS3 | GINS1 | 0.997 | 0.931 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS3 | GINS2 | 0.929 | 0.845 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS4 | GINS2 | 0.66 | 0.697 | bioplex_WMM Malo fraction |
| GINS3 | GINS4 | 0.434 | 0.578 | hein_WMM bioplex (GINS3) bioplex_WMM Guru Malo fraction |
Images
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Complex HuMAP2_03710 has an average edge precision of 0.825 which is ranked 857 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GINS2 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS1 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS4 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS3 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 |