hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_03714
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PKM | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) | UniProt NCBI |
| PRDX2 | Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) | UniProt NCBI |
| ACLY | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4290 | 0.000824391260345 | 0.666666666667 | PKM ACLY | Metabolic reprogramming in colon cancer |
| WP:WP4018 | 0.00302048413579 | 0.666666666667 | PKM ACLY | Pathways in clear cell renal cell carcinoma |
| WP:WP3925 | 0.00365767654025 | 0.666666666667 | PKM ACLY | Amino Acid metabolism |
| MIRNA:hsa-miR-125b-5p | 0.00685635788537 | 1.0 | PKM PRDX2 ACLY | hsa-miR-125b-5p |
| WP:WP2366 | 0.0142843877495 | 0.333333333333 | ACLY | Butyrate-induced histone acetylation |
| CORUM:7403 | 0.0499776345577 | 0.333333333333 | PKM | SREBP-1a-PKM2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PKM | PRDX2 | 0.981 | 0.896 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PKM | ACLY | 0.701 | 0.723 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| ACLY | PRDX2 | 0.004 | 0.011 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_03714 has an average edge precision of 0.543 which is ranked 2243 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PKM | HuMAP2_00276 HuMAP2_01232 HuMAP2_03714 HuMAP2_04933 |
| PRDX2 | HuMAP2_01228 HuMAP2_03714 HuMAP2_03724 HuMAP2_05584 HuMAP2_06137 |
| ACLY | HuMAP2_01206 HuMAP2_03714 HuMAP2_04933 |